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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 2 of 2. This is the beginning of the thread.
Posted by iforgotmypassword on December 28, 2007, at 12:28:56
Memantine produces modest reductions in heroin-induced subjective responses in human research volunteers.
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i don't understand. i figured memantine would increase subjective effects of opiates.
or does it just fight tolerance? does it even do that?
does NMDA antagonism, as with memantine, improve normal opioid function in the brain? i mean, in the sense of keeping things ideally level and not prone to peaks-pitfalls or extremes?
keeping glutamatergic activity under control makes things more constant and more conducive to real life functioning?
Posted by bleauberry on December 28, 2007, at 21:05:57
In reply to Memantine produces modest reductions in heroin-ind, posted by iforgotmypassword on December 28, 2007, at 12:28:56
Ah you ran with my thoughts. I was going to start an inquisitive thread on memantine. I hope we get some good info.
I know memantine has been shown to prevent tolerance to opiates, stimulants, and cannabis. It also significantly reduces withdrawals from those things.
What I'm wondering is if memantine could prevent your own natural tolerance to an antidepressant. For example, any time I start St Johns Wort I get a real nice effect at about day 3. It feels quite dopaminergic to me. After that, it is completely gone and all downhill. I have had the same reaction with a number of meds. I'm wondering if I were to use memantine it would prevent that tolerance, somehow prevent the feedback mechanism from undoing what the med is doing.
Or, the first day I take Ritalin, wow, I'm so much better in mood and energy. Day 2 is only half as good. Day 3 even less than that. I wonder if memantine could keep each day as good as day 1?
> Memantine produces modest reductions in heroin-induced subjective responses in human research volunteers.
>
> http://www.ncbi.nlm.nih.gov/pubmed/17406858?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
>
> -----
>
> i don't understand. i figured memantine would increase subjective effects of opiates.
>
> or does it just fight tolerance? does it even do that?
>
> does NMDA antagonism, as with memantine, improve normal opioid function in the brain? i mean, in the sense of keeping things ideally level and not prone to peaks-pitfalls or extremes?
>
> keeping glutamatergic activity under control makes things more constant and more conducive to real life functioning?
This is the end of the thread.
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Dr. Bob is Robert Hsiung, MD,
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