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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 3 of 3. This is the beginning of the thread.
Posted by Jeroen on December 16, 2007, at 5:09:54
check out this pubmed article, overdose leads to torsades de pointes but not on clinical doses, tested on dogs, and why the hell are you people testing this on DOGS
http://www.ventricular-fibrillation.com/showabstract.php?pmid=12966159
Posted by yxibow on December 21, 2007, at 2:41:50
In reply to sertindole overdose tested on dogs ..., posted by Jeroen on December 16, 2007, at 5:09:54
> check out this pubmed article, overdose leads to torsades de pointes but not on clinical doses, tested on dogs, and why the hell are you people testing this on DOGS
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> http://www.ventricular-fibrillation.com/showabstract.php?pmid=12966159Because torsades-de-pointes is FATAL, it is not your common QTc arrhythmia.
This is the 21st century and while I strongly believe that we should minimize animal use when at all possible (I'm a vegetarian) ultimately the advancement of health (not shoving bunnies with mascara) in man comes first if we are ever to get past the major hurdles in what is the dawn of new medicine. It is something that has to be treated in the cardiac ward and is a do or die disorder for people.
Dogs and mice share certain characteristics with man and alas unfortunately remain candidates in LD50 (50% of X substance caused death for such and such reason) studies. Human testing (Phase I) only begins -after- those lab tests are done, and even those are risky small scale tests.
A lot of life-saving drugs would not have been brought to market without disheartening testing for those of us who love our animal brethren. But if one really believes in that strong enough, don't take them.
One agent that is fortunately in our arsenal, acetaminophen/paracetamol (Tylenol), would never have gotten past today's regulatory environment. It has strong liver issues. But it is the only proven antipyretic besides aspirin.
Ibuprofen (Advil), a newer generation drug and part of the series of NSAIDs that have come from it, is marvelous for things even as strong as injections for kidney stones, but fails shortly as a fever-reducer regardless what the package may say.
Posted by Jeroen on December 21, 2007, at 3:37:07
In reply to Re: sertindole overdose tested on dogs ... » Jeroen, posted by yxibow on December 21, 2007, at 2:41:50
hi, nice info on this one thanks
This is the end of the thread.
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