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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by malcolm64 on May 8, 2007, at 18:39:28
I didn't get any responses the first time around, so I'm reposting this.
I was on as much as 90 mgs a year ago, but my doc adamantly refused to let me go any higher (he later reduced it to 75 mgs). I'm just wondering what the max dose of Nardil anyone has been on for an extended period of time and what the side effects were?
I wonder if that's the reason that the med stopped being effective, and I needed to be on a much higher dose (say, 150 mgs, but I'm really guessing here) for the drug to continue to work. B/C most docs have that handbook of recommended dosages for most meds and are loath to go beyond those recommendations. Perhaps he just needed to be educated and reassured.
Malcolm
Posted by Quintal on May 8, 2007, at 19:17:35
In reply to Max dose of Nardil, posted by malcolm64 on May 8, 2007, at 18:39:28
I've followed these boards for many years and there haven't been many that went beyond the 90mg range. Here's a post from ace the self confessed 'Nardil Whore' on the subject of extreme dosing: http://www.dr-bob.org/babble/20030301/msgs/205921.html
Hopefully the man himself will pop up and explain in more detail?
Q
Posted by ace on May 9, 2007, at 12:28:51
In reply to Re: Max dose of Nardil *Calling ace* ?malcolm64, posted by Quintal on May 8, 2007, at 19:17:35
> I've followed these boards for many years and there haven't been many that went beyond the 90mg range. Here's a post from ace the self confessed 'Nardil Whore' on the subject of extreme dosing: http://www.dr-bob.org/babble/20030301/msgs/205921.html
>
> Hopefully the man himself will pop up and explain in more detail?
>
> QI have popped up!!
OK, the reccoemended maximum dose is 90mg in 98% of momographs. However I have seen in the other 2% I have seen 105mg has been reccomended as maximum dose. Thes %'s are rough, but basically, as you can tell, I'm saying the VAST majority stipulate 90mg as maximum dose.
That being said, I have myself gone up to 150mg (for a brief time). BP did rise, but no other s/effects. However to stay at a dosage greater than 105mg for an extended period of time could very well lead to hepatic problems, ongoing hypertension, and many other problems.
I would not reccomend it. I would say no higher than 105mg.
Hope this helps!
Ace
Posted by malcolm64 on May 9, 2007, at 13:23:10
In reply to Re: Max dose of Nardil *Calling ace* » Quintal, posted by ace on May 9, 2007, at 12:28:51
> > I've followed these boards for many years and there haven't been many that went beyond the 90mg range. Here's a post from ace the self confessed 'Nardil Whore' on the subject of extreme dosing: http://www.dr-bob.org/babble/20030301/msgs/205921.html
> >
> > Hopefully the man himself will pop up and explain in more detail?
> >
> > Q
>
> I have popped up!!
>
> OK, the reccoemended maximum dose is 90mg in 98% of momographs. However I have seen in the other 2% I have seen 105mg has been reccomended as maximum dose. Thes %'s are rough, but basically, as you can tell, I'm saying the VAST majority stipulate 90mg as maximum dose.
>
> That being said, I have myself gone up to 150mg (for a brief time). BP did rise, but no other s/effects. However to stay at a dosage greater than 105mg for an extended period of time could very well lead to hepatic problems, ongoing hypertension, and many other problems.
>
> I would not reccomend it. I would say no higher than 105mg.
>
> Hope this helps!
> Ace
>
>Can you please tell me whether you noticed a theraputic effect from 150 mgs, or was it just an experiment that didn't work? B/C if you noticed any beneficial effect to being on 150 mgs, perhaps it would be worth staying on that high of a dose, with strict monitoring of course.
Come to think of it, are you still on 105 mgs and does it help and if so, how? Does it still produce that hypomanic reaction that's so common when you start MAOI's.
I've really had a very bad day, a job interview didn't go very well, I totally embarassed myself and am getting desperate at my inability to do well at things like these which 95% of the world seems to take for granted. And it's not my imagination.
So to recap, I'm getting desperate for some answers. Why does nothing seem to work for the long term?
Malcolm
Posted by gardenergirl on May 9, 2007, at 14:21:37
In reply to Re: Max dose of Nardil *Calling ace* » Quintal, posted by malcolm64 on May 9, 2007, at 13:23:10
I may have missed you posting this, but have you tried augmenting Nardil? I've had good luck with adding Lamictal and lithium.
gg
Posted by Quintal on May 9, 2007, at 14:30:50
In reply to Re: Max dose of Nardil *Calling ace* » Quintal, posted by malcolm64 on May 9, 2007, at 13:23:10
>So to recap, I'm getting desperate for some answers. Why does nothing seem to work for the long term?
Because of swings and roundabouts - homeostasis and equilibrium. When you upset a system by pushing it in one direction this usually sets in motion a force in the opposite direction that will sooner or later restore equilibrium. This is called homeostasis:
--------------------------------------------------
"Homeostasis is the property of an open system, especially living organisms, to regulate its internal environment to maintain a stable, constant condition, by means of multiple dynamic equilibrium adjustments, controlled by interrelated regulation mechanisms.
http://en.wikipedia.org/wiki/Homeostasis
--------------------------------------------------This phenomena is behind three terms you'll probably be familiar with that are often used when discussing long-term drug use: tolerance, addiction and dependence.
Q
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