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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 10 of 10. This is the beginning of the thread.
Posted by Malcolm64 on May 7, 2007, at 16:29:26
I've written several times on this board on the fantastic result I had with Nardil about a year ago. It vaporized (and there's no other word that can describe it) my social anxiety unlike any med I've ever tried (I'm now experimenting with Parnate, although at 30 mg, I haven't even come close to reaching the theraputic dose). BTW, what is the theraputic dose of Parnate?
My question for other board members is why Nardil had such a short-lived reaction?
B/C for those few weeks, I literally felt on top of the world: there was nothing I felt I couldn't do - make a speech to a group of people, be the head of a nonprofit (or a similar leadership position), approach just about any stranger with virtually no hesitation whatsoever. I felt engaged with the world in a way that I've never felt before, nor since the med stopped working.
Since I don't understand the psychoparmacology of these drugs nor how they work, and I know that there are a few folks in here who probably know more about these meds than many docs, I was hoping that someone would be willing to spend a few minutes explaining the Nardil poop out.
Not to go on and on and on about it, but those few weeks last year will forever be etched in my memory as the happiest I've ever been. I'm just hoping that I can recapture it with the Parnate and augment it with another med so that it continues to work.
But back to my question, why did the Nardil stop working? And if the Parnate achieves a similar result, wll its effect also be short-lived? GOD, I HOPE NOT!!
Posted by Phillipa on May 7, 2007, at 16:34:13
In reply to Why do MAOI's poop out?, posted by Malcolm64 on May 7, 2007, at 16:29:26
Well since it seems a lot ot people want me to start on nardil I'd like to follow your thread is that okay? If not I will never know why this happened. Thanks Phillipa
Posted by Racer on May 7, 2007, at 17:25:20
In reply to Why do MAOI's poop out?, posted by Malcolm64 on May 7, 2007, at 16:29:26
I can't give you anything like a definitive answer, but I can tell you a bit about how they work, and something that might be involved in the short effectiveness you experienced.
OK, so monoamine oxydase (MAO) is a little fellow who scurries around with a little broom to sweep up all the used neurotransmitters after they've delivered their messages. MAOIs stop the production of MAO, so the neurotransmitters stick around in the synapse and repeat their messages. (Obviously, that's not how any text book would describe it, but it's the way it makes most sense to me...)
So, the receptors in your brain are calibrated to the neurotransmitters in your brain. If you suddenly get, say, 20% more serotonin, the serotonin receptors will recalibrate as they adjust, to become about 20% less responsive. That takes some time to happen, but it effects the effectiveness of drugs.
I've never taken an MAOI, and I haven't heard much about MAOIs pooping out, so I can't say that my next thought means anything at all. Someone with some more knowledge than I have will be along, though, to answer better. My guess would be that you didn't achieve quite enough MAO inhibition, and so your receptors could reset back to baseline, and it was as though you hadn't done anything.
That's only one thought, and it's likely wrong. I look forward to seeing what the experts have to say. (But, while that thought may be wrong, the explanation of MAOI activities is pretty accurate, if simplistic...)
Posted by Ines on May 7, 2007, at 17:38:16
In reply to Re: Why do MAOI's poop out?, posted by Racer on May 7, 2007, at 17:25:20
> OK, so monoamine oxydase (MAO) is a little fellow who scurries around with a little broom to sweep up all the used neurotransmitters after they've delivered their messages. MAOIs stop the production of MAO, so the neurotransmitters stick around in the synapse and repeat their messages.What a great way to explain that! You should write science books for young people...
Posted by Honore on May 7, 2007, at 18:10:05
In reply to Re: Why do MAOI's poop out? » Racer, posted by Ines on May 7, 2007, at 17:38:16
Of course, Racer's explanation would apply to any drug you took, not just to Maois. The more interesting question really is why they don't stop working-- which, in many cases, doesn't happen.
I wondered what dose you were taking, and whether you tried to either take more, or use anything to augment the effect, after it became less.
Honore
Posted by malcolm64 on May 7, 2007, at 18:54:04
In reply to Re: Why do MAOI's poop out?, posted by Honore on May 7, 2007, at 18:10:05
> Of course, Racer's explanation would apply to any drug you took, not just to Maois. The more interesting question really is why they don't stop working-- which, in many cases, doesn't happen.
>
> I wondered what dose you were taking, and whether you tried to either take more, or use anything to augment the effect, after it became less.
>
> HonoreAt one point I went up as high as 90 mgs, but then upon my doc's orders he told me to reduce it down to 75 mg. As a I recall, I didn't take anything else to augment the Nardil. Of course, it was over a year ago, so my memory could be faulty on that, but I don't think I ever did.
But as I said, right now I'm taking 30 mgs Parnate along with 1.5 mgs of Klonopin. Since I'm nowhere near the theraputic dose of the Parnate, I'm pretty sure my doc will authorize me to go up on the Parnate (or perhaps Parnate and Klonopin); and I'm going to ask him about going on Xanax XR the next time I see him on May 15th.
Posted by Honore on May 7, 2007, at 19:03:51
In reply to Re: Why do MAOI's poop out?, posted by malcolm64 on May 7, 2007, at 18:54:04
By the way, Michael, a therapeutic dose of Parnate is considered to be between 30-60 mg, although I think most pdocs think it takes 40-60 mg.
Seems like many people here, myself included, needed more than that-- but I assume that the 40-60 mg range is more common.
Honore
Posted by malcolm64 on May 7, 2007, at 20:54:48
In reply to Re: Why do MAOI's poop out? » malcolm64, posted by Honore on May 7, 2007, at 19:03:51
> By the way, Michael, a therapeutic dose of Parnate is considered to be between 30-60 mg, although I think most pdocs think it takes 40-60 mg.
>
> Seems like many people here, myself included, needed more than that-- but I assume that the 40-60 mg range is more common.
>
> HonoreHonore: Can you tell me how many mgs of Parnate you take daily? And has it come with any side effects? For example, are you more prone to headaches, or other symptoms of hypertensive reactions? What about insomnia (the most common side effect of the MAOI's)? Are you experiencing any problems sleeping? And if so, what meds are you talking to counteract the insomnia?
Basically, anything and everything you can tell me about your experience with Parnate at whatever dose you're taking would really be a HUGE help!!
And btw, how did you get your doc to agree to prescribe more than the recommended dose?
Malcolm
Posted by UgottaHaveHope on May 8, 2007, at 0:58:07
In reply to Re: Why do MAOI's poop out?, posted by malcolm64 on May 7, 2007, at 20:54:48
I know at least five ppl who have been taking Nardil since the 1970s.
Posted by medievil on May 11, 2007, at 7:03:06
In reply to Re: Why do MAOI's poop out?, posted by malcolm64 on May 7, 2007, at 20:54:48
inositol might be able to reverse poop out, but it hasnt been tried yet so i cant tell
it does upregulate receptors tough
This is the end of the thread.
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