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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 18 of 18. This is the beginning of the thread.
Posted by jenny80 on April 27, 2007, at 6:36:03
I have tried everything so far for this TRD. Don't know what else to do.
Tried the SSRIs and SNRIS. tried parnate and nardil both gave me intolerable cold and shivering.
Is there anything else for me to try that will last? I don't think i can take this pain anymore.
Posted by linkadge on April 27, 2007, at 7:19:42
In reply to feel i have reached the end, posted by jenny80 on April 27, 2007, at 6:36:03
You can't say that nardil didn't work, only that you couldn't tollerate it for long enough to see. Nardil can take longer to work than other antidepressants.
You still havn't tried the TCA's. Lamotrigine is another option, as is psychostimulant augmentation. Reboxetine is also worth a try if you are in a country that prescribes it.
Linkadge
Posted by jenny80 on April 27, 2007, at 7:30:14
In reply to Re: feel i have reached the end, posted by linkadge on April 27, 2007, at 7:19:42
i can handle the sideeffects except for the shivering and coldness. at nights i am sweating with heat. its driving me mad. It really upsets me as i had such high hopes for it to work. As far as i know this sideeffect does not go away with time.
Have tried lamotrigine but no effect. guess i have not tried reboxetine.
most people on this website seem to only hold MAOIs as being effective.
Posted by Deniseuk190466 on April 27, 2007, at 8:04:07
In reply to Re: feel i have reached the end, posted by jenny80 on April 27, 2007, at 7:30:14
Hi Jenny,
Don't give up, I know it's easy to say and in a few days time I'll probably feel like giving up again too.
I was resistant to medication for two years (including Nardil) and then for some inexplicable reason Seroxat 40mg started to work, even though I'd tried it at 20mg two years previously. Unfortunately it stopped working in 2005.
I am at the end of the tether a lot of the time. I do have thoughts of suicide and the only drug which helps and has kept me going (when taken either now and again or regularly) has been Zyprexa.
I still feel depressed but the Zyprexa helps me when I feel really bad.
There is going to be something out there that works for you. I have to tell myself that as well.
Denise
Posted by linkadge on April 27, 2007, at 8:05:56
In reply to Re: feel i have reached the end, posted by jenny80 on April 27, 2007, at 7:30:14
Were you taking an SSRI before you started the MAOI? The shivering sounds like a symptom of serotoin syndrome. If you didn't allow a long enough wash out between a SSRI and MAOI, you the shivering may be a symptom of serotoin syndrome.
Linkadge
Posted by jenny80 on April 27, 2007, at 8:23:08
In reply to Re: feel i have reached the end, posted by linkadge on April 27, 2007, at 8:05:56
No i wasn't on an SSRI before. i tried parnate before this but stopped them 1 month before starting nardil. i have tried so far cipramil, escitalopram, mirtazapin, venlafaxine, duloxetine, lamotrigine, sulpiride, buspirone, fluxoetine and parnate and nardil.
from what ive read the cold and shivering can be a side effect from MAOi may be because they are related to amphetamines. i am thinking of trying transcranial magnetic stimulation. anyome have any experience ?
Posted by Deniseuk190466 on April 27, 2007, at 8:38:37
In reply to Re: feel i have reached the end, posted by jenny80 on April 27, 2007, at 7:30:14
Also,
The worst thing about this condition is that you don't even know what it is you are trying to fight so people say don't give up but you wonder "don't give up what exactly".
At least if you are trying to climb a mountain you can see the top at the end of the journey and you know what you need to do in order to get to the top and when you get to the top you know you are there. People say the same thing in a way with depression "take small steps". I do that every day just keep taking small steps but it doesn't seem to get me any where because I don't feel any better for it.
Even so just try and keep going, do what you can and keep trying everything there is to try.
Denise
Posted by polarbear206 on April 27, 2007, at 8:50:40
In reply to Re: feel i have reached the end, posted by jenny80 on April 27, 2007, at 8:23:08
> No i wasn't on an SSRI before. i tried parnate before this but stopped them 1 month before starting nardil. i have tried so far cipramil, escitalopram, mirtazapin, venlafaxine, duloxetine, lamotrigine, sulpiride, buspirone, fluxoetine and parnate and nardil.
> from what ive read the cold and shivering can be a side effect from MAOi may be because they are related to amphetamines. i am thinking of trying transcranial magnetic stimulation. anyome have any experience ?Have you tried a mood stabilizer on a ROUTINE basis with an antidepressant?
Polarbear
Posted by jenny80 on April 27, 2007, at 8:59:59
In reply to Re: feel i have reached the end » jenny80, posted by polarbear206 on April 27, 2007, at 8:50:40
No i haven't yet. Do you think this will work. I have dysthymia/depression. no manic episodes at all.
Posted by polarbear206 on April 27, 2007, at 9:15:13
In reply to Re: feel i have reached the end, posted by jenny80 on April 27, 2007, at 8:59:59
> No i haven't yet. Do you think this will work. I have dysthymia/depression. no manic episodes at all.
Bipolar spectrum disorders are so misunderstood. Many people walk around wondering why there depression isn't responding to multiple AD trials when this COULD be the underlying problem. You don't have to have full blown mania or hypomania to have this disorder. It may show up as agitation, anger, anxiety, or so subltle that it is easily missed by a doctor. Are you seeing a p-doc? If you haven't gone this route, I would stongly suggest you consider this. You are never going to know unless you try. I will give you some links for further education if you would like. There is also some very good books out there written by top psychiatrist in the field if you are interested. Please, Please, don't give up!! If you don't mind, can you give me a little more of your history? Age of onset, family history, symptoms, etc...
Polarbear
Posted by linkadge on April 27, 2007, at 9:22:26
In reply to Re: feel i have reached the end » jenny80, posted by polarbear206 on April 27, 2007, at 9:15:13
>Many people walk around wondering why there >depression isn't responding to multiple AD >trials when this COULD be the underlying problem.
Or it could just be that antidepressants suck! *More than half* of all published clinical trials fail to show that antidepressants are more effective than placebo.
I think a lot of people are simply experiencing the reality of things.
Linkadge
Posted by jenny80 on April 27, 2007, at 9:28:04
In reply to Re: feel i have reached the end, posted by linkadge on April 27, 2007, at 9:22:26
I thought about bipolar so went on lamotrigine for 2 months but no effect.
I am 26. It started when I was 17 gradually feeling more withdrawn, tired and could not be motivated to attend my classes.
Went on to develop body dysmorphic disorder and anorexia. Now just plain old depression. So far i have had no response whatsoever from any medication.
i am seeing a doc who has just about given up on me. I am from the UK and thinking about flying over the US for TMS as we don't have that here yet.
Posted by polarbear206 on April 27, 2007, at 9:33:44
In reply to Re: feel i have reached the end, posted by jenny80 on April 27, 2007, at 9:28:04
> I thought about bipolar so went on lamotrigine for 2 months but no effect.
> I am 26. It started when I was 17 gradually feeling more withdrawn, tired and could not be motivated to attend my classes.
> Went on to develop body dysmorphic disorder and anorexia. Now just plain old depression. So far i have had no response whatsoever from any medication.
> i am seeing a doc who has just about given up on me. I am from the UK and thinking about flying over the US for TMS as we don't have that here yet.How much were you on and what AD were you taking with it at the time. Why not a p-doc? Is your family supportive?
Posted by Phillipa on April 27, 2007, at 10:09:37
In reply to Re: feel i have reached the end » jenny80, posted by polarbear206 on April 27, 2007, at 9:33:44
Have you considered VNS? Love Phillipa
Posted by linkadge on April 27, 2007, at 10:45:00
In reply to Re: feel i have reached the end, posted by Phillipa on April 27, 2007, at 10:09:37
I would certainly consider the TCA's. With anorexia, I would think that doxapin or amitryptaline might be worth a shot, if you have experienced marked weight loss.
Somtimes the SSRI's can make anorexia worse.
I certainly found the TCA's more effective than the SSRI's for depression.
Linkadge
Posted by football on April 27, 2007, at 12:57:41
In reply to feel i have reached the end, posted by jenny80 on April 27, 2007, at 6:36:03
Have you done ECT?
Posted by jenny80 on April 27, 2007, at 13:16:11
In reply to Re: feel i have reached the end, posted by football on April 27, 2007, at 12:57:41
No i haven't. Im kind of worried about the effects on my memory.
I have read all your posts about nardil and was so pleased to start on it. I took my last dose last night and still feel shivery cold. My depression has become much worse over night. I have been crying uncontrollably all day with only these messages to keep me sane.
Has any one found that they had the cold shiver type effects on the MAOIs? Also i have found that my depression has become much worse on nardil and parnate but obviously did not give it long enough.
Anyone have worsening depression to start off with ?
Posted by football on April 27, 2007, at 23:27:13
In reply to Re: feel i have reached the end, posted by jenny80 on April 27, 2007, at 13:16:11
Don't give up. You're stronger then the side-effects.
This is the end of the thread.
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