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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 8 of 8. This is the beginning of the thread.
Posted by Tom Twilight on April 5, 2007, at 4:26:18
I was thinking of adding a low dose of Emsam or Sellegiline Citrate (Liquid Sellegiline) to my Nardil.
Something tells me that I need more Dopamine!
I'm an absolute Caffeine addict now I'm on Nardil, because although I'm no longer depressed I'm tired & Lazy all the time.
It seems to make my ADD tendencies worse.I've combined low dose Methylphenidate to Nardil no problem.
However I wary of Sellegiline because its an MAOI inhibitor & its related to PEA.I won't try Sellegiline tabs because they metabolise to L-Amphetamine-Bad idea with MAOI's
Posted by djmmm on April 5, 2007, at 6:15:31
In reply to Emsam with Nardil?, posted by Tom Twilight on April 5, 2007, at 4:26:18
> I was thinking of adding a low dose of Emsam or Sellegiline Citrate (Liquid Sellegiline) to my Nardil.
>
> Something tells me that I need more Dopamine!
>
> I'm an absolute Caffeine addict now I'm on Nardil, because although I'm no longer depressed I'm tired & Lazy all the time.
> It seems to make my ADD tendencies worse.
>
> I've combined low dose Methylphenidate to Nardil no problem.
> However I wary of Sellegiline because its an MAOI inhibitor & its related to PEA.
>
> I won't try Sellegiline tabs because they metabolise to L-Amphetamine-Bad idea with MAOI'sInteresting... one thing about selegiline is that it comes in liquid form (Liquid Deprenyl Citrate-- a med I use) allowing you to take smaller doses.
As far as I know, LDC is still metabolized into amphetamine, although at lower concentrations than the tablet form. You have a far greater chance of having an adverse reaction to ritalin (with Nardil) then you do with the very small amount of l-amphetamine metabolized from LDC.
I think you may run into other problems combining selegiline and nardil (independent of MAO-B inhibition) Plus, I think your reasoning for the combo may be wrong... If increasing dopamine levels is your goal, adding ritalin should have helped.
As far as your PEA (phenylethylamine) concern, it is true selegiline is related to PEA, but so are MANY drugs, including all of the amphetamines, wellbutrin, and effexor.. also, Nardil is metabolized into PEA.
Have you considered switching to Parnate?
Posted by Tom Twilight on April 5, 2007, at 11:35:56
In reply to Re: Emsam with Nardil?, posted by djmmm on April 5, 2007, at 6:15:31
I'll respond to the points you've raised
Firstly I have tried Parnate, but it made me very tired, bizarley.
Secondly Ritalin does work-
however I live in the UK where doctors are extremely stimulant Phobic!
Therefore I have a very limmited supply which I was able to obtain online.I like the affects or Ritalin, however they are very short lived & feel kind of Yucky after it wears off.
I am looking for a smoother dopamine raising affect.
In a perfect world I would add low dose Dexedrine maybe, but try getting that prescribed here!
Oddly I had a Hypertensive reaction to PEA powder
Posted by djmmm on April 5, 2007, at 13:08:35
In reply to Re: Emsam with Nardil?, posted by Tom Twilight on April 5, 2007, at 11:35:56
You had a bad response to PEA powder because PEA is also metabolized by MAO-A.
Oxidation of Phenylethylamine by Both Types of Monoamine Oxidase: Examination of Enzymes in Brain and Liver Mitochondria of Eight Species
Posted by Declan on April 5, 2007, at 18:46:24
In reply to Emsam with Nardil?, posted by Tom Twilight on April 5, 2007, at 4:26:18
Is it true that selegeline/deprenyl somehow undoes the benefit you get from Nardil and the <o dear, a senior moment. What's the brain thingo Nardil affects but not parnate?>, well that one.
Someone who is able to be more coherant than me said this once.
Posted by djmmm on April 6, 2007, at 6:29:05
In reply to Re: Emsam with Nardil? » Tom Twilight, posted by Declan on April 5, 2007, at 18:46:24
> Is it true that selegeline/deprenyl somehow undoes the benefit you get from Nardil and the <o dear, a senior moment. What's the brain thingo Nardil affects but not parnate?>, well that one.
>
> Someone who is able to be more coherant than me said this once.I think you're talking about GABA... Nardil effects GABA levels-- unique among antidepressants.
Posted by Declan on April 6, 2007, at 21:03:34
In reply to Re: Emsam with Nardil?, posted by djmmm on April 6, 2007, at 6:29:05
I think the idea was that taking deprenyl with Nardil might undo the GABA effect of Nardil.
Posted by psychobot5000 on April 7, 2007, at 22:34:37
In reply to Emsam with Nardil?, posted by Tom Twilight on April 5, 2007, at 4:26:18
I think that taking two MAOis together is considered more dangerous than adding a stimulant. I'd be more worried by the selegiline than any amphetamine metabolites...
This is the end of the thread.
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