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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 43 to 67 of 71. Go back in thread:
Posted by Squiggles on February 7, 2007, at 19:46:27
In reply to Re: Benzo Confidential - clonazepam's history » Phillipa, posted by laima on February 7, 2007, at 19:18:50
Do you people who are prescribed benzos,
take them every day or when/as needed;
that may be the missing link. I was/am
prescribed K every single day-- it's been
about 17 yrs. now taking 0.5-1.50mg. Still
can't figure out how w/d almost killed me
with a seizure/stroke-- maybe the anti-benzo
poltergeists were responsible.Squiggles
Posted by Phillipa on February 7, 2007, at 21:18:22
In reply to Re: Benzo Confidential - clonazepam's history, posted by Squiggles on February 7, 2007, at 19:46:27
Squiggles it must have been them just kidding. Love Phillipa
Posted by Squiggles on February 8, 2007, at 7:48:26
In reply to Re: Benzo Confidential - clonazepam's history » Squiggles, posted by Phillipa on February 7, 2007, at 21:18:22
> Squiggles it must have been them just kidding. Love Phillipa
Yeah, i'm not sure i got the joke.
Here's a neighbourhood find:
1: Prog Neuropsychopharmacol Biol Psychiatry. 1983;7(4-6):669-73. Links
New concepts in benzodiazepine therapy: rebound anxiety and new indications for the more potent benzodiazepines.* Chouinard G,
* Labonte A,
* Fontaine R,
* Annable L.Abrupt withdrawal of benzodiazepine treatment in generalized anxiety patients was found to induce a rebound anxiety state in addition to minor physical symptoms. Controlled clinical trials suggest that the newer high potency benzodiazepines (alprazolam, clonazepam and bromazepam) have novel psychiatric indications and greater anxiolytic effect than the classical benzodiazepines. Alprazolam, a triazolobenzodiazepine, was superior to placebo in the treatment of panic disorder, for which medium or low potency benzodiazepines are generally inefficacious. Clonazepam, an anticonvulsant which increases 5HT synthesis, was more efficacious than lithium in reducing manic symptoms. Bromazepam, a new potent benzodiazepine, was superior to diazepam in the treatment of generalized anxiety disorder.
PMID: 6141609 [PubMed - indexed for MEDLINE]
Dr. Chouinard seems to be the local expert on this. He shows interest in the application of benzos to various psychiatric conditions. I'm not sure if I would volunteer as a guinea pig for clonazepam monotherapy for bipolar, though he does qualify it for 'manic symptoms' and not the entire spectrum. But *that* he suggests it, at least show how exceptional clonazepam must be, not just on the grounds of its potency, but its chemical idiosyncrasy.
Squiggles
Posted by laima on February 8, 2007, at 7:59:21
In reply to Re: Benzo Confidential - clonazepam's history, posted by Squiggles on February 7, 2007, at 19:46:27
If you guys are referring to anything I wrote, not kidding- sudden withdrawal from higher dose of klonopin/clonazapam, or any anticonvulsant, after a long period of daily use, carries with it a RISK of seizure. (Perhaps this is one of the reasons most doctors don't like to use more than 4mg clonazapam for most cases?) That doesn't mean if you quit cold, you definately GET seizure. It is a real and well known risk to be aware of though. If you taper off of an anticonvulsant properly, body gets a chance to readjust, less of a surprsise to the system. An important key is "taper". Naturally, if the person is already using another anticonvulsant, say lamictal, that will naturally help to protect against the risk. I've definately experienced body shocks and worsened myoclonus from too-rapid clonazapam withdrawal, though no full blown seizures. The few days I attempted to quit cold on my own were much worse, and I didn't attempt to continue. Those first real withdrawal symptoms took over a day or two to even begin to appear, because clonazapam is a long-acting benzo- so one missed dose also does not equal seizure. You'll notice that the instructions which come with medications like lamictal and clonazepam sternly warn against quitting suddenly. And again, the obvious risk factors would incude how high the dose is, how long person has been on that dose, if person is taking any other meds which carry increased risk of seizure (ie, plausably wellbutrin?), if person is taking any other meds which reduce risk of seizure, individual brain and nervous system characteristics.
Your dose doesn't sound all that high Squiggles, and I don't understand from your post if you are still taking it, or if you are saying you quit cold and lived to tell the tale. I'm sure your doctor or pharmacist would be able to advise you of the risk level for your own situation.
> Do you people who are prescribed benzos,
> take them every day or when/as needed;
> that may be the missing link. I was/am
> prescribed K every single day-- it's been
> about 17 yrs. now taking 0.5-1.50mg. Still
> can't figure out how w/d almost killed me
> with a seizure/stroke-- maybe the anti-benzo
> poltergeists were responsible.
>
> Squiggles
Posted by Squiggles on February 8, 2007, at 8:13:37
In reply to Re: Benzo Confidential )Phillipa, » Squiggles, posted by laima on February 8, 2007, at 7:59:21
>
> Your dose doesn't sound all that high Squiggles, and I don't understand from your post if you are still taking it, or if you are saying you quit cold and lived to tell the tale. I'm sure your doctor or pharmacist would be able to advise you of the risk level for your own situation.
>
It has never been high-- God bless my dr.;
I am still taking it. I was unable to withdraw because after 18 months, I got a seizure and or stroke. I was very sick-- brain wise. I increased the dose. This is after about 15 yrs. on 1.0mg. That's why I'm curious about the nature of this withdrawal. BTW, I found an article that confirms what I am suggesting about K-- that tolerance does not build. What I'm saying is that it was not due to tolerance that I had that withdrawal, but something else.
>It seems that the longer you take this benzo, the harder it is to withdraw. And it is not a novel idea to have withdrawl without tolerance in drugs, e.g. the recent reports of the SSRI withdrawal difficulties.
BTW, if anyone can suggest a tapering schedule for a person taking it for only a year-- just to reduce the dose from 3.0mg to 2.0mg, i would appreciate any advice.
Thanks.
>
> 1: Psychopharmacol Bull. 1998;34(2):199-205. Links
Long-term experience with clonazepam in patients with a primary diagnosis of panic disorder.* Worthington JJ 3rd,
* Pollack MH,
* Otto MW,
* McLean RY,
* Moroz G,
* Rosenbaum JF.Department of Psychiatry, Massachusetts General Hospital, Boston 02114-3117, USA.
This study examined the use patterns and efficacy of the high potency benzodiazepine (HPB) clonazepam in panic patients who were treated and followed naturalistically in the Massachusetts General Hospital Longitudinal Study of Panic Disorder. Of 204 patients followed over a 2-year period, 46 percent were receiving clonazepam alone or in combination with an antidepressant. Treatment was not controlled at initial evaluation or during the followup period. The main variables assessed in this analysis included global severity of the panic disorder and stability of clonazepam dose. All treatment groups tended to improve over time without significant differences in outcome between groups. Clonazepam doses remained stable over time. Results of this study suggest that treatment of panic disorder with the HPB clonazepam achieved and maintained a therapeutic benefit similar to that obtained with alternative pharmacologic treatments, without the development of tolerance as manifested by dose escalation or worsening of clinical status.
PMID: 9641001 [PubMed - indexed for MEDLINE]
Squiggles
Posted by laima on February 8, 2007, at 9:07:34
In reply to Re: Benzo Confidential )Phillipa,, posted by Squiggles on February 8, 2007, at 8:13:37
I just don't know what to say about the study you found about tolerance- I've seen that some respectable sources say no tolerance with clonazapam, other credible sources say yes. My experience was a yes, in that a steady dose would completely lose efficacy, raising it would reinstate efficacy, that would lose efficacy, then dose would be raised...I went from .5 knocking me out, to 2 doing absolutely nothing. And off, my base anxiety turns out to be less than what it was when I started clonazapam in the first place-whereas I was convinced it was FAR worse. For whatever reason, the fact for me is, I went from bad anxiety to clonazapam use, which initially resulted in no anxiety or just very little-- then it steadily got worse. A lot worse. Despite dose being raised by doctor, several times. Never ever had any panic episodes before starting clonazapam and being on it for long time. Several months out, again, anxiety near vaporized, no panic attacks, no hyperventilation. And those were very common experiences for me while on clonazapam! What mechanism caused this? I can't help but believe it was related to building up a tolerance, and experiencing chronic mild withdrawal. That's the best explanaition I've got. And no, haven't used the zyprexa at all for over a month either, so it's not that helping me now.
So maybe the "tolerance question" is a matter of semantics, or a matter of if they are talking about the anti-convulsant properties or the anti-anxiety properties?
I don't know what a proper taper schedule would be- Mine was a mere 3 weeks, and I was miserably anxious, hyperventilation, even emergency room visit. Of course, at the very end of my using it, I took up to 4-5 mg at a time more than once in desperate effort to (unsucesssfully) deal with some excruciating panic episodes. (That probably didn't exactly help matters.) Though the zyprexa (2.5-5 mg at night) certainly helped, especially with sleep, I still think this taper was way too fast for me, anxiety- wise. Chopped by .5 every few days to a week. Dr.'s philosophy was that prolonging it would prolong my misery. On the other hand, Heather Ashton lists some various detailed schedules on her site, and she recommends a much slower and gradual taper.
I've definately also gathered an impression that the longer one uses this drug, the harder to withdraw- but that sure doesn't make it impossible or mean it's not worth the effort. I don't know who has got the "misery avoidance" philosphy better figured out- the Ashton style long taper, or my doctor's more rapid, get it over with taper. I suppose it might even be a matter of opinion.
Posted by Squiggles on February 8, 2007, at 9:25:24
In reply to Re: Benzo Confidential ) » Squiggles, posted by laima on February 8, 2007, at 9:07:34
> So maybe the "tolerance question" is a matter of semantics, or a matter of if they are talking about the anti-convulsant properties or the anti-anxiety properties?Is it possible that the paradoxical results are dependent on a model of clonazepam putting it in the same class as the anxiolytic benzos and old barbiturates, and alcohol? An anti-epileptic drug may share some of the same brain receptor stimulation but have other brain effects or different ones.
I am looking at some German studies in PubMed now, which talks about ligands (that awful German language-- after Mark Twain:-), and some poor animals have been put to the test to see how chronic administration and discontinuation of various benzos, result. It's over my head, but i'll try to understand some articles.
What you say about having nasty withdrawal effects, reinstating the dose or raising and yet still getting no stability, is interesting.
My withdrawal which took so long, and just got worse, better, worse, and then led to seizure and/or stroke, may indicate a change in a receptor (i've never seen a recepor) which no longer responds to the drug. And after some time that particular receptor or string of them, may have changed forever--is that possible? The reinstatement, may just be a fresh start on the effects of discontinuation.>
> I don't know what a proper taper schedule would be- Mine was a mere 3 weeks, and I was miserably anxious, hyperventilation, even emergency room visit. Of course, at the very end of my using it, I took up to 4-5 mg at a time more than once in desperate effort to (unsucesssfully) deal with some excruciating panic episodes. (That probably didn't exactly help matters.) Though the zyprexa (2.5-5 mg at night) certainly helped, especially with sleep, I still think this taper was way too fast for me, anxiety- wise. Chopped by .5 every few days to a week. Dr.'s philosophy was that prolonging it would prolong my misery. On the other hand, Heather Ashton lists some various detailed schedules on her site, and she recommends a much slower and gradual taper.I see some point to your dr.'s view-- but again I don't know much about this drug-- would he say the same about Xanax for example? I doubt it.
Yeah, I have Dr. Ashton's book-- clonazepam is tricky though-- but I will take a look.
Thanks
>
> I've definately also gathered an impression that the longer one uses this drug, the harder to withdraw- but that sure doesn't make it impossible or mean it's not worth the effort. I don't know who has got the "misery avoidance" philosphy better figured out- the Ashton style long taper, or my doctor's more rapid, get it over with taper. I suppose it might even be a matter of opinion.
Posted by laima on February 8, 2007, at 9:35:28
In reply to Re: Benzo Confidential ), posted by Squiggles on February 8, 2007, at 9:25:24
Here’s what medline says:
http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a682279.html“Tolerance may develop with long-term or excessive use, making the drug less effective.
They don’t mention seizure risk or say much of anything about withdrawal, though.
Another source does mention seizures:
http://www.mentalhealth.com/drug/p30-r04.html“Abrupt withdrawal of clonazepam particularly in those patients on long-term, high dose therapy, may precipitate status epilepticus. Therefore, as with any other anticonvulsants, gradual withdrawal is essential when discontinuing clonazepam. While clonazepam is being gradually withdrawn, the simultaneous substitution of incremental doses of another anticonvulsant may be indicated.”
Drugs.com also warns of possibility of seizures:
http://www.drugs.com/clonazepam.htmlDo not stop taking Clonazepam suddenly if you have been taking it for several weeks. Stopping suddenly could cause seizures and withdrawal symptoms. Talk to your doctor if you need to stop treatment with Clonazepam.
Wikipedia is always interesting, and includes this tidbit:
http://en.wikipedia.org/wiki/Clonazepam“Up to 30% of individuals treated on a long-term basis develop a form of dependence known as "low-dose-dependence". These patients do not develop a tolerance, and do not need increasingly large doses to experience the euphoric side effects of the drug.”
(So what does that mean?)
Wikipedia also has a link to the official package insert for clonazapam.
And here’s a link to the ever-controversial Heather Ashton’s detailed withdrawal tables and advice. I’ve actually personally found much of her information to be quite helpful, and thought some of it sounded exaggerated.http://www.benzo.org.uk/manual/bzsched.htm
I realize these are not hard-hitting science sites, but why gamble with chances?
Posted by laima on February 8, 2007, at 9:51:17
In reply to Re: Benzo Confidential ), posted by Squiggles on February 8, 2007, at 9:25:24
> Is it possible that the paradoxical results are dependent on a model of clonazepam putting it in the same class as the anxiolytic benzos and old barbiturates, and alcohol? An anti-epileptic drug may share some of the same brain receptor stimulation but have other brain effects or different ones.
That makes sense to me.
> What you say about having nasty withdrawal effects, reinstating the dose or raising and yet still getting no stability, is interesting.
Isn't it? For the longest time, I thought the problem was that I was just obviously deteriorating into a mess. Didn't think the drug could have anything to do it, but Heather Ashton actually planted the notion in me that it could be withdrawal/tolerance/drug related. My own doctor noted I was developing a tolerance, but didn't address the question of whether or not the actual clonazapam could be making matters worse. Just never came up, and it didn't occur to me to ask.
Well, my doctor did talk about seizure risk from too rapid withdrawal, noting clonazapam is of course also an anti-convulsant, but evidently felt his schedule was slow enough to prevent that risk from manifesting- and indeed, no seizure.
So I don't know what he'd think about withdrawing from xanax- I actually used it for awhile around the beginning of my clonazapam era- just switched over. Xanax is shorter acting, and I would get agitated when it wore off. (Hmm..another clue to short term withdrawal?) It also is not considered an anticonvulsant, and doesn't do anything for restless sleep, or myoclonus. A few years later it came up again, and this time he said he'd soured on prescribing xanax because it could be troublesome- didn't elaborate- I heard it has a pretty nasty withdrawal. Maybe he had patients with addiction or withdrawal problems? Maybe it's especially tempting for people to abuse, because it can produce an awfully "nice" feeling along with its anti-anxiety effects? Or some other reason? I just don't know.
He has mentioned that withdrawal, particularly sudden withdrawal, off most drugs can result in a rebound effect of whatever the drug was treating, until brain restabilizes from the shock.
But I say, just to be on the safe side, taper plenty slow enough to reduce any possible seizure risk. Give your body a chance to adjust itself. My comprehension of clonazapam withdrawal is: you got the benzo/rebound anxiety issues to deal with, and you got the anti-convulsant issues to deal with. I have no idea if other benzos could ever cause seizures if stopped suddenly, but I don't remember that being mentioned. I'm not up for digging out the answer- someone else would have to do that if curious.
Good luck!
Posted by Squiggles on February 8, 2007, at 10:05:05
In reply to Re: Benzo Confidential ) » Squiggles, posted by laima on February 8, 2007, at 9:51:17
At high dosages, you can get convulsions with
any GABA drug, including alcohol. But there
is variation. AEDs are far more likely, even
at small dosages (with time a variable)to
produce seizures, as they
treat mainly that-- convulsions.Personally, I think Xanax is one of the best
benzos, for short term, intermittent, when-needed
anxiety or panic. I believe there are some that
are even shorter-life but I forget.I thank you for your advice and for the Dr. Ashton's table, now right at my fingertips.
Squiggles
Posted by Phillipa on February 8, 2007, at 18:35:51
In reply to Re: Benzo Confidential )Phillipa,, posted by Squiggles on February 8, 2007, at 8:13:37
You know it's kind of funny as when working in psych the most popular med for anxiety was klonopin. The docs didn't blink to order it all the patients were on it and went home on it. I tried it and hated it. Just depressed me so changed back to xanax. No problem just switched which is what my pdoc said to do. Love Phillipa ps oh just remembered when EMSAM came out someone had me taking 2mg of klonopin didn't like it so again switched back never took the EMSAM either
Posted by Phillipa on February 8, 2007, at 18:41:23
In reply to Re: Benzo Confidential ) » Squiggles, posted by laima on February 8, 2007, at 9:35:28
I think it's because klonopin was meant for seizure control so hence the dire warnings. Love Phillipa
Posted by Phillipa on February 8, 2007, at 18:44:41
In reply to Re: Benzo Confidential ) » Squiggles, posted by laima on February 8, 2007, at 9:51:17
A lot of people use xanax for recreational purposes combined with alchohol. I had a young neighbor who would always ask for some xanax to party with. Love Phillipa
Posted by laima on February 8, 2007, at 19:56:50
In reply to Re: Benzo Confidential ), posted by Squiggles on February 8, 2007, at 10:05:05
I rather like xanax myself, and can't figure out what could have soured my Dr. on it. Maybe he was talking about in context of daily use?I think ativan might be shorter-lived than xanax.
Posted by Phillipa on February 8, 2007, at 20:42:43
In reply to Re: Benzo Confidential ), posted by laima on February 8, 2007, at 19:56:50
No it's longer lasts about six hours. Haven't taken it in a long time but then it was very calming. Love Phillipa
Posted by Larry Hoover on February 11, 2007, at 16:09:18
In reply to Re: Benzo Confidential - clonazepam's history, posted by Squiggles on February 6, 2007, at 21:11:45
> Well, i'm the curious type.
So am I. ;-)
> Let's start with the IPCS:
>
> Definitely addictive and definitely productive
> of cognitive impairment-- see description:
>
> http://www.inchem.org/documents/pims/pharm/pim326.htmI'm somewhat perplexed. Why would you refer to the PIM? It's mainly for emergency room personnel, I would think, or poison control centres. I don't know how it informs the typical user.
I do appreciate your bringing this site back into my consciousness. I had the link, but had forgotten about it. There's an especially good monograph re: aspirin overdose. However, I found the cannabis document to border on absurdity. The toxic threshold is 1/10 of the typical dose from a single joint? <smirk>
Anyway, I digress.
Lar
Posted by Squiggles on February 11, 2007, at 16:42:00
In reply to Re: Benzo Confidential - clonazepam's history » Squiggles, posted by Larry Hoover on February 11, 2007, at 16:09:18
> > Let's start with the IPCS:
> >
> > Definitely addictive and definitely productive
> > of cognitive impairment-- see description:
> >
> > http://www.inchem.org/documents/pims/pharm/pim326.htm
>
> I'm somewhat perplexed. Why would you refer to the PIM? It's mainly for emergency room personnel, I would think, or poison control centres. I don't know how it informs the typical user.
>
The PIM? Uhm.... I find this a really good link
for drug info.; the other one is the one I posted from the U of Alberta. Poison control info. is very good for finding the toxicity levels of all drugs. I'm sorry that there are discrepancies in this one... you must be very well-educated in the area.> I do appreciate your bringing this site back into my consciousness. I had the link, but had forgotten about it. There's an especially good monograph re: aspirin overdose. However, I found the cannabis document to border on absurdity. The toxic threshold is 1/10 of the typical dose from a single joint? <smirk>
I remember an article from a dr. at a Montreal hospital, where he reported an overdose on aspirin, on the grounds of the aspirin being coated and taking longer to have the intened lethal effect; presumably the person kept adding to the dose.
Don't know much about marijuana -- never could inhale at the best of parties :-).>
> Anyway, I digress.
>
> Lar
Posted by notfred on February 11, 2007, at 22:48:04
In reply to Re: Benzo Confidential - clonazepam's history, posted by Squiggles on February 11, 2007, at 16:42:00
> > I'm somewhat perplexed. Why would you refer to the PIM? It's mainly for emergency room personnel, I would think, or poison control centres. I don't know how it informs the typical user.
> >
> The PIM? Uhm.... I find this a really good link
> for drug info.; the other one is the one I posted >from the U of Alberta.
The PIM for the most part assumes an overdose so it is out of place for giving info about normal doses. I think it tends to scare people.
Posted by Squiggles on February 12, 2007, at 6:19:37
In reply to Re: Benzo Confidential - clonazepam's history, posted by notfred on February 11, 2007, at 22:48:04
>
> The PIM for the most part assumes an overdose so it is out of place for giving info about normal doses. I think it tends to scare people.
>Sorry-- maybe it's good to know? But it is
an excellent site, imho.Squiggles
Posted by Larry Hoover on February 12, 2007, at 6:56:30
In reply to Re: Benzo Confidential - clonazepam's history, posted by Squiggles on February 12, 2007, at 6:19:37
>
> >
> > The PIM for the most part assumes an overdose so it is out of place for giving info about normal doses. I think it tends to scare people.
> >
>
> Sorry-- maybe it's good to know? But it is
> an excellent site, imho.
>
> SquigglesI want to say, it is still a valuable site. Some people get symptoms of overdose at what are thought to be normal physiological doses. Sensitivities are not consistent across the population; e.g. I can't tolerate 1/8 of a 0.5 mg tablet of clonazepam. That's my body, and that's life.
Also, some monographs are complete, and include data about normal dosing, and normal response to the medication in question. However, many do not. Their information is solely about acute overdose management.
What I'm saying is, the context matters. No matter how scholarly the source, the information must remain in its context to be reliable.
Lar
Posted by Squiggles on February 12, 2007, at 7:03:33
In reply to Re: Benzo Confidential - clonazepam's history » Squiggles, posted by Larry Hoover on February 12, 2007, at 6:56:30
> >
> > >
> > > The PIM for the most part assumes an overdose so it is out of place for giving info about normal doses. I think it tends to scare people.
> > >
> >
> > Sorry-- maybe it's good to know? But it is
> > an excellent site, imho.
> >
> > Squiggles
>
> I want to say, it is still a valuable site. Some people get symptoms of overdose at what are thought to be normal physiological doses. Sensitivities are not consistent across the population; e.g. I can't tolerate 1/8 of a 0.5 mg tablet of clonazepam. That's my body, and that's life.
>
> Also, some monographs are complete, and include data about normal dosing, and normal response to the medication in question. However, many do not. Their information is solely about acute overdose management.
>
> What I'm saying is, the context matters. No matter how scholarly the source, the information must remain in its context to be reliable.
>
> Lar
>
You sound very well-educated in this area, so
I hope that you can emphasize which Drug Info websites are more appropriate, and that this is strictly for "work-related/environmental danger warnings".I would like to see a databank of the good ones; maybe we can start one with contributions from posters here?
Just a suggestion -- I placed a couple on Social.
Squiggles
Posted by laima on February 12, 2007, at 7:37:57
In reply to Re: Benzo Confidential - clonazepam's history, posted by Squiggles on February 12, 2007, at 7:03:33
I like this idea- I'm also interested to know if anyone knows of a good and thorough drug interaction checker, one complete enough to include supplements.
> I would like to see a databank of the good ones; maybe we can start one with contributions from posters here?
>
> Just a suggestion -- I placed a couple on Social.
>
> Squiggles
>
Posted by Squiggles on February 12, 2007, at 8:01:18
In reply to Re: Benzo Confidential - clonazepam's history » Squiggles, posted by laima on February 12, 2007, at 7:37:57
1. University of Alberta
http://redpoll.pharmacy.ualberta.ca/drugbank/cgi-bin/getCard.cgi?CARD=APRD00054.txt2. CMG Current Medicine Group
http://redpoll.pharmacy.ualberta.ca/drugbank/cgi-bin/getCard.cgi?CARD=APRD00054.txt3. Scott Schofield's Psych Drug Chart
http://sl.schofield3.home.att.net/medicine/psychiatric_drugs_chart.html4. Drug Information Online
http://www.drugs.com/5. Ask A Patient (testimonials)
http://www.askapatient.com/viewrating6. WebMD Symptom Checker
http://www.medicinenet.com/imipramine/article.htm7. Prof. Heather Ashton's Benzo Withdrawal Guide
http://www.benzo.org.uk/manual/bzsched.htm............please feel free to add your findings
Squiggles
Posted by laima on February 12, 2007, at 8:26:42
In reply to Drug Checkers, posted by Squiggles on February 12, 2007, at 8:01:18
Wow, thanks! This is a great and varied compilation. I like the idea of looking at numerous sources to get well-rounded information.
I've got a couple:
Medline is very mainstream, but not always as complete as I wish:
http://www.nlm.nih.gov/medlineplus/druginformation.html
...and there's this, but I don't know who runs it, and it doesn't say WHY an interaction can occur:http://www.drugdigest.org/DD/Interaction/ChooseDrugs
> 1. University of Alberta
> http://redpoll.pharmacy.ualberta.ca/drugbank/cgi-bin/getCard.cgi?CARD=APRD00054.txt
>
> 2. CMG Current Medicine Group
> http://redpoll.pharmacy.ualberta.ca/drugbank/cgi-bin/getCard.cgi?CARD=APRD00054.txt
>
> 3. Scott Schofield's Psych Drug Chart
> http://sl.schofield3.home.att.net/medicine/psychiatric_drugs_chart.html
>
> 4. Drug Information Online
> http://www.drugs.com/
>
> 5. Ask A Patient (testimonials)
> http://www.askapatient.com/viewrating
>
> 6. WebMD Symptom Checker
> http://www.medicinenet.com/imipramine/article.htm
>
> 7. Prof. Heather Ashton's Benzo Withdrawal Guide
> http://www.benzo.org.uk/manual/bzsched.htm
>
> ............please feel free to add your findings
>
> Squiggles
Posted by Squiggles on February 12, 2007, at 8:43:51
In reply to Re: Drug Checkers » Squiggles, posted by laima on February 12, 2007, at 8:26:42
The P450 CYTOCHROME interaction drug chart:
http://medicine.iupui.edu/flockhart/table.htmdrkoop.com drug interactions
http://www.drugs.com/data/channel/md/drkoop.cfm?int=1German J. of Psych. Drug Interact. Calculator
http://www.gjpsy.uni-goettingen.de/interactions_calculator.phpCollege of Pharmacy: Drug Info. RESOURCES:
http://dir.pharmacy.dal.ca/drugprobinteraction.php
-- there are also sub-categories,e.g. herb-drug,
elderly, HIV, etc.... but i have to go now.tx for the cooperation;
Squiggles
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