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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 12 of 12. This is the beginning of the thread.
Posted by Jimmyboy on January 10, 2007, at 14:17:16
I always hear that antidepressants raise levels of BDNF after awhile and that this could be the reason they help. Anyone kno wany other ways to raise this .. two that I have seen are
1. Exercise
-- what type of exercise? Aerobic I assume, how long how intense?
2, Idebenone
--
JB
Posted by Phillipa on January 10, 2007, at 14:25:37
In reply to BDNF - how do you raise your levels?, posted by Jimmyboy on January 10, 2007, at 14:17:16
Well if it's Aerobic and I'm assuming it is at least a half hour intense before the heart and lungs, muscles have adequately been excercised. Aerobic means with oxygen. Love Phillipa the old Aerobics instuctor for years.
Posted by Jimmyboy on January 10, 2007, at 15:25:26
In reply to Re: BDNF - how do you raise your levels? » Jimmyboy, posted by Phillipa on January 10, 2007, at 14:25:37
Here is an article on drugs that raise BDNF , its on Alzheimer's .. the info on the drugs in lower on the page, if anyone wants to check it out .
Interesting that <Delta 9 - THC> raises BDNF and so many people think pot is helpful for their depression.
http://www.nature.com/tpj/journal/v6/n1/full/6500337a.html
Posted by Jimmyboy on January 10, 2007, at 15:25:32
In reply to Re: BDNF - how do you raise your levels? » Jimmyboy, posted by Phillipa on January 10, 2007, at 14:25:37
Here is an article on drugs that raise BDNF , its on Alzheimer's .. the info on the drugs in lower on the page, if anyone wants to check it out .
Interesting that <Delta 9 - THC> raises BDNF and so many people think pot is helpful for their depression.
http://www.nature.com/tpj/journal/v6/n1/full/6500337a.html
Posted by dessbee on January 10, 2007, at 16:13:04
In reply to Re: BDNF - how do you raise your levels?Article, posted by Jimmyboy on January 10, 2007, at 15:25:32
Intermittent fasting is known to increase BDNF.
Posted by linkadge on January 10, 2007, at 18:59:45
In reply to Re: BDNF - how do you raise your levels?Article » Jimmyboy, posted by dessbee on January 10, 2007, at 16:13:04
Yeah, fasting and exercise. Perhaps there is a biochemical basis to anorexia.
Actually, thats not my idea. Some smart guy proposed that people with anorexia nervosa are using exercise and fasting to replace BDNF which is deficiant for some reason.
I think the data is strong for lithium and valproate with BDNF.
Antidepressants, yes, but not all studies show an effect, nor a sustained effect.
Too much attention on BDNF though, as there are other neurotrophins such as NT-3 which also seem to have antidepressant effect.
Linkadge
Posted by Jimmyboy on January 10, 2007, at 21:14:43
In reply to Re: BDNF - how do you raise your levels?Article, posted by linkadge on January 10, 2007, at 18:59:45
Thats interesting, does anyone know the detail on how to fast, how long, how often, etc.
Also, linkadge.. kow how to raise the NT-3 ?
Thanks,
JB
Posted by linkadge on January 10, 2007, at 21:34:08
In reply to Re: BDNF - how do you raise your levels?Article » linkadge, posted by Jimmyboy on January 10, 2007, at 21:14:43
NT-3, exercise and vitamin D. Probably lots of other things.
Exercise increases a *number* of growth factors. GAP-43, BDNF, NGF, GDNF, NT-3, FGF-2, probably more.
Fasting. I think periodic fasting, ie meal skiping can do something.I don't think you need to starve yourself, and it may not be a good idea if you are underweight.
I know there is some information on the topic under research done for treatments for Huntingons disease. I know that fasting can forstall or slow the progression of a number of neurodegenertive illnesses.
Linkadge
Posted by ronaldo on January 11, 2007, at 6:00:47
In reply to BDNF - how do you raise your levels?, posted by Jimmyboy on January 10, 2007, at 14:17:16
Hi folks,
Having gone to considerable lengthes to discover what you are talking about I thought I would share my new found knowledge.
BDNF = Brain Derived Neurotrophic Factor
Brain-derived neurotrophic factor (BDNF) is exactly as it states; a neurotrophic factor found originally in the brain, but also found in the periphery. More specifically, it is a protein which has activity on certain neurons of the central nervous system and the peripheral nervous system; it helps to support the survival of existing neurons, and encourage the growth and differentiation of new neurons and synapses
http://en.wikipedia.org/wiki/BDNF
Neurotrophic:
neuro = nerve
trophic = nourishingThus BDNF is a substance manufactured in the brain which feeds and nourishes neurons...QED
brought to you, free of charge, by rolando
A new Boffin is born every second....
Rolando
> I always hear that antidepressants raise levels of BDNF after awhile and that this could be the reason they help. Anyone kno wany other ways to raise this .. two that I have seen are
>
> 1. Exercise
>
> -- what type of exercise? Aerobic I assume, how long how intense?
>
> 2, Idebenone
>
> --
>
>
> JB
> I always hear that antidepressants raise levels of BDNF after awhile and that this could be the reason they help. Anyone kno wany other ways to raise this .. two that I have seen are
>
> 1. Exercise
>
> -- what type of exercise? Aerobic I assume, how long how intense?
>
> 2, Idebenone
>
> --
>
>
> JB
Posted by dessbee on January 11, 2007, at 7:31:16
In reply to Re: BDNF - how do you raise your levels?, posted by ronaldo on January 11, 2007, at 6:00:47
In animal models they use alternate-day-fasting.
Rats on periodic fasting exhibited increased levels of Heat Shock Protein-70 (HSP-70) and Glucose Regulated Protein-78 (GRP-78). These protein chaperones can protect neurons against excitotoxic and oxidative stress, suggesting that their increased levels contribute to the neuroprotective effects of periodic fasting. In addition to the above, studies have documented activities of several other neuroprotective factors such as nerve growth factor, brain derived neurotrophic factor (BDNF), fibroblastic growth factors and IGF1.
Another benefit from intermittent fasting is improved insulin sensitivity (low insulin levels).Mark Mattson, a neuroscientist at the National Institute on Aging in Baltimore is one of the leading scientists in this area. I beleive he himself is on a calory restriction diet (30 percent fewer calories daily) where he only eats during a 2-3 hour period every evening.
Posted by Jimmyboy on January 11, 2007, at 9:37:53
In reply to Re: BDNF - how do you raise your levels?, posted by dessbee on January 11, 2007, at 7:31:16
Another list of drugs, mainly anti-depressants that rasie or lower BDNF.
http://hdlighthouse.org/see/drugs/bdnfdrugs.htm
Tumeric (Curcumiin) regulates levels of BDNF
Posted by Jimmyboy on January 11, 2007, at 9:54:45
In reply to Re: BDNF - how do you raise your levels?, posted by Jimmyboy on January 11, 2007, at 9:37:53
Zinc supposedly raises BDNF also
This is the end of the thread.
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