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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 19 of 19. This is the beginning of the thread.
Posted by linkadge on November 25, 2006, at 11:37:19
http://cat.inist.fr/?aModele=afficheN&cpsidt=16331715
Linkadge
Posted by Jost on November 25, 2006, at 13:12:30
In reply to NRI induces higher BDNF expression than SSRI, posted by linkadge on November 25, 2006, at 11:37:19
And higher BDNF does... what exactly?
Jost
Posted by Quintal on November 25, 2006, at 16:46:21
In reply to NRI induces higher BDNF expression than SSRI, posted by linkadge on November 25, 2006, at 11:37:19
I don't know, but whatever it is it made me feel much worse. Reboxetine was the scariest experience I've had with any med.
Q
Posted by linkadge on November 25, 2006, at 16:54:38
In reply to Re: NRI induces higher BDNF expression than SSRI » linkadge, posted by Quintal on November 25, 2006, at 16:46:21
I wonder if the finding of this study would extend to other norepinephrine drugs.
Could you describe how the med made you feel worse? Sadder? Angry? Insomnia?You don't have to answer if you don't feel comfortable doing so.
Linkadge
Posted by tensor on November 25, 2006, at 17:15:13
In reply to Re: NRI induces higher BDNF expression than SSRI » Quintal, posted by linkadge on November 25, 2006, at 16:54:38
Reboxetine was also one of the worst AD's I've ever tried, probably due to the high NRI in combination with the lack of NE-alpha1 blockade. I experienced the same with Ixel. I gave me pain in my testicels/prostate, not sure exactly which but it was a chronic pain in my lower abdomen/genitals. I had severe difficulties to urinatate, my penis shrinked to a fifth of normal size(save it, plz...) and the orgasm, if I ever reached one felt like I kick in my scrotum simultaneously with a punch in my stomach.
I think an antidote might me tamsulosin, however, I was never given the oppurtunity to try it.The study pretty much concludes what my therapist says to me, you need to activate yourself, the meds alone aint enough, try to swim or walk everyday, it's the best antidepressant. It's true, but first you need a little push from the meds.
/Mattias
Posted by SLS on November 25, 2006, at 17:18:39
In reply to Re: NRI induces higher BDNF expression than SSRI » linkadge, posted by Quintal on November 25, 2006, at 16:46:21
> I don't know, but whatever it is it made me feel much worse. Reboxetine was the scariest experience I've had with any med.
It made me suicidal.
- Scott
Posted by linkadge on November 25, 2006, at 17:19:45
In reply to Re: NRI induces higher BDNF expression than SSRI » linkadge, posted by tensor on November 25, 2006, at 17:15:13
I know what you are saying. My brief exposure to straterra (a NRI) confirms your experience.
Linkadge
Posted by linkadge on November 25, 2006, at 17:25:03
In reply to Re: NRI induces higher BDNF expression than SSRI, posted by linkadge on November 25, 2006, at 17:19:45
Sorry, above post was meant to respond to tensor's sexual difficulty with reboxetine.
Linkadge
Posted by Quintal on November 25, 2006, at 17:28:43
In reply to Re: NRI induces higher BDNF expression than SSRI » Quintal, posted by linkadge on November 25, 2006, at 16:54:38
I started having panic attacks even though I was taking 4mg Klonopin at the time. It also made me very depressed and suicidal. Took me a while to figure out it was the reboxetine, though it should have been obvious. It was prescribed by a professor of psychopharmacology too, so it seems they don't know much better either.
I remember the penis shrinkage well - just a mushroom head and hardly any 'stalk' left at all. I had the cystitis and painful ejaculation too - also had the problem at times from Effexor.
Q
Posted by Quintal on November 25, 2006, at 17:31:10
In reply to Re: NRI induces higher BDNF expression than SSRI » linkadge, posted by Quintal on November 25, 2006, at 17:28:43
Ice cold hands, purple lips and blue veins standing out too.
Q
Posted by linkadge on November 25, 2006, at 18:05:05
In reply to Re: NRI induces higher BDNF expression than SSRI » linkadge, posted by Quintal on November 25, 2006, at 17:28:43
I suppose its the noradrenergic actions. Apparently when you are in fight or flight mode, the man downstairs goes into hiding.
Linkadge
Posted by tensor on November 25, 2006, at 18:12:10
In reply to Re: NRI induces higher BDNF expression than SSRI, posted by linkadge on November 25, 2006, at 18:05:05
>Apparently when you are in fight or flight mode, the man downstairs goes into hiding.
Ha! :-)
Posted by blueberry on November 25, 2006, at 20:42:43
In reply to NRI induces higher BDNF expression than SSRI, posted by linkadge on November 25, 2006, at 11:37:19
NRI meds for me were just awful. I couldn't get past two days they were so bad. Deeply worsened depression along with very severe side effects.
Two exceptions though. St Johns Wort was good. And the alpha-1 agonist adrafinil was great. It was the reuptake inhibitors that were horror shows. Reboxetine. Milnacipran. When I see the clinical studies showing how good these meds are I just absolutely cannot understand it. Who were those patients that took these meds and made it? Were they from another planet or something?
Moclobemide did the same thing to me as NRIs.
Posted by Quintal on November 25, 2006, at 21:03:47
In reply to Re: NRI induces higher BDNF expression than SSRI, posted by blueberry on November 25, 2006, at 20:42:43
>Who were those patients that took these meds and made it? Were they from another planet or something?
Maybe they're just very physically active people leading busy lives so the strong stimulant effect is beneficial? - sounds far fetched though considering the severity of the adverse reactions. Many meds failed to have any effect but I've never taken a drug that has worsened my symptoms to such a degree and even caused new problems (never panicked before taking reboxetine).
I never felt any effect from Adrafinil, but I was taking a hefty dose of clonazepam at the time - have you noticed the effect changing in response to your benzo dose blueberry? I can say much the same thing about moclobemide, but I'm wondering if it is worth another trial as my GP will probably be willing to prescribe it, or Nardil, which she will probably not be willing to prescribe but I have never taken?
Q
Posted by SLS on November 25, 2006, at 21:08:05
In reply to Re: NRI induces higher BDNF expression than SSRI, posted by blueberry on November 25, 2006, at 20:42:43
> Moclobemide did the same thing to me as NRIs.
For me, moclobemide was the worst of the horrors I have suffered, followed closely by reboxetine. Moclobemide left me curled up in a fetal position and wimpering. That is no exaggeration.
- Scott
Posted by Quintal on November 25, 2006, at 21:19:27
In reply to Re: NRI induces higher BDNF expression than SSRI, posted by SLS on November 25, 2006, at 21:08:05
>> Moclobemide did the same thing to me as NRIs.
>For me, moclobemide was the worst of the horrors I have suffered, followed closely by reboxetine. Moclobemide left me curled up in a fetal position and wimpering. That is no exaggeration
Odd, considering it is one of the few drugs to be licensed for Social Anxiety in the UK. How many drugs licensed for this condition actually work? At times it seems the only truly effective meds for are prescribed off label after much persuasion from the patient.
Q
Posted by Meri-Tuuli on November 26, 2006, at 12:26:46
In reply to Re: NRI induces higher BDNF expression than SSRI, posted by blueberry on November 25, 2006, at 20:42:43
> Were they from another planet or something?
Perhaps they were chicks? I tried reboxetine and it was pretty benign for me (and I'm a chick) I found it great for panic, and indifferent for depression. It made me go the other way - I was, ahem, rather prosexual on it and generally, it was okay, not bad not great (hahaha the prosexualness was great, but I meant in general). I stopped it because I got bad acne and my periods stopped which freaked me out abit, but there weren't really any serious s/e.... but other than that it was a welcome relief from my sleeping/eating zombie days of celexa...... goes to show how we're all different. I wonder what it says about our unique biochemistries.
Posted by Sabre on November 26, 2006, at 15:57:09
In reply to Re: NRI induces higher BDNF expression than SSRI, posted by Meri-Tuuli on November 26, 2006, at 12:26:46
Hi
Reboxetine made me feel great for about 2 or 3 days. I felt energised and calm. But on about the 3rd or 4th day I felt a bleak deep depression...scarey. (I am v. physically active every day.)
I now use it on occasion - about 1/3 of a tablet for e.g. job interviews. I find it better than a beta blocker. Although after a few hrs it makes me very tired and sleepy. It doesn't seem to stimulate like it did the first time. Tyrosine is better for that.
Regards
Sabre
Posted by Meri-Tuuli on November 27, 2006, at 14:31:24
In reply to Re: NRI induces higher BDNF expression than SSRI, posted by Sabre on November 26, 2006, at 15:57:09
How often do you take tyrosine? I took it once and liked it very much, but I'm somehow afraid it won't work long-term for some reason. Have you tried rhodiola rosea? It's quite good too.
M
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