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Dr. Bob is Robert Hsiung, MD,
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Posted by anhedonic on September 4, 2006, at 13:06:52
In reply to Re: Lyrica (pregabalin) - Side Effects ? » anhedonic, posted by SLS on September 3, 2006, at 19:09:54
Hi Scott,
I haven't tried any MAO yet, other than oral Selegaline years ago to no effect. I think most pdocs today don't consider them much anymore, or just don't want to take the risk. I see a new pdoc on Sept. 11th, my first one in 3 years. Hopefully he is open to suggestions. I am not taking anything right now, how about yourself? I'm also considering ordering Tianeptine (Stablon), if I don't get the Emsam for some reason.Shane
> Hi Shane.
>
> No. I am having a difficult time choosing between Emsam or going back to Nardil and trying to augment it with other drugs.
>
> Have you tried any MAOI yet?
>
>
> - Scott
Posted by SLS on September 4, 2006, at 15:42:41
In reply to Re: Lyrica (pregabalin) - Side Effects ?, posted by anhedonic on September 4, 2006, at 13:06:52
> I am not taking anything right now, how about yourself?
I'm currently taking:
Lamictal 150mg
nortriptyline 100mg
Abilify 10mg
Topamax 100mg
Lyrica 75mg
> I'm also considering ordering Tianeptine (Stablon), if I don't get the Emsam for some reason.I keep forgetting about that drug. It's on my list, but I haven't spoken to my doctor about it yet.
I hope this new doctor works out well for you.
- Scott
Posted by Anhedonic on September 4, 2006, at 16:34:11
In reply to Re: Lyrica (pregabalin) - Side Effects ? » anhedonic, posted by SLS on September 4, 2006, at 15:42:41
Scott,
do you have an epileptic condition as well? Three of the meds you take are used as anti-seizure meds as well as off label. I actually am on one medication, Keppra, which works great for my epilepsy. I don't know that it has any mood altering affect though. Maybe a mild stablizer.
I'm not sure where your located, but if it's the USA, you're gonna have to order the Tianeptine from overseas as it's patent has run out over here.Shane
> I'm currently taking:
>
> Lamictal 150mg
> nortriptyline 100mg
> Abilify 10mg
> Topamax 100mg
> Lyrica 75mg
>
>
Posted by SLS on September 4, 2006, at 19:57:07
In reply to Re: Lyrica (pregabalin) - Side Effects ? » SLS, posted by Anhedonic on September 4, 2006, at 16:34:11
> Scott,
> do you have an epileptic condition as well?No. Just bipolar disorder.
> Three of the meds you take are used as anti-seizure meds as well as off label. I actually am on one medication, Keppra, which works great for my epilepsy.
I tried Keppra. I found it to be destabilizing and depressogenic at higher dosages while being somewhat antidepressant at lower dosages.
Lyrica made me feel kind of dopey and really impaired my memory for awhile today. I wasn't too happy with that. I hope this is just a passing side effect.
Thanks for the info on tianeptine.
- Scott
Posted by hattree on September 5, 2006, at 12:59:06
In reply to Re: Lyrica (pregabalin) - Side Effects ? » Anhedonic, posted by SLS on September 4, 2006, at 19:57:07
I've been taking Neurontin for several years with some minor success. About to try Lyrica. Do you think I need to stop the Neurontin first? Substitute a dose of Lyrica for the Neurontin? Take them both at the same time?
?
Posted by Crazy Horse on September 5, 2006, at 14:09:30
In reply to Neurontin/Lyrica together, posted by hattree on September 5, 2006, at 12:59:06
> I've been taking Neurontin for several years with some minor success. About to try Lyrica. Do you think I need to stop the Neurontin first? Substitute a dose of Lyrica for the Neurontin? Take them both at the same time?
>
> ?The Lyrica will replace the neurontin. Think of the Lyrica as a new improved neurontin, that is basically what it is. It is 3-10 times more powerful than neurontin. Lyrica mimics GABA. My prediction is eventually neurontin will become obselete, as Lyrica is so way more effective then neurontin, in all forms of treatment potential. I'm talking from experience as well, as i have been on both of these medications. For me, Lyrica works very well, neurontin did nothing for me.
-Monte
Posted by ed_uk on September 5, 2006, at 15:09:30
In reply to Re: Lyrica (pregabalin) - Side Effects ? » Anhedonic, posted by SLS on September 4, 2006, at 19:57:07
Hi Scott
Keep us up to date with the Lyrica trial. Hope the cognitive side effects wear off.
Ed
Posted by MARTY on September 5, 2006, at 15:32:29
In reply to Lyrica (pregabalin) - Side Effects ?, posted by SLS on September 1, 2006, at 7:29:58
To Scott:
Do you intend to keep trying Lyrica until high dose whatever what ? Because that's what I would recommend you to do. About 6 months ago I tried Lyrica at low dose and I hated it so I stopped it. Since then I gave Lyrica a another trial at high dose because I heard high dose was feeling different (more energy etc) .. for me it made the difference between a med that was making me feel bad and one that is actually changing (saving) my life.
Wish you best luck with Lyrica,
Marty
Posted by SLS on September 5, 2006, at 17:07:22
In reply to Re: Lyrica (pregabalin) - Side Effects ? » SLS, posted by MARTY on September 5, 2006, at 15:32:29
Yes. I intend to ask my doctor to continue to increase the dosage of Lyrica. I mentioned to him 600mg last time I saw him. He has a few patients on 300mg. I have an appointment with him later in the week. I took 75mg yesterday. I had less cognitive side effects today. So far, so good.
- Scott
Posted by Daisey on September 7, 2006, at 12:22:32
In reply to Re: Lyrica (pregabalin) - Side Effects ? » SLS, posted by MARTY on September 5, 2006, at 15:32:29
I have Thoracic Outlet Syndrome and have been taking Nurontin for 3 years.
I just started taking the Lyrica yesterday (75mg).
I had my second dose today (75mg).
I hope it doesn't cause me to gain weight.
Posted by willyee on September 7, 2006, at 15:28:01
In reply to Re: Lyrica (pregabalin) - Side Effects ?, posted by Daisey on September 7, 2006, at 12:22:32
Also just to note,i was doing absolutly horrable today,and i tried to think back to how i was doing quite manageable all week and i went out and refilled my nuerontin.
I cant be sure of this,but i have recently used with parnate a partial approx 300 mg nuerontin/partial depakote approx 150 mg .
Drink some caffiene with this to fight off the more initial sedation however afterward if u sit u feel a sense of calm,from this point using pebble sized pieaces of klonopin or vice cersa soda for residue anxiety or sedating is optional,this seems to depend on the time of day,morning commonly would require a bit of the benzo afternoon im fighting off sleep so i dont have any problems there.
Im gonna lower parnate and use this anxiety method in between more,perhaps the too meds in conjunction have a synergy?
I just know benzos are really in my opinion best used in the smallest dose possable,in increments as needed,i find taking a benzo at a higher dose truly is not meeting my needs at all neiter for anxiety or depression,least now all my limbs are loose i can move freely,i dont feel that axle attatchment to my spine anymore,and at this point its alll i want. im fine with how i feel this very second,STAY STAY STAY but it wont.Anyway too early to tell but i do suspect this combo was reasonbable for me having a fair week last week so that would give it a weeks fair play under ones belt.
How many people are so exhausted playing this game......whew.
Posted by SLS on September 12, 2006, at 11:16:35
In reply to Re: Lyrica (pregabalin) - Side Effects ? » SLS, posted by MARTY on September 5, 2006, at 15:32:29
Ok. Here's one. How about anorgasmia?
It is taking me longer and longer to reach orgasm as I increase the dosage of Lyrica. Hopefully, it will be a temporary effect.
- Scott
Posted by TJO on September 12, 2006, at 13:45:11
In reply to Re: Lyrica (pregabalin) - Side Effects ?, posted by SLS on September 12, 2006, at 11:16:35
Hi Scott,
How about adding Wellbutrin? If the problem continues? But I seem to remember that you did not react well to it and it made you "worse". Hope I'm wrong about that.:-D.
Tammy
Posted by Crazy Horse on September 12, 2006, at 15:35:35
In reply to Re: Lyrica (pregabalin) - Side Effects ?, posted by SLS on September 12, 2006, at 11:16:35
> Ok. Here's one. How about anorgasmia?
>
> It is taking me longer and longer to reach orgasm as I increase the dosage of Lyrica. Hopefully, it will be a temporary effect.
>
>
> - ScottPersonally, i have had no sexual problems at all w/Lyrica.
-Monte
Posted by KayeBaby on September 13, 2006, at 4:30:32
In reply to Re: Lyrica (pregabalin) - Side Effects ?, posted by SLS on September 12, 2006, at 11:16:35
I have noticed lowered libido but not too bad.
When I adjusted to the new dose things worked pretty normally.This has been a very good med for me-it's just rather touch some times.
I think you will find luck with this one,Scott.
Peace,
Kaye
Posted by SLS on September 13, 2006, at 5:38:15
In reply to Re: Lyrica (pregabalin) - Side Effects ?, posted by KayeBaby on September 13, 2006, at 4:30:32
Hi KB.
Thanks much for the response.
How much Lyrica are you taking?
- Scott
> I have noticed lowered libido but not too bad.
> When I adjusted to the new dose things worked pretty normally.
>
> This has been a very good med for me-it's just rather touch some times.
>
> I think you will find luck with this one,Scott.
>
> Peace,
> Kaye
Posted by TJO on September 13, 2006, at 6:27:21
In reply to Re: Lyrica (pregabalin) - Side Effects ? » KayeBaby, posted by SLS on September 13, 2006, at 5:38:15
Hi All.
Wikipedia mentioned that amantadine (Symmetrel) is used somtimes to treat anorgasmia from SSRI's. I took Symmetrel briefly for EPS from Risperdal, and the drug agreed with me, and didn't cause more problems than it solved. I'm not sure Lyrica is a SSRI, however.Tammy
Posted by poop'd-out on September 13, 2006, at 15:37:46
In reply to Re: Lyrica (pregabalin) - Side Effects ?, posted by SLS on September 12, 2006, at 11:16:35
> Ok. Here's one. How about anorgasmia?
>
> It is taking me longer and longer to reach orgasm as I increase the dosage of Lyrica. Hopefully, it will be a temporary effect.
>
>
> - Scott
Hi Scott,
I just started Lyrica last week. I couldn't really tell you yet from experience. Some of the stuff that I have read about Lyrica here and there on the Web was that at low doses it could cause some sexual dysfunction, but that at higher doses it was prosexual? (600mg and up) I am only at 300mg alternating with my neurontin currently. I hope this medication gives you some relief!!
Beth
Posted by KayeBaby on September 13, 2006, at 21:37:00
In reply to Re: Lyrica (pregabalin) - Side Effects ? » KayeBaby, posted by SLS on September 13, 2006, at 5:38:15
Hey Scott!
I am taking 300mg total per day 150mg 2x daily.
However, I am experimenting with my dosage and timing.I wish it didn't have such a short half life. Every 6 hrs is a pain.
It has been a good med for me all in all.The sedation and goofy feeling really does pass and when I take it before bed I sleep sooo well. I wonder how much of the improvements I have experienced with Lyrica are attributable to simply getting some quality sleep ?
Hows it going with you?
I am looking forward to detecting some perky-ness in your posts soon!Peace,
Kaye
Posted by TJO on September 14, 2006, at 5:44:37
In reply to Re: Lyrica (pregabalin) - Side Effects ? » SLS, posted by KayeBaby on September 13, 2006, at 21:37:00
Hi Scott,
This site had the mechanism of action of Lyrica-http://www.lyricapro.com/cwpb/appmanager/lyrica/lyricaDesktop?_nfpb=true&_pageLabel=lyrica_pro_mechanismofaction
And here it is touted as a replacement for Neurontin
http://www.drugdevelopment-technology.com/projects/pregabalin/
Thought the info on the Neurontin comparison might be helpful :-)Tammy
Posted by TJO on September 14, 2006, at 5:46:45
In reply to Re: Lyrica (pregabalin) - Side Effects ? » SLS, posted by KayeBaby on September 13, 2006, at 21:37:00
Hiya,
and one more interesting place-http://www.epilepsy.com/medications/b_lyrica_most.html
Tam
Posted by yxibow on September 15, 2006, at 3:41:33
In reply to Lyrica (pregabalin) - Side Effects ?, posted by SLS on September 1, 2006, at 7:29:58
> What side effects can I expect from Lyrica?
Everyone on this has a completely different angle.
Unfortunately it wasn't the Cat-V super-Neurontin replacer I wanted it to be. At a test dose (of course I'm on multiple medications including a reduced dose of Neurontin at the time to prevent seizures from over-GABA) of 50mg (like 1/6 of a target dose), it reduced my approx 20/20 to 20/40. As soon as it was removed, I was back to my normal vision.
Vision and focus impairment is a small but definately known side effect of Lyrica. It's even smaller but I think listed with Neurontin though I don't get much of any side effects from Neurontin.
Posted by SLS on September 15, 2006, at 6:21:20
In reply to Re: Lyrica (pregabalin) - Side Effects ? » SLS, posted by yxibow on September 15, 2006, at 3:41:33
> > What side effects can I expect from Lyrica?
>
>
> Everyone on this has a completely different angle.
> Unfortunately it wasn't the Cat-V super-Neurontin replacer I wanted it to be. At a test dose (of course I'm on multiple medications including a reduced dose of Neurontin at the time to prevent seizures from over-GABA) of 50mg (like 1/6 of a target dose), it reduced my approx 20/20 to 20/40. As soon as it was removed, I was back to my normal vision.I understand that the vision disturbance often disipates with continued treatment.
I'm sorry Lyrica didn't work out for you. Are drugs that are potentially beneficial for fibromyalgia on your radar screen?
- Scott
Posted by yxibow on September 15, 2006, at 23:20:18
In reply to Re: Lyrica (pregabalin) - Side Effects ? » yxibow, posted by SLS on September 15, 2006, at 6:21:20
> > > What side effects can I expect from Lyrica?
> >
> >
> > Everyone on this has a completely different angle.
> > Unfortunately it wasn't the Cat-V super-Neurontin replacer I wanted it to be. At a test dose (of course I'm on multiple medications including a reduced dose of Neurontin at the time to prevent seizures from over-GABA) of 50mg (like 1/6 of a target dose), it reduced my approx 20/20 to 20/40. As soon as it was removed, I was back to my normal vision.
>
> I understand that the vision disturbance often disipates with continued treatment.
>
> I'm sorry Lyrica didn't work out for you. Are drugs that are potentially beneficial for fibromyalgia on your radar screen?
>
>
> - Scott
I'm not suffering from fibromyalgia. I have a rare somatiform disorder which causes things to appear brighter than they should be, contrast off, etc... going on 5 years, things are much better. Fluorescent, metal halide, and certain artificial lighting settings are still annoying to a degree.
I've been through most AEDs except for Lamictal. Trileptal just increased one of the few other odd sensory feelings (thirst/saliva) before reaching any notable dose. Lithium has not been tried and probably would be of little help.
Mostly therapy is focused more on goal orientation, returning to society more, (being that this came to my attention about the night of Nov 17. 2001 while attempting to drive in the mountains to the Leonid showers it is likely to have been triggered by my extreme reaction to 9/11) volunteer work, and eventually hopefully pushing the hyperawareness which is going on out of my head to a more background level by engaging in more activity. At least that is the current and probable theory. The one thing that can said in common about most of the medications I take is that they are sedating, which may contribute a percentage to their efficacy. The two main ones that seem to be the actors on the scene are Seroquel (D2 antagonism, the visual receptors which are even in the eye itself) and benzodiazepines, specifically Valium and Xanax (on a bad day), which demonstrably help "screen out" the information which most everyone could imagine if they actually thought about it. E.g., those new replacement traffic lights that are becoming more common in cities, with bright LEDs, someone could say, yes, that's rather bright, but it would be gone -- for myself, the "psychic pain" and the non-screening out of these items make them more miserable. Palinopsia does occur in the dark, like seeing images of cellphones, bright car consoles, bright TVs briefly for a snap to one direction or another. Haloform auras sometimes develop on objects at night briefly. When this first started, if someone took a flash picture of me, the flash would remain for 15 minutes. And I would be wearing sunglasses in nightclubs.
But I digress anyhow -- visual effects are something that can happen with Lyrica, I forget, around 5 or 10% maybe.
I wish you luck with it if you are still continuing on.-- tidings
Jay
Posted by SLS on September 16, 2006, at 2:55:16
In reply to Re: Lyrica (pregabalin) - Side Effects ? » SLS, posted by yxibow on September 15, 2006, at 23:20:18
Hi Jay.
Thanks for sharing so much.
I always appreciate when you do.
I am just starting to contemplate "returning to society" despite my condition. I am working with a counselor to help me make this transition. I have not completely committed myself to this yet, but I am entertaining the thought.
> I wish you luck with it if you are still continuing on.
Thank you.
- Scott
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