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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 15 of 15. This is the beginning of the thread.
Posted by foreigner on July 19, 2006, at 15:21:50
I have read that tianeptine and omega-3 together can can cause liver demage because of some mechaisms ( I think I read it in this forum but I couldn't find it again).
I am using Tianeptine and It is very useful for OCD and some depression. But I want to use omega-3( EPA and DHA) for especially my depression and general health. I know It is useful for OCD too. What is your thoughts? Can I use both of them(tianeptine and fish oil or omega-3 (EPA-DHA)? )
Thanks.
Posted by Declan on July 19, 2006, at 15:23:44
In reply to tianeptine and omega-3, posted by foreigner on July 19, 2006, at 15:21:50
I'm using them together, but I know nothing about this. Hmmmm.
Posted by foreigner on July 19, 2006, at 15:52:57
In reply to Re: tianeptine and omega-3, posted by Declan on July 19, 2006, at 15:23:44
Oh I have found where I read:
http://www.avantlabs.com/forum/index.php?showtopic=23178&mode=threaded&pid=322289
What is your thoughts?
And how much fish oil or omega-3 is too much? Or Is there a thing like too much for these?
Posted by Declan on July 19, 2006, at 16:18:06
In reply to Re: tianeptine and omega-3, posted by foreigner on July 19, 2006, at 15:52:57
Sesamin is sesame lignan extact, I suppose. It's in lots of things these days, not just in my EPA/DHA.
I take around 350mg EPA and 250mg DHA per day, which is a small dose compared to some I read about, but there's the sesame too.
I don't understand the abstract, but will read it carefully later.
Thanks for posting this.
Declan
Posted by linkadge on July 19, 2006, at 18:12:16
In reply to Re: tianeptine and omega-3 » foreigner, posted by Declan on July 19, 2006, at 16:18:06
I don't think this page was suggesting that the two would cause liver dammage. I got that they were suggesting that fish oil might alter the metabolism of tianeptine, though I didn't get any conclusive link from what I read.
Linkadge
Posted by Declan on July 19, 2006, at 18:51:57
In reply to Re: tianeptine and omega-3, posted by linkadge on July 19, 2006, at 18:12:16
Do you know if sesamin is another name for sesame lignans?
Given that it's in the Vitamin E I take, should I worry?
Are we just talking about altering the processing of tianeptine, speeding up the half-life?
I didn't understand the abstract.
Posted by TENMAN on July 19, 2006, at 23:27:21
In reply to Linkadge??, posted by Declan on July 19, 2006, at 18:51:57
Sesamin is sesame lignans but from what I've read all or most is converted in the gut to enterolactone making it ineffective unless you are a rat.
The beta oxidation issue is not going to cause liver damage but rather a reduction of half-life.
Posted by Declan on July 20, 2006, at 0:21:46
In reply to Re: Linkadge??, posted by TENMAN on July 19, 2006, at 23:27:21
Different to the oxidation as such?
Posted by fuchsia on July 20, 2006, at 8:23:18
In reply to Re: tianeptine and omega-3, posted by Declan on July 19, 2006, at 15:23:44
Declan
I didn't know tianeptine was available in Australia. Did you order it from overseas?
Do you think it works?
fuchsia
Posted by linkadge on July 20, 2006, at 16:05:12
In reply to Re: tianeptine and omega-3, posted by fuchsia on July 20, 2006, at 8:23:18
I did't totally understand the whole thing.
"In addition, these data show that lowering
of plasma triglycerides can occur independently of any deleterious peroxisome proliferation"At the end of the abstract seemed to suggest, that taking omega-3 woudn't pose a risk to liver cells. I don't know the doses used either.
The doses used for cholesterol in this study may have been significantly more than those used in mood disorders. I can't see that a gram or two of EPA/DHA would pose a risk since they are theoretically obtainable in the diet.
I honestly don't see any evidence here that taking tianeptine and omega-3 together would pose any risk.
Larry, would be able to know for sure though.
Linkadge
Posted by Declan on July 21, 2006, at 4:26:33
In reply to Re: tianeptine and omega-3, posted by fuchsia on July 20, 2006, at 8:23:18
The worst thing about tianeptine is a (bearable)sense of nervous irritation. I guess that is a smaller version of what is intolerable for some people, feeling weird and stuff. I've only tried Parnate, moclobemide and Remeron (one dose) and tianeptine is tolerable for me, and those aren't. It's better than SJW and SAMe too. I can even do volunteer work.
It's not available in Australia...I ordered it from overseas, but my doctors are quite OK with it
Posted by fuchsia on July 21, 2006, at 21:41:34
In reply to Re: tianeptine and omega-3 » fuchsia, posted by Declan on July 21, 2006, at 4:26:33
Thanks Declan
I am thinking tianeptine is one I can hold in reserve; I don't have many left to try. Parnate is also one I haven't tried.
> The worst thing about tianeptine is a (bearable)sense of nervous irritation. I guess that is a smaller version of what is intolerable for some people, feeling weird and stuff. I've only tried Parnate, moclobemide and Remeron (one dose) and tianeptine is tolerable for me
Do you mean you haven't tried any SSRIs?
, and those aren't. It's better than SJW and SAMe too. I can even do volunteer work.
> It's not available in Australia...I ordered it from overseas, but my doctors are quite OK with itI did once get my doctor to approve one that I ordered from overseas; maybe it was Zyban before it came here. It was a few years ago and I can't remember which it was for sure. So I could order tianeptine if it seemed like it might help.
fuchsia
Posted by Declan on July 22, 2006, at 0:29:09
In reply to Re: tianeptine and omega-3 » Declan, posted by fuchsia on July 21, 2006, at 21:41:34
Are you from Australia then, Fuschia?
I've never taken an SSRI.
Tianeptine feels kinda dopaminergic, but not like deprenyl. It's a more comforting feel. Recovering alcoholics can tolerate it (unlike moclobemide), always a good sign. If you take a double dose your teeth press together.
Posted by fuchsia on July 22, 2006, at 21:37:33
In reply to Re: tianeptine and omega-3, posted by Declan on July 22, 2006, at 0:29:09
> Are you from Australia then, Fuschia?
>I am.
> I've never taken an SSRI.
That is so unusual. How did you manage that?
>
> Tianeptine feels kinda dopaminergic, but not like deprenyl. It's a more comforting feel. Recovering alcoholics can tolerate it (unlike moclobemide), always a good sign. If you take a double dose your teeth press together.I just read some more about it and it sounds like a wonder drug. Do you have any side effects?
As regards volunteer work there was no way I could have done it last year until I went on Lamictal. Now I think I could do it but at this point I have family obligations (now fulfillable). Of course, before, people were always telling me to do volunteer work and it was very annoying. It only indicated their total lack of awareness of my predicament.
Posted by Declan on July 23, 2006, at 3:01:14
In reply to Re: tianeptine and omega-3 » Declan, posted by fuchsia on July 22, 2006, at 21:37:33
Hi Fuchsia.
No side effects for me. Seems to be sex and weight neutral.
It's not perfect, but life for me is better with than without it.
I never took an SSRI because I was sceptical about the industry.
Declan
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