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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 14 of 14. This is the beginning of the thread.
Posted by honeybee on June 28, 2006, at 12:00:51
Well, rather, to use of Anti-Parkinson's drugs, but the subject line was too short to clarify.
Now, can someone post a happy story about how ADs make us live longer, happier superhero lives?
hb
+++++++++++
Antidepressant and Lithium Therapy Linked to Future Use of Antiparkinson DrugsNEW YORK (Reuters Health) Jun 16 - Treatment with antidepressants and lithium is associated with an increased risk of later treatment with antiparkinson drugs, according to findings from a Danish study.
The findings suggest that "patients with anxiety or affective disorders are at increased risk of developing Parkinson's disease," Dr. M. Brandt-Christensen, from the University of Copenhagen, and colleagues note.
The study, reported in the Journal of Neurology, Neurosurgery, and Psychiatry for June, involved an analysis of prescription data for nearly 1.3 million people logged in a Danish national registry between 1995 and 1999.
Treatment with an antidepressant raised the risk of later treatment with an antiparkinson medication by 2.27- and 1.50-fold in men and women, respectively. The corresponding rate ratios with lithium were 2.22 and 1.64.
The new findings support other recent reports suggesting an association between affective/anxiety disorders and Parkinson's disease. It is possible that the treatments for these disorders, and not the disorders themselves, are what precipitate Parkinson's disease, the authors point out.
J Neurol Neurosurg Psychiatry 2006;77:781-783.
Posted by linkadge on June 28, 2006, at 16:51:04
In reply to AD and Lithium Therapy linked to Parkinsons..., posted by honeybee on June 28, 2006, at 12:00:51
Thats because lithium and most AD's are antidopaminergic.
Linkadge
Posted by Klavot on June 29, 2006, at 14:41:58
In reply to Re: AD and Lithium Therapy linked to Parkinsons..., posted by linkadge on June 28, 2006, at 16:51:04
> Thats because lithium and most AD's are antidopaminergic.
>
> LinkadgeLinkadge, please tell me, would Wellbutrin cancel out the antidopaminergic effect of Zoloft?
Posted by linkadge on June 29, 2006, at 15:57:13
In reply to Re: AD and Lithium Therapy linked to Parkinsons..., posted by Klavot on June 29, 2006, at 14:41:58
Contrary to popular belief, wellbutrin really isn't that strong a dopaminergic. It seems to have stronger effects on norepinephrine than dopamine.
Comparitively it is only a weak inhibitor of dopamine uptake.
Zoloft *may* be the least likely to cause these effects. I believe it is chosen over other SSRI's in parkinson's disease. That does not absolve it from possable long term effects, but perhaps.
Taking the least effective dose its probably your best bet.
Coffee seems to have a protective effect against parkinsons, it may be of some use to protect against such changes (?)
Linkadge
Posted by nellie7 on June 29, 2006, at 16:23:02
In reply to Re: AD and Lithium Therapy linked to Parkinsons..., posted by linkadge on June 28, 2006, at 16:51:04
> Thats because lithium and most AD's are antidopaminergic.
>
> LinkadgeIn that case, why do you suppose APs are not mentioned, as they are the most antidopaminergic?
Posted by honeybee on June 29, 2006, at 16:25:01
In reply to Re: AD and Lithium Therapy linked to Parkinsons... » linkadge, posted by nellie7 on June 29, 2006, at 16:23:02
So, Link,
Why do you not have the same tachycardia reaction to Fish Oil? Doesn't it increase NE and Dopamine in the brain?? I had somehow assumed it was in some way a kind of natural wellbutrin.
Posted by linkadge on June 29, 2006, at 17:00:06
In reply to Re: AD and Lithium Therapy linked to Parkinsons... » linkadge, posted by nellie7 on June 29, 2006, at 16:23:02
Probably just cause they weren't tested. I'm sure they confer a similar risk.
Linkadge
Posted by fuchsia on July 1, 2006, at 2:42:57
In reply to AD and Lithium Therapy linked to Parkinsons..., posted by honeybee on June 28, 2006, at 12:00:51
Oh god; this is the last thing I want to hear. Whenever I'm depressed I always think I've got parkinson's.
I thought that if you are going to get parkinson's because of genetic reasons or other reasons (not a result of depression or its treatment) then it could make itself first apparent with the symptom of depression.
Posted by linkadge on July 1, 2006, at 14:53:26
In reply to Re: AD and Lithium Therapy linked to Parkinsons... » honeybee, posted by fuchsia on July 1, 2006, at 2:42:57
I posted below:
I don't think there is a conspiracy, I just think that we don't know enough about these drugs.For instance, from a study done on sertraline:
http://psy.psychiatryonline.org/cgi/content/full/42/2/163-a
We cannot know whether this illness would have developed in our patient if the SSRI had never been started. A recent study has demonstrated that SSRIs can induce neuroanatomical changes in the thalamus.4 Systematic studies are needed to address whether SSRI's can induce Parkinson's disease.
------------------------Linkadge
Posted by fuchsia on July 4, 2006, at 7:23:42
In reply to Re: AD and Lithium Therapy linked to Parkinsons..., posted by linkadge on July 1, 2006, at 14:53:26
http://psy.psychiatryonline.org/cgi/content/full/42/2/163-a
>
> We cannot know whether this illness would have developed in our patient if the SSRI had never been started. A recent study has demonstrated that SSRIs can induce neuroanatomical changes in the thalamus.4 Systematic studies are needed to address whether SSRI's can induce Parkinson's disease.
>That's interesting.
I got extrapyramidal effects from paroxetine (which I took hot on the heels of sertraline).
I used to tell my then pdoc all the time that I would get/might be getting parkinson's and I'm sure she thought I was a real bore.When I get my depressions now (and they are frequent) I can get a kind of paralysis. I wonder if someone with bipolar could show parkinson's only in the down phase. Maybe someone who was doomed to get parkinson's anyway.
Posted by linkadge on July 4, 2006, at 19:03:59
In reply to Re: AD and Lithium Therapy linked to Parkinsons..., posted by fuchsia on July 4, 2006, at 7:23:42
I don't know. I remember reading a study recently that linked risk taking and thrill seeking behavior to a *lower* risk of Parkinsons.
Linkadge
Posted by fuchsia on July 5, 2006, at 23:21:47
In reply to Re: AD and Lithium Therapy linked to Parkinsons..., posted by linkadge on July 4, 2006, at 19:03:59
> I don't know. I remember reading a study recently that linked risk taking and thrill seeking behavior to a *lower* risk of Parkinsons.
>My diagnosisis bipolar and GAD. I've exhibited some risk taking behaviour but maybe that was out of desperation.
What about these people (obviously not talking about myself here) who were really active in sports at school? My friend commented that he thought they tended to be much more confident and less likely to be socially anxious. I don't know if that's true but it seemed that way when I was at school. I'll bet they don't get parkinson's very often.
Posted by honeybee on July 6, 2006, at 8:49:39
In reply to Re: AD and Lithium Therapy linked to Parkinsons..., posted by fuchsia on July 5, 2006, at 23:21:47
I was on swim-team, an avid runner, and then a really dedicated yoga practitioner. Still have walloping depression and not a big risk taker! Can't say I have a whole lot of self-confidence, either. So I think it really depends, especially if athletes are performing under high pressure situations. There are lots of anxiety disorders associated with sports: eating disorders with gymnastics, running, wrestling, and swimming, for one.
Posted by fuchsia on July 9, 2006, at 8:08:35
In reply to Re: AD and Lithium Therapy linked to Parkinsons..., posted by honeybee on July 6, 2006, at 8:49:39
> I was on swim-team, an avid runner, and then a really dedicated yoga practitioner. Still have walloping depression and not a big risk taker! Can't say I have a whole lot of self-confidence, either. So I think it really depends, especially if athletes are performing under high pressure situations. There are lots of anxiety disorders associated with sports: eating disorders with gymnastics, running, wrestling, and swimming, for one.
Yes, you're right there. I guess I was thinking of team sports where you have to be quick-witted and co-ordinated but yes anything gets stressful at the top. I did do competition running; maybe I was thinking of sports with more brain involvement.
fuchsia
This is the end of the thread.
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