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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 9 of 9. This is the beginning of the thread.
Posted by capricorn on July 2, 2006, at 2:51:17
Posted by pseudoname on July 2, 2006, at 10:58:03
In reply to Damaged DNA:Depression's hidden culprit??, posted by capricorn on July 2, 2006, at 2:51:17
Thanks very much for posting this, capricorn.
To sum it up for the click-shy: Problems with other chemicals around our DNA molecules may prevent DNA segments from giving instructions for the creation of brain-derived neurotropic factor (BDNF). The reduced BDNF levels may then result in depression symptoms. An antidepressant like imipramine partially opens the DNA back up so that it can produce more BDNF again.
Neato!
But there's much I don't get about it. Why does it affect just BDNF creation? Why doesn't the hypermethylation shut down protein production generally?
Posted by pseudoname on July 2, 2006, at 11:23:32
In reply to very interesting » capricorn, posted by pseudoname on July 2, 2006, at 10:58:03
> Why does it affect just BDNF creation? Why doesn't the hypermethylation shut down protein production generally?
“The underlying mechanisms for the initiation and targeting of ectopic hypermethylation are not known, although it has been suggested that DNMTs [the chemicals that control methylation] may preferentially bind to damaged or mismatched DNA.”
–DNA hypermethylation http://www.humpath.com/article.php3?id_article=1931“…the establishment of DNA methylation patterns [is] a long-standing mystery in epigenetics.”
–histone methylation http://www.humpath.com/article.php3?id_article=8552My confusion feels more tolerable now.
Posted by Phillipa on July 2, 2006, at 13:07:56
In reply to very interesting » capricorn, posted by pseudoname on July 2, 2006, at 10:58:03
Does this mean prozac works too and at what does does the imipramine and prozac work? Love Phillipa click shy
Posted by linkadge on July 2, 2006, at 16:08:57
In reply to Re: very interesting » pseudoname, posted by Phillipa on July 2, 2006, at 13:07:56
My question is wheather the methylation they are talking about has anything to do with the process of methylation affected by things like SAMe.
Linkadge
Posted by pseudoname on July 2, 2006, at 19:16:55
In reply to Re: very interesting » pseudoname, posted by Phillipa on July 2, 2006, at 13:07:56
Posted by rod on July 2, 2006, at 20:05:20
In reply to Re: very interesting, posted by linkadge on July 2, 2006, at 16:08:57
> My question is wheather the methylation they are talking about has anything to do with the process of methylation affected by things like SAMe.
>
> LinkadgeAlso wonder about that, since SAMe makes me worse... And i furhter wonder if the drug Nicergoline, whis is said to increase proteine synthesis, also has the ability to "reverse" the hypermethylation they are talking about here...
Rod
Posted by capricorn on July 2, 2006, at 20:56:25
In reply to Re: very interesting, posted by rod on July 2, 2006, at 20:05:20
> > My question is wheather the methylation they are talking about has anything to do with the process of methylation affected by things like SAMe.
> >
> > Linkadge
>
> Also wonder about that, since SAMe makes me worse... And i furhter wonder if the drug Nicergoline, whis is said to increase proteine synthesis, also has the ability to "reverse" the hypermethylation they are talking about here...
>
> RodAre you bipolar Rod?
Posted by rod on July 3, 2006, at 10:17:14
In reply to Re: very interesting, posted by capricorn on July 2, 2006, at 20:56:25
> > > My question is wheather the methylation they are talking about has anything to do with the process of methylation affected by things like SAMe.
> > >
> > > Linkadge
> >
> > Also wonder about that, since SAMe makes me worse... And i furhter wonder if the drug Nicergoline, whis is said to increase proteine synthesis, also has the ability to "reverse" the hypermethylation they are talking about here...
> >
> > Rod
>
>
>
> Are you bipolar Rod?Well my last 2 docs say I have dysthymia. And I think they are right.
This is the end of the thread.
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