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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 4 of 4. This is the beginning of the thread.
Posted by idolamine on May 31, 2006, at 0:55:24
So, I'm stabilized on the 6mg patch now. No hyperkinesia, no dyskinesia or tounge problems. More energy, etc. No agitation. However, my anxiety is comparable to not being on it. Specifically, I have an awful torticollis (spasms) in my neck that are only helped with a lot of serotonin. I want to try upping the patch- are two 6mg patches equivalent to one 12 pharmacokinetically? Thanks sls.
Posted by SLS on May 31, 2006, at 6:43:54
In reply to ok, emsam update. 1-800-SLS, posted by idolamine on May 31, 2006, at 0:55:24
> So, I'm stabilized on the 6mg patch now. No hyperkinesia, no dyskinesia or tounge problems. More energy, etc. No agitation. However, my anxiety is comparable to not being on it. Specifically, I have an awful torticollis (spasms) in my neck that are only helped with a lot of serotonin. I want to try upping the patch- are two 6mg patches equivalent to one 12 pharmacokinetically? Thanks sls.
I'm not absolutely sure, but I suspect that they are equivalent. The concentration (mg/cm2) of selegiline is the same between the three dosage forms. Doubling the surface area should double the amount of drug being absorbed through the skin.
http://www.cnsspectrums.com/aspx/articledetail.aspx?articleid=400
"Pharmacokinetics of Selegiline Transdermal SystemOver 30 human pharmacokinetics studies have examined dermally applied selegiline in over 650 subjects. STS is extensively absorbed through the skin with plasma levels maintained over a 24-hour period permitting once-daily application. About 25% to 30% of selegiline in STS is delivered within 24 hours. Selegiline delivered by 20 mg/20 cm2, 30 mg/30 cm2, and 40 mg/40 cm2 STS approximates 6 mg, 9 mg, and 12 mg over 24 hours, respectively."
If hyperkinesia remains a problem, you could go with Nardil. It doesn't act like amphetamine. Also, a drug similar to selegiline named rasagiline is not metabolized into amphetamines.
- Scott
Posted by Phillipa on May 31, 2006, at 22:02:14
In reply to Re: ok, emsam update. 1-800-SLS, posted by SLS on May 31, 2006, at 6:43:54
Have you gone to 9mg yet? Maybe don't double it so quick. Love Phillipa
Posted by Donna Louise on June 1, 2006, at 5:53:20
In reply to ok, emsam update. 1-800-SLS, posted by idolamine on May 31, 2006, at 0:55:24
> So, I'm stabilized on the 6mg patch now. No hyperkinesia, no dyskinesia or tounge problems. More energy, etc. No agitation. However, my anxiety is comparable to not being on it. Specifically, I have an awful torticollis (spasms) in my neck that are only helped with a lot of serotonin. I want to try upping the patch- are two 6mg patches equivalent to one 12 pharmacokinetically? Thanks sls.
I am not Scott but I do have an experience. I cut the 6mg in half to make 9mg. It hasn't hurt me to do it, the pdoc won't know about it until the 15th and if it helps she can write me an rx for it. It does seem to have helped some with the anxiety to go up but I don't know about the neck thing. serotonin tends to give me that, not make it better but in your case maybe it is just the thing. I take klonopin for muscular tension as it is related to the dang anxiety.
Donna
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