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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 55 to 79 of 85. Go back in thread:
Posted by Declan on May 9, 2006, at 20:34:24
In reply to Re: MAOIs » ed_uk, posted by yxibow on May 9, 2006, at 17:25:47
Posted by Jost on May 9, 2006, at 23:27:19
In reply to Re: MAOIs, posted by Caedmon on May 9, 2006, at 19:30:31
> Hi Don,
>
> The figures you quoted, were they from http://www.emedicine.com/EMERG/topic318.htm ? You posted a link to the aapcc's website, but I honestly couldn't make heads or tails of anything on it.
>
The figures Don quoted, unless I'm mistaken (which I might be) were from a "Summary of fatal exposures reported to TESS in 2002" published in the Am J. of Emergency Med.However, the Summary, as I read it, noted only one death from an maoi, ie parnate; and the cause of death was "ther. err."--ie therapist error, rather than an adverse drug reaction.
Possibly, Don's statistics are from another source. However, the type of AD associated with the highest number of fatalities on this report, by far, was tricyclics, particularly. amitriptyline. Is this the most widely prescribed tricylic?
Most of the deaths were intentional. There are a few other causes, such as "malicious," "adv. react." and "ther. err." The number of adverse reactions is so small that it would seem hard to draw any conclusions from this one report.
Last night I came across a paper--I can't find it now--that suggested that deaths from tricyclics were greater in absolute numbers than those from maois, although a somewhat greater proportion of the maoi fatalities were intentional. The difference didn't seem so great as to make the argument that maois are to be avoided at all costs. Obviously, care must be taken in their use..
I'd be interested in Don's sources, though.
Jost
Posted by yxibow on May 9, 2006, at 23:31:54
In reply to Re: MAOIs, posted by Phillipa on May 9, 2006, at 19:49:36
> Jay are you saying most schizophrenics are catatonic? I've never seen that. Most are out of reality. Hearing voices in their heads and delusinal. Did I read you wrong? And why the dicussion of codeine. So what if someone takes it to feel better. People drink alchohol to feel better or euphoric as you call it and it's legal. I think this discussion has gotten out of hand. Maybe E-mail would be better. I thought this was on MAOIS? Love Phillipa
Email was better, if you want to know the truth, Ed and I have been bantering there and its come out here and I believe Ed has been a bit obsessive about my views, and we've been there over and over so I ended my opinions. I don't believe that it should have been diverted for euphoria in the US because now we can't take it over the counter for cough medication in the US like we used to. I also don't think it is the best choice of a psychiatric medication when there are others out there with less potential for morphine addiction, etc, etc, etc... and that was the whole content of countless emails. End of story, and I've closed the chapter with Ed. And please for goodness sakes, I like ya Eddy, so lets not go on again. And you agree with Ed about alcohol and I agree in moderation, so I'm not going to argue with it. It was not about one-offs, Phillipa, it was about continuous use of it as people use alcohol continuously for GABA use and the continuous use of either drug can be more harmful than some psychiatric medications. Finit, okay.
I used the wrong medical term -- what I meant was the vast majority of schizophrenics that I've observed are dysphoric and exhibit part of the symptoms of catatonia - stupor and stereotypy. My mistake. My point with this whole thread as for schizophrenia was yes, you're right, the vast majority are quiescent and introverted and the word is on the tip of my tongue but I misplaced it.Yes, this started as MAOIs but the whole thread as you can see is multifaceted.
Cheers
-- Jay
Posted by Phillipa on May 9, 2006, at 23:39:14
In reply to Re: MAOIs and everything else » Phillipa, posted by yxibow on May 9, 2006, at 23:31:54
Jay I know you are friends and like to banter about meds. And I like both of you a whole bunch. I just thought some of the stuff you were talking about wasn't meant for everyone. Are we still friends? Love Phillipa
Posted by yxibow on May 9, 2006, at 23:49:45
In reply to Re: MAOIs and everything else » yxibow, posted by Phillipa on May 9, 2006, at 23:39:14
> Jay I know you are friends and like to banter about meds. And I like both of you a whole bunch. I just thought some of the stuff you were talking about wasn't meant for everyone. Are we still friends? Love Phillipa
We are and Ed and I are. It wasn't meant for everyone but somehow there was an obsessive need, and don't take this the wrong way, Eddy dear, for Ed (and I) to play one upmanship and continue this thread where it should have been private. I mean no intrinsic harm by the previous comment but if you look at the whole thread and the number of emails about it , it strikes me as obsessiveness. At any rate, nobody I hope is hurt or harmed by this interruption in the thread, its all good as far as I am concerned, agreements to disagree, and laid to rest.
Posted by Don_Bristol on May 10, 2006, at 9:35:55
In reply to Re: MAOIs » Don_Bristol, posted by ed_uk on May 9, 2006, at 15:22:01
> Hi Don
>
> >there is a good case for trying the less-lethal ADs first and then moving towards MAOIs if nothing else works
>
> I have never heard of MAOIs being used until a
> variety of other ADs have been tried. Have you?I have never heard of MAOIs being used until a variety of other ADs have been tried, either. The poster was hoping for safer MAOIs so they could be tried sooner.
>
> You seem concerned about MAOIs.
>I am concerned about the food reaction with MAOIs. Yes.
>
> I thought you took Parnate?
>Yes I take Parnate. And very good it is too.
Don
Posted by ed_uk on May 10, 2006, at 10:01:59
In reply to Re: MAOIs » ed_uk, posted by yxibow on May 9, 2006, at 17:25:47
>I have no idea if you were feeling better, feeling better because of euphoria, or feeling euphoric
Not sure what that's supposed to mean. Are you saying that if a med makes someone feel better this is a form of euphoria?
>intended purpose
And who is to say what a drug's intended purpose should be? Some people believe that atypical APs should never be used to treat insomnia.......other people believe that using APs to treat insomnia is perfectly acceptable. It's all a matter of opinion.
>divert OTC medications
It seems that you're referring to the diversion of OTC meds after using them to synthesize other drugs. I was thinking more of diversion of drugs in their original state.
>Catatonic" "Vast majority." That means "most all people." I just said it!
I wouldn't say most people with schizophrenia are catatonic. Most people with schizophrenia suffer from delusions, hallucinations and disorganised behaviour. Catatonia is present in some but not the vast majority.
>only Canada and the UK have caps
That's not true at all. Many countries have price controls. Certainly, most European countries do.
>I wouldn't want a end-all happy pill for antidepression that cost only $1 million to produce to come to market. That would scare me and suggest that they tested it on like 2 patients.
Well no, but for widely prescribed drugs like APs pharmaceutical companies do not need to charge such high prices to regain the money they spent on research. They quickly end up making huge profits.
>Go petition the FDA, but you're not likely to get anywhere.
Nah, I won't bother thanks.
Ed
Posted by ed_uk on May 10, 2006, at 10:07:33
In reply to Re: MAOIs and everything else » Phillipa, posted by yxibow on May 9, 2006, at 23:31:54
>Ed has been a bit obsessive about my views
Perhaps, it's in my nature to be obsessive.
>I don't believe that it should have been diverted for euphoria in the US because now we can't take it over the counter for cough medication in the US like we used to
I don't believe my having taken codeine has affected your ability to obtain it Yxi.
Ed
Posted by ed_uk on May 10, 2006, at 10:10:14
In reply to Re: MAOIs » ed_uk, posted by Don_Bristol on May 10, 2006, at 9:35:55
Hi Don
>Yes I take Parnate. And very good it is too.
Did you tell your pdoc what I said about the maximum dose not being 30mg?
Ed
Posted by Don_Bristol on May 10, 2006, at 10:10:32
In reply to Re: MAOIs, posted by Jost on May 9, 2006, at 23:27:19
> > Hi Don,
> >
> > The figures you quoted, were they from http://www.emedicine.com/EMERG/topic318.htm ? You posted a link to the aapcc's website, but I honestly couldn't make heads or tails of anything on it.
> >
>
>
> The figures Don quoted, unless I'm mistaken (which I might be) were from a "Summary of fatal exposures reported to TESS in 2002" published in the Am J. of Emergency Med.
>
> However, the Summary, as I read it, noted only one death from an maoi, ie parnate; and the cause of death was "ther. err."--ie therapist error, rather than an adverse drug reaction.
>
> Possibly, Don's statistics are from another source. However, the type of AD associated with the highest number of fatalities on this report, by far, was tricyclics, particularly. amitriptyline. Is this the most widely prescribed tricylic?
>
> Most of the deaths were intentional. There are a few other causes, such as "malicious," "adv. react." and "ther. err." The number of adverse reactions is so small that it would seem hard to draw any conclusions from this one report.
>
> Last night I came across a paper--I can't find it now--that suggested that deaths from tricyclics were greater in absolute numbers than those from maois, although a somewhat greater proportion of the maoi fatalities were intentional. The difference didn't seem so great as to make the argument that maois are to be avoided at all costs. Obviously, care must be taken in their use..
>
> I'd be interested in Don's sources, though.
>
> Jost
>
>--------------------
Hi Jost
This is the document in PDF form
<http://www.aapcc.org/Annual%20Reports/02report/AnnlRpt02Table22.pdf>;
Go to page 404 (PDF doc page 12).
Read the line across for MAOIs. Last figures shows 2 deaths, 26 major and 81 moderate. I put it into a spreadsheet. http://tinyurl.com/ppmd5 Let me know if the percentages are wrong because I did for my own use and approximate figures were good enough for what I needed. The breakdown by type occurs there which is why I said about a third were intentional (81 out of 181 intentional plus the 81 intentional) because the data is patchy and the categories overlap so UNintentional + Intentional + unknowns will equal the total population sampled.
That is what I was quoting. I used those 2003 figures in June 2004 because they were the lastest available. Now newer figures are available and you can compile them (save me the trouble!) from http://www.aapcc.org/annual.htm then "View Report By Sections" then "Table 22A-22B".
Not sure where you got your data about "ther. err." and that sort of breakdown. Do you have a link?
Was it you who posted this to this thread?: "However the chance of a stroke and unilateral or bilateral neurological damage is higher. Its worse than death. Its immobilization and life debilitating."
In a funny way I really do agree. When you're dead, you're dead. But to live with severe brain damage is a living death and is an even more frightening prospect to me than death.
rgds, Don
Posted by ed_uk on May 10, 2006, at 10:17:37
In reply to Re: MAOIs » Jost, posted by Don_Bristol on May 10, 2006, at 10:10:32
>But to live with severe brain damage is a living death and is an even more frightening prospect to me than death.
I agree. I hope you weren't offended by my last post to you. MAOIs can be frightening. Do you carry a nifedipine capsule yourself?
Ed
Posted by ed_uk on May 10, 2006, at 10:19:21
In reply to Re: MAOIs and everything else » Phillipa, posted by yxibow on May 9, 2006, at 23:49:45
Hi J
Please reply in private if you wish. I don't want to talk on the board anymore. Thank you.
Regards
Ed
Posted by yxibow on May 10, 2006, at 12:38:18
In reply to Re: MAOIs and everything else » yxibow, posted by ed_uk on May 10, 2006, at 10:19:21
> Hi J
>
> Please reply in private if you wish. I don't want to talk on the board anymore. Thank you.
>
> Regards
>
> Ed
>Good idea, I just did. And let's all be civil -- actually I think I have been fairly so.
Evening, sweetness.
Posted by Don_Bristol on May 10, 2006, at 14:34:30
In reply to Re: MAOIs » Don_Bristol, posted by ed_uk on May 10, 2006, at 10:17:37
> But to live with severe brain damage is a
> living death and is an even more frightening
> prospect to me than death.
>
> I agree. I hope you weren't offended by my last
> post to you. MAOIs can be frightening. Do you
> carry a nifedipine capsule yourself?
>
> Ed------------
You have given no offense at all. Not even faintly.
AIUI, Nifedapine is contra-indicated for a hypertensive crisis.
"The Dangers of Immediate-Release Nifedipine for Hypertensive Crises"
<http://www.ptcommunity.com/ptjournal/fulltext/27/7/PTJ2707362.pdf>;"Alternatives to Nifedipine in the Oral Treatment of Hypertensive Urgencies"
<http://www.rxfiles.ca/acrobat/nifed-hu.pdf>;I used to carry Captopril but now I don't usually bother.
best wishes
Don
Posted by gardenergirl on May 10, 2006, at 15:48:04
In reply to Re: MAOIs » ed_uk, posted by Don_Bristol on May 10, 2006, at 14:34:30
My pdoc did not give me nifidepine. I do wear a medical alert bracelet which states I take an MAOI, and cautions about food and drug interactions. It also points out the risk of hypertensive crisis. I am hopeful that in the unlikely and unfortunate event that I am in an ER unconscious, someone will use this to make informed diagnosis and treatment decisions.
gg
Posted by Phillipa on May 10, 2006, at 18:28:04
In reply to Re: MAOIs, posted by gardenergirl on May 10, 2006, at 15:48:04
GG I don't want to sound negative but I certainly hope they know what an MAOI is. Most ER personal know nothing about psych meds. Sad but true. Please someone tell me I'm wrong. Love Phillipa
Posted by ed_uk on May 10, 2006, at 18:41:27
In reply to Re: MAOIs » ed_uk, posted by Don_Bristol on May 10, 2006, at 14:34:30
Hi Don
>Nifedapine is contra-indicated for a hypertensive crisis
I think we discussed this once before, do you rememeber? And captopril too. I remember you posting some links.
Some psychiatrists consider nifedipine to be an appropriate treatment for an MAOI hypertensive crisis. The dose should be low, and the patient should still go to hospital.
As you rightly point out, immediate-release nifedipine is not suitable for most types of hypertensive crisis. Many (non-MAOI) hypertensive crises occur in people with chronic hypertension and cardiovascular disease. Immediate-release nifedipine should not be prescribed to these patients. This does not mean that immediate-release nifedipine is contra-indicated in MAOI crises however, which occur in very different circumstances, in different types of patients, who do not, in general, suffer from chronic cardiovascular disease.
Regards
Ed
Posted by ed_uk on May 10, 2006, at 18:42:33
In reply to Re: MAOIs » gardenergirl, posted by Phillipa on May 10, 2006, at 18:28:04
One would hope that the medic-alert bracelet provides enough info :S
Ed
Posted by Jost on May 10, 2006, at 19:10:38
In reply to Re: MAOIs » Phillipa, posted by ed_uk on May 10, 2006, at 18:42:33
> One would hope that the medic-alert bracelet provides enough info :S
>
> EdAlso that medical personnel would have the sense,if you have a bracelet, and they don't recognize the medication, to check the PDR.
It might be extra protection to carry a card in your wallet that repeats the information, and has the name or phone number of your psych doctor. That's what I did, anyway.
Jost
Posted by Phillipa on May 10, 2006, at 19:22:33
In reply to Re: MAOIs, posted by Jost on May 10, 2006, at 19:10:38
Excellent idea gg what does the bracelet say? Maybe if it doesn't your Doc's name and phone number should be included. Love Phillipa
Posted by gardenergirl on May 10, 2006, at 22:19:25
In reply to Re: MAOIs, posted by Jost on May 10, 2006, at 19:10:38
> > One would hope that the medic-alert bracelet provides enough info :S
> >
> > Ed
>
> Also that medical personnel would have the sense,if you have a bracelet, and they don't recognize the medication, to check the PDR.Yep.
>
> It might be extra protection to carry a card in your wallet that repeats the information, and has the name or phone number of your psych doctor. That's what I did, anyway.I have that, too. Plus an article about MAOI's on my Palm, so if I'm coherent, I can show them.
gg
Posted by Phillipa on May 10, 2006, at 22:22:23
In reply to Re: MAOIs » Jost, posted by gardenergirl on May 10, 2006, at 22:19:25
gg what if you are not? Love Phillipa
Posted by gardenergirl on May 10, 2006, at 22:23:47
In reply to Re: MAOIs » Jost, posted by Phillipa on May 10, 2006, at 19:22:33
> Excellent idea gg what does the bracelet say? Maybe if it doesn't your Doc's name and phone number should be included. Love Phillipa
The front has:
My name
Takes MAOI
No Demerol
See backThe back says:
Warning:
Drug and food interactions
Anesthesia cautions (guess that's a line that's not needed)
Hypertensive crisis riskI'm not planning to get a new one anytime soon, as this one cost $65. I opted for gold since I wear it all the time, and most of my jewelry is gold. I figure that is enough information to make a reasonable person be cautious and get more information if they don't understand. Hopefully, it will never be needed, but I feel better wearing it.
gg
Posted by Phillipa on May 10, 2006, at 23:23:50
In reply to Medic alert bracelet information » Phillipa, posted by gardenergirl on May 10, 2006, at 22:23:47
That sounds good to me. Someone would have to be in zombie land not to look into that. Thanks for telling me . I had no ideas what the bracelets say and I'd opt for gold too. Love Phillipa
Posted by yxibow on May 11, 2006, at 2:36:56
In reply to Re: Medic alert bracelet information » gardenergirl, posted by Phillipa on May 10, 2006, at 23:23:50
I carry a credit card sized printed medical alert on card stock with the entire list of my current medications and their doses in my wallet prominantly visible with a medical symbol under my drivers license, as well as my doctor's name, address, and all his contacts for the unforseen circumstances. I update this as it changes.
I think it is a good thing for peace of mind for people especially who take polypharmacy.
-- tidings
Jay
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