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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by chess on January 11, 2006, at 19:31:13
i know that Nardil elevates the level of GABA in the brain, but can Parnate also elevate the level of GABA too?
Posted by linkadge on January 11, 2006, at 19:54:51
In reply to can Parnate increase GABA like Nardil does?, posted by chess on January 11, 2006, at 19:31:13
I don't think it does directly. Nardil decreases an enzyme that metabolizes GABA. I don't think parante has this property.
It may increase GABA indirectly, thought its effects on monoamines.
Linkadge
Posted by djmmm on January 11, 2006, at 21:56:44
In reply to can Parnate increase GABA like Nardil does?, posted by chess on January 11, 2006, at 19:31:13
> i know that Nardil elevates the level of GABA in the brain, but can Parnate also elevate the level of GABA too?
>
>Parnate increases GABA(B) receptor activity in the cerebral cortex. (Effects of stress and tranylcypromine on amphetamine-induced locomotor activity and GABA(B) receptor function in rat brain.
)
Posted by chess on January 11, 2006, at 23:04:25
In reply to Re: can Parnate increase GABA like Nardil does?, posted by djmmm on January 11, 2006, at 21:56:44
GABA(B) is the sedative receptor
GABA(A) is the anxiolytic receptor
right?
that's why drugs they're working on (like ocinaplon) only affect GABA(A) receptors
benzos affect GABA A + B receptors> > i know that Nardil elevates the level of GABA in the brain, but can Parnate also elevate the level of GABA too?
> >
> >
>
> Parnate increases GABA(B) receptor activity in the cerebral cortex. (Effects of stress and tranylcypromine on amphetamine-induced locomotor activity and GABA(B) receptor function in rat brain.
> )
Posted by djmmm on January 12, 2006, at 7:55:38
In reply to Re: can Parnate increase GABA like Nardil does?, posted by chess on January 11, 2006, at 23:04:25
Well, GABA-B agonism typically causes muscle relaxation (like Baclofen), I think GHB mainly effects that receptor subtype, also.
Posted by willyee on January 12, 2006, at 15:01:36
In reply to can Parnate increase GABA like Nardil does?, posted by chess on January 11, 2006, at 19:31:13
I could be wrong here but i thought on that site biopysh i saw a small study on the difference between nardil/parnate.In it something was said to the effect while we know nardil results in a gaba increase,that parnate actualy DECREASED overall gaba,and was used to show how to counter act a overload of gaba from nardil,i could have gotten that out of it when it was saying something else,but thats what i remebered reading,ill look for it to post.
This is the end of the thread.
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