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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 25 of 35. This is the beginning of the thread.
Posted by BennyJ on January 6, 2006, at 21:28:25
Hi, i'm starting nardil tommorrow for the first time. I take 100mg of trazadone for sleep at night. Wondering if anyone out there has had good success with this combo. I'm a little bit nervous but also looking forward to the nardil as social anxiety for me is bad. The precautions say avoid alergy meds...is it safe to take benadryl though? man do i really need to give up coffee? lol thats tough
Posted by sdb on January 6, 2006, at 21:57:15
In reply to Nardil and Trazadone?, posted by BennyJ on January 6, 2006, at 21:28:25
I have never heard somebody taking this two meds together. Trazodone is a strong serotonin 5ht-2 receptor inhibitor whereas phenelzine increases serotonin too. That could be dangerous. I would not recommend it.
Posted by BennyJ on January 6, 2006, at 23:34:41
In reply to Re: Nardil and Trazadone?, posted by sdb on January 6, 2006, at 21:57:15
The GP who rx'd the nardil today for me didnt say anything negative...he ran it through his database and said traz is not on the list for adverse reaction with nardil...although he could be wrong...I pressed him for a maoi, he hadn't rx'd them in many years. Where would I find out for sure?
> I have never heard somebody taking this two meds together. Trazodone is a strong serotonin 5ht-2 receptor inhibitor whereas phenelzine increases serotonin too. That could be dangerous. I would not recommend it.
Posted by gibber on January 6, 2006, at 23:44:10
In reply to Nardil and Trazadone?, posted by BennyJ on January 6, 2006, at 21:28:25
I do drink coffee on Nardil 1-2 cups a day. I know it not recommended, but what can I say? coffee is great. I think benedryl is definitely NOT OK.
Posted by BennyJ on January 6, 2006, at 23:52:56
In reply to Re: Nardil and Trazadone?, posted by sdb on January 6, 2006, at 21:57:15
I just searched online...thnx for the headsup on this combo...looks like it could be potentially nasty. Time to find a new GP? lol
> I have never heard somebody taking this two meds together. Trazodone is a strong serotonin 5ht-2 receptor inhibitor whereas phenelzine increases serotonin too. That could be dangerous. I would not recommend it.
Posted by ed_uk on January 7, 2006, at 4:29:19
In reply to Re: Nardil and Trazadone?, posted by BennyJ on January 6, 2006, at 23:52:56
Trazodone was the traditional 'drug of choice' for Nardil-induced insomnia.
Ed
Posted by Tom Twilight on January 7, 2006, at 4:33:38
In reply to Re: Nardil and Trazadone?, posted by BennyJ on January 6, 2006, at 23:52:56
I thought Trazadone was about the only AD it was reasonably safe to combine with MAOIs.
Your GP doesn't want you to die, I should think you'll be safe on this combo
I combine Coffee with Marplan, another MAOI without ill effects, and I've heard of others combining Coffee with Parnate.
If your really worried check your get a blood pressure monitor and check your BP.I have to say that although Caffeine is probably OK you should be very carefull with stronger stimulants including Decongenstant pills!
Posted by sdb on January 7, 2006, at 10:15:22
In reply to Re: Nardil and Trazadone?-Should be safe, posted by Tom Twilight on January 7, 2006, at 4:33:38
Trazodone's serotonergic properties are often very underestimated. Take care not to have a serotonin syndrom.
But if people's experience is saying a yes, I have absolutely no problems to support it. Be aware that all depends of the dosages you take.
Trazodone put me never to sleep; it did even the contrary. But it is common experience people react very differently to this drug.~sdb
Posted by BennyJ on January 7, 2006, at 14:32:56
In reply to Re: Nardil and Trazadone?-Should be safe, posted by Tom Twilight on January 7, 2006, at 4:33:38
Do you of any alergy meds you can combine with nardil? I use benedryl alot for bad environmental allergies.
> I thought Trazadone was about the only AD it was reasonably safe to combine with MAOIs.
>
> Your GP doesn't want you to die, I should think you'll be safe on this combo
>
> I combine Coffee with Marplan, another MAOI without ill effects, and I've heard of others combining Coffee with Parnate.
> If your really worried check your get a blood pressure monitor and check your BP.
>
> I have to say that although Caffeine is probably OK you should be very carefull with stronger stimulants including Decongenstant pills!
Posted by ed_uk on January 7, 2006, at 15:25:33
In reply to any alergy meds ok with nardil?, posted by BennyJ on January 7, 2006, at 14:32:56
>Do you of any alergy meds you can combine with nardil?
There is a lot of clinical mythology surrounding the interactions of MAOIs.
Nardil does not interact with topical steroids eg. steroid nasal sprays. It does not interact with sodium cromoglicate eye drops (for allergic conjunctivitis). It does not interact with any of the commonly used non-sedating antihistamines eg. cetirizine, levocetirizine, loratadine, desloratadine, fexofenadine etc.
Although diphenhydramine is often said to be contraindicated with MAOIs, there is little or no evidence of an interaction. Increased sedation and anticholinergic side effects may allegedly occur.
Decongestants (including decongestant nasal sprays, nasal drops and eye drops) must *not* be combined with Nardil. Common decongestants include ephedrine, pseudoephedrine, phenylpropanolamine, phenylephrine, propylhexedrine, oxymetazoline, naphazoline, tramazoline and xylometazoline. There are many more. Decongestants are present in a lot of the popular 'eye bright' drops.
Dextromethorphan (present in some cough/cold/flu medicines) must not be combined with Nardil.
THOROUGHLY check ALL ingredients of ANY medicines taken. Medicines include tablets, capsules, creams, ointments, gels, nasal sprays, nose drops, eye drops, inhalers, liquids/syrups, suppositories, pessaries, injections etc.
Regards
Ed
Posted by ed_uk on January 7, 2006, at 15:34:13
In reply to Allergy meds + Nardil » BennyJ, posted by ed_uk on January 7, 2006, at 15:25:33
Decongestants are present in a lot of...............
Nasal sprays
Nose drops
Eye drops
Tablets/capsules/syrups used to treat the symptoms of colds, flu, allergies etc.Anal creams/ointments/suppositories used to relieve the symptoms of piles ie. hemorrhoids.
Similar drugs are also present in some treatments for headches eg. Midrid.
Any doctor/dentist/nurse/pharmacist who treats you must know that you're taking an MAOI.
Posted by Phillipa on January 7, 2006, at 20:35:38
In reply to Re: Allergy meds + Nardil, posted by ed_uk on January 7, 2006, at 15:34:13
Hi Ed haven't heard from you. Love PJ O
Posted by djmmm on January 7, 2006, at 22:22:41
In reply to Nardil and Trazadone?, posted by BennyJ on January 6, 2006, at 21:28:25
> Hi, i'm starting nardil tommorrow for the first time. I take 100mg of trazadone for sleep at night. Wondering if anyone out there has had good success with this combo. I'm a little bit nervous but also looking forward to the nardil as social anxiety for me is bad. The precautions say avoid alergy meds...is it safe to take benadryl though? man do i really need to give up coffee? lol thats tough
I've taken Trazadone while on Nardil. It is not contraindicated. Benadryl is also fine...as is Coffee. Avoid drinking too much alcohol, some varieties of cheese, and some types of aged meat. The MAOI diet is, honestly, VERY simple.
Posted by djmmm on January 7, 2006, at 22:28:59
In reply to Re: Allergy meds + Nardil, posted by ed_uk on January 7, 2006, at 15:34:13
> Decongestants are present in a lot of...............
>
> Nasal sprays
>
> Nose drops
>
> Eye drops
>
> Tablets/capsules/syrups used to treat the symptoms of colds, flu, allergies etc.
>
> Anal creams/ointments/suppositories used to relieve the symptoms of piles ie. hemorrhoids.
>
> Similar drugs are also present in some treatments for headches eg. Midrid.
>
> Any doctor/dentist/nurse/pharmacist who treats you must know that you're taking an MAOI.
>I have used Afrin and Flonase with NO problems.
Posted by ed_uk on January 8, 2006, at 7:21:05
In reply to Re: Allergy meds + Nardil, posted by djmmm on January 7, 2006, at 22:28:59
Hi Dj
>I have used Afrin and Flonase with NO problems.
Flonase is fine, as are other topical steroids. I wouldn't recommend decongestants though, some people react badly.
Regards
Ed
Posted by zeugma on January 8, 2006, at 8:40:49
In reply to Re: Allergy meds + Nardil » djmmm, posted by ed_uk on January 8, 2006, at 7:21:05
Hi Ed,
My pdoc told me not to combine Afrin with Provigil. This is not good news for me, as I have a perpetually runny nose and Afrin is the only thing which has helped with this condition.
I imagine that my pdoc's reasons for not wanting to combine Provigil with Afrin are similar to contraindications regarding Afrin and Nardil.
-z
Posted by ed_uk on January 8, 2006, at 9:45:01
In reply to Re: Allergy meds + Nardil » ed_uk, posted by zeugma on January 8, 2006, at 8:40:49
Hi Z
The Afrin brand is not marketed in the UK. I see that 'Afrin' has been used as a brand for various different decongestants etc. Which product in particular did you find helpful?
>I imagine that my pdoc's reasons for not wanting to combine Provigil with Afrin are similar to contraindications regarding Afrin and Nardil.
I have never heard of modafinil interacting with decongestants. Some, but probably not all, decongestants may interact with Nardil to produce a hypertensive crisis.
Perhaps you pdoc was concerned about you using decongestants given your response to Ritalin ie. chest pain etc.
>I have a perpetually runny nose
Do you have a diagnosis? What have you tried so far?
Regards
Ed
Posted by zeugma on January 8, 2006, at 13:34:21
In reply to Re: Allergy meds + Nardil » zeugma, posted by ed_uk on January 8, 2006, at 9:45:01
hi Ed,
you;re probably right about the chest pains with ritalin being a reason for his caution.
I have lots of allergies, according to an allergist I saw when a child. I got shots every week until I realized he was a quack because my nose kept running- and that was my main symptom. No doubt I have allergies, because my nose runs a lot in the summer too (see below). Maybe he wasn't a quack. maybe civility rules are valuable.
I have dealt with so many quacks- this is why these boards are tricky for me sometimes. No, never a diagnosis. A non-quack diagnosed a peniccilin allergy and remedied a dramatic rash that covered my entire body. My nose runs whenever there is a sudden change in temperature- say if I get on a heated bus in wintertime. This is an inevitable, invariant effect, and doesn't sound like an allergy to me. If it's below about 55 degrees, my nose will run, and when it stops running, the temperature change effect will set it off again.
But there really is no time of year that is free from this problem. I don't know what the active ingredient in Afrin is, but it works where antihistamines don't.
-z
Posted by last chance on January 8, 2006, at 13:43:30
In reply to Re: Nardil and Trazadone?, posted by ed_uk on January 7, 2006, at 4:29:19
While on Nardil I would occasionally take trazadone for sleep - no problems. I also drank coffee - a double in the morning, and one in the afternoon without any bad effect.
Posted by BennyJ on January 8, 2006, at 14:48:48
In reply to Allergy meds + Nardil » BennyJ, posted by ed_uk on January 7, 2006, at 15:25:33
Thanks for the info Ed, that was much more informative that anything my gp or pharmacist had to say. I took my trazodone as normal last night with 25mg of benedryl and didnt notice anything odd with being combined with the nardil...although this is only the 2nd day. One thing I did notice in general though is that nardil depresses the hell out of me...is this a common sideeffect? perhaps one that will dissipate at a higher dose?
> >Do you of any alergy meds you can combine with nardil?
>
> There is a lot of clinical mythology surrounding the interactions of MAOIs.
>
> Nardil does not interact with topical steroids eg. steroid nasal sprays. It does not interact with sodium cromoglicate eye drops (for allergic conjunctivitis). It does not interact with any of the commonly used non-sedating antihistamines eg. cetirizine, levocetirizine, loratadine, desloratadine, fexofenadine etc.
>
> Although diphenhydramine is often said to be contraindicated with MAOIs, there is little or no evidence of an interaction. Increased sedation and anticholinergic side effects may allegedly occur.
>
> Decongestants (including decongestant nasal sprays, nasal drops and eye drops) must *not* be combined with Nardil. Common decongestants include ephedrine, pseudoephedrine, phenylpropanolamine, phenylephrine, propylhexedrine, oxymetazoline, naphazoline, tramazoline and xylometazoline. There are many more. Decongestants are present in a lot of the popular 'eye bright' drops.
>
> Dextromethorphan (present in some cough/cold/flu medicines) must not be combined with Nardil.
>
> THOROUGHLY check ALL ingredients of ANY medicines taken. Medicines include tablets, capsules, creams, ointments, gels, nasal sprays, nose drops, eye drops, inhalers, liquids/syrups, suppositories, pessaries, injections etc.
>
> Regards
>
> Ed
Posted by ed_uk on January 8, 2006, at 15:19:51
In reply to Re: Allergy meds + Nardil, posted by BennyJ on January 8, 2006, at 14:48:48
Hi
What dose of Nardil are you on at the moment?
>I took my trazodone as normal last night with 25mg of benedryl and didnt notice anything odd with being combined with the nardil...although this is only the 2nd day.
I think it's best to avoid combining high doses of trazodone with Nardil but low doses seem OK. As you increase the dose of Nardil you will have to be alert to symptoms of the serotonin syndrome.
>One thing I did notice in general though is that nardil depresses the hell out of me...
Although Nardil is often an effective antidepressant, a few people do find that it makes them more depressed. Give it time, you might feel a lot better in a few weeks.
Ed
Posted by ed_uk on January 8, 2006, at 15:22:18
In reply to Re: Allergy meds + Nardil » ed_uk, posted by zeugma on January 8, 2006, at 13:34:21
Hi Z
Alpha blockers sometimes cause nasal congestion. Notriptyline is a weak alpha blocker, does it make your symptoms worse?
>I don't know what the active ingredient in Afrin is, but it works where antihistamines don't.
Have you tried cetirizine? What about topical steroids?
Ed
Posted by zeugma on January 8, 2006, at 16:28:47
In reply to Re: Allergy meds + Nardil » zeugma, posted by ed_uk on January 8, 2006, at 15:22:18
> Hi Z
>
> Alpha blockers sometimes cause nasal congestion. Notriptyline is a weak alpha blocker, does it make your symptoms worse?not at all.
>
> >I don't know what the active ingredient in Afrin is, but it works where antihistamines don't.
>
> Have you tried cetirizine? What about topical steroids?
>topical steroids? should i put them up my nose??
you know Ed, I didn't like your idea of the pessary either!
:-)
-z
> Ed
Posted by BennyJ on January 8, 2006, at 17:33:46
In reply to Re: Allergy meds + Nardil » BennyJ, posted by ed_uk on January 8, 2006, at 15:19:51
Just started nardil at 15mg 3x daily...ive upped the trazodone, as i've noticed some positive effects as an ad, to 150mg at night...I let it put me to sleep and its ad effects carry well into the next day. I read that nardil plays on GABA similarly to benzo's (think someone on here said that)...also noticed a more depressed feeling while on benzos. I hope nardil is the right med though, ssri's give me anxiety.
> Hi
>
> What dose of Nardil are you on at the moment?
>
> >I took my trazodone as normal last night with 25mg of benedryl and didnt notice anything odd with being combined with the nardil...although this is only the 2nd day.
>
> I think it's best to avoid combining high doses of trazodone with Nardil but low doses seem OK. As you increase the dose of Nardil you will have to be alert to symptoms of the serotonin syndrome.
>
> >One thing I did notice in general though is that nardil depresses the hell out of me...
>
> Although Nardil is often an effective antidepressant, a few people do find that it makes them more depressed. Give it time, you might feel a lot better in a few weeks.
>
> Ed
Posted by JayDee on January 8, 2006, at 17:34:10
In reply to Re: Allergy meds + Nardil, posted by zeugma on January 8, 2006, at 16:28:47
Ive read this is contradicted, and ive also read that folks take them both just fine. Does anyone have any experiences with dextroamphetmine (adderall etc...) and Nardil? I think i am going to ask for Nardil tomorrow, and i am rxed 40mg dextroamph a day.
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