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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 10 of 10. This is the beginning of the thread.
Posted by mattdds on November 24, 2005, at 11:35:12
Hello to everyone, and anyone who might remember me!
Does anyone have any information about the release date of Ocinaplon?
I'm currently taking 2mg clonazapam daily (have been for over 2 years now). I'm hoping this med will be to benzos what benzos are to barbiturates.
Benzos are fine, but this med seems particularly promising.
Thanks,
Matt
Posted by lunesta on November 24, 2005, at 13:19:14
In reply to Ocinaplon? What ever happened?, posted by mattdds on November 24, 2005, at 11:35:12
I believe it is in its final (phase III) trial. If all goes well, it could be on shelves late 2006, but more likely 2007. Yes it does seem quite promising. No benzo effects other than pure anxiety relief. The withdrawl would probably be severe anxiety, but bettr than seizures and other problems.
I am very forward looking to it. That company actually has a highly unique drug developments. The next AD : The SSNDRI - Uptakes all 3 neurotransmitters including dopamine. It could be the MAO of the 'ssri' world. But other things on the horizon are more promising just take awhile to get out
Posted by Phillipa on November 24, 2005, at 22:29:27
In reply to Re: Ocinaplon? What ever happened? » mattdds, posted by lunesta on November 24, 2005, at 13:19:14
Sounds good to me and I'm gettin older each day. Fondly, Phillipa
Posted by jrbecker on November 26, 2005, at 9:29:17
In reply to Ocinaplon? What ever happened?, posted by mattdds on November 24, 2005, at 11:35:12
due to liver complications that occurred in one of the Phase III subjects, ocinaplon was discontinued a couple of months ago.
http://biz.yahoo.com/prnews/051108/nytu067.html?.v=26
Posted by SLS on November 26, 2005, at 9:53:16
In reply to Re: Ocinaplon? What ever happened?, posted by jrbecker on November 26, 2005, at 9:29:17
> due to liver complications that occurred in one of the Phase III subjects, ocinaplon was discontinued a couple of months ago.
http://biz.yahoo.com/prnews/051108/nytu067.html?.v=26
That's a shame.
Do you think they found other examples of liver enzyme elevations when evaluating their data retrospectively?
I am becoming alarmed at what I perceive as a reluctance among drug companies to bring good drugs to market for fear of excessive liability to law suites.
Would Depakote have made it to market in today's litigious environment? No way.
There are very few perfect drugs. People forget that each allotropic medicinal treatment often represents a risk versus benefit evaluation due to the nature of introducing a foreign substance to the body (or the unnatural amounts of natural substances).
Would Tylenol have made it to market in today's litigious environment? No way.ONE patient?
I think we are really hurting ourselves.
I'm scared.
- Scott
Posted by mattdds on November 26, 2005, at 12:28:00
In reply to Re: Ocinaplon? What ever happened?, posted by SLS on November 26, 2005, at 9:53:16
What a bummer! I'm worried about the future of pharmaceutical development also.
But hey, at least we'll be left with much safer alternatives such as the barbiturates, meprobamate or benzos! I'm so happy the lawyers and the FDA put the pressure on DOV and saved my liver from this evil drug! Blah...
Thanks for the update, though.
Matt
Posted by pseudoname on November 26, 2005, at 13:02:58
In reply to Ocinaplon? What ever happened?, posted by mattdds on November 24, 2005, at 11:35:12
> Would Depakote have made it to market...?
> Would Tylenol...?I read just a few days ago that no company would invest in developing *aspirin* today because its side-effects are too big & bad by today's standards. But the reason given was not lawsuits as much as the structure of the FDA approval process.
It'd be nice if we could sue the drug companies for NOT producing the drugs they have on their laboratory shelves..... Hmmm.... That would even things out a little....
> Hello to everyone, and anyone who might remember me!
Matt, welcome back! I've wondered where you'd gone. (I had a different Babble-ID when last we spoke.) I think you left Babble after you asked about CBT interest and the response was sort of underwhelming. Nice to know you're still around.
Posted by mattdds on November 27, 2005, at 8:28:56
In reply to drug development » SLS; welcome back » mattdds, posted by pseudoname on November 26, 2005, at 13:02:58
>Matt, welcome back! I've wondered where you'd gone. (I had a different Babble-ID when last we spoke.) I think you left Babble after you asked about CBT interest and the response was sort of underwhelming. Nice to know you're still around.
Hey, thanks for the response! Yeah, disinterest here in CBT along with being stationed overseas (I'm a dentist currently working for the Army) prompted me to post less. Also, I feel like I had contributed / gleaned all the knowledge I needed (concerning meds)...then all the babble just tends to repeat.
I'll probably never really "leave". And if I did it wouldn't likely be because I got offended or angry.
I'm doing pretty well overall, but will always maintain an interest in pipeline meds.
I guess with your new name, it's only polite not to get curious about who you "were".
All the best,
Matt
Posted by pseudoname on November 27, 2005, at 10:15:23
In reply to Re: drug development, posted by mattdds on November 27, 2005, at 8:28:56
> I guess with your new name, it's only polite not to get curious about who you "were".
Nobody big.
I left Babble for a while because I was too depressed to participate. Too depressed to Babble that's pretty depressed. Some weeks/months later, when I decided to come back to ask for some new med info, I was afraid that my online acquaintances would see how screwy I really was, even if "I" was still anonymous. That was a pretty screwy fear itself (nobody cares, and almost nobody would remember). Anyway, I temporarily used a different IDΉ, and now temporary has become permament.....
TMI, I'm sure.
An old post you may remember: http://dr-bob.org/babble/psycho/20031030/msgs/277260.html
> I'm doing pretty well overall
Truly happy to hear it.
> stationed overseas...working for the Army
Interesting!
> then all the babble just tends to repeat
Many Psych board themes/threads seem to go round & round & round. Which may be fine & helpful to some, but it also seems to make for a cautionary tale....
ΉNote to Dr Bob: I have *not* posted under two names at the same time.
Posted by Dr. Bob on November 27, 2005, at 12:47:21
In reply to here's Too Much Information » mattdds, posted by pseudoname on November 27, 2005, at 10:15:23
> Note to Dr Bob: I have *not* posted under two names at the same time.
Thanks, but for the record, there's also a procedure now for changing your posting name:
http://www.dr-bob.org/babble/faq.html#names
Bob
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