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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 16 of 16. This is the beginning of the thread.
Posted by linkadge on September 29, 2005, at 21:10:58
Larry posted a site a while back where you could type in a drug and a receptor and it would search a database to find a drug's particular affinity for that receptor. Anyone know that site?
Linkadge
Posted by chemist on September 29, 2005, at 23:45:08
In reply to anyone have that recepor affinity site ?, posted by linkadge on September 29, 2005, at 21:10:58
> Larry posted a site a while back where you could type in a drug and a receptor and it would search a database to find a drug's particular affinity for that receptor. Anyone know that site?
>
> Linkadgehello link, chemist here...the PDSP K$_{\rm i}$ freebie is likely what you're looking for...try kidb dot cwru dot edu for entry....all the best, c
Posted by linkadge on September 30, 2005, at 12:06:56
In reply to Re: anyone have that recepor affinity site ? » linkadge, posted by chemist on September 29, 2005, at 23:45:08
Posted by jgm on September 30, 2005, at 12:37:44
In reply to Re: anyone have that recepor affinity site ? » linkadge, posted by chemist on September 29, 2005, at 23:45:08
Hi Link, Hi Chemist,
I'm interested in that matter too.... but WHAT IS THE MEANING of:
"...the PDSP K$_{\rm i}$ freebie is likely what you're looking for...try kidb dot cwru dot edu for entry"Is it a web address?
In few words...for a stranger...
Thank you very much indeed!!
JGmax
Posted by ed_uk on September 30, 2005, at 14:26:46
In reply to Re: anyone have that recepor affinity site ?, posted by jgm on September 30, 2005, at 12:37:44
Hi
~Ed
Posted by jgm on September 30, 2005, at 18:19:30
In reply to Re: anyone have that recepor affinity site ? » jgm, posted by ed_uk on September 30, 2005, at 14:26:46
Posted by linkadge on September 30, 2005, at 20:47:43
In reply to Thank you very much Ed for your help! (nm) » ed_uk, posted by jgm on September 30, 2005, at 18:19:30
yeah, I just put what chemist said into a search engine, and found the site.
I had no idea what all that stuff meant :)
Linkadge
Posted by gromit on October 1, 2005, at 1:55:54
In reply to Re: Thank you very much Ed for your help!, posted by linkadge on September 30, 2005, at 20:47:43
> yeah, I just put what chemist said into a search engine, and found the site.
>
> I had no idea what all that stuff meant :)I think he was trying to confuse the bots...
Posted by ed_uk on October 1, 2005, at 14:32:59
In reply to Re: Thank you very much Ed for your help!, posted by linkadge on September 30, 2005, at 20:47:43
>I had no idea what all that stuff meant :)
Link, you are not alone :-)
Btw, I thought you might be interested in the Ki values for cyproheptadine.
Kind regards
~ed
Posted by ed_uk on October 1, 2005, at 14:33:33
In reply to Thank you very much Ed for your help! (nm) » ed_uk, posted by jgm on September 30, 2005, at 18:19:30
Posted by rod on October 1, 2005, at 14:57:22
In reply to Re: anyone have that recepor affinity site ? » linkadge, posted by chemist on September 29, 2005, at 23:45:08
> ... PDSP K$_{\rm i}$ freebie is ...
hehe looks a lot like LaTex or TeTex ?! right? I am not too familiar with it and have forgotten the little I once knew.... so I could be wrong.
Posted by chemist on October 1, 2005, at 16:20:00
In reply to Re: anyone have that recepor affinity site ? » chemist, posted by rod on October 1, 2005, at 14:57:22
> > ... PDSP K$_{\rm i}$ freebie is ...
>
> hehe looks a lot like LaTex or TeTex ?! right? I am not too familiar with it and have forgotten the little I once knew.... so I could be wrong.
>
>
...but you're not...knuth's plain \TeX\ ported to TeTeX...\vskip 0.5 cm \noindent{\sl Yours, Chemist}\vfil\eject\bye
Posted by linkadge on October 2, 2005, at 14:19:58
In reply to Re: anyone have that recepor affinity site ? » rod, posted by chemist on October 1, 2005, at 16:20:00
How to I know if a particular returned value is an agonist or an antagonist value ?
For instance if I look up buspar, I get a certain KI value for the 5-ht1a receptor. I know it is an agonist at 5-ht1a but how would somebody know this ?
Linkadge
Posted by ed_uk on October 2, 2005, at 14:26:34
In reply to one question though,, posted by linkadge on October 2, 2005, at 14:19:58
Hi Link,
>How to I know if a particular returned value is an agonist or an antagonist value ?
The Ki database doesn't tell you this, it only tells you about the affinity.
Kind regards
~Ed
Posted by linkadge on October 2, 2005, at 14:45:21
In reply to Re: one question though, » linkadge, posted by ed_uk on October 2, 2005, at 14:26:34
I see,
I also don't know what the difference between cyproheptadine, and cyproheptidine is.
Linkadge
Posted by ed_uk on October 2, 2005, at 15:06:46
In reply to Re: one question though,, posted by linkadge on October 2, 2005, at 14:45:21
Hiya Link,
>I also don't know what the difference between cyproheptadine, and cyproheptidine is.
A typo ;-) The correct spelling is cyproheptadine. Nortriptyline is also spelt wrong in the Ki database.
Ya know, you just can't get the staff.......
Kind regards
~Ed
This is the end of the thread.
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