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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 16 of 16. This is the beginning of the thread.
Posted by Aussie4All on May 4, 2005, at 9:31:43
Any Marplan users? I currently went off Nardil because I ended up on 5 meds for side effects, the worse being weight gain. Any bad side effects with Marplan?
Posted by Rjlockhart98 on May 4, 2005, at 19:44:21
In reply to Marplan Users, posted by Aussie4All on May 4, 2005, at 9:14:10
I want to try Marplan so bad. But im 18, almost all doctors wont consider that treatment.
Posted by stargazer on May 4, 2005, at 21:42:57
In reply to Marplan Users, posted by Aussie4All on May 4, 2005, at 9:14:10
Marplan worked well for me many years ago. I would almost say it's the only med for depression I was on that made me feel normal. And it was the only drug I was on, not the 4 I take today. I had to stop in 1992 when the drug was discontinued. I have not tried it again because now I'm on so many other meds and it may not work for me now. If I knew for certain it would I would go back to it in a second.
SG
Posted by cubbybear on May 5, 2005, at 10:58:15
In reply to Re: Marplan Users, posted by Rjlockhart98 on May 4, 2005, at 19:44:21
> I want to try Marplan so bad. But im 18, almost all doctors wont consider that treatment.
Did the doctor(s) say that they wouldn't prescribe it for you because you're only 18, or are you just assuming that? I ask this because many many doctors won't prescribe Marplan or either of the other two related ADs, Parnate and Nardil (MAOI inhibitors) to *anyone* because of the exaggerations and misconceptions about them being overly dangerous.
The fact is that, while the MAOIs have inherent drawbacks and have more contraindications than other antidepressants, the latter have different inherent problems like killing off your sex drive and ability. And, these drugs, such as Prozac, Zoloft, Paxil, etc. are the ones that the government has targetted for being dangerous and more likely to cause suicidal behavior in teens.
So any doctor who says that the MAOIs are not suitable for someone who's "only" 18, is just handing you a lot of BS. If you're already 18, you can vote for president, sign contracts, get a credit card and do all of those "wonderful" things that come with being an adult, so you have the right to stand up for what you want and are entitled to get.
Also, there is nothing on the patient insert that states that MAOIs should not be given to someone of your age bracket.
My advice is for you to do your homework on the MAOI ihibitors through websites and if you're sure that you want to give an MAOI antidepressant a try, then post another note here about locating a doctor in your city who would prescribe it. Also try the Yahoo group (message board) on MAOIs.
Good luck
cubbybearP.S. I had my first severe anxiety/depressive episode when I was 20 and I only wish I had been properly diagnosed and prescribed Parnate then instead of 14 years later. It would have prevented a whole lot of needless suffering if I'd started on this medication at an early age.
Posted by Chairman_MAO on May 5, 2005, at 20:38:27
In reply to Re: Marplan Users--go for it! » Rjlockhart98, posted by cubbybear on May 5, 2005, at 10:58:15
Amen! You will see I express a like sentiment in another recent posting in response to Maxime. I wish I was put on an MAOI at birth, for god's sake, because whatever the deal is up there, it's been that way for as long as I can remember (I posted a very long message detailing this on alternative if anyone cares enough about my story to read it, heh). I am so tired of these drugs being demonized; the fact that it is easier for me to cop heroin than buy buprenorphine and phenelzine is a travesty.
Now that I'm on phenelzine (my 2nd MAOI), I am thoroughly convinced that these drugs were demonized by drug companies simply because THEY WORK FAR BETTER THAN ANYTHING, and I mean _ANYTHING_ that has come out since (in the US at least). There was merital (nomifensine), a DA/NE/SE reuptake inhibitor, but that was withdrawn after being on the market for like 6 months due to some rare blood disorder, or so says the FDA. Maybe it's because it had "abuse potential", i.e. WORKED. If you haven't tried an MAOI or a drug like nomifensine, you really have no idea what sort of effect the word "antidepressant" was coined to refer to. It's not a blunting of emotions, it is like being injected with euthymia! I fully anticipate to be on an MAOI for many, many years, because I don't see any big pharma company coming out with anything better anytime soon. If MAOIs ever went off the market and a new drug didnt come along that worked as well, my life would effectively collapse. I start feeling suicidal if anyone in a position of power over me talks about taking away my meds; I am totally serious. I was a shell of myself without them.
I went on tranylcypromine at 24 only out of earnestly BEGGING my shrink at the clinic--who just barely got her license, nonetheless--to put me on one. I will be forever grateful to them because at least they BELIEVED ME about NOTHING ELSE WORKING instead of wanting to try me on 17 more permutations of SSRI + x + y + z. My heart goes out to people like cubbybear who suffered for years and years before they finally got placed on one. The pain I endured before I got on one was excrutiating enough; I have no idea how one survives decades of that as an adult before getting effective treatment.
Posted by cubbybear on May 6, 2005, at 1:15:43
In reply to Re: Marplan Users--go for it! » cubbybear » cubbybear, posted by Chairman_MAO on May 5, 2005, at 20:38:27
This might be straying off the topic, but people who know me here know that I'm pretty outspoken---
It makes me wonder sometimes, whether a complaint should be filed against any doctor who does NOT prescribe a drug that has been proven to work for an individual, but refuses, simply out of his/her own personal biases. It's a form of negligence. Something to consider.
Posted by Cecilia on May 6, 2005, at 5:05:24
In reply to Re: Marplan Users--go for it!, posted by cubbybear on May 6, 2005, at 1:15:43
Marplan is one of the few AD`s I haven`t tried. I couldn`t tolerate Nardil or Parnate. I`ve been waiting for the selegilene patch, but may have to wait forever for that. (And doubt that I`ll be able to tolerate it anyway, I do not do well with stimulating meds.) Anyone been able to tolerate Marplan who couldn`t take Nardil or Parnate? Cecilia
Posted by Chairman_MAO on May 6, 2005, at 8:42:38
In reply to Re: Marplan Users--go for it! » cubbybear » cubbybear, posted by Chairman_MAO on May 5, 2005, at 20:38:27
I meant to say that my shrink just barely got her license in that she is really young, not incompetent. Not like anyone here cares what I say, but I don't like libelling people on principle. ;)
Posted by bobbiedobbs on May 7, 2005, at 5:49:58
In reply to Re: Marplan, posted by Cecilia on May 6, 2005, at 5:05:24
>I was on Nardil and Parnate for about 20 yrs, got off because of side effects and limited effectiveness, after trying a bunch of other things, I tried Marplan...have been on it for about 9 months...works very well and is more tolerable than Nardil, at least for sexuality ... However, it is temporarily unavailable due to problems with continued FDA approval past 4/30/05.
Posted by Cecilia on May 8, 2005, at 2:45:06
In reply to Re: Marplan, posted by bobbiedobbs on May 7, 2005, at 5:49:58
When is it supposed to be available again? That`s awful-to find a med that works and have it taken away for bureaucratic reasons. Typical of the FDA. Cecilia
Posted by Chairman_MAO on May 8, 2005, at 12:32:49
In reply to Re: Marplan-Bobbiedobbs, posted by Cecilia on May 8, 2005, at 2:45:06
This is another case where it might pay to try to scour the internet for research chemical suppliers to find bulk isocarboxazid powder (USP is preferable). If I were "resistant" to every FDA-approved drug, I would do my best to try things like chlorgyline, etc. that are available as research chemicals. This is my right, and my right for my life, and that comes before any FDA mandate.
Whatever happened to "life, liberty, and the pursuit of happiness?" I wish I could publicly try to help broker these drugs for people from chemical suppliers, but the FDA would try to have me imprisoned. At the very least, Dr. Bob would stop me from posting. :(
Posted by cubbybear on May 9, 2005, at 0:42:22
In reply to Re: Marplan-Bobbiedobbs » Cecilia, posted by Chairman_MAO on May 8, 2005, at 12:32:49
> This is another case where it might pay to try to scour the internet for research chemical suppliers to find bulk isocarboxazid powder (USP is preferable). If I were "resistant" to every FDA-approved drug, I would do my best to try things like chlorgyline, etc. that are available as research chemicals. This is my right, and my right for my life, and that comes before any FDA mandate.
>
> Whatever happened to "life, liberty, and the pursuit of happiness?" I wish I could publicly try to help broker these drugs for people from chemical suppliers, but the FDA would try to have me imprisoned. At the very least, Dr. Bob would stop me from posting. :(This is a fascinating concept that I've never seen posted here before. What you're really talking about is the right to free enterprise--the right to establish a legitimate business with a legitimate product. On paper, you can do it. But unfortunately there are such things as big fat profit-oriented drug companies with high-paid lawyers, and they would probably pay you a "friendly" visit. They woukl be working hand-in-glove with a big t government agency that would also try to bully and/or imprison you on legal grounds.
Yet, If it were a matter of life or death (as wuld probably be the case with me too, vis a vis Parnate), and if I possessed the monetary resources to obtain bulk tranylcypromine,, I would first check with an attorney. He/she would have to scour the laws--old and new--for any hidden or archaic laws that might prohibit a oprivate citizen from making home made medicine.
. If such a law existed, you'd be litigating to overturn the law.Who knows? You could fight this issue all the way to the Supreme Court, and if you won, it wold be a landmark decision that would send shock waves throughout the pharmaceutical industry. Just my thoughts.
Posted by bobbiedobbs on May 9, 2005, at 19:17:36
In reply to Re: Marplan-Bobbiedobbs, posted by Cecilia on May 8, 2005, at 2:45:06
> When is it supposed to be available again? That`s awful-to find a med that works and have it taken away for bureaucratic reasons. Typical of the FDA. Cecilia
Per the FDA drug shortage unit, timeframe for reapproval is 1-2 weeks. We'll see about that. I have another 3 weeks or so before I need more. My doctor's contingency plan is to temporarily switch me to Nardil is there's a gap.
Posted by Chairman_MAO on May 11, 2005, at 20:41:06
In reply to Re: Marplan- making it at home » Chairman_MAO, posted by cubbybear on May 9, 2005, at 0:42:22
Bulk tranylcypromine is actually way cheaper than buying the tablets. I used to buy 5g for $65, then they jacked up the price to 5g for $122, which I no longer was able to afford after a while. As it turns out, a friend is going to be buying phenelzine in bulk, I think, so I will probably be switching to that, eventually. I may actually take both together in lower dosages so that I can have some of the dopaminergic effects from the tranylcypromine. I am going to try a number of DA agonists first (primarily for sex issues) before I go that cavalier route, though.
30mg/day of parnate is 0.9g/month, just to illustrate the profound difference. If one were to broker a kilogram or more of tranylcypromine from an actual manufacturer, and not a research chemical supply house, it would be many times cheaper than that.
When one buys medication, one is buying a chemical, plain and simple. It is my right to get that chemical from wherever I want to unless it is a controlled substance or a watched chemical. I do not AGREE with those laws, but I observe them. There is no law stating I cannot possess tranylcypromine powder, and I felt a tremendous sense of glee knowing that I was taking tranylcypromine while avoiding funding GlaxoSmithKline, whose board of directors answer only to Satan, IMO. Notice the lack of "H" in IMO there. ;)
$0.72 per 10mg of a drug which was FDA-approved in 1961. Sure GSK, I will gleefully pleasure the organ of your choice! Yeah, right! Oh, yeah, I forgot, those R&D costs, that's why it cost so much ...
How dare they so usurously price such an old drug which is obviously only used as a LIFESAVER for those with treatment-resistant depression, etc.! And it's only cyclicized amphetamine; there was no "drug discovery" technology or anything involved.
Posted by Chairman_MAO on May 11, 2005, at 20:43:14
In reply to Re: Marplan-Bobbiedobbs, posted by bobbiedobbs on May 9, 2005, at 19:17:36
I wish I had the money to front and the connection I used to have; I would buy some isocarboxazid powder, USP and make you some capsules, lol. ;)
I love how it's easier to buy crack than an MAOI. Love that drug policy! It works wonders!
Posted by willyee on May 11, 2005, at 22:07:08
In reply to Re: Marplan-Bobbiedobbs » bobbiedobbs, posted by Chairman_MAO on May 11, 2005, at 20:43:14
> I wish I had the money to front and the connection I used to have; I would buy some isocarboxazid powder, USP and make you some capsules, lol. ;)
>
> I love how it's easier to buy crack than an MAOI. Love that drug policy! It works wonders!
If im not mistaken u said you were going to be taking both parnate and nardil??Im very curious about this,reason being after stopping my nardil trial of a few weeks,i had a job interview and had no "washout" time and quickly switched back to my first dose of parnate again.
My curiosty stems from remebering the day i stopped nardil and re-continued parnate i had a PROFOUND remission of depression,it was unbeliavable.
Since mixing two Maois is implanted as SUCH a NO NO i contrbiuted the remission to simply having stopped/restarted parnate,but have done so since and have never come across that feeling again.
I have no access to nardil any longer,but am very curious to know the reaction between the two,if you said u already have,or plan to please please share the results here,i really think having the two in my system was the reason i had that robust release from depression,it was incredable i felt so alive again depression was gone.
This is the end of the thread.
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