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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 9 of 9. This is the beginning of the thread.
Posted by smith562 on April 27, 2005, at 14:12:25
Hey Ron,
I recall you asking babblers about selegiline because you were thinking of replacing adderal with it. Here is my experience ...
I have been on selegiline for 4 weeks now at 10 mgs (added to zoloft 75mg, lithium 450mg, klonopin 1mg .... I have atypical depression with panic disorder and a family history of BP II). I added it because I still was very lethargic and apathetic. Selegiline has resolve about 75% of the fatigue and lack of pleasure. I feel my senses have come back to life ... I can smell again, sense of touch has returned. I also feel like my ability to feel normal love, sadness, happiness has returned to a large degree. Over all I am very happy with this addition.
Hope you are well.
Sincerely,
Smith
Posted by linkadge on April 27, 2005, at 14:53:22
In reply to Ron Hill: Listening to Selegiline, posted by smith562 on April 27, 2005, at 14:12:25
That is good to hear. Dopamine can play a big part of the picture.
Take Care.
Linkadge
Posted by Declan on April 27, 2005, at 17:22:38
In reply to Re: Ron Hill: Listening to Selegiline, posted by linkadge on April 27, 2005, at 14:53:22
Its good stuff, isn't it? You sleep OK on that? What's the difference between an AD and a mood brightener?
Declan
Posted by Phillipa on April 27, 2005, at 18:41:24
In reply to Re: Ron Hill: Listening to Selegiline, posted by Declan on April 27, 2005, at 17:22:38
Want to know. Fondly, Phillipa
Posted by Sarah T. on April 27, 2005, at 19:29:37
In reply to Ron Hill: Listening to Selegiline, posted by smith562 on April 27, 2005, at 14:12:25
Hi. This is wonderful news. Can you tell me what form you're taking? I assume you're referring to oral selegiline, but I think there are other forms (i.e., forms other than the patch and the tablets).
Posted by Ron Hill on May 1, 2005, at 1:02:02
In reply to Ron Hill: Listening to Selegiline, posted by smith562 on April 27, 2005, at 14:12:25
> Hey Ron,
>
> I recall you asking babblers about selegiline because you were thinking of replacing adderal with it. Here is my experience ...
>
> I have been on selegiline for 4 weeks now at 10 mgs (added to zoloft 75mg, lithium 450mg, klonopin 1mg .... I have atypical depression with panic disorder and a family history of BP II). I added it because I still was very lethargic and apathetic. Selegiline has resolve about 75% of the fatigue and lack of pleasure. I feel my senses have come back to life ... I can smell again, sense of touch has returned. I also feel like my ability to feel normal love, sadness, happiness has returned to a large degree. Over all I am very happy with this addition.
>
> Hope you are well.
>
> Sincerely,
>
> Smith
Smith,Thank you very much for your post and thanks for the babblemail message to let me know that you had posted to me. I've been swamped and I've not had time to do my usual scan of PB.
I'm happy to hear that you are finding some benefit from Selegiline. I think I will conduct a trial of it myself soon. However, I have some reservations regarding how it will work for me after a few months of use.
It seems like every dopaminergic substance I take works really well initially in the treatment of the atypical depressive phase of my bipolar II disorder. However, within a few months or less the dopaminergic substance turns against me and it induces SEVERE IRRITABILITY (GRRRRRRRRRRRRRRR).
The later is the stage that I am currently in with Adderall XR after using a very low dosage on and off for the past five months. It's a "darned if I do and darned if I don't" kinda thing. If I don't take it, I loose my energy and motivation and I slide into depression. If I do take it, I quickly become a screaming rage-a-holic. My layman's interpretation of this is that, for me, continued use of a dopaminergic substance causes my dopamine levels to get out ahead of my serotonin levels and, as a result, I get VERY IRRITABLE.
I'm currently experimenting with an Adderall XR dosage of 2.5 mg every other day. But even this causes irritabilty.
Thanks again for the information that you provided in your post.
-- Ron
BP II and OCPD
600 mg/day Lithobid
900 mg/day Trileptal
50 mg/day Lamictal
2.5 mg Adderall XR once every other day
Posted by smith562 on May 1, 2005, at 7:50:15
In reply to Re: Ron Hill: Listening to Selegiline » smith562, posted by Ron Hill on May 1, 2005, at 1:02:02
Hey Ron,
To offset my apathy and lethargy, I tried wellbutrin and ritalin before selegiline. They gave me lots of energy and motivation for about 2 to 3 days, then I would crash. I felt "strung" out ... even less energy, anorexic, irritable. Selegiline and other MAOIs have been different then stimulants/wellbutrin, despite both being highly dopaminergic. The apathy and lethergy have subsided and there has been no crash thus far.
Have a great weekend!
Smith
PS I was perplexed by this. I noted my sleep was terrible too, having horrible vivid dreams. With the selegiline (and other MAOIs) the dreams (REM sleep) are gone/reduced. I review REM sleep and wellbutrin/stimulants and found that they increase REM sleep!
Posted by Phillipa on May 1, 2005, at 17:12:38
In reply to Re: Ron Hill: Listening to Selegiline » smith562, posted by Ron Hill on May 1, 2005, at 1:02:02
I just looked it up. It is used for Parkinson's Disease when L'Dopa is not working in doses not to exceed l0mg. It doesn't appear to lead to hypertensive crisis and food restrictions aren't necessary. It called it an MAO B. What does that mean? It doesn't say a thing about it being used for depression. So this is another use of a drug meant for something else? Fondly, Phillipa
Posted by hok on May 4, 2005, at 14:15:15
In reply to Re: Ron Hill: Listening to Selegiline, posted by Phillipa on May 1, 2005, at 17:12:38
> I just looked it up. It is used for Parkinson's Disease when L'Dopa is not working in doses not to exceed l0mg. It doesn't appear to lead to hypertensive crisis and food restrictions aren't necessary. It called it an MAO B. What does that mean? It doesn't say a thing about it being used for depression. So this is another use of a drug meant for something else? Fondly, Phillipa
fyi..., rasagiline is also a potent MAO-B inhibitor.
I found these somewhat helpful in explaining MAO-A v. MAO-B...
http://www.rasagiline.com/maois.htmlhttp://www.acnp.org/g4/GN401000046/CH046.html
This is the end of the thread.
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