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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 9 of 9. This is the beginning of the thread.
Posted by neo on January 24, 2005, at 19:56:17
Hi to all.
I'm on xanax (immediate release) 0.25 x 3 day, that seems to work against anxiety quite well.
Higer dosage (0.5) gave me somnolence and sedation.
The strange fact is that after about 5 h all anti-anxiety effect seem to vanish and the anxienty seems to reapper more strong.
Is it possible or it is an illusion?
Perhaps i could dose it more frequently? or try to increase dosage very slow to counteract somnolence and fatigue effect?
All your share will be very appriciate!
Tank you so much!
Neo
Posted by Impermanence on January 24, 2005, at 20:55:35
In reply to XANAX lose efficacy within 5 hours?!?, posted by neo on January 24, 2005, at 19:56:17
Xanax has a very short half life, it's main purpose is to alleviate panic, there's many other benzodiazepines you could try that have much longer half lives or you could try Xanax XR (extended-release) which has a slower rate of absorption.
Posted by Glydin on January 24, 2005, at 20:57:02
In reply to XANAX lose efficacy within 5 hours?!?, posted by neo on January 24, 2005, at 19:56:17
> The strange fact is that after about 5 h all anti-anxiety effect seem to vanish and the anxienty seems to reapper more strong.
> Is it possible or it is an illusion?
Not so strange at all. Regular Xanax is a short acting med. Xanax, by it's nature, burns out quickly, but the time released XR version has a delivery system that would, in theory, make for a single dose lasting longer.
Posted by cubbybear on January 25, 2005, at 4:22:26
In reply to XANAX lose efficacy within 5 hours?!?, posted by neo on January 24, 2005, at 19:56:17
> Hi to all.
> I'm on xanax (immediate release) 0.25 x 3 day, that seems to work against anxiety quite well.
> Higer dosage (0.5) gave me somnolence and sedation.
> The strange fact is that after about 5 h all anti-anxiety effect seem to vanish and the anxienty seems to reapper more strong.
> Is it possible or it is an illusion?
> Perhaps i could dose it more frequently? or try to increase dosage very slow to counteract somnolence and fatigue effect?
> All your share will be very appriciate!
> Tank you so much!
> NeoWhat the other posters said is quite true. Not only that, you're on a very small dosage. If your anxiety is on ongoing problem, you should definitely switch to a longer-acting benzo like Klonopin. I have a similar problem now with anxiety, and the Xanax doesn't even last long enough to keep me asleep for more than about 4 horus once my anxiety reaches a certain level. I plan to ask for a switch to Klonopin.
Posted by neo on January 25, 2005, at 18:22:12
In reply to Re: XANAX lose efficacy within 5 hours?!? » neo, posted by cubbybear on January 25, 2005, at 4:22:26
Posted by Lindsay Rae on January 25, 2005, at 20:18:16
In reply to Thanx you all for your help!!! (nm), posted by neo on January 25, 2005, at 18:22:12
I am facing the same problem and have switched to Valium. However, these are the reasons I have found out that it is not doing the trick the way Xanax has for me:
These belong to the benzodiazepine family of drugs. They all bind to the GABA receptor complex and make it easier for GABA to open the receptor's chloride ion channel, hyperpolarizing the neuron, making it less excitable and less likely to fire. Benzodiazepines are used as sedative/huypnotics (sleeping pills), anti-anxiety meds (anxiolytics), anti-panic agents, and anticonvulsants (anti-epileptics). The primary differences between all benzodiazepines are in their pharmacokinetic properties (their absorption, distribution, metabolism and excretion).
V = Valium (diazepam); A = Ativan (lorazepam); X = Xanax (alprazolam)
Indications (Uses):
V - anxiolytic, preoperative sedative, anticonvulsant.
A - anxiolytic, preoperative sedative.
X - anxiolytic, panic disorder.Equivalent Doses:
V - 5mg
A - 1mg
X - 0.5mgApproximate Half-life:
V - 100h
A - 10-20h
X - 12-15hOnset of Action
V - < 1h
A - 1-3h
X - 1-3hAre Metabolites Active?
V - yes
A - no
X - yesMetabolism:
V - oxidation
A - conjugation
X - oxidation
I think I will try the Xanax ER, although it is quite expensive (no generic). Keep me posted on how this is working for you!L Rae
Posted by missamor on January 27, 2005, at 12:24:11
In reply to Re: Thanx you all for your help!!!, posted by Lindsay Rae on January 25, 2005, at 20:18:16
does anyone know what the metabolism part is in the above post? and how klonopin factors in to this?
just wondering.
Posted by neo on January 27, 2005, at 12:32:37
In reply to Re: Thanx you all for your help!!!, posted by missamor on January 27, 2005, at 12:24:11
Posted by Lindsay Rae on January 31, 2005, at 12:50:40
In reply to ALPRAZOLAM GENERIC v/s XANAX, any difference btw? (nm), posted by neo on January 27, 2005, at 12:32:37
It depends on who you ask. And the generic brand.
Mylan makes generic Xanax (Alprazolam), which are round instead of oval. If you take a survey, about 80% will say that Mylan is "weaker" than it's generic counterpart, Greenstone Labs, who also make real Xanax. Generic drugs are legally supposed to be within a certain efficacy (strength), and Mylan is believed to be on the lower end of the spectrum. But that is just anecdotal and based solely on reports from other users of the drug.Klonopin (Clonazepam) is less addictive than Valium or Xanax, and is prescribed predominantly for seizure patients, but is widely used for anxiety in patients who are trying to come off of one of the aforementioned benzos. They metabolize slower than Xanax, at about the same rate as Valium (Diazepam).
This is the end of the thread.
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