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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by dondon on January 18, 2005, at 18:36:03
Do they use antipsychotics for levodopa induced psychosis in parkinson's disease? My grandmother has PD and takes levodopa and she recently had a psychotic episode. Can you take antipsychotics while taking antiparkinson drugs? Wouldn't the antipsychotic antagonize the effects of the anti-parkinson's drugs? Abilify seems like the best med to use for parkinson's disease becaues it has dopamine agonist activity and antagonist activity at the same time.
Posted by linkadge on January 18, 2005, at 18:42:09
In reply to drug induced psychosis in PD, posted by dondon on January 18, 2005, at 18:36:03
Yes, Olanzapine is often used.
Linkadge
Posted by ed_uk on January 19, 2005, at 7:39:00
In reply to Re: drug induced psychosis in PD, posted by linkadge on January 18, 2005, at 18:42:09
Hi,
Olanzapine (Zyprexa) tends to worsen the symptoms of Parkinson's disease, as do most antipsychotics. Quetiapine (Seroquel) and clozapine (Clozaril) are sometimes used because they are much less likely to worsen the symptoms of PD.
Regards,
Ed.
Posted by DanielJ on January 19, 2005, at 9:21:08
In reply to drug induced psychosis in PD, posted by dondon on January 18, 2005, at 18:36:03
My son took ARTANE for 6 months along with Zyprexa and Zoloft with no ill effects. He was given Artane (anti Parkinsonian) to cancel out any tendency toward tremor. Abilify caused him to tremor after 1 month so it was discontinued.
Posted by Mistermindmasta on January 19, 2005, at 11:39:01
In reply to drug induced psychosis in PD, posted by dondon on January 18, 2005, at 18:36:03
> Do they use antipsychotics for levodopa induced psychosis in parkinson's disease? My grandmother has PD and takes levodopa and she recently had a psychotic episode. Can you take antipsychotics while taking antiparkinson drugs? Wouldn't the antipsychotic antagonize the effects of the anti-parkinson's drugs? Abilify seems like the best med to use for parkinson's disease becaues it has dopamine agonist activity and antagonist activity at the same time.
What I just want to point out is that the worst side effects of antipsychotics, the EPS effects, are basically mimicking parkinson's disease, from a biochemical standpoint. Would you really want to add parkinson's disease symptoms on top of actual parkinson's disease?
Levodopa increases dopamine nonspecifically in the brain, and for parkison's, you want specificity. You want more dopamine in the nigrostriatal dopamine tract. A side effect is the increases in dopamine in other brain areas, which causes the psychosis. By taking an antipsychotic, yes, you would be able to lower dopamine in these other brain areas, but there's also the chance you'd be lowering it in that nigtrostriatal chance. Abilify SEEMS like a good choice for a drug that would minimize EPS events, but I've heard a good amount of posts here of abilify giving akasthisia, which is definitely a lowering of dopamine in the nigrostriatal tract.
Whatever you do, be careful with these antipsychotics and good luck. Hopefully you find something that works.
This is the end of the thread.
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