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Dr. Bob is Robert Hsiung, MD,
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Posted by ed_uk on November 28, 2004, at 13:37:22
In reply to Laudanum, Salts- Ed_UK????, posted by jasmineneroli on November 28, 2004, at 13:16:35
Hi Jas,
Laudanum was the name given to tinctures of opium. The main active ingredients were morphine, codeine and alcohol.
Smelling salts consisted of salts of ammonium. They had a very pungent smell and were used to 'revive' a lady who had fainted.
Early treatments for anxiety...
alcohol
opium
The bromides... used in vast quantities before the introduction of the barbiturates
Hyoscine (still used to prevent motion sickness)
chloral hydrate (from the 1800s)
Barbiturates.. the first was barbitone (Veronal)... so named because Verona was said to be a peaceful town.
Meprobamate (Equanil/Miltown) from the 1950s.
Ed.
Posted by mmcconathy on November 28, 2004, at 13:44:05
In reply to Re: 'Remedies' for neurosis, posted by ed_uk on November 28, 2004, at 13:37:22
Yes.... good sourses, i should of put those on there.
But still i think the main nuerosis treatment where barbiturates, in the 40's. Opiates i belive by that time where not in favor of doctors becuase of the vast epidemic during the 1910's, afther the Narcotics Act of 1914, where barbiturates were used to calm opiate withdrawl.
but good info.
Posted by ed_uk on November 28, 2004, at 13:53:15
In reply to Re: 'Remedies' for neurosis, posted by mmcconathy on November 28, 2004, at 13:44:05
Hi,
You misunderstood what I wrote.....Yes, barbiturates were used in the 1940s. I wasn't saying that opium was used for anxiety in the 1940s, I was just saying that it has been used as a treatment for anxiety in the past, as have the other drugs that I listed. Perhaps I wasn't very clear.
All the best...
Ed.
Posted by ed_uk on November 28, 2004, at 13:59:02
In reply to Laudanum, Salts- Ed_UK????, posted by jasmineneroli on November 28, 2004, at 13:16:35
One of the oldest treatments for anxiety and insomnia was to be given a bromide drug. (Much *earlier* than the 1940s!!!!!!!!!)
Examples of bromide drugs include: acecarbromal, bromisoval, potassium bromide and carbromal. Long term use could cause a severe rash. These drugs are very rarely used today in human medicine. Potassium bromide, however, is very occasionally used to treat severe intractable epilepsy. It is necessary to monitor the serum bromide concentration to reduce the risk of accumulation and toxicity.
Ed.
Posted by Slinky on November 28, 2004, at 14:42:26
In reply to Re: Back then anxiety was classified as nuerosis, posted by mmcconathy on November 28, 2004, at 12:51:49
Oh..I'm sorry..I'm severely brain dead ..I saw the title as depression not anxiety..
Blimey : )
Posted by mmcconathy on November 28, 2004, at 15:23:40
In reply to Re: Back then anxiety was classified as nuerosis, posted by Slinky on November 28, 2004, at 14:42:26
That's ok, i actually do want to talk about what they used for depression back then.
I think it was just Shock therapy and Dexedrine and Benzedrine.
Posted by ed_uk on November 28, 2004, at 15:37:53
In reply to Re: Slinky, posted by mmcconathy on November 28, 2004, at 15:23:40
Amphetamines were widely prescribed for depression before the tricyclics and MAOIs were introduced. It was claimed that the new ADs were 'specific' for the treatment of depression whereas the stimulants were not. My opinion is that none of our current drugs are really 'specific' for depression.
Pills containing combinations of amphetamines and barbiturates were popular eg. Dexamyl- amobarbital+dextroamphetamine.
Ed.
Posted by linkadge on November 28, 2004, at 16:52:02
In reply to Re: The earliest anti-depressants, posted by ed_uk on November 28, 2004, at 15:37:53
The stimulant sedative combinations would've been particularly addictive. There would probably be a synergy effect of dopamine in the neucleus accumbens.
Linkadge
Posted by denise1904 on November 28, 2004, at 16:54:41
In reply to Re: Back then anxiety was classified as nuerosis, posted by Slinky on November 28, 2004, at 14:42:26
I often think I'm so lucky that I wastn't born in the early 20th century, I don't think I would have lived this long. I dread to think of how much some people must have suffered.
I always hope opium helped people in the early 20th Century, I can't bear to think of people feeling the way I have felt with nothing to give them any release.
Denise
Posted by ed_uk on November 28, 2004, at 17:08:53
In reply to Re: The earliest anti-depressants, posted by linkadge on November 28, 2004, at 16:52:02
Have you seen the advert for Dexamyl from the 1960s. It's quite amusing. I found it in the 'American Gallery of Psychiatric Art'.
Ed.
PS. Dexamyl certainly had a high abuse potential!
Posted by paulbwell on November 28, 2004, at 19:13:26
In reply to Re: The earliest anti-depressants, posted by ed_uk on November 28, 2004, at 17:08:53
> Have you seen the advert for Dexamyl from the 1960s. It's quite amusing. I found it in the 'American Gallery of Psychiatric Art'.
>
> Ed.
>
> PS. Dexamyl certainly had a high abuse potential!Not as high as this one
DESBUTAL=Methamphetamine (Desoxyn)15mgs+ Pentobabital (Numbutal)50mgs combined!
People would seperate these two, and use at different times.-A fav of ELVIS during the 60's
Discontinued due to large 'Non-Medical use' HA!!
These combos were known as 'Goofballs'
Posted by mmcconathy on November 28, 2004, at 19:15:20
In reply to Re: The earliest anti-depressants, posted by ed_uk on November 28, 2004, at 17:08:53
yes they were implified it made her very happy vacumming.
Why would it have abuse potential? the sedative should of numbed the euphoria.
Posted by mmcconathy on November 28, 2004, at 19:19:22
In reply to Re: DEXAMYL--DESBUTAL, posted by paulbwell on November 28, 2004, at 19:13:26
when combined with a sedative, that should of pullled back some dopmaine, reducing the euphoria, or leveling the effect, i thought that was the main reason of there creation.
What where they prescribed for anyways?
Posted by ed_uk on November 28, 2004, at 19:49:52
In reply to Re: DEXAMYL--DESBUTAL why where they abused?, posted by mmcconathy on November 28, 2004, at 19:19:22
They were certainly euphoric..... people were even happy when they were vacuuming!!!
They were used for depression and obesity amongst other things. The barbiturate was present to reduce anxiety while the stimulant was intended to elevate mood (or decrease appetite). Remember, some people find short-acting barbiturates euphoric on their own!
Ed.
Posted by paulbwell on November 28, 2004, at 19:59:29
In reply to Re: DEXAMYL--DESBUTAL why where they abused?, posted by mmcconathy on November 28, 2004, at 19:19:22
> when combined with a sedative, that should of pullled back some dopmaine, reducing the euphoria, or leveling the effect, i thought that was the main reason of there creation.
>
> What where they prescribed for anyways?Stim-Barb combos were used extensively during the 1950's-60's for weight loss, depression, fatigue.
The idea was to use the Neuro-stimulating effects of The Amphetamine to do the main job of treating the above ills, and the sedative to prevent-minimise overstimulation.
Following the Controlled Substances Act- of 1970, Amphetamine use dropped 80-90% due to fear being placed into Docs, who prescribed Amphetamines, as all use except, Narcolepsy, Morbid Obesity, and probably sever, treatment-resistant Depression was tolerated.
Goofballs were ceased to be maunfactured around this time too.
Cheers
Posted by ed_uk on November 28, 2004, at 20:07:08
In reply to Re: DEXAMYL--DESBUTAL why where they abused?, posted by paulbwell on November 28, 2004, at 19:59:29
Does anyone know of any other stim-barb combinations which were formerly used in medicine?
Ed
Posted by mmcconathy on November 28, 2004, at 20:46:50
In reply to Re: Amphetamine-barbiturates, posted by ed_uk on November 28, 2004, at 20:07:08
I read an article somewhere, an older one, that a combination of dextroamphetamine and meprobamate was being considered, which was reasonable since Miltown was a blockbuster in late 50's. But it was never marketed, just a consideration. They were explaining testing results with individuels.
This is intresting...
Cheers
Posted by paulbwell on November 28, 2004, at 21:28:59
In reply to Re: Amphetamine-barbiturates, posted by ed_uk on November 28, 2004, at 20:07:08
> Does anyone know of any other stim-barb combinations which were formerly used in medicine?
>
> Ed
>After Buying all patent rights to Amphetamines in 1932, SKF then released the non-script Speed driven 'Benzedrine' levo-Amphetamine, nasel inhaler. It worked like a charm, and felt good too. It took less than a few minutes for some to break the thing open and suck out the insides. Jack Kerouac was amoung many who broke them open and swished the speed-impregnated paper strip into his Coffee-nice buzz. SKF stopped making this inhaler in 1949.
The next two decades saw Smith-Kline-French put their L and D Amphetamine to endless uses and combined with many other Drugs:
-Eskatrol Dexedrine and Compazine
-Appetrol Dex and Miltown
-Edrisal Benzedrine and Aspirin-1948
-Ambar Methamphetamine and Phenobarbital-not SKF
-Thoradex Thorazine and Dex (no kiding)
-Benzabar Benzadrine and Phenobarbital
-Miltrate Miltown and Pent, Tranqualiser- not SKF
-Miltown and Estrogen -not SKF
-Prozine Miltown and Promazine anxiety-not SKF
-Milpath Miltown and Tridihexethyl iodide-anxiety and ulcer-not SKF
-Deprol Miltown and Benactyzine, depression-not SKF
-Carbrital Pentobarbital and Carbromal-Bromide, sleep-not SKF
-Eskabarb Benzadrine SR SpansualAnd I'm sure there were more.
Cheers
Posted by gromit on November 28, 2004, at 23:20:00
In reply to Re: DEXAMYL--DESBUTAL why where they abused?, posted by ed_uk on November 28, 2004, at 19:49:52
> They were certainly euphoric..... people were even happy when they were vacuuming!!!
You say that like it's a bad thing. ;) As long as it isn't having negative effects, what would be wrong with that? Almost anything can be abused, people inhale spray paint or canned whip cream. Some people just seem happier and more positive than others. Why is it considered bad if your meds have the same effect?
Rick
Posted by HermanMunster on November 28, 2004, at 23:49:56
In reply to What were the standard anxiety meds in the 1940's?, posted by mmcconathy on November 27, 2004, at 14:57:39
Masturbation.
Posted by ed_uk on November 29, 2004, at 2:08:56
In reply to Re: Amphetamine-barbiturates, posted by paulbwell on November 28, 2004, at 21:28:59
Hi,
One of the authors of my psycho-pharm textbook reports hallucinating on Benzedrine. At the time, he says he had no idea a 'harmless' inhaler could be responsible!
Ed.
Posted by Cecilia on November 29, 2004, at 3:46:16
In reply to Re: Imagine how bad it was back then!, posted by denise1904 on November 28, 2004, at 16:54:41
Back then, now, for a lot of us there`s no difference. I`ve tried probably dozens of different antidepressants and combinations and never found anything that helped. Cecilia
Posted by paulbwell on November 29, 2004, at 3:58:43
In reply to Re: Amphetamine-barbiturates- to paulbwell, posted by ed_uk on November 29, 2004, at 2:08:56
> Hi,
>
> One of the authors of my psycho-pharm textbook reports hallucinating on Benzedrine. At the time, he says he had no idea a 'harmless' inhaler could be responsible!
>
> Ed.Hi ED
Unusual reaction. Perhaps the author liked the inhalers a little to much? and consumed-Inhaled more than 1? for this to happen :)
Posted by linkadge on November 29, 2004, at 11:34:49
In reply to Re: Amphetamine-barbiturates- to ED_UK, posted by paulbwell on November 29, 2004, at 3:58:43
There were a few proposals for stimulant antipyshotic combinations for obesity. Manufacturers argued that the antipsychotic blocked the psychosis produced by the high doses of amphetamine.
I've tried a combination like this. It is probably the most messed up thing you can experience.
You're blocking certain dopamine receptors and over-loading others. I remember trying ritalin and thioridazine and I was staring at a water hydrent for close to 8 hours. It was really funny the way it popped out of the ground like that.
I felt like I was on another planet.
Linkadge
Posted by paulbwell on November 29, 2004, at 12:57:02
In reply to Re: Amphetamine-barbiturates- to ED_UK, posted by linkadge on November 29, 2004, at 11:34:49
> There were a few proposals for stimulant antipyshotic combinations for obesity. Manufacturers argued that the antipsychotic blocked the psychosis produced by the high doses of amphetamine.
>
> I've tried a combination like this. It is probably the most messed up thing you can experience.
>
> You're blocking certain dopamine receptors and over-loading others. I remember trying ritalin and thioridazine and I was staring at a water hydrent for close to 8 hours. It was really funny the way it popped out of the ground like that.
> I felt like I was on another planet.
>
>
>
>
> Linkadge
>
>Hi Link,
8 hours? time for Med change for Link.;)
Cheers
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