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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 14 of 14. This is the beginning of the thread.
Posted by linkadge on October 10, 2004, at 20:40:21
does lamictal have any effect on neurogenesis ?
Linkadge
Posted by jdawg on October 10, 2004, at 22:18:22
In reply to lamictal neurogenesis, posted by linkadge on October 10, 2004, at 20:40:21
This probably has not been studied. SSRIs have been shown to lead to neurogenesis but not other drugs. Look at Santorelli et al, Science 2003 for some of the data. I don't think people have gotten around to studying drugs from other classes. You can tell for sure by searching on Pubmed.
Why are you interested in this?
JDawg
> does lamictal have any effect on neurogenesis ?
>
>
> Linkadge
Posted by linkadge on October 10, 2004, at 22:33:59
In reply to Re: lamictal neurogenesis » linkadge, posted by jdawg on October 10, 2004, at 22:18:22
Lithium induces hippocampal neurogenesis, and this is probaby why it leads to fewer suicides, less wanning of the hippocampus, and perhaps a few extra neurons to replace the lost and shrunken.
Linkadge
Posted by jdawg on October 10, 2004, at 22:37:33
In reply to Re: lamictal neurogenesis, posted by linkadge on October 10, 2004, at 22:33:59
Do you have the citation for this finding (re. Lithium)?
Thanks,
JDawg
Posted by linkadge on October 11, 2004, at 9:58:23
In reply to Re: lamictal neurogenesis » linkadge, posted by jdawg on October 10, 2004, at 22:37:33
In this article.
http://www.mcmanweb.com/article-191.htm
or this one
http://www.sciencenews.org/articles/20001111/fob3ref.asp
If in doubt, go to any search engine and type in
lithium + neurogenesisor
lithium + "grey matter"
linkadge
Posted by jdawg on October 11, 2004, at 10:20:00
In reply to Re: lamictal neurogenesis, posted by linkadge on October 11, 2004, at 9:58:23
Thank you.
JDawg
Posted by linkadge on October 11, 2004, at 10:34:03
In reply to Re: lamictal neurogenesis » linkadge, posted by jdawg on October 11, 2004, at 10:20:00
No problem. Personally I wish I had stayed on it. I didn't feel *great* on it like some AD's can make me feel, but it was probably a lot better for my brain.
Linkadge
Posted by jdawg on October 11, 2004, at 10:59:40
In reply to Re: lamictal neurogenesis, posted by linkadge on October 11, 2004, at 10:34:03
Have similar neurogenesis studies have been done for anti-psychotics?
Posted by linkadge on October 11, 2004, at 11:27:03
In reply to Re: lamictal neurogenesis » linkadge, posted by jdawg on October 11, 2004, at 10:59:40
I think that clozaril and zyprexa have been shown to increase temporal lobe volume (usually shrunken in those with schitsophrenia)
Linkadge
Posted by jdawg on October 11, 2004, at 11:55:37
In reply to Re: lamictal neurogenesis, posted by linkadge on October 11, 2004, at 11:27:03
Can you refer me to the original literature describing these findings?
BTW, it's nice to discuss these issues with someone like yourself who is so well informed.
JDawg
> I think that clozaril and zyprexa have been shown to increase temporal lobe volume (usually shrunken in those with schitsophrenia)
>
> Linkadge
Posted by Daniel Woodfield on October 11, 2004, at 13:43:29
In reply to Re: lamictal neurogenesis, posted by jdawg on October 11, 2004, at 11:55:37
I'll tell you what i'd like to know,
what if someone is on an AD like Paxil for example, and neurogenesis occurs when it is not needed,
Surely then someone would be left with too much serotonin being recieved in their brain leading to a myriad of problems.
I actually believe this to the cause of many of my issues, Paxil having increased the level of serotonin being recieved in my brain where it wasn't needed.
how the hell do you go about fixing that.
Posted by linkadge on October 11, 2004, at 17:43:14
In reply to Re: lamictal neurogenesis, posted by Daniel Woodfield on October 11, 2004, at 13:43:29
Fixing what ?? You need to describe your problem.
I would think that enhanced neurogenesis is not going to do you any harm. I dont even know if enhanced neurotrophin expression even occurs in someone on AD's who doesn't have decreased BDNF.Ie theres no research to suggest that AD's boost neurogenesis if you are not depressed.
Neurogenesis happens when you jog too. This doesn't mean that jogging is bad if you aren't depressed!!!
Linkadge
Posted by DynaUnity333 on October 12, 2004, at 4:22:08
In reply to Re: lamictal neurogenesis, posted by linkadge on October 11, 2004, at 17:43:14
Hey linkadge,
Im very new to this term "Neurogenesis" so don't take anything i say as gospel or anything, im just trying to learn like the rest of us.
The way i was thinking about it was this,
If a person has enough serotonin receptor sites and not enough dopamine receptor sites and is given an AD that supported Neurogenesis for serotonin neurons,would that not lead to an increase of new serotonin receptor sites which would inturn decrease the already lacking dopamine receptor sites.
If that was the case would it not make the problems that someone who needs increased dopamine receptors magnified, with all the extra serotonin being picked up and even less dopamine recieved.
Just a thought that was plugging through my head. Im no scientist though so i really have no idea.
Posted by linkadge on October 12, 2004, at 11:24:40
In reply to Re: lamictal neurogenesis, posted by DynaUnity333 on October 12, 2004, at 4:22:08
This can be the case. Oftentimes if the drug is the wrong one it can create more problems than it solves.
Linkadge
This is the end of the thread.
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