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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 3 of 3. This is the beginning of the thread.
Posted by aazospiro on September 8, 2004, at 20:36:52
NMDA receptor antagonist disrupts acute and chronic effects of methylphenidate.
Interesting Stuff...for ADD'ers and stimulants Tolerance. Read more @http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11134695&itool=iconabstrADDITIONALLY & Interestingly, The cough suppressant dextromethorphan is an NMDA antagonist at least in low doses i.e. < 15 mg
and maybe of some value in preventing stimulant tolerance before it has occurred. hmmmmmmm!I think memantine is also an NMDA antagonist. Also Valproate might have some value in prevent longterm stimulant tolerance resulting in lower maintenance doses.
Posted by paulbwell on September 10, 2004, at 7:17:45
In reply to N-methyl d-Aspartate Methylphenidate [Ritalin], posted by aazospiro on September 8, 2004, at 20:36:52
I am aware of the talk of Dextromethorphan preventing tolance (namely AME SANS VIE being an advocate)to Amphetamines, does this work on Methylphenidate?.
Thanks, Paul
Posted by Philidor on September 13, 2004, at 15:27:18
In reply to RE:RITALIN-DOES DMX PREVENT TOLERANCE. AME?, posted by paulbwell on September 10, 2004, at 7:17:45
There is no hard evidence that I know of that taking DXM, or anything else, will prevent tolerance to stimulants developing in humans.
Until now, there has been only a lot of speculation, often couched in impressive-sounding scientific jargon and combined with a big dose of esoteric information (often factual), explaining exactly how and why substance X WILL (not "may" or "might")prevent tolerance developing to stimulants.
It would not be hard to design a study to test all this specualation. You take a big group of unmedicated ADHD subjects, say, and spilt them in half. Group A gets dosed with Adderall plus DXM (or memantadine or amantadine or whatever you please). Group B gets the stimulant plus placebo.
After 6 months, which group has more subjects experiencing tolerance? Is the difference significant? I'd LOVE to know!
So would lots of other people. Who wouldn't? The drug companies, you say? Even if they could, why would they? Why would Shire, for example, want to stand in the way of a drug that helps THEIR drug (Adderall) work longer and better and not poop out on so many people so they quit taking it?
I think there might be someone, however, who might NOT welcome such a breakthrough. And that would be our friends at theantidrug.com and such-like minded people.
I have NO evidence for this. But remember, a drug that prevented tolerance to amphetamines or opiates would be good news not just for the people taking the them for medical reasons but for those taking them recreationally/and or illegally. It's that very tolerance that gets many of those coke and meth users to the point where they can no longer afford to maintain their habits and must enter treatment.
For the drug prohibitionists, many of them fanatical in their commitment, "tolerance" has always been a good thing, a word they've always used to scare people away from using drugs (read their stuff).
Up until about 1990 that is, when adult ADHD suddenly made amphetamine use legitmate again for a large number of people, no longer just "uppers" or "speed" or terrible, life-wrecking drugs of addiction. But medication.
I could be dead wrong, but....
(I've got to get back to work now.)
phil
This is the end of the thread.
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