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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 8 of 8. This is the beginning of the thread.
Posted by Violet4EVR on August 30, 2004, at 0:47:04
Does anyone know if it is okay to take Tramadol (Ultram) and Effexor together?
I know that Effexor and Tramadol both raise Serotonin and Norepinephrine levels.
Thanks,
Violet
Posted by Larry Hoover on August 30, 2004, at 0:47:05
In reply to Effexor and Tramdaol (Ultram), posted by Violet4EVR on August 28, 2004, at 13:27:59
> Does anyone know if it is okay to take Tramadol (Ultram) and Effexor together?
>
> I know that Effexor and Tramadol both raise Serotonin and Norepinephrine levels.
>
> Thanks,
> VioletThere is very little structural difference between the two drugs. Both share the same dependence on liver enzymes. The combination can lead to serotonin syndrome. Is there some reason you want to combine them?
Lar
Posted by Violet4EVR on August 30, 2004, at 0:47:06
In reply to Re: Effexor and Tramdaol (Ultram) » Violet4EVR, posted by Larry Hoover on August 28, 2004, at 14:39:04
Thank you so much for responding...I am on Ultram for foot surgery I had recently...
How long would it take to develop serotonin syndrome off the two drugs?? i've taken it for 3 days (the ultram)...i think i'm stopping tonight...
thanks,
violet
Posted by Larry Hoover on August 30, 2004, at 0:47:06
In reply to Effexor and Tramdaol (Ultram), posted by Violet4EVR on August 28, 2004, at 15:13:54
> Thank you so much for responding...I am on Ultram for foot surgery I had recently...
>
> How long would it take to develop serotonin syndrome off the two drugs?? i've taken it for 3 days (the ultram)...i think i'm stopping tonight...
>
> thanks,
> violetI honestly don't know how long it might take to develop serotonin syndrome. If you can manage it, switching to e.g. tylenol or ibuprofen or naproxen might be in order.
Lar
Posted by SLS on August 30, 2004, at 0:47:07
In reply to Effexor and Tramdaol (Ultram), posted by Violet4EVR on August 28, 2004, at 15:13:54
Hi.
Violet - Larry did his homework on this one. Although I have seen people report using it safely, there have been reports of SS occurring with this combination. Please disregard my comments on the other PB board.
Larry - Is it your thought that venlafaxine is more apt to produce SS when combined with tramadol compared to other SRIs because of a structural similarity between the two?
- Scott
Posted by Larry Hoover on August 30, 2004, at 0:47:08
In reply to Re: Effexor and Tramdaol (Ultram), posted by SLS on August 29, 2004, at 11:01:46
> Hi.
>
> Violet - Larry did his homework on this one. Although I have seen people report using it safely, there have been reports of SS occurring with this combination. Please disregard my comments on the other PB board.
>
> Larry - Is it your thought that venlafaxine is more apt to produce SS when combined with tramadol compared to other SRIs because of a structural similarity between the two?
>
>
> - ScottYes, exactly so.
venlafaxine is:
R/S-1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl] cyclohexanol hydrochloridetramadol is:
(±)cis-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl) cyclohexanol hydrochloride
Posted by Charm on August 30, 2004, at 13:26:18
In reply to Effexor and Tramdaol (Ultram), posted by Violet4EVR on August 28, 2004, at 13:27:59
Hi Violet -
While I'm not suggesting that you do it, I have been taking Effexor and Tramadol together for over a year. I have been taking Tramadol/Ultram for about 9 years. During this nine year period I've been have always been on sime type of AD. I take 400 mg of Tramadol per day for arthritis. My Effexor has recently been cut from 300 mg to 150 mg because I now also take Wellbutrin. I also take buspar (45 mg day).
To be honest with you, I'm probably a serotonin syndrome case ready to happen at any moment.
I happen to know its a risk because I cannot get all three prescriptions filled at one pharmacy. When the third medication was added and I took my prescriptions to Kroger to be filled, they told me that I had to drop either the tramadol or the buspirone because in their system it shows a warning for serotonin syndrome when combined with Effexor. Being the idiot I am, I simply take my third prescription to a different pharmacy and get it filled there.
All that being said the answer is yes, there is a possibility of serotonin syndrome with Effexor and Tramadol. Of course, it is also probably directly related to the dose.
Hope this long story was of some assistance. Perhaps you can call your doc and get a different prescription called in to help with your post surgery pain?
Happy Recovery!
Charm
Posted by SLS on August 31, 2004, at 7:55:14
In reply to Re: Effexor and Tramadol (Ultram) ....Mixing » SLS, posted by Sad Panda on August 29, 2004, at 12:05:26
> This is one of the rare occasions that I disagree with Scott. These two are very closely related & would also raise each others plasma levels. I would urge caution, or better still, get a different pain killer. Something with hydrocodone like Vicodin would be more suitable.
I agree with Panda!
- Scott
This is the end of the thread.
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