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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by eugenia on February 3, 2004, at 6:11:29
I am on Prozac and it is a life saver for anxiety issues and lifts my spirits a bit, but also makes me kind of flatline emotionally speaking. I was wondering whether selegilene might help that and whether, like the other MAOIs, it is deadly with an SSRI.
Posted by Chairman_MAO on February 3, 2004, at 8:29:56
In reply to can selegeline be combined with Prozac, posted by eugenia on February 3, 2004, at 6:11:29
Can J Neurol Sci. 1994 Aug;21(3):259-61.
Fluoxetine and selegiline--lack of significant interaction.Waters CH.
Department of Neurology, University of Southern California, Los Angeles 90033.
The use of the combination of fluoxetine, an anti-depressant serotonin uptake inhibitor, and selegiline, a monoamine oxidase -B inhibitor, was reviewed in a large population of patients with Parkinson's disease. All records were reviewed from a Parkinson's disease clinic to determine how many patients were treated simultaneously with selegiline and fluoxetine. Patient characteristics, duration and dose of treatment, side effects and reasons for discontinuation were noted. Twenty-three patients received both medications at the same time. No additional side effects were noted with the combination therapy that had not already been reported with each medication alone. No serious side effects were found. In this clinic population, fluoxetine and selegiline were used in combination without major side effects, but further observation is warranted.
Posted by SLS on February 3, 2004, at 14:58:23
In reply to Re: can selegeline be combined with Prozac » eugenia, posted by Chairman_MAO on February 3, 2004, at 8:29:56
Hi C_M.
I wonder what dosage of selegiline they used. The higher dosages that seem to be necessary for depression might preclude the addition of a SRI.
- Scott
> Can J Neurol Sci. 1994 Aug;21(3):259-61.
>
>
> Fluoxetine and selegiline--lack of significant interaction.
>
> Waters CH.
>
> Department of Neurology, University of Southern California, Los Angeles 90033.
>
> The use of the combination of fluoxetine, an anti-depressant serotonin uptake inhibitor, and selegiline, a monoamine oxidase -B inhibitor, was reviewed in a large population of patients with Parkinson's disease. All records were reviewed from a Parkinson's disease clinic to determine how many patients were treated simultaneously with selegiline and fluoxetine. Patient characteristics, duration and dose of treatment, side effects and reasons for discontinuation were noted. Twenty-three patients received both medications at the same time. No additional side effects were noted with the combination therapy that had not already been reported with each medication alone. No serious side effects were found. In this clinic population, fluoxetine and selegiline were used in combination without major side effects, but further observation is warranted.
>
Posted by eugenia on February 3, 2004, at 17:31:30
In reply to Re: can selegeline be combined with Prozac, posted by SLS on February 3, 2004, at 14:58:23
Thanks for responding! I really appreciate it.
Posted by Chairman_MAO on February 3, 2004, at 18:36:11
In reply to Re: can selegeline be combined with Prozac, posted by SLS on February 3, 2004, at 14:58:23
I assume this was a 10mg/day dose, for that's the dose they generally use in treating Parkinson's. I took 15mg/day sublingually for about 8 months with celexa/lexapro as well as remeron with no untoward effects. I _love_ that stuff. Too bad my current doctor won't prescribe it.
Dosages higher than 15mg/day are not safe without dietary and drug restrictions; it's around 30mg/day that MAO-A inhibition becomes certain.
This is the end of the thread.
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