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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by mattdds on February 2, 2004, at 12:42:06
Does anyone know why they wouldn't explore an MAOI with a better track record (phenelzine, tranylcipromine, isocarboxazid) for transdermal delivery?
There is likely a reason, perhaps that the other MAOI compounds cause dermatitis or something like that.
Otherwise, I just couldn't imagine why a manufacturer would choose selegiline out of all the MAOI's, when it has the least supporting evidence for efficacy, especially with all those other wonderful MAOI's. Can you imagine transdermal Nardil, with no worries of food-induced hypertensive crises?
Matt
Posted by Chairman_MAO on February 2, 2004, at 12:52:23
In reply to Selegiline transdermal, why not phenelzine ?, posted by mattdds on February 2, 2004, at 12:42:06
Perhaps because Eldepryl (Somerset) doesn't sell because it's way more expensive than the generic? A bottle of 30 Eldepryl capsules costs $141, whereas generic costs $28. They also could more easily get the patch approved for Parkinson's. People often forget that this patch could be a big convenience for use in the elderly with Parkinson's.
I never understood why Mylan and Watson both make generic selegiline capsules while Somerset, a joint venture between Watson and Mylan, makes the brand name ...
Five other firms also make generic selegiline for sale in the US.
Posted by Ilene on February 2, 2004, at 12:59:01
In reply to Selegiline transdermal, why not phenelzine ?, posted by mattdds on February 2, 2004, at 12:42:06
> Does anyone know why they wouldn't explore an MAOI with a better track record (phenelzine, tranylcipromine, isocarboxazid) for transdermal delivery?
>
> There is likely a reason, perhaps that the other MAOI compounds cause dermatitis or something like that.
>
> Otherwise, I just couldn't imagine why a manufacturer would choose selegiline out of all the MAOI's, when it has the least supporting evidence for efficacy, especially with all those other wonderful MAOI's. Can you imagine transdermal Nardil, with no worries of food-induced hypertensive crises?
>
> MattI'm with Chairman Mao on this--I think the potential market for a Parkinson's med is much larger than the market for a 3rd line AD. At the dose required for AD effect, I think people would still need to follow an MAOI diet.
Ilene
Posted by Metalblade on February 2, 2004, at 14:16:41
In reply to Selegiline transdermal, why not phenelzine ?, posted by mattdds on February 2, 2004, at 12:42:06
I have an idea on how you could make your own transdermal nardil. Well first off I use to be into lifting weights with steroids. Specifically a steroid called fina. Its a steroid meant for cows but body builders take it too because its easy to get and works really well. So anyway these body builders use DMSO gel to get the fina in their bodes transdermaly. It works really well and I don't see why it wouldn't work with nardil. You could just crush up some nardil mix it in about a teaspoon of DMSO and put it in the microwave for about 5 seconds ( helps the medication devolve in the DMSO) and apply to skin. Of course I don't currently take nardil but I have almost a full bottle if I ever wanted to try it. Any one want to be a ginipig?
> Does anyone know why they wouldn't explore an MAOI with a better track record (phenelzine, tranylcipromine, isocarboxazid) for transdermal delivery?
>
> There is likely a reason, perhaps that the other MAOI compounds cause dermatitis or something like that.
>
> Otherwise, I just couldn't imagine why a manufacturer would choose selegiline out of all the MAOI's, when it has the least supporting evidence for efficacy, especially with all those other wonderful MAOI's. Can you imagine transdermal Nardil, with no worries of food-induced hypertensive crises?
>
> Matt
Posted by djmmm on February 2, 2004, at 16:14:59
In reply to Selegiline transdermal, why not phenelzine ?, posted by mattdds on February 2, 2004, at 12:42:06
> Does anyone know why they wouldn't explore an MAOI with a better track record (phenelzine, tranylcipromine, isocarboxazid) for transdermal delivery?
>
> There is likely a reason, perhaps that the other MAOI compounds cause dermatitis or something like that.
>
> Otherwise, I just couldn't imagine why a manufacturer would choose selegiline out of all the MAOI's, when it has the least supporting evidence for efficacy, especially with all those other wonderful MAOI's. Can you imagine transdermal Nardil, with no worries of food-induced hypertensive crises?
>
> Mattbecause transdermal selegiline can be marketed for not only depression, but for ADD, and Parkinsons...plus Selegiline is a far superior med than Phenelzine (as far as side-effects, and toxicity) Selegiline has numerous other positive benefits (anti-oxidant, neuroprotection, etc)
This is the end of the thread.
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