![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 8 of 8. This is the beginning of the thread.
Posted by krybrahaha on January 25, 2004, at 4:51:40
I read so much stuff on here about Klonopin. I am curious though why does most people think that Klonopin has the longest half life of any benzo? Thats bs ---it has a long half life, but it cant beat Valium or even Tranxene for that matter. If you dont believe me, i believe DR Bob has a benzo equivalency table on this site that will say the same.
Posted by Sad Panda on January 25, 2004, at 6:44:17
In reply to Klonopin does NOT have the longest half life, posted by krybrahaha on January 25, 2004, at 4:51:40
> I read so much stuff on here about Klonopin. I am curious though why does most people think that Klonopin has the longest half life of any benzo? Thats bs ---it has a long half life, but it cant beat Valium or even Tranxene for that matter. If you dont believe me, i believe DR Bob has a benzo equivalency table on this site that will say the same.
Hard to beat Valium for half-life, it has alot of active metabolites such as Temazepam & Oxazepam.
Cheers,
Panda.
Posted by mattdds on January 25, 2004, at 11:37:06
In reply to Klonopin does NOT have the longest half life, posted by krybrahaha on January 25, 2004, at 4:51:40
Hello,
While it is true that Klonopin has a half life that is not as long as Valium or Tranxene, that really is not the imporant part. The important part is the duration of action.
Klonopin, I understand has a longer *duration of action* than Valium or Tranxene.
This is because Valium and Tranxene tend to get redistributed to the fat and muscle stores(therefore made unavailable to the bloodstream and CNS). Meanwhile, Klonopin does not get redistributed to the same extent.
So you are right about the half lives, but the duration of action of Valium and Tranxene are not nearly as long as their half life.
Matt
Posted by Sad Panda on January 26, 2004, at 0:05:28
In reply to Valium and Tranxene undergo redistribution » krybrahaha, posted by mattdds on January 25, 2004, at 11:37:06
> Hello,
>
> While it is true that Klonopin has a half life that is not as long as Valium or Tranxene, that really is not the imporant part. The important part is the duration of action.
>
> Klonopin, I understand has a longer *duration of action* than Valium or Tranxene.
>
> This is because Valium and Tranxene tend to get redistributed to the fat and muscle stores(therefore made unavailable to the bloodstream and CNS). Meanwhile, Klonopin does not get redistributed to the same extent.
>
> So you are right about the half lives, but the duration of action of Valium and Tranxene are not nearly as long as their half life.
>
> MattI think it varies from person to person. My mum has bad panic disorder & takes 5mg Valium once per day before bed at night. On Klonopin she needed it twice a day & Xanax was needed 4 times a day so Valium is best for her. YMMV
Cheers,
Panda.
Posted by Ame Sans Vie on January 26, 2004, at 7:17:51
In reply to Re: Valium and Tranxene undergo redistribution » mattdds, posted by Sad Panda on January 26, 2004, at 0:05:28
Matt and Panda are right -- Klonopin is typically a medication that can be taken each 8-12 hours (though there are some anomalous situations, such as my bipolar next-door neighbor who takes it six times daily). Valium (and perhaps Tranxene) may be good choices to help with benzo withdrawal (analagous to Prozac for withdrawal from short T1/2 SSRIs), but must be taken constantly to remain effective. Valium usually wears off after two hours, three tops. There is extended-release Valium though... do they still make Valrelease?
Posted by djmmm on January 26, 2004, at 21:53:11
In reply to Re: Valium and Tranxene undergo redistribution, posted by Ame Sans Vie on January 26, 2004, at 7:17:51
> Matt and Panda are right -- Klonopin is typically a medication that can be taken each 8-12 hours (though there are some anomalous situations, such as my bipolar next-door neighbor who takes it six times daily). Valium (and perhaps Tranxene) may be good choices to help with benzo withdrawal (analagous to Prozac for withdrawal from short T1/2 SSRIs), but must be taken constantly to remain effective. Valium usually wears off after two hours, three tops. There is extended-release Valium though... do they still make Valrelease?
I think so...it comes in regular, extended and liquid forms
Posted by 8 Miles on January 27, 2004, at 19:05:44
In reply to Re: Valium and Tranxene undergo redistribution » mattdds, posted by Sad Panda on January 26, 2004, at 0:05:28
Dr. Bob has a very excellent Benzo equivalence chart somewhere in these boards. It provides a lot of detail about half-lives, doses and other salient data. I highly recommend that you all look it up.
8
Posted by 8 Miles on January 27, 2004, at 19:10:41
In reply to Re: Valium and Tranxene undergo redistribution, posted by 8 Miles on January 27, 2004, at 19:05:44
Check it out at top of this page under "statistics" then page on down until you see the benzo chart.
8
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.