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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by ace on November 21, 2003, at 22:47:04
At 2.5 mg would zyprexa boost or reduce levels of dopamine? I have heard contradictory reports about this.
at 2.5 mg it would boost serotonin, right?
Ace.........
Posted by linkadge on November 22, 2003, at 6:03:48
In reply to Zyprexa pharmacological properties.., posted by ace on November 21, 2003, at 22:47:04
All atypticals have the unique property that when combined with SSris seem to boost dopamine and norepinephrine in the prefrontal cortex. I would assume this occurs at any dose.
Zyprexa blocks the 5t2a receptor which leads to increased dopamine in certain areas of the brain as well.
Linkadge
Posted by LostBoyinNC34 on November 22, 2003, at 17:16:01
In reply to Zyprexa pharmacological properties.., posted by ace on November 21, 2003, at 22:47:04
> At 2.5 mg would zyprexa boost or reduce levels of dopamine? I have heard contradictory reports about this.
all anti-psychotics decrease dopamine...period. Thats why they have the dopamine "antagonism" mechanism built into them. Dopamine antagonism is the main thing that combats psychosis. Zyprexa doesnt increase serotonin either. Blocking dopamine is blocking your ability to experience pleasure.
>
> at 2.5 mg it would boost serotonin, right?No...you would need a serotoninergic antidepressant to do that (prozac, effexor, MAOIs, etc.).
Eric
>
> Ace.........
Posted by linkadge on November 23, 2003, at 17:12:48
In reply to Re: Zyprexa pharmacological properties.., posted by LostBoyinNC34 on November 22, 2003, at 17:16:01
Does the guy who made the previous post know anything at all ???
Antipsychotics, block specific receptors, and in doing so, can leave more dopamine for other receptors, such as the D3,D4 receptors which are involved in novelty and BDNF expression. As well the atypicals, block the ht2a receptor, which again leaves more serotonin for other receptors. This is also how mirtazapine works.I may or may not be correct, but I believe the atypicals have some specific action at the 5ht1a receptor, which may acount for some of their antidepressant effects.
Adding a low dose of an atypical, is quite often done. Infact the addition of an atypical to an SSRI, has been shown to increase dopamine, and norepinephrine in the prefrontal cortex.
The mechanizm for this augmentation effect is not clearly understood.
Linkadge
Posted by ace on November 23, 2003, at 22:45:10
In reply to nonsense, posted by linkadge on November 23, 2003, at 17:12:48
> Adding a low dose of an atypical, is quite often done. >
> LinkadgeHey Linkadge!,
What about Nardil + Amisulpride 50mg- we are talking major dopamine stimulation there, right?
Zyprexa with Nardil seems to work good for a while and the works against the Nardil- any clues?
Ace.
Posted by Dr. Bob on November 24, 2003, at 19:37:17
In reply to nonsense, posted by linkadge on November 23, 2003, at 17:12:48
> Does the guy who made the previous post know anything at all ???
You may think someone's wrong about something, but please don't post anything that could lead them to feel put down, thanks.
Bob
PS: Complaints about posts, and follow-ups regarding posting policies, should be redirected to Psycho-Babble Administration; otherwise, they may be deleted.
Posted by linkadge on November 24, 2003, at 21:31:30
In reply to Re: nonsense » linkadge, posted by ace on November 23, 2003, at 22:45:10
This may be because of the upregulation of the receptor in responce to 5ht2a receptor blockade.
Sometimes cylcing of secondary meds can help, although controversial, I often did the following. Celexa, primary med, then I cycled between - the following at bedtime (low dose seroquel, then benzo) I always slept fine, and the throwing in of the benzo now every second day, kept the augmentation effects of the seroquel, withouth developing tollerance to benzo.
Of course this was not something my doctor *condoned* it worked well, but often the doctors are not open to these sorts of schemes.
Linkadge
This is the end of the thread.
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