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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 2 of 2. This is the beginning of the thread.
Posted by jparsell82 on September 10, 2003, at 4:36:36
I have some questions about Nardil that I'd like answered from people that have experience with it. First how's the price of it and is it readily available? Does it effect your cognitive abilities such as memory, concentration, IQ, attention? Is it effective for anxiety and for increasing your desire to socialize? Does it make you tired or demotivated? Do you know what neurotransmitters it effects(dopamine,seratonin,gaba,etc)? Thanks, I'm just trying to find as much info as I can on Nardil/Parnate because nothing else has worked. Time to beg my doctor.
Posted by Ame Sans Vie on September 10, 2003, at 6:04:09
In reply to Nardil Questions, posted by jparsell82 on September 10, 2003, at 4:36:36
Though I personally was a non-responder to Nardil, I can answer a few of your questions. The price is fairly reasonable, all things considered -- about $60 per 100 15mg tablets. Availability is a whole 'nother issue, though. On and off since last November, a few people on the board have had trouble getting their prescription (I'm not sure of the specifics, though I know there was a recall of Nardil in early November '02 due to expired sub-potent product). I don't think anyone's having trouble obtaining it these days, but more than likely your pharmacy will have to special order it for you, which is a real pain to go through every month -- I was on 120mg for quite a while, and the last few days of every month I had to conserve by lowering my dose to 75-90mg for a few days while awaiting my next shipment to arrive at the pharmacy. I'm sure not everyone has this problem though.
I noticed no adverse cognitive effects, though the sexual dysfunction, weight gain, and orthostatic hypotension were quite pronounced.
Nardil's primary mechanisms of action are to inhibit monoamine oxidase types A and B. MAO-A is the enzyme which breaks down serotonin, noradrenaline, and adrenaline, while MAO-B has the same effect on dopamine and several other neurotransmitters... acetylcholine perhaps? Anyway, because these neurochemicals are protected from premature degradation/destruction from MAO, their levels rise within the brain. Nardil also inhibits GABA-transaminase (GABA-T), which breaks down GABA -- it is this action that increases the total amount of GABA available.
As for the other questions, I'm sure someone else will answer -- I ztayed on it for eight months total (six months at 120mg) and had nothing but side effects. It was sooo disappointing. But hell, it's worth a shot.
This is the end of the thread.
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