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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 18 of 18. This is the beginning of the thread.
Posted by Ame Sans Vie on August 6, 2003, at 18:15:38
I started on Dexedrine Spansules today, 10mg twice a day for two weeks, then 20mg twice a day for two weeks, then 30mg twice a day. All my supplements considered, I take 2,000mg of vitamin C daily, but I just read in the dextroamphetamine prescribing info that ascorbic acid decreases its effectiveness... do you think should I stop taking the individual C supplements and just get my supply from what's in my whole-food multinutrient supplement? Or should I just wait to see if the inhibition of dex's effects is bad enough to warrant this? Thanks!!
Posted by HenryO on August 7, 2003, at 4:59:25
In reply to Vitamin C intereference with Dexedrine??, posted by Ame Sans Vie on August 6, 2003, at 18:15:38
I had this problem myself back in '73 I found that by taking my vitamin C with sixteen Alka-Seltzer tablets it seemed to lessen the interactin and helped the Dexadrine to be more stoney. If you want to enhance it further try some over the counter nasal spray with it. Some can multiply your high considerably.
Posted by Ame Sans Vie on August 7, 2003, at 10:24:39
In reply to Re: Vitamin C intereference with Dexedrine??, posted by HenryO on August 7, 2003, at 4:59:25
It's definitely not a high that I'm after, but I am aware that sodium bicarb increases the effects of amphetamines... maybe I should just drink a 1/2 tsp of it mixed with water along with each Spansule (well, they're not "Spansules" actually--I wasn't even aware they made these in generic form... they're dextroamphetamine sulphate SR, manufactured by Barr)?
Posted by gabbix2 on August 10, 2003, at 20:32:37
In reply to Re: Vitamin C intereference with Dexedrine?? » HenryO, posted by Ame Sans Vie on August 7, 2003, at 10:24:39
I take the spansules as well and noticed a drastic difference if I take vitamin C with them,
it nullify's the effect almost entirely for me.
Everyone is so differnt though I suppose you'd probably want to try for yourself. I just take my vitamin C at night, or if I find the Dexedrine is making me too anxious, it can be very handy to have a few vitamin C on hand.
Posted by Ame Sans Vie on August 11, 2003, at 1:25:11
In reply to Re: Vitamin C intereference with Dexedrine?? » Ame Sans Vie, posted by gabbix2 on August 10, 2003, at 20:32:37
Thanks for the reply. I too noticed a drastic decrease in Dexedrine's effectiveness when taken with vitamin C (or anything acidic for that matter). I found a way around this though -- I just take 1/2 tsp of baking soda in some water along with my Dexedrine to raise the Ph in my stomach a bit. Works great; in fact, it actually makes a 10mg dose seem more like a 15mg dose, which means less drug to have to take. :-)
Posted by Henryo on August 11, 2003, at 4:50:51
In reply to Re: Vitamin C intereference with Dexedrine?? » gabbix2, posted by Ame Sans Vie on August 11, 2003, at 1:25:11
Ame Sans Vie, have you ever tried inhaling the steam off simmering dilluted elderberry vinegar and several reconstituted gouda cheese rinds? It has a powerful selubrious effects. It also gets you way way higher on the dexadrine. You can really get your freak on. All organic of course.
Posted by Larry Hoover on August 11, 2003, at 7:26:53
In reply to Re: Vitamin C intereference with Dexedrine??, posted by Henryo on August 11, 2003, at 4:50:51
> Ame Sans Vie, have you ever tried inhaling the steam off simmering dilluted elderberry vinegar and several reconstituted gouda cheese rinds? It has a powerful selubrious effects. It also gets you way way higher on the dexadrine. You can really get your freak on. All organic of course.
Tee-hee.
If you plug dexedrine and ascorbic into Google, you'll find a number of sites with information on substances that block or potentiate the effects of dexedrine.
Interesting enough, absorption from the stomach is substantially affected by acid content. The protonated amine does not absorb well, so sodium bicarbonate enhances uptake by neutralizing stomach acidity. Ascorbic acid (vitamin C) would presumably do the converse, but there has to be more to ascorbate than that....normal stomach acid (HCl) is far more acidic than ascorbic acid. Moreover, I didn't see other common acids (e.g. vinegar) mentioned as being problematic.
Vitamin C is a cofactor for a number of enzymatic processes, so perhaps it also enhances dexedrine breakdown.
Lar
Posted by blondegirl47 on August 12, 2003, at 9:28:40
In reply to Re: Vitamin C intereference with Dexedrine?? » gabbix2, posted by Ame Sans Vie on August 11, 2003, at 1:25:11
Once in a while its ok to take baking soda, but as a rule it isn't good for you. It is very high in sodium which can tranlate into your bloodpressure sky rocketing. Go to a vitamin shop and get buffered vitamin c or take your regular vitamin c before bed. Just don't take time release C.
If my insurace company will comply, I will be starting 15 mg of generic dexedrine sr. I hope its worth all the hassle.
Posted by gabbix2 on August 13, 2003, at 19:17:42
In reply to Re: Vitamin C intereference with Dexedrine?? » Ame Sans Vie, posted by blondegirl47 on August 12, 2003, at 9:28:40
Baking Soda is sodium,(salt) Sodium Bicarbonate
It wouldn't be any more harmful to use than having a dash of salt used as a seasoning. Actually though its the carbonation which enhances the effect of the dexedrine, so carbonated beverages will work too.
Posted by Festus on August 13, 2003, at 21:39:24
In reply to Baking Soda.. Dexedrine, posted by gabbix2 on August 13, 2003, at 19:17:42
If carbonation enhances the Dex,why do they say not to drink soda,s while taking it?I,ve been told that soft drinks "run" the Dex through your system and out,faster.What,s the real scoop?
Festus
Posted by BekkaH on August 13, 2003, at 22:18:56
In reply to Baking Soda.. Dexedrine, posted by gabbix2 on August 13, 2003, at 19:17:42
Gabbix2,
Actually, carbonation (carbon dioxide gas added to water) increases the acidity of the solution. Although it won't be as acidic as vitamin C or citrus juices, it is still acidic. Also, nearly all sodas, including many sugar-free sodas, contain phosphoric acid, which is extremely corrosive to tooth enamel and other substances.
Posted by Larry Hoover on August 13, 2003, at 22:40:12
In reply to Re: Baking Soda.. Dexedrine, posted by Festus on August 13, 2003, at 21:39:24
> If carbonation enhances the Dex,why do they say not to drink soda,s while taking it?I,ve been told that soft drinks "run" the Dex through your system and out,faster.What,s the real scoop?
> FestusThe real scoop is that you want to avoid acidity altogether. The higher the stomach acidity, the less dexedrine is absorbed, because dexedrine can pick up a proton, and become positively charged (it becomes a cation). Cationic dexedrine doesn't get absorbed very well. (As a consequence, a higher proportion will be passed in the stool, wasted.)
Carbonic acid (carbon dioxide dissolved in water) is not a very strong acid. If it can get rid of a proton, it becomes bicarbonate anion (what is known as the conjugate base of the acid). Bicarbonate ion fairly readily accepts a proton from other sources (like stomach HCl, hydrochloric acid), which can then lead to the formation of water and free carbon dioxide.....you burp.
So, if you take in some sodium bicarbonate (the sodium salt of the bicarbonate ion), you'll reduce the acidity of your stomach (and burp), and thereby protect the dexedrine from picking up a proton. It's kind of like a sacrifice; bicarbonate instead of dexedrine. Sodium carbonate would work better, I suppose, but I don't know if its safe to ingest. Calcium carbonate ought to work, but I don't see it listed in the "increase dexedrine activity" lists.
Lar
Posted by gabbix2 on August 13, 2003, at 22:52:29
In reply to Re: Baking Soda.. Dexedrine » Festus, posted by Larry Hoover on August 13, 2003, at 22:40:12
I'm not going to Argue with the Rev. Larry Hoover but according to my book "Prozac and other psychiatric drugs" Carbonation does increase the effect of dexedrine, and this includes soft drinks.
In my experience I've found this to be the case. However books have been wrong, and I also drink diet soda generally which has Phenylaline in it, which can act as a stimulant in itself.
So I will bow to your respected research
Posted by BekkaH on August 13, 2003, at 23:21:28
In reply to Re: Baking Soda.. Dexedrine » Larry Hoover, posted by gabbix2 on August 13, 2003, at 22:52:29
Hi gabbix2,
I think the confusion might be with the terminology. Carbonation (adding carbon dioxide gas to water) is NOT the same thing as adding baking soda (sodium bicarbonate) to water. Taking sodium bicarbonate with dexedrine, adderall and some other medications will delay urinary excretion of those drugs and enhance their effects. I was just trying to explain to you that carbonation, which initially acidifies aqueous solutions, refers to a different process.
Posted by gabbix2 on August 14, 2003, at 7:46:32
In reply to Re: Baking Soda.. Dexedrine - gabbix2, posted by BekkaH on August 13, 2003, at 23:21:28
No I'm aware they aren't interchangeable terms, The write up of food interactions which increase the effect of dexedrine specifies in the book I have specifies carbonated beverages.
I double checked it, however its older and not the bastion of psychiatric medication information and probably incorrect. It most likely seemed correct to me as I said, because I was getting a boost from the phenylaline
Posted by Larry Hoover on August 14, 2003, at 8:47:39
In reply to Re: Baking Soda.. Dexedrine » Larry Hoover, posted by gabbix2 on August 13, 2003, at 22:52:29
> I'm not going to Argue with the Rev. Larry Hoover but according to my book "Prozac and other psychiatric drugs" Carbonation does increase the effect of dexedrine, and this includes soft drinks.
> In my experience I've found this to be the case. However books have been wrong, and I also drink diet soda generally which has Phenylaline in it, which can act as a stimulant in itself.
> So I will bow to your respected researchI was speaking to the issue of acidity (something I used to teach at university), but I failed to consider the issue of carbonation, per se.
It is possible that the gas pressure of carbon dioxide released from the decomposition of carbonic acid "pushes" the dexedrine into the blood, protonated or not. Carbonated wines (e.g. champagne) increase the rate of alcohol uptake.
If your experience is that carbonated beverages enhance the dexedrine effect, I bow to empirical evidence. Theories don't trump data.
Lar
Posted by blondegirl47 on August 14, 2003, at 9:12:17
In reply to Re: Baking Soda.. Dexedrine » Festus, posted by Larry Hoover on August 13, 2003, at 22:40:12
That was a great explanation, Thanks. I have noticed when I drink diet dew that my adderall goes away faster.
Blondegirl
Posted by stjames on August 17, 2003, at 12:27:11
In reply to Re: Baking Soda.. Dexedrine » gabbix2, posted by Larry Hoover on August 14, 2003, at 8:47:39
> > I'm not going to Argue with the Rev. Larry Hoover but according to my book "Prozac and other psychiatric drugs" Carbonation does increase the effect of dexedrine, and this includes soft drinks.
> > In my experience I've found this to be the case. However books have been wrong, and I also drink diet soda generally which has Phenylaline in it, which can act as a stimulant in itself.
> > So I will bow to your respected research
>
> I was speaking to the issue of acidity (something I used to teach at university), but I failed to consider the issue of carbonation, per se.
>
> It is possible that the gas pressure of carbon dioxide released from the decomposition of carbonic acid "pushes" the dexedrine into the blood, protonated or not. Carbonated wines (e.g. champagne) increase the rate of alcohol uptake.
>
> If your experience is that carbonated beverages enhance the dexedrine effect, I bow to empirical evidence. Theories don't trump data.
>
> Lar
One to the treatments for Amphetamine OD is to make the urine more acidic, thus it is cleared more quickly. It's in a back of the PDR.
This is the end of the thread.
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