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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 4 of 4. This is the beginning of the thread.
Posted by Questionmark on June 17, 2003, at 1:51:37
Does anyone know if Nardil's pharmacology beyond its MAO inhibition and its metabolite's inhibition of GABA transaminase-- like, any direct receptor effects?
Also, why does Nardil often cause insomnia and afternoon fatigue (like Parnate)? It makes some sense to me why Parnate would because of its immediate catecholamine-stimulating effects (which could make it stimulating in the morning followed by a moderate "crash" of sorts in the afternoon). But Nardil does not induce catecholamine release, right? So .. why does it do this?
Maybe the afternoon fatigue is due in part to the elevated GABA levels? Does taking Nardil at night/ before bed alleviate the afternoon fatigue to some degree then? Anyone try this? And maybe taking at night would allow the elevated GABA to assist w/ the insomnia? Yes/no?
Finally, if Nardil has no direct effects beyond those on MAO and GABA, then what is the need to take in divided doses, as it seems most people do? How would this help with fatigue, blood pressure problems, or other side effects (since the MAO inhibition is irreversible-- i.e., would last all day anyway)?
Comments much appreciated!
Posted by Cosis on June 17, 2003, at 12:42:38
In reply to Nardil, posted by Questionmark on June 17, 2003, at 1:51:37
> Does anyone know if Nardil's pharmacology beyond its MAO inhibition and its metabolite's inhibition of GABA transaminase-- like, any direct receptor effects?
>
> Also, why does Nardil often cause insomnia and afternoon fatigue (like Parnate)? It makes some sense to me why Parnate would because of its immediate catecholamine-stimulating effects (which could make it stimulating in the morning followed by a moderate "crash" of sorts in the afternoon). But Nardil does not induce catecholamine release, right? So .. why does it do this?
> Maybe the afternoon fatigue is due in part to the elevated GABA levels? Does taking Nardil at night/ before bed alleviate the afternoon fatigue to some degree then? Anyone try this? And maybe taking at night would allow the elevated GABA to assist w/ the insomnia? Yes/no?
> Finally, if Nardil has no direct effects beyond those on MAO and GABA, then what is the need to take in divided doses, as it seems most people do? How would this help with fatigue, blood pressure problems, or other side effects (since the MAO inhibition is irreversible-- i.e., would last all day anyway)?
> Comments much appreciated!Nardil never caused me insomnia, if anything it helps me sleep because I am not worrying over things before I go to bed.
Posted by ace on June 17, 2003, at 23:50:52
In reply to Re: Nardil, posted by Cosis on June 17, 2003, at 12:42:38
Nardil has always helped me sleep - it has a nice calm hypnotic effect at night.
Ace.
Posted by Questionmark on June 19, 2003, at 1:24:06
In reply to Re: Nardil, posted by ace on June 17, 2003, at 23:50:52
This is the end of the thread.
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