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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 4 of 4. This is the beginning of the thread.
Posted by btnd on May 31, 2003, at 14:32:39
I've been wondering lately why do I feel much better when Adderall wears off, than in previous months. The only thing I've added to my regime is nicotinamide (and Enada NADH rarely). So here's the study I've found on pubmed:
Brain Res Bull 1999 Oct;50(3):167-71
Related Articles, LinksD-amphetamine-induced depletion of energy and dopamine in the rat striatum is attenuated by nicotinamide pretreatment.
Wan FJ, Lin HC, Kang BH, Tseng CJ, Tung CS.
Institute of Undersea and Hyperbaric Medicine, Taipei, Taiwan, Republic of China.
The present study examined the effects of nicotinamide on the D-amphetamine (AMPH)-induced dopamine (DA) depletion and energy metabolism change in the rat striatum. In chronic studies, co-administration of AMPH with desipramine, a drug that retards the metabolism of AMPH, (10 mg/kg, intraperitoneal [i.p.], respectively) caused a significant decrease of striatal DA content measured 7 days later. Pretreatment with nicotinamide (500 mg/kg, i.p.), the precursor molecule for the electron carrier molecule nicotinamide adenine dinucleotide (NAD), attenuated this effect of AMPH, whereas itself exerted no long-term effect on striatal DA content. In acute studies, a decrease in striatal adenosine triphospate/adenosine diphosphate (ATP/ADP) ratio was found 3 h after co-injection of AMPH and desipramine. However, nicotinamide pretreatment blocked the reduced striatal ATP/ADP ratio and resulted in a striking increase in striatal NAD content in AMPH-treated rats. Furthermore, nicotinamide was noted to increase striatal ATP/ADP ratio and NAD content in saline-treated rats. These findings suggest that nicotinamide protects against AMPH-induced DAergic neurotoxicity in the striatum of rats via energy supplement.
PMID: 10566977 [PubMed - indexed for MEDLINE]
Posted by samplemethod on May 31, 2003, at 23:45:17
In reply to Yet another great study on nicotinamide, posted by btnd on May 31, 2003, at 14:32:39
Hey btnd,
You seemed to have scoured medline for niacinamide studies that affect the mind. If ya got a whole bunch of abstracts in one file, it would be great if you could post them all at once for a nice comprehensive overview of the effects of niacinamide.
It would be great.
What I got from nicotinamide was a feeling of hunger suppression, and I guess you could say a little calmer.
I am going to restart my b3 supplementation and see how i go.
cheers
> I've been wondering lately why do I feel much better when Adderall wears off, than in previous months. The only thing I've added to my regime is nicotinamide (and Enada NADH rarely). So here's the study I've found on pubmed:
>
>
>
> Brain Res Bull 1999 Oct;50(3):167-71
> Related Articles, Links
>
> D-amphetamine-induced depletion of energy and dopamine in the rat striatum is attenuated by nicotinamide pretreatment.
>
> Wan FJ, Lin HC, Kang BH, Tseng CJ, Tung CS.
>
> Institute of Undersea and Hyperbaric Medicine, Taipei, Taiwan, Republic of China.
>
> The present study examined the effects of nicotinamide on the D-amphetamine (AMPH)-induced dopamine (DA) depletion and energy metabolism change in the rat striatum. In chronic studies, co-administration of AMPH with desipramine, a drug that retards the metabolism of AMPH, (10 mg/kg, intraperitoneal [i.p.], respectively) caused a significant decrease of striatal DA content measured 7 days later. Pretreatment with nicotinamide (500 mg/kg, i.p.), the precursor molecule for the electron carrier molecule nicotinamide adenine dinucleotide (NAD), attenuated this effect of AMPH, whereas itself exerted no long-term effect on striatal DA content. In acute studies, a decrease in striatal adenosine triphospate/adenosine diphosphate (ATP/ADP) ratio was found 3 h after co-injection of AMPH and desipramine. However, nicotinamide pretreatment blocked the reduced striatal ATP/ADP ratio and resulted in a striking increase in striatal NAD content in AMPH-treated rats. Furthermore, nicotinamide was noted to increase striatal ATP/ADP ratio and NAD content in saline-treated rats. These findings suggest that nicotinamide protects against AMPH-induced DAergic neurotoxicity in the striatum of rats via energy supplement.
>
> PMID: 10566977 [PubMed - indexed for MEDLINE]
Posted by btnd on June 1, 2003, at 11:46:43
In reply to Re: Yet another great study on nicotinamide » btnd, posted by samplemethod on May 31, 2003, at 23:45:17
> Hey btnd,
>
> You seemed to have scoured medline for niacinamide studies that affect the mind. If ya got a whole bunch of abstracts in one file, it would be great if you could post them all at once for a nice comprehensive overview of the effects of niacinamide.
>
> It would be great.
>
> What I got from nicotinamide was a feeling of hunger suppression, and I guess you could say a little calmer.
Yes, lately I've been digging studies on nicotinamide/niacinamide/nadh/enada nadh, because of great effects those supplements have on my dysthymic symptoms. I will post all of the studies I've found in a day or so.
Posted by Questionmark on June 3, 2003, at 3:02:35
In reply to Yet another great study on nicotinamide, posted by btnd on May 31, 2003, at 14:32:39
This is the end of the thread.
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