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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by btnd on May 30, 2003, at 13:50:24
Trends Pharmacol Sci 2003 May;24(5):228-32
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Nicotinamide: necessary nutrient emerges as a novel cytoprotectant for the brain.Maiese K, Chong ZZ.
Division of Cellular and Molecular Cerebral Ischemia, Wayne State University, School of Medicine Detroit, St Antoine, 48201, Detroit, MI, USA
Although usually identified as an essential cellular nutrient for cellular growth and maintenance, nicotinamide is under development as a novel cytoprotectant for acute and chronic neurodegenerative disorders. Here, we outline support for the premise that nicotinamide both prevents and reverses neuronal and vascular cell injury. Nicotinamide fosters DNA integrity and maintains phosphatidylserine membrane asymmetry to prevent cellular inflammation, cellular phagocytosis and vascular thrombosis. The downstream cellular and molecular cascades are considered vital for the cytoprotection offered by nicotinamide. These pathways encompass the modulation of Akt, the forkhead transcription factor FKHRL1, mitochondrial membrane potential, caspase activities and cellular energy metabolism, but remain independent of intracellular pH and mitogen-activated protein kinases. As both a therapeutic agent and an investigational tool, nicotinamide offers new therapeutic strategies for degenerative disorders of the CNS.
PMID: 12767721 [PubMed - in process]
Posted by Ron Hill on May 30, 2003, at 14:28:37
In reply to Nicotinamide great new study!, posted by btnd on May 30, 2003, at 13:50:24
Posted by shar on June 1, 2003, at 12:02:50
In reply to Nicotinamide great new study!, posted by btnd on May 30, 2003, at 13:50:24
The abstract, I mean. Into sort of low-tech language?
Not urgent, not necessary, just sounded interesting (I think), but obviously went over my head so fast it would have burned my hair off if I hadn't ducked.
:)
Shar
Posted by Larry Hoover on June 1, 2003, at 12:39:24
In reply to Any chance someone could translate that?, posted by shar on June 1, 2003, at 12:02:50
> The abstract, I mean. Into sort of low-tech language?
>
> Not urgent, not necessary, just sounded interesting (I think), but obviously went over my head so fast it would have burned my hair off if I hadn't ducked.
>
> :)
> SharNo problem. It will have lost some meaning in the process, but that's not an issue if the original had no meaning, eh?
Nicotinamide blocks neuron injury, as well as treating existing damage. It protects the genetic information, helps cell membranes resist oxidative damage and immune system reactivity, and protects the blood vessels from clotting. It blocks damaging processes before they begin, by preventing the release of signalling compounds, yet is resistant to influences that would shut it down. It protects and maintains key energy-producing processes, so neurons function at a higher capacity.
How's that?
Lar
Posted by shar on June 1, 2003, at 23:47:42
In reply to Re: Any chance someone could translate that? » shar, posted by Larry Hoover on June 1, 2003, at 12:39:24
This is the end of the thread.
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