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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 20 of 20. This is the beginning of the thread.
Posted by SalArmy4me on August 21, 2001, at 4:08:15
After having tried every antidepressant there is, I finally found the right one: moclobemide. I received it from Farmacia Cerati. Any questions about moclo I would be happy to answer. Hope you all are well...
Posted by JohnL on August 21, 2001, at 4:51:20
In reply to Moclobemide Miracle, posted by SalArmy4me on August 21, 2001, at 4:08:15
This is awesome news! Very cool.
In literature, as well as in anecdotal observations, Moclobemide seems to be one of those meds that has a tendency to poop out requiring higher and higher doses. I hope that doesn't happen with you, but if it does you can simply increase the dose. Also, some psychiatrists say that the best dose is actually much higher than the recommended highest dose. So if you eventually get up to the maximum dose, you can actually go even higher than that. Supposedly at these very high doses it also has more of a stimulating effect, which could be a welcome relief to someone who has been feeling sluggish and blah.
Anyway, best wishes to you! I'm very happy for ya!
John> After having tried every antidepressant there is, I finally found the right one: moclobemide. I received it from Farmacia Cerati. Any questions about moclo I would be happy to answer. Hope you all are well...
Posted by SLS on August 21, 2001, at 8:26:07
In reply to Moclobemide Miracle, posted by SalArmy4me on August 21, 2001, at 4:08:15
> After having tried every antidepressant there is, I finally found the right one: moclobemide. I received it from Farmacia Cerati. Any questions about moclo I would be happy to answer. Hope you all are well...
Hi Sal.John's descriptions are accurate. One nice spin that can be put on just about any antidepressant is that it is absolutely a miracle drug for at least some people. If you do experience diminishing returns with moclobemide and fail to find a workable augmentation strategy (lithium might be worth considering), keep an eye out for another RIMA called befloxatone. I would probably make it my very next choice were it available. I believe Sanofi is pushing it to phase III trials in the US. I wouldn't look at moclobemide as being the archetype RIMA from which to extrapolate its trial results to the group in general. It is probably unfortunate that moclobemide was the first to be brought to market.
Wishing you well...
- Scott
Posted by Cam W. on August 21, 2001, at 8:43:42
In reply to Re: Moclobemide Miracle » SalArmy4me, posted by SLS on August 21, 2001, at 8:26:07
Posted by DN on August 21, 2001, at 9:12:48
In reply to Moclobemide Miracle, posted by SalArmy4me on August 21, 2001, at 4:08:15
> After having tried every antidepressant there is, I finally found the right one: moclobemide. I received it from Farmacia Cerati. Any questions about moclo I would be happy to answer. Hope you all are well...
-------------------------------
If you don't mind me asking, had you tried any of the other MOAI's before. Second question, what were your underlying symptoms.Thanks,
Dave
Posted by JahL on August 21, 2001, at 10:07:58
In reply to Re: Moclobemide Miracle » SalArmy4me, posted by SLS on August 21, 2001, at 8:26:07
> > keep an eye out for another RIMA called befloxatone. I would probably make it my very next choice were it available. I believe Sanofi is pushing it to phase III trials in the US.
Hi Scott.
Nice to see you back. Briefly (I know you're not feeling up to much), can you tell me what it is about Befloxatone that excites you so?
Cheers,
J.BTW yr experience with Effexor is similar to my own. No withdrawal symptoms to speak of but plenty of 'fogginess' upstairs. I got up to 425mg but the side-effects seemed to increase exponentially. I think (no, I *KNOW*) it's what set off my current major depressive 'episode'. Hope you have better luck with it...
PS. Congrats Sal. Hope this one sticks. Just goes to show YMMV. I'm yet to meet a pdoc who has a good word to say about it. The best I can say is that it was remarkably free of side-effects, even @ 'past the limit' doses.
Posted by SalArmy4me on August 21, 2001, at 12:50:36
In reply to Re: Moclobemide Miracle SalArmy4me, posted by DN on August 21, 2001, at 9:12:48
I was on phenelzine and tranylcypromine...they didn't work. I was on a high dose of them too.
Posted by DN on August 21, 2001, at 13:18:54
In reply to Re: Moclobemide Miracle SalArmy4me » DN, posted by SalArmy4me on August 21, 2001, at 12:50:36
> I was on phenelzine and tranylcypromine...they didn't work. I was on a high dose of them too.
---------------------------------------------
I'm currently on 300 mg of effexor with no success. Would I need a three week wash out period when switching to Moclobemide. What were you symptoms and how quickly did this medication take to work.
Posted by Bob on August 21, 2001, at 13:31:15
In reply to Moclobemide Miracle, posted by SalArmy4me on August 21, 2001, at 4:08:15
> After having tried every antidepressant there is, I finally found the right one: moclobemide. I received it from Farmacia Cerati. Any questions about moclo I would be happy to answer. Hope you all are well...
************
I'm very happy to hear you found some relief. You mentioned that you were going to try reboxetine at one point... did you? Also, how long have you been taking the Moclobemide?
Posted by SalArmy4me on August 21, 2001, at 13:46:29
In reply to Re: Moclobemide Miracle SalArmy4me, posted by DN on August 21, 2001, at 13:18:54
I took mega doses of Moclobemide and I got results in a week. Its very tiring though. But it would be worth a try. Since its reversible, I wouldn't worry about the washout situation.
Posted by DN on August 21, 2001, at 14:37:50
In reply to Re: Moclobemide Miracle SalArmy4me » DN, posted by SalArmy4me on August 21, 2001, at 13:46:29
> I took mega doses of Moclobemide and I got results in a week. Its very tiring though. But it would be worth a try. Since its reversible, I wouldn't worry about the washout situation.
-------------------------------------------------
Tried nardil once for mult. anxiety syptoms(SP,GAD,Ruminations). Did do much. Do you think that Moclobemide may a good match for my symptoms. How many Mgs are you on.
Posted by SalArmy4me on August 21, 2001, at 22:46:55
In reply to Re: Moclobemide Miracle SalArmy4me, posted by DN on August 21, 2001, at 14:37:50
I take like 1200 mg per day. Give it a try...it might work for you.
Posted by SLS on August 23, 2001, at 8:02:12
In reply to Re: Moclobemide Miracle, Sal. » SLS, posted by JahL on August 21, 2001, at 10:07:58
Hi JahL.
> > > keep an eye out for another RIMA called befloxatone. I would probably make it my very next choice were it available. I believe Sanofi is pushing it to phase III trials in the US.
> Nice to see you back. Briefly (I know you're not feeling up to much), can you tell me what it is about Befloxatone that excites you so?
I have grown partial to the strategy of inhibiting selectively the MAO-A enzyme to treat severe depression. Clorgyline, an irreversible inhibitor of MAO-A, was the single most impressive antidepressant I have ever been on. Unfortunately, it is no longer manufactured for human consumption. In a conversation I had with William Z. Potter, he suggested that the inhibition of MAO-B might actually be counterproductive when treating depression.
With moclobemide, a reversible inhibitor of MAO-A (RIMA), I experienced a brief antidepressant response that was qualitatively substantially better than those I had experienced with Parnate and Nardil and more similar to that of clorgyline. Unfortunately, within a week, it exacerbated my depression to a degree so horrendous that I remained motionless and curled up into a fetal position, moaning and wimpering for days. It was easily the worst I had ever felt. I have some thoughts as to why this occured, and perhaps why moclobemide rarely seems to "stick". It has been my belief over the last 18 years that alterations in dopaminergic neurotransmission are critically involved in the etiology of my illness (unremitting bipolar II type depression with mania occuring only in association with drug exposure). I found an abstract on Medline that suggests that moclobemide promotes a passive release of dopamine from neuron terminals. This might be the mechanism by which it allows for relapse and exacerbation of depression. I imagine that such a continuous "leakage" of dopamine from the neuron eventually leads to neurotransmitter depletion, especially when such an increase in synaptic dopamine "noise" could further reduce presynaptic vesicular output via negative feed-back inhibition of DA synthesis directed by autoreceptor stimulation. Don't know for sure. However, it seems that this property is idiosyncratic of moclobemide, and is not possessed by the others. If I were God, I would have chosen another RIMA to be marketed before moclobemide. Of course, I would also have chosen to consider the possibility of never having invented depression in the first place. :-)
For me, befloxatone represents the possibility of achieving selective MAO-A inhibition, which I believe is desirable, without promoting dopamine depletion. The question remains whether reversibility equates to reduced efficacy.
- Scott
Posted by Vince on August 26, 2001, at 23:25:05
In reply to Moclobemide Miracle, posted by SalArmy4me on August 21, 2001, at 4:08:15
> After having tried every antidepressant there is, I finally found the right one: moclobemide. I received it from Farmacia Cerati. Any questions about moclo I would be happy to answer. Hope you all are well...
Is it still working for you?
Vince
Posted by Vince on August 26, 2001, at 23:30:09
In reply to Re: Moclobemide Miracle, Sal. » JahL, posted by SLS on August 23, 2001, at 8:02:12
> Hi JahL.
>
> > > > keep an eye out for another RIMA called befloxatone. I would probably make it my very next choice were it available. I believe Sanofi is pushing it to phase III trials in the US.
>
> > Nice to see you back. Briefly (I know you're not feeling up to much), can you tell me what it is about Befloxatone that excites you so?
>
> I have grown partial to the strategy of inhibiting selectively the MAO-A enzyme to treat severe depression. Clorgyline, an irreversible inhibitor of MAO-A, was the single most impressive antidepressant I have ever been on. Unfortunately, it is no longer manufactured for human consumption. In a conversation I had with William Z. Potter, he suggested that the inhibition of MAO-B might actually be counterproductive when treating depression.
>
> With moclobemide, a reversible inhibitor of MAO-A (RIMA), I experienced a brief antidepressant response that was qualitatively substantially better than those I had experienced with Parnate and Nardil and more similar to that of clorgyline. Unfortunately, within a week, it exacerbated my depression to a degree so horrendous that I remained motionless and curled up into a fetal position, moaning and wimpering for days. It was easily the worst I had ever felt. I have some thoughts as to why this occured, and perhaps why moclobemide rarely seems to "stick". It has been my belief over the last 18 years that alterations in dopaminergic neurotransmission are critically involved in the etiology of my illness (unremitting bipolar II type depression with mania occuring only in association with drug exposure). I found an abstract on Medline that suggests that moclobemide promotes a passive release of dopamine from neuron terminals. This might be the mechanism by which it allows for relapse and exacerbation of depression. I imagine that such a continuous "leakage" of dopamine from the neuron eventually leads to neurotransmitter depletion, especially when such an increase in synaptic dopamine "noise" could further reduce presynaptic vesicular output via negative feed-back inhibition of DA synthesis directed by autoreceptor stimulation. Don't know for sure. However, it seems that this property is idiosyncratic of moclobemide, and is not possessed by the others. If I were God, I would have chosen another RIMA to be marketed before moclobemide. Of course, I would also have chosen to consider the possibility of never having invented depression in the first place. :-)
>
> For me, befloxatone represents the possibility of achieving selective MAO-A inhibition, which I believe is desirable, without promoting dopamine depletion. The question remains whether reversibility equates to reduced efficacy.
>
>
> - ScottIs befloxatone available now anywhere in the world?
Vince
Posted by SalArmy4me on August 26, 2001, at 23:43:42
In reply to Re: Moclobemide Miracle » SalArmy4me, posted by Vince on August 26, 2001, at 23:25:05
Yes, moclobemide still works for me.
Posted by Vince on August 28, 2001, at 15:00:49
In reply to Re: Moclobemide Miracle » Vince, posted by SalArmy4me on August 26, 2001, at 23:43:42
> Yes, moclobemide still works for me.
From what I've read of some of your posts, your depression sounds alot like mine. Maybe I should give it a try. How long did it take before it started working? Are there any AD's or AP's that you can't take with it?Thanks, Vince
Posted by amigan on December 5, 2007, at 21:16:26
In reply to Re: Moclobemide Miracle » SLS, posted by Vince on August 26, 2001, at 23:30:09
<snipped text>
> With moclobemide, a reversible inhibitor of MAO-A (RIMA), I experienced a brief antidepressant response that was qualitatively substantially better than those I had experienced with Parnate and Nardil and more similar to that of clorgyline. Unfortunately, within a week, it exacerbated my depression to a degree so horrendous that I remained motionless and curled up into a fetal position, moaning and wimpering for days. It was easily the worst I had ever felt. I have some thoughts as to why this occured, and perhaps why moclobemide rarely seems to "stick". It has been my belief over the last 18 years that alterations in dopaminergic neurotransmission are critically involved in the etiology of my illness (unremitting bipolar II type depression with mania occuring only in association with drug exposure). I found an abstract on Medline that suggests that moclobemide promotes a passive release of dopamine from neuron terminals. This might be the mechanism by which it allows for relapse and exacerbation of depression. I imagine that such a continuous "leakage" of dopamine from the neuron eventually leads to neurotransmitter depletion, especially when such an increase in synaptic dopamine "noise" could further reduce presynaptic vesicular output via negative feed-back inhibition of DA synthesis directed by autoreceptor stimulation.
Hello.
I have searched the net to find information about this subject. but couldn't find anything. On the contrary, i have found that Moclobemide can be safely administrated to depressed parkinson patients.
Could anyone provide me a link about Moc and DA depletion?
Posted by amigan on December 15, 2007, at 11:36:43
In reply to Moclobemide Miracle, posted by SalArmy4me on August 21, 2001, at 4:08:15
"After having tried every antidepressant there is, I finally found the right one: moclobemide. I received it from Farmacia Cerati. Any questions about moclo I would be happy to answer...."
"...I was on phenelzine and tranylcypromine...they didn't work. I was on a high dose of them too."
Now, why i have difficulties to believe what you've said in this thread and that something else is going on here? Perhaps i'm being over-suspicious/paranoid and all is ok.
Posted by Sigismund on December 16, 2007, at 13:45:31
In reply to Re: Moclobemide Miracle » SalArmy4me, posted by amigan on December 15, 2007, at 11:36:43
I haven't (admittedly) read the thread but take it to be one of those flurries of enthusiasm that petered out.
You think?
This is the end of the thread.
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