![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by JETT55 on February 20, 2001, at 19:36:44
could Cam or anyone out there answer this question? is
there any connection with ssri's , like zoloft, and
tardive dyskinesia? Do ssri's interfere with dopamine
and therefore maybe cause t.d. somewhere down the
road? i can't seem to get a straight answer about this
from any doctor. is it that these medicines haven't
been out long enough to know the long term effects?
Posted by JahL on February 21, 2001, at 21:54:11
In reply to Re:SSRIs/TARDIVE DYSKINESIA?, posted by JahL on February 21, 2001, at 21:48:18
> could Cam or anyone out there answer this question? is
> there any connection with ssri's , like zoloft, and
> tardive dyskinesia? Do ssri's interfere with dopamine
> and therefore maybe cause t.d. somewhere down the
> road? i can't seem to get a straight answer about this
> from any doctor. is it that these medicines haven't
> been out long enough to know the long term effects?
> JET55I think there's been some vague talk in the medical press recently regarding reports possibly linking long-term SSRI use with movement disorders...
Jah.
Posted by pat123 on February 23, 2001, at 13:19:28
In reply to Re:SSRIs/TARDIVE DYSKINESIA?, posted by JahL on February 21, 2001, at 21:54:11
> > could Cam or anyone out there answer this question? is
> > there any connection with ssri's , like zoloft, and
> > tardive dyskinesia? Do ssri's interfere with dopamine
> > and therefore maybe cause t.d. somewhere down the
> > road? i can't seem to get a straight answer about this
> > from any doctor. is it that these medicines haven't
> > been out long enough to know the long term effects?
> > JET55
>
> I think there's been some vague talk in the medical press recently regarding reports possibly linking long-term SSRI use with movement disorders...
>
> Jah.SSRI DO NOT effect dopamine so there is no possibility of movement disorders !
Pat
Posted by JahL on February 23, 2001, at 21:14:02
In reply to Re:SSRIs/TARDIVE DYSKINESIA?, posted by pat123 on February 23, 2001, at 13:19:28
> SSRI DO NOT effect dopamine so there is no possibility of movement disorders !
>
> PatActually Sertraline is weakly doperminergic. However I agree (though in less absolute terms) that it is *very* unlikely SSRIs cause tardive-dyskinesia.
Jah.
Posted by Sunnely on February 23, 2001, at 21:47:07
In reply to Re:SSRIs/TARDIVE DYSKINESIA?, posted by pat123 on February 23, 2001, at 13:19:28
SSRIs (selective serotonin reuptake inhibitors), via their serotonergic effect can affect dopamine. Actually, serotonin is a "neuromodulator" of dopamine i.e., a neurotransmitter that affects the action of another neurotransmitter. Specifically, serotonin inhibits the action of dopamine. This is postulated mechanism as to how SSRIs cause movement disorders, in particular extrapyramidal symptoms or EPS (e.g., dystonia, akathisia, parkinsonism). There have been anecdotal reports of SSRIs causing dyskinetic disorder (e.g., tardive dyskinesia or TD).
As of December 31, 1996, postmarketing surveillances indicated 383 cases of dystonia, 403 cases of akathisia, 503 cases of parkinsonism, and 120 cases of tardive dyskinesia associated with the use of fluoxetine (Prozac), sertraline (Zoloft), and paroxetine (Paxil). Given that patient marketing of the aforementioned SSRIs is estimated to exceed 30 million, movement disorders associated with SSRIs use are uncommon.
=========================================
> > I think there's been some vague talk in the medical press recently regarding reports possibly linking long-term SSRI use with movement disorders...
> >
> > Jah.
>
> SSRI DO NOT effect dopamine so there is no possibility of movement disorders !
>
> Pat
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.