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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 2 of 2. This is the beginning of the thread.
Posted by dean on February 12, 2000, at 17:22:45
Since taking only two 30 mg tablets of Remeron almost 3 months ago, I've been plagued by a hangover of the initial stupefaction it induced and that caused me to discontinue it immediately. Up to that point, I'd been taking a combination of Luvox and Risperdal successfully for several years as a treatment for depression. The two instances, about 12 hours apart, in which I took the Remeron, I took it as a substitute for the Luvox, in combination with the Risperdal. I'd like to know if there is any information out there on negative interactions between Remeron and Risperdal (or, for that matter, between Remeron and Luvox, which would then still have been in my system). The "hangover" consists of a continual mild grogginess/wooziness and a permanently incipient tension headache, at the back of my head where the head joins the neck, that sporadically becomes an actual tension headache accompanied in worst cases by some dizziness and nausea. I may note, too, that when, some weeks after I discontinued the Remeron, I tried to resume taking my former antidepressant medications, I suffered a return of the original Remeron-induced stupefaction, and accordingly immediately ceased taking (and have not since resumed taking) these medications. The psychiatrist who suggested I try the Remeron has confessed himself clueless as to what might be going on and evinced no interest in finding out, so I'm initiating this research. Has anyone reading this suffered a like reaction, know anyone who has, and/or have any information concerning what can be done about it?
Posted by jd on February 13, 2000, at 3:59:45
In reply to Remeron reaction, posted by dean on February 12, 2000, at 17:22:45
Dean,
Sorry to hear about the unpleaseant reaction. Both Remeron and risperidone act to blockade the same serotonin (5HT2) receptor, which may have something to do with what happened. Alternatively, it might also have to do with the effects each of these has on a second neurotransmitter, norepinephrine. (Luvox is simply an inhibitor of serotonin reuptake without much effect on norepinephrine, and is in a quite different class of meds.) In addition, if I understand your story correctly, 60mg of Remeron is quite a lot to take in a 24 hour period if you hadn't been taking it previously. (Most people don't go this high per day even after being on the medication for several weeks.) Unfortunately, a sudden high dose of Remeron on top of the risperidone (and the residual Luvox) could likely have caused a kind of "double-whammy" effect. The problems you've been having will almost certainly subside over time, but I can't help but wonder how competently your psychiatrist performed in this entire episode. (Then again, I don't know all the details, so I'm only wondering...) But especially since you've discontinued the meds entirely now--always a bit risky--perhaps the best thing to do would be to try to get a consultation with a different physician to help get things back on track.
Best to you,
jd
> Since taking only two 30 mg tablets of Remeron almost 3 months ago, I've been plagued by a hangover of the initial stupefaction it induced and that caused me to discontinue it immediately. Up to that point, I'd been taking a combination of Luvox and Risperdal successfully for several years as a treatment for depression. The two instances, about 12 hours apart, in which I took the Remeron, I took it as a substitute for the Luvox, in combination with the Risperdal. I'd like to know if there is any information out there on negative interactions between Remeron and Risperdal (or, for that matter, between Remeron and Luvox, which would then still have been in my system). The "hangover" consists of a continual mild grogginess/wooziness and a permanently incipient tension headache, at the back of my head where the head joins the neck, that sporadically becomes an actual tension headache accompanied in worst cases by some dizziness and nausea. I may note, too, that when, some weeks after I discontinued the Remeron, I tried to resume taking my former antidepressant medications, I suffered a return of the original Remeron-induced stupefaction, and accordingly immediately ceased taking (and have not since resumed taking) these medications. The psychiatrist who suggested I try the Remeron has confessed himself clueless as to what might be going on and evinced no interest in finding out, so I'm initiating this research. Has anyone reading this suffered a like reaction, know anyone who has, and/or have any information concerning what can be done about it?
This is the end of the thread.
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