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Dr. Bob is Robert Hsiung, MD,
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Posted by med-amorphosis on May 18, 2010, at 11:13:10
In reply to Re: Imipramine really that good? » gman22, posted by med-amorphosis on May 18, 2010, at 5:53:58
Surprisingly, my pdoc's first suggestion was to add bupropion the the mixture, keeping the lofepramine too. But I opted for a switch in TCAs 1st. He was willing to try 3 TCAs starting with trimipramine (Surmontil). If that fails then amitryptyline and finally, imipramine. Although imipramine would be used after various other options have been tried- ie a last resort.
So im swapping 210mg/day lofepramine to 25mg trimipramine, slowly titrating to 100mg at week 3.
Any trimipramine experiences anyone would like to share? Any knowledgable babblers explain how its meant to work? Apart from re-uptake inhibition the remainder of its actions slightly baffle me in this description:
http://en.wikipedia.org/wiki/Trimipramine
maybe its not the best source. Can anyone explain its effects in plain english (or there abouts)?med
Posted by ed_uk2010 on May 18, 2010, at 15:36:15
In reply to Re: Imipramine really that good? » ed_uk2010, posted by med-amorphosis on May 17, 2010, at 18:05:23
>But im taking Marplan not Parnate. Very different drug. Thats the problem with MAOIs- they are now looked upon as one group of similar drugs, like SSRIs.
I know, but they both inhibit the break down of serotonin. Just looking out for you :)
Posted by med-amorphosis on May 19, 2010, at 13:32:53
In reply to Re: Imipramine really that good? » med-amorphosis, posted by ed_uk2010 on May 18, 2010, at 15:36:15
> >But im taking Marplan not Parnate. Very different drug. Thats the problem with MAOIs- they are now looked upon as one group of similar drugs, like SSRIs.
>
> I know, but they both inhibit the break down of serotonin. Just looking out for you :)
>
>Cool! Thanx
Posted by Dr. Bob on May 20, 2010, at 18:43:41
In reply to Gone with trimipramine, posted by med-amorphosis on May 18, 2010, at 11:13:10
> Any knowledgable babblers explain how its meant to work? Apart from re-uptake inhibition the remainder of its actions slightly baffle me in this description:
> http://en.wikipedia.org/wiki/TrimipramineSorry to interrupt, but I'd like to redirect follow-ups regarding more advanced medication-related issues to Psycho-Babble Neurotransmitters. Here's a link:
http://www.dr-bob.org/babble/neuro/20100223/msgs/948075.html
That'll be considered a new thread, so if you'd like to be notified by email of follow-ups to it, you'll need to request that there.
> Any trimipramine experiences anyone would like to share?
Please feel free, however, to continue to use this board to share your experiences. Thanks,
Bob
Posted by topcatclr on May 21, 2010, at 1:06:46
In reply to Re: Imipramine really that good?, posted by ed_uk2010 on May 17, 2010, at 14:50:01
Took it years ago, in 1995. Doctor combined with a blood pressure med as she new it would ramp it! My memories of it were not great. Like a very sloppy form of Cymbalta. Uneven feeling of it in my system. Sometimes sleepy, hyper, anxiety, rapid heartbeat. No thanks, i will stick with Cymbalta.
Posted by Dr. Bob on May 25, 2010, at 17:34:51
In reply to Imipramine really that good?, posted by med-amorphosis on May 17, 2010, at 14:11:37
> My current regime is...
Please don't change your posting name without following these steps:
http://www.dr-bob.org/babble/faq.html#names
Follow-ups regarding this should be redirected to Psycho-Babble Administration.
Thanks,
Bob
Posted by med-amorphosis on May 31, 2010, at 9:12:35
In reply to Re: posting name » med-amorphosis, posted by Dr. Bob on May 25, 2010, at 17:34:51
> > My current regime is...
>
> Please don't change your posting name without following these steps:
>
> http://www.dr-bob.org/babble/faq.html#names
>
> Follow-ups regarding this should be redirected to Psycho-Babble Administration.
>
> Thanks,
>
> BobSorry bob, but I've good reason to change my name, and do not want my previous i.d. known. I dont want certain people knowing who I am (again). A matter of privacy thats all. Hope thats ok.
Posted by Dr. Bob on June 1, 2010, at 15:20:49
In reply to Re: posting name » Dr. Bob, posted by med-amorphosis on May 31, 2010, at 9:12:35
> > Please don't change your posting name without following these steps:
> >
> > http://www.dr-bob.org/babble/faq.html#names
>
> Sorry bob, but I've good reason to change my name, and do not want my previous i.d. known. I dont want certain people knowing who I am (again). A matter of privacy thats all. Hope thats ok.That's fine. I just ask that you follow the above steps next time. You don't have to say what your previous name was. Thanks,
Bob
Posted by med-amorphosis on June 2, 2010, at 5:14:15
In reply to Re: posting name, posted by Dr. Bob on June 1, 2010, at 15:20:49
Posted by med-amorphosis on June 5, 2010, at 14:08:49
In reply to Gone with trimipramine, posted by med-amorphosis on May 18, 2010, at 11:13:10
Well trimipramine might zonk me out, but its a good early riser. Im awake well within 8hrs now. Great for my hypersomnia. Problem is I'm still really depressed so I stay in bed- who wants even more morbid wakefullness than they already have? lol
I hope this is one of those extra-down times you get before it 'switches on'. Otherwise...i dunno. Lost.
Posted by Brainbeard on June 7, 2010, at 3:15:33
In reply to Re: Gone with trimipramine, posted by med-amorphosis on June 5, 2010, at 14:08:49
That's a bummer, that it doesn't lift your depression.
Posted by med-amorphosis on June 7, 2010, at 6:08:01
In reply to Re: Gone with trimipramine, posted by Brainbeard on June 7, 2010, at 3:15:33
> That's a bummer, that it doesn't lift your depression.
Well im over my last blast of Concerta from last week-I dont feel so tearfull today (yes it was used abusively, free from a 'friend' whos an ADHD sufferer who hates the stuff).
Plus Im stopping nicotine, alcohol (I'm alcoholic) AND chronic weed toking all in one go. So that dont help either. But last night I had no bad dreams or terrors. I even woke up feeling more positive, I think!? Sort of forgot what positive feeling is like but im sure its this.
Oh-I wacked my trimipramine up to 100mg last night too and slept the least yet-6hrs! Ok so I went back to sleep but was still up by 10:30 which is amazing for me. Not only that but it didn't knock me out like it has been. I just went to bed and slept 2 hours after taking it. Maybe its a little like mirtazapine where the higher you go the more activating it becomes.
Still too early to tell but I 'might' be on to a winner here (PLEASE!!!)
Posted by chujoe on June 7, 2010, at 7:06:06
In reply to Re: Gone with trimipramine » Brainbeard, posted by med-amorphosis on June 7, 2010, at 6:08:01
Good luck to you, Med-
Stopping all those things at one time is going to put you through some serious changes & you need to be patient with yourself. Keep posting here so folks know how you're doing.
Posted by med-amorphosis on June 7, 2010, at 9:24:46
In reply to Re: Gone with trimipramine » med-amorphosis, posted by chujoe on June 7, 2010, at 7:06:06
> Good luck to you, Med-
> Stopping all those things at one time is going to put you through some serious changes & you need to be patient with yourself. Keep posting here so folks know how you're doing.Thanks chujoe, I will.
Feels like it may be kickin in. Something has allowed me to step outside the depression today (somewhat). Dont feel so lonely (I should do). I'm more relaxed and more clear-headed. Yet the depression still feels very close, like it wants to pull me back in. Make sense?
Tomorrow is payday (yay!) so I plan to take a bus ride to the coast to soak up some sea air. Not the best coastline here but I know a few spots. Should do me some good.med
Posted by chujoe on June 7, 2010, at 12:44:30
In reply to Re: Gone with trimipramine » chujoe, posted by med-amorphosis on June 7, 2010, at 9:24:46
I've heard that sea air is a really good anti-depressant!
Posted by med-amorphosis on June 7, 2010, at 18:09:31
In reply to Re: Gone with trimipramine » med-amorphosis, posted by chujoe on June 7, 2010, at 12:44:30
> I've heard that sea air is a really good anti-depressant!
Yes it certainly has an effect. Probably more so for city dwellers (like myself). And I love the coast in the autumn too so it aint just the sight of sea & sun. Im sure I'll let you know how it went.
Posted by med-amorphosis on June 9, 2010, at 9:16:24
In reply to Re: Gone with trimipramine » chujoe, posted by med-amorphosis on June 7, 2010, at 18:09:31
Well this is odd. Trimipramine 100mg is already helping. Its gentle but a definite improvement in mood. But it seems paradoxical.
Last night I took my 100mg (4 pills) around midnight. When I next checked the time it was 4am! Not even a yawn. I went to bed and had to wait a good 1/2hr for sleep. But when I tried waking this morning it was near impossible. Very vivid dreams with just about enough energy to wake, turn over and fall back to sleep.
So I'm gonna try daytime dosing. Already took my 1st dose of 50mg THIS MORNING-NO DROWSINESS :)
I plan to take my 2nd 50mg between lunch & dinner (4pm-ish). None at night. Lets see what happens.
Its also comforting to know that I can go to 300mg & beyond if need be. This med is looking more like an activating med day by day, even taken along with Klonopin, which I've lowered from 4 to 3mg without apparent consequences. Which also means I have an extra 1mg to help me sleep if needed. I doubt the Marplan has changed any mechanism of trimipramine, except maybe potentiate it.med
Posted by med-amorphosis on June 12, 2010, at 3:48:13
In reply to Re: Gone with trimipramine, posted by med-amorphosis on June 9, 2010, at 9:16:24
Surmontil (trimipramine) has kicked in solidly now. YESSS!
I'm in a fairly constant good mood (within normal range) and I feel alive once more :)
And im still taking it in the daytime.
Theres sooo much I wanna say, but must hold back. Its just the sense of RELEEF which is riding along side. Its GREAT!
I've had much depression throughout my life, mainly related to alcoholism & drug use/abuse and of course fromm the inevitable lonelyness which accompanies/results from social phobia & AvPD. But this was my 1st true ON ITS OWN bout of depression I've ever had. Very scarey. Dead clinical. Unprovoked. Came from (seemingly) nowhere. Constant crying for NO REASON WHATSOEVER (at 1st). OUCH!
Its still early but I'm there. THANKS DOC!
Still one thing bugging me- the dreams. And they aren't just vivid, they're LUCID. Scarey at 1st but getting used to them. Can manipulate them too, in a way. Last night I dreamt I was out fishing but that my med was blurring my vision. Was virtually blind. So I 'decided' its best to tell everyone there for my own safety. They all took the piss at 1st but eventually we were ALL rolling in laughter! Bloody odd. NOT a nightmare at all. I just wish I could wake up from them at will but I struggle with that part. It must be both the side effects of the med (mentioned earlier in the thread) + the effects of giving up chronic cannabis use rolled into one. I would rather it went really.
"Thats all Folks!"
For now :)
Contributions still wellcome of course!
med
Posted by Brainbeard on June 12, 2010, at 3:54:57
In reply to BINGO!, posted by med-amorphosis on June 12, 2010, at 3:48:13
Good to hear you're doing so well, congrats! And that with this atypical med that seems to virtually have been abandoned at the edges of pharmacotherapeutical history.
I was hoping that trimipramine might foster lucid dreaming, so I find your post most interesting. I have ordered a batch of trimipramine, 25mg pills, intending to try it occasionally for doing dream work.
Posted by med-amorphosis on June 12, 2010, at 3:59:55
In reply to BINGO!, posted by med-amorphosis on June 12, 2010, at 3:48:13
> Surmontil (trimipramine) has kicked in solidly now. YESSS!
> I'm in a fairly constant good mood (within normal range) and I feel alive once more :)
> And im still taking it in the daytime.
> Theres sooo much I wanna say, but must hold back. Its just the sense of RELEEF which is riding along side. Its GREAT!
> I've had much depression throughout my life, mainly related to alcoholism & drug use/abuse and of course fromm the inevitable lonelyness which accompanies/results from social phobia & AvPD. But this was my 1st true ON ITS OWN bout of depression I've ever had. Very scarey. Dead clinical. Unprovoked. Came from (seemingly) nowhere. Constant crying for NO REASON WHATSOEVER (at 1st). OUCH!
> Its still early but I'm there. THANKS DOC!
> Still one thing bugging me- the dreams. And they aren't just vivid, they're LUCID. Scarey at 1st but getting used to them. Can manipulate them too, in a way. Last night I dreamt I was out fishing but that my med was blurring my vision. Was virtually blind. So I 'decided' its best to tell everyone there for my own safety. They all took the piss at 1st but eventually we were ALL rolling in laughter! Bloody odd. NOT a nightmare at all. I just wish I could wake up from them at will but I struggle with that part. It must be both the side effects of the med (mentioned earlier in the thread) + the effects of giving up chronic cannabis use rolled into one. I would rather it went really.
> "Thats all Folks!"
> For now :)
> Contributions still wellcome of course!
> medAs a side note, I wanted to mention also that whilst dreaming, I'm also aware that I'm asleep. Bizzare! lol
Posted by med-amorphosis on June 12, 2010, at 4:12:02
In reply to Re: BINGO!, posted by Brainbeard on June 12, 2010, at 3:54:57
> Good to hear you're doing so well, congrats! And that with this atypical med that seems to virtually have been abandoned at the edges of pharmacotherapeutical history.
>
> I was hoping that trimipramine might foster lucid dreaming, so I find your post most interesting. I have ordered a batch of trimipramine, 25mg pills, intending to try it occasionally for doing dream work.
>
>THANKS MATE! Yes, sounds like a good 'legal' way of inducing that lucid state, esp 'without' constant use, as I would imagine the effect will diminish with time (I hope). Taking at night would give the best results, hence why I changed to daytime dosing- it has a medium-long half life- 11 to 23hrs. And it will knock you out, at least at 1st. Good luck with it. I'll be whatching for your results. Please babblemail me when you start.
med
Posted by SLS on June 12, 2010, at 5:38:00
In reply to BINGO!, posted by med-amorphosis on June 12, 2010, at 3:48:13
> Surmontil (trimipramine) has kicked in solidly now. YESSS!
Great!
Use it in good health!
- Scott
Posted by med-amorphosis on June 12, 2010, at 11:40:20
In reply to Re: BINGO! » med-amorphosis, posted by SLS on June 12, 2010, at 5:38:00
Posted by Phillipa on June 12, 2010, at 20:27:47
In reply to Re: BINGO! » med-amorphosis, posted by SLS on June 12, 2010, at 5:38:00
Congrats great news!!!! Phillipa
Posted by med-amorphosis on June 12, 2010, at 22:55:45
In reply to Re: BINGO!, posted by Phillipa on June 12, 2010, at 20:27:47
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Dr. Bob is Robert Hsiung, MD,
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