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Dr. Bob is Robert Hsiung, MD,
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Posted by Ines on March 4, 2007, at 9:01:02
In reply to Re: Atypical depression, posted by laima on March 4, 2007, at 7:44:39
I think a problem with atypical depression is that a lot (obviously not all) of sufferers are 'high functioning'- they can function reasonably in day to day life, and it stops other people (and doctors) from realising how bad it is. That could be why 'typical' depression has had so much more medical attention- when someone is going through a bout of typical depression it is obvious that help is a matter of life or death. For an atypical depressive it might not be obvious to anyone but the person that the level of suffering is actually very high. River's post about his niece Jessica struck me as so sad, and so typical of an atypical depressive... I can certainly understand her but like he said, most people wouldn't understand it at all.
In defense of those involved in medical research, noone really knows what is the biological cause of this disease, and what it is about MAOI's that makes them so much more effective in these cases; without that sort of knowledge developing effective treatments is a long process of trial and error... I just think that if it was more obvious to society at large how much suffering this causes, there would be more money going into the research, so the chances of finding something that works would be higher.
Having a blue day as you can probably see....
I.
Posted by gardenergirl on March 4, 2007, at 10:42:20
In reply to Re: Atypical depression, posted by Ines on March 4, 2007, at 9:01:02
Perhaps if we could identify one or two, we could ask Dr. Bob to invite them to be a guest expert here.
namaste
gg
Posted by bulldog2 on March 4, 2007, at 14:23:29
In reply to Re: Atypical depression, posted by Ines on March 4, 2007, at 9:01:02
By the way rn320 suffered a bad hypertensive crisis on emsam 12 mg. So if your an emsam user and you're up to 12 mg be as careful as if you're on nardil or parnate.
Maybe the reason that maois are effective in atypical depression is they're the only ads that boost serotonin and dopamine which is the amine of pleasure. Maybe atypicals have some disruption of their dopamine pathways or levels. I've also read that ssris lower dopamine. No wonder many complain that they feel numb on ssris.
Posted by Maxime on March 4, 2007, at 17:27:29
In reply to Re: Atypical depression » Maxime, posted by Declan on March 3, 2007, at 22:55:03
> Hi Maxi
>
> Your doc's worried about addiction with you? Astonishing.
>
> Of course bupe might not work for you, but (given your history) it surely should be an option.Declan:
I can't tell if your first sentence is sarcasm or not. You've never been sarcastic with me before though.
I believe that I am prediposed to addiction. Look at what I have done to myself with anorexia. Luckily, I made choices NOT to try certain things (illegal) because I know I would get hooked.
xxx
Maxime
Posted by Ines on March 4, 2007, at 17:29:32
In reply to Re: Atypical depression » Ines, posted by laima on March 4, 2007, at 8:54:01
Hi Laima,
Thanks for that awesome message-really helpful. I knew a bit about selegiline- I asked doc for a trial but didn't get it- but not that much. I'm gonna check the articles out properly. I'm on reboxetine at the mo, not working all that well but I'm giving it a proper chance. If this doesn't work I'm going to really push for the selegiline/ DLPA combo. Like Meri suggested, I'll try and go in armed with papers and knowledge. GP is keen on having me try paroxetine or venlafaxine but dismisses seleginline or wellbutrin! I don't get it, but perhaps he's got access to secret research we don't
know about ;-)I've read about the amphetamine / d-phenylalanine connection somewhere. I think the end product in the brain is the same and it's possible that atypical dps don't produce a lot of it. PEA I think? I'll see if I can dig that out.
Meri, thanks for advice on how to prep for meeting with GP/ pdoc. It really got me thinking and I'll definitely try that for next time. Show you know what you're talking about and the risks involved. We were talking about meds I've tried- not much at all. An SSRI, St John's Wort and mirtazapine- no luck with any. So I guess I've got loads of options still.
I'm glad I found this board- it really helps to feel you are not isolated...
BTW Laima, dark chocolate features heavily on my menu ! :-)
Cheers I.
Posted by Ines on March 4, 2007, at 17:33:40
In reply to Any atypical depression experts/researchers?, posted by gardenergirl on March 4, 2007, at 10:42:20
> Perhaps if we could identify one or two, we could ask Dr. Bob to invite them to be a guest expert here.
>
> namaste
>
> ggWhat a great idea!! I don't know of any, but will look into it during the week. If nothing else we'll know of research to watch out for.
I.
Posted by laima on March 4, 2007, at 17:52:13
In reply to Any atypical depression experts/researchers?, posted by gardenergirl on March 4, 2007, at 10:42:20
That would be awesome! But how/where to identify one?
> Perhaps if we could identify one or two, we could ask Dr. Bob to invite them to be a guest expert here.
>
> namaste
>
> gg
Posted by laima on March 4, 2007, at 17:53:32
In reply to Re: Atypical depression, posted by bulldog2 on March 4, 2007, at 14:23:29
Thanks for mentioning this- good reminder one can't believe everything one reads. Sorry to hear about it though.
> By the way rn320 suffered a bad hypertensive crisis on emsam 12 mg. So if your an emsam user and you're up to 12 mg be as careful as if you're on nardil or parnate.
> Maybe the reason that maois are effective in atypical depression is they're the only ads that boost serotonin and dopamine which is the amine of pleasure. Maybe atypicals have some disruption of their dopamine pathways or levels. I've also read that ssris lower dopamine. No wonder many complain that they feel numb on ssris.
>
Posted by Ines on March 4, 2007, at 18:09:26
In reply to Re: Atypical depression, posted by bulldog2 on March 4, 2007, at 14:23:29
> By the way rn320 suffered a bad hypertensive crisis on emsam 12 mg. So if your an emsam user and you're up to 12 mg be as careful as if you're on nardil or parnate.
> Maybe the reason that maois are effective in atypical depression is they're the only ads that boost serotonin and dopamine which is the amine of pleasure. Maybe atypicals have some disruption of their dopamine pathways or levels. I've also read that ssris lower dopamine. No wonder many complain that they feel numb on ssris.
>I believe wellbutrin is the only non MAOI AD that acts directly on dopamine? It acts on dopamine+noradrenaline/epinephrine. If it was the dopamine+ serotonin factor that made MAOIs effective then it could be that a combination of wellbutrin and an ssri would be effective as well. Any experiences? (I seem to remember reading that venlafaxine above a certain dose also acts on dopamine, but not sure about that)
I.
Posted by Declan on March 4, 2007, at 19:10:40
In reply to Re: Atypical depression » Declan, posted by Maxime on March 4, 2007, at 17:27:29
No Maxi, not at all scarcastic or ironic.
I meant given the seriousness of your situation, the problems with bupe pale in comparison should it be of use to you.
Does that make sense?
Posted by FredPotter on March 4, 2007, at 19:10:57
In reply to Re: Atypical depression » bulldog2, posted by Ines on March 4, 2007, at 18:09:26
> > By the way rn320 suffered a bad hypertensive crisis on emsam 12 mg. So if your an emsam user and you're up to 12 mg be as careful as if you're on nardil or parnate.
> > Maybe the reason that maois are effective in atypical depression is they're the only ads that boost serotonin and dopamine which is the amine of pleasure. Maybe atypicals have some disruption of their dopamine pathways or levels. I've also read that ssris lower dopamine. No wonder many complain that they feel numb on ssris.
> >
>
> I believe wellbutrin is the only non MAOI AD that acts directly on dopamine? It acts on dopamine+noradrenaline/epinephrine. If it was the dopamine+ serotonin factor that made MAOIs effective then it could be that a combination of wellbutrin and an ssri would be effective as well. Any experiences? (I seem to remember reading that venlafaxine above a certain dose also acts on dopamine, but not sure about that)
> I.
>
>
I've heard that too but the dose has to be high. Strangely I didn't find Wellbutrin effective. When I asked the pdoc if too much SSRI caused degradation of dopamine system he waved his hands about a lot, but as it was a hot day managed to keep the room really cool. But he did nothing about it.I want to try to persuade my GP to give me Nardil or buprenorphine. The alternative would be things that don't work, or ECT which they'd say I'm not bad enough for
Fred
Posted by bulldog2 on March 4, 2007, at 19:30:53
In reply to Re: Atypical depression » bulldog2, posted by Ines on March 4, 2007, at 18:09:26
Wellbutrin is primarily norandregenic. It's effect on dopamine is very weak. The stimulants do hit dopamine.
Posted by Maxime on March 4, 2007, at 20:43:18
In reply to Re: Atypical depression » Maxime, posted by Declan on March 4, 2007, at 19:10:40
> No Maxi, not at all scarcastic or ironic.
>
> I meant given the seriousness of your situation, the problems with bupe pale in comparison should it be of use to you.
>
> Does that make sense?Yes, it DOES make sense. I didn't think you were being sarcastic. But I am on other board for eating disorders and the environment there is a lot different than here.
Thanks Declan. I did ask my pdoc about it and he said no. Wonder if he would reconsider?
Maxime
Posted by Maxime on March 4, 2007, at 20:52:30
In reply to Re: Atypical depression, posted by FredPotter on March 4, 2007, at 19:10:57
>
> I've heard that too but the dose has to be high. Strangely I didn't find Wellbutrin effective. When I asked the pdoc if too much SSRI caused degradation of dopamine system he waved his hands about a lot, but as it was a hot day managed to keep the room really cool. But he did nothing about it.
>
> I want to try to persuade my GP to give me Nardil or buprenorphine. The alternative would be things that don't work, or ECT which they'd say I'm not bad enough for
> Fred
>I love the description of what you pdoc doc did.
How can you not be bad enough for ECT when nothing works. I love how they decide that for you. Sigh. It's not fair.
I hope you find that something works Fred.
Maxime
Posted by River1924 on March 5, 2007, at 4:18:02
In reply to Re: Atypical depression » FredPotter, posted by Maxime on March 4, 2007, at 20:52:30
http://www.mcmanweb.com/rapid-cycling.htm
For me, although I'm never up (much above normal), I was really surprised when mood swings were not included with the diagnosis of depression. I was on one med (geodon or zonegran or it may have been another) that made me giddy and then turn suicidal the second I stopped. Sometimes I'd be having a blast and feel suicidal at exactly the same time. That was far worse than being unmotivated and blah on zoloft. Plus I am always much more outgoing and full of possibilities just before bed than when I awaken.
Anybody else like this?
Posted by Ines on March 5, 2007, at 11:50:05
In reply to Re: Atypical depression, posted by River1924 on March 5, 2007, at 4:18:02
> http://www.mcmanweb.com/rapid-cycling.htm
>
> For me, although I'm never up (much above normal), I was really surprised when mood swings were not included with the diagnosis of depression. I was on one med (geodon or zonegran or it may have been another) that made me giddy and then turn suicidal the second I stopped. Sometimes I'd be having a blast and feel suicidal at exactly the same time. That was far worse than being unmotivated and blah on zoloft. Plus I am always much more outgoing and full of possibilities just before bed than when I awaken.
>
> Anybody else like this?
>
Yes, I can have very quick and dramatic mood changes, but they are usually triggered by something external (often something completely unsignificant like bus driver being unfriendly etc). I'm on reboxetine right now and that aspect of things has got worse- like you on that med I can actually feel elated one moment and hopeless the next, sometimes they overlap. With respect to cycling during the day though, I've heard that atypical depressives usually feel best in the morning straight after waking up, and for typical depressives the depression is worst in the morning. No idea if that's actually documented in some way. It's tue for me- I tend to feel more hopeful in am.
Posted by FredPotter on March 5, 2007, at 13:47:01
In reply to Re: Atypical depression » River1924, posted by Ines on March 5, 2007, at 11:50:05
Me too. I feel best in the morning, the earlier the better, unless I've been drinking the night before, which I don't usually do. Even then I sometimes feel best in the morning. Worst probably evening. Often I feel better come bed time
Posted by River1924 on March 5, 2007, at 16:17:37
In reply to Re: Atypical depression » Ines, posted by FredPotter on March 5, 2007, at 13:47:01
Hi,
Those answers were helpful.
(Actually, I think the most important "symptom" is age of onset. One adapts to feelings during the more structured time of childhood and learns to live on top of them.)
My niece (who I mentioned in an earlier post) and I had/have a terrible time awakening. I've never been sure if that was part of my depression, some anxiety related psychological issue or (as it is called by the makers of provigil) excessive daytime sleepiness, or some circadian quirk.... but if I read you correctly, atypicals probably feel better earlier in the day.
I don't really have feeling in the morning because I have to work to stay awake. And I make a strong effort not to get too entangled in people's lives. I absorb their feelings. I used to catch others headaches.
So, if atypical depression is a true category of people.... maybe feeling better in the morning isn't important enough to kick me out of the camp.
Posted by River1924 on March 10, 2007, at 17:13:41
In reply to Re: Atypical depression, posted by Ines on March 2, 2007, at 8:01:15
I wrote this letter to John Davidson (UW-Madison (Wisconsin, USA.) He heads psychiatric research.
"I simply wish to raise an issue with the studies listed on your site. It seems as you are vetting out a large number of people with mental health problems. Atypical depression is the largest group of defined depressives. (Off the top of my head, I'd prefer conflicting contiguous ambiguous distressing mood states.) For example, I recall feeling depressed at age 11, and made a suicide attempt at 19. Many many people are in the same boat but your studies only allow those with no diagnosis and/or off meds. This favors those with melancholic or situational depression. I can't imagine anyone with my type of depression, which turns suicidal 10 days off an SSRI ever being in a placebo controlled medication study. How could someone with severe early onset depression not get some kind of diagnosis early on? This kind of depression is terminal. To use a "real" disease as an analogy, does skin cancer research recruit only those with mild squamous cell carcinoma or not allow those with skin cancer to participate? It seems as if the study models and precision have become more important than people with imprecise but serious non-psychotic mental illness."
Posted by Ines on March 18, 2007, at 4:53:41
In reply to Atypical depression vetted out of studies?, posted by River1924 on March 10, 2007, at 17:13:41
Hey River,
Just seen this- that's great! I hope they actually pay attention. I can't believe my GP won't even aknowledge that atypical depression exists- he waved it off and told me that that's irrelevant when choosing a treatment. It is so sad that there's huge numbers of us out there suffering and we just don't seem to get much focused help. I wonder if it is because there are less biological correlates with this type of depression, and it makes doctors think of it as either something the patients have control over or something that fits into the domain of psychologists rather than psychiatrists.
I'm still trying to find a psychiatrist who specialises in atypical depression, so we could try and get them as gust experts, but no luck so far...
Ines
Posted by FredPotter on March 18, 2007, at 7:03:52
In reply to Re: Atypical depression vetted out of studies? » River1924, posted by Ines on March 18, 2007, at 4:53:41
Ines well I'm not convinced that my GP recognises atypical depression either but my pharmacist does and he knows that MAOIs are best for it. Which is why I'm going through the throes of effexor withdrawal so I can start on Nardil after 7 days.
Atypical depression for me is pretty bad and goes hand-in-hand with anxiety. But being atypical doesn't mean I have any insight into it. Also anger against treatments that don't work and their apologists, and anger against people who's sum total of suffering is a sprained wrist or hayfever. A friend is recovering from a hip replacement and my! how the queue stretches up her path to her door! I'm there too as she needs practical help. But no-one comes to my door. How about you? The stigma has gone they say. I believe it's just not spoken out loud anymore.
Atypical for me also means sleeping too much, generally saved till the weekend when I can get my "natural" 12 hours. But that may have been Effexor, as now during withdrawal I either don't sleep at all or I dip in and out of shallow dreams in which I cry, to awaken with encrusted eyes. It also means sleepiness in the day and limbs and brain cells that feel like lead. I don't hyperphage though (why don't they say over-eat?)
Now what the hell was I talking about? Yes - atypical depression responds to MAOIs like Nardil and Parnate, though Moclobemide doesn't tend to work well. The downside of these is they cause anorgasmia and other sexual difficulty and you have to cut out all your favourite foods like pickled herring (?), broad pean pods (?) etc and weight gain can occur although I'm hoping the lift of the depression will lead to a more active lifestyle. One thing that (almost) annoys me is my ability to chirp up when conversing with people. This confirms to them there's nothing wrong with me.
I forget where we started now. All the best to you and let me know how you get on. Yes atypical depression constitutes 40% of all depression including bipolar tell your GP
best
Fred
Posted by Ines on March 19, 2007, at 17:57:58
In reply to Re: Atypical depression vetted out of studies? » Ines, posted by FredPotter on March 18, 2007, at 7:03:52
Hey Fred,
You know reading your post is like reading something I wrote... I'm really glad you managed to get a prtespcription for Nardil- hope it works all the wonders for you. Keep us posted.
I too sleep a lot, but I seem to have dreams or nightmares constantly. I wake up feeling exhausted, very often drenched in sweat. Some days I feel like a robot, completely sleep deprived. And that's after hours and hours in bed. I'm so anxious I've cracked a few teeth by tooth grinding at night. I have so much mental clutter I can't seem to concentrate on anything properly, not even reading fiction, which I used to really enjoy. And I eat way too much. I've recently started thinking I must also have some ocd, I have some weird obsessive thoughts.
I spend a lot of time thinking I wish I'd never been born. And yet I perk up when I talk to people, I can actually be quite sociable and happy if I'm with people and I've had a few drinks, and can keep up a pretense of normality. Like you say, it confims to people there's nothing wrong. When I do need serious help, or time off work (fairly frequent these days) I feel like people think I'm just lazy. It infuriates me that even with people who ask how I am seem to genuinely care to know, I'll smile and say I'm fine, or doing much better thank you. I smile all the time, people comment on it! Just today my boss came to find out how I was after I've been off work for a few weeks, he's genuinely nice and wanted to know, and I had this idiotic grin and told him how much better I feel. Just before he stopped by I'd been in the loo crying, and wondering how much longer I'll have to endure this before something wroks, and thinking I really feel like I'm at my end's wit. But it's like a compulsion to pretend, I can't control it. And it really makes life harder in a way...
Anyway, I'll shut up. Didn't mean to completely unload on you there. Hopefully we'll all find the key that works one day. Best of luck to you with the Nardil, fingers crossed!
Ines
Posted by River1924 on March 20, 2007, at 0:01:46
In reply to Re: Atypical depression vetted out of studies? » FredPotter, posted by Ines on March 19, 2007, at 17:57:58
Hi,
Thanks for reading my previous posts and the comments.
I'm not sure how to respond to your post. I am much the same. (My niece who died recently was much more like you.... Crying in the toliet and feeling phoney seem to be more of a female experience.) When people ask me how are you, I feel like a fake if I say awful because at that moment, I usually don't. I think the right question with those with atypical depression is "How were you when you were alone ten minutes ago?" I can usually answer, I felt kinda down and was thinking of suicide. I understand the the ocd component. Without zoloft, I can kinda live with suicidal thoughts (which will appear) for a few days because they don't even seem like my ideas... slowly the ideas leak in and I feel swamped with sorrow. My emergency meds are stelazine and razadyne. Stelazine calms me down without making me sleepy. I can take it alone but, after a week, I feel kinda brain dead. The razadyne prevents that. Abilfy isn't sedating either. You might want to try it. It can make one feel tense and cause insomnia initially. I think if one is prone to suicidal thoughts, one needs an anti-psychotic to use for a month or two now and then. There is a connection between atypical depression and bipolar depression. Don't let youself treat your illness according to how you appear to others. It is serious. Even at my best, I test extremely depressed when my pdoc has me feel out a form. I can't imagine life any other way and most people don't really think there is much wrong with me. Perhaps, I should carry around the test and ask other people to take it. I'm sure they would be shocked at my answers. That's their problem.
Does any of this make sense? I hope so. River.
Posted by FredPotter on March 20, 2007, at 5:04:19
In reply to Re: Atypical depression vetted out of studies? » Ines, posted by River1924 on March 20, 2007, at 0:01:46
Thanks Ines are you female? I have a dear (I thought) friend back in Wales where I used to live. He emailed a little while ago saying he'd always thought that there was nothing wrong with my mind but that often I didn't realise this. Well, so long as he's got it straight in his mind and is free from worrying about it. His daughter has had CFS for years. I could say something spiteful back in the same vein, but I won't.
River said, "How were you when you were alone ten minutes ago?" That's a good question. But it must be mystifying to friends to whom we appear normal. I even make people laugh. But it's not faked. I respond well to people.
Now that the Effexor withdrawal is nearly over I hope, I have felt pretty good today. Particularly lucid as a colleague said to me at work "considering you haven't slept properly for 5 days".
I'll let you know how Nardil works. I'm worried about getting fat(ter) and about all the nice foods and drinks I'll have to forego.
Thanks for your kind response
Fred
Posted by Ines on March 20, 2007, at 13:13:13
In reply to Re: Atypical depression vetted out of studies? » Ines, posted by River1924 on March 20, 2007, at 0:01:46
Hi River and Fred,
I so agree with the 'how were you 10 minutes ago when you were alone' question!. Your posts got me thinking- I don't so much pretend that I'm feeling ok but rather I actually do feel ok at the moment I'm asked. It's so true and I'd never thought of it like that. I seem to perk up immediately when in company- unless it is someone I really trust; paradoxically, the contrary can happen then, i.e. feeling really low. It's almost like I have permission to feel bad then.
You know, it really helps to hear other people's similar experiences. It makes me feel less of an outsider... Thanks a lot for support.
River, I've thought of the bipolar connection- and the possibility that I'd respond well to mood stabilisers. So far I haven't responded to any to the AD medications I've tried- in fact, they've made it worse. I'm on the waiting list to see a psychiatrist and hopefully I'll get a proper diagnosis then, and proper help. Although the idea of being diagnosed is slightly scary as well: 'have-for-sure': atypical depression & binge eating disorder. Very probables: OCD, generalised anxiety disorder. Possibles: bipolar spectrum, even some borderline personality disorder traits. Yikes!
Just a few weeks ago I did a depression scale test on a not-so-bad day and tested extremely depressed as well. It actually shocked me: I was expecting moderately depressed or something along those lines. I'm down to very depressed now. The small victories!
Take care and keep well,
Ines
(Fred, yes I am female btw)
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