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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 21 to 45 of 70. Go back in thread:
Posted by ed_uk on July 24, 2005, at 16:21:46
In reply to Re: OK, so who wants to try Rozerem when it comes out?, posted by linkadge on July 24, 2005, at 15:09:49
Oh well, it probably won't be released in Canada for a few years yet!
~Ed
Posted by ed_uk on July 24, 2005, at 16:44:36
In reply to Re: OK, so who wants to try Rozerem when it comes out? » linkadge, posted by ed_uk on July 24, 2005, at 16:21:46
Surely someone is interested in Rozerem!!!
~Ed
Posted by linkadge on July 24, 2005, at 17:02:47
In reply to Where are all the INSOMNIA sufferers???, posted by ed_uk on July 24, 2005, at 16:44:36
They're just running out of the necessary letters to create euphonic medication names.
Linkadge
Posted by linkadge on July 24, 2005, at 17:04:18
In reply to Re: Where are all the INSOMNIA sufferers???, posted by linkadge on July 24, 2005, at 17:02:47
And when Rozerem came down from the mountain, God spakeith to him saying...
Linkadge
Posted by ed_uk on July 24, 2005, at 17:06:12
In reply to Re: Where are all the INSOMNIA sufferers???, posted by linkadge on July 24, 2005, at 17:02:47
Rozerem sounds kind of euphoric, not as much as Quaalude though!
~Ed
Posted by ed_uk on July 24, 2005, at 17:20:10
In reply to Re: Where are all the INSOMNIA sufferers???, posted by linkadge on July 24, 2005, at 17:04:18
>And when Rozerem came down from the mountain, God spakeith to him saying...
LOL, that gave me a good laugh!
~Ed
Posted by Phillipa on July 24, 2005, at 19:28:15
In reply to Re: Where are all the INSOMNIA sufferers??? » linkadge, posted by ed_uk on July 24, 2005, at 17:20:10
So, if I continue on luvox it's another drug that luvox potentiates the action of like xanax. See Ed I do know a little. Fondly, PJ O
Posted by Cecilia on July 25, 2005, at 4:17:56
In reply to OK, so who wants to try Rozerem when it comes out?, posted by ed_uk on July 24, 2005, at 8:46:38
> Who's gonna be queueing (sp) up outside the pharmacy?
>
> Who's gonna be collecting Rozerem samples?
>
> ~EdNot me, Melatonin didn`t help me sleep and gave me nightmares when I finally did. One thing I`ve never understood, though, is how Melatonin got classified as a non prescription "nutritional supplement." It`s a hormone, and other hormones like estrogen and thyroid require prescriptions. Cecilia
Posted by Cecilia on July 25, 2005, at 4:58:07
In reply to OK, so who wants to try Rozerem when it comes out?, posted by ed_uk on July 24, 2005, at 8:46:38
> Who's gonna be queueing (sp) up outside the pharmacy?
>
> Who's gonna be collecting Rozerem samples?
>
> ~EdNot me, Melatonin didn`t help me sleep and gave me nightmares when I finally did. One thing I`ve never understood, though, is how Melatonin got classified as a non prescription "nutritional supplement." It`s a hormone, and other hormones like estrogen and thyroid require prescriptions. Cecilia
Posted by Jakeman on July 26, 2005, at 20:08:24
In reply to Where are all the INSOMNIA sufferers???, posted by ed_uk on July 24, 2005, at 16:44:36
> Surely someone is interested in Rozerem!!!
>
> ~EdHi Ed,
This drug leaves me scratching my head. I was very hopeful that the makers had come up with a break-thru in sleep medication, but I don't see it from the reports I've read (of course a lot of the research is not on the web). Looking at the phase 1 and 2 trials...it didn't do much other than making you fall asleep earlier...so it may help in resetting circadian rhythm which is good for people with "delayed sleep phase". I've read nothing about it making you sleep longer, deeper, or more efficiently.
Apparently it is more potent than melatonin, but why no head to head studies with melatonin? As some have speculated, maybe they are positioning themselves as the "doctor prescribed" alternative to self-medication with melatonin. Can you get melatonin by prescription in the UK? As you know, it's an over-the-counter supplement here.
warm regards ~Jake
Yes Phillipa I think drug company reps and other observers read this board. One reason being to gauge whether or not to buy stock in a pharma co. about to release another drug :-)
Posted by jerrympls on July 26, 2005, at 20:46:32
In reply to Where are all the INSOMNIA sufferers???, posted by ed_uk on July 24, 2005, at 16:44:36
> Surely someone is interested in Rozerem!!!
>
> ~EdCount me in.
Posted by Phillipa on July 26, 2005, at 21:12:30
In reply to Re: Where are all the INSOMNIA sufferers??? » ed_uk, posted by Jakeman on July 26, 2005, at 20:08:24
Jake, I never thought of that. But wouldn't the stock of MAOI's go up if that were the case? Fondly, Phillipa
Posted by Jakeman on July 26, 2005, at 22:00:12
In reply to Re: Where are all the INSOMNIA sufferers??? » Jakeman, posted by Phillipa on July 26, 2005, at 21:12:30
> Jake, I never thought of that. But wouldn't the stock of MAOI's go up if that were the case? Fondly, Phillipa
Phillipa,
These companies all are racing to get in first place in the insomnia market. Whoever produces the perfect sleep drug will make billions. But it hasn't happened. Takeda has got a lot of interest but I don't think they will pass snuff. (non-southerners will wonder about that expression).
If anything goes up, it will be the the existing products. Best bets for a stock bet (in my opinion) is the long acting Ambien. I recently tried Restoril but switched back to Lunesta.warm regards, Jake
Posted by ed_uk on July 27, 2005, at 16:48:01
In reply to Re: Where are all the INSOMNIA sufferers??? » ed_uk, posted by Jakeman on July 26, 2005, at 20:08:24
Hi Jake,
>Apparently it is more potent than melatonin, but why no head to head studies with melatonin?
.......the manufacturer would never carry out such a study unless they have very good reason to suspect that it's more effective than melatonin.......which it probably isn't IMHO!
>Can you get melatonin by prescription in the UK?
It's not approved here so it's very rarely prescribed. Doctor's can prescribe meds which aren't approved but they rarely do.
Warm regards
~Ed
Posted by ed_uk on July 27, 2005, at 16:50:45
In reply to Re: Where are all the INSOMNIA sufferers???, posted by Jakeman on July 26, 2005, at 22:00:12
Hi Jake,
>I recently tried Restoril but switched back to Lunesta.
What do you prefer about Lunesta? What doses of Restoril and Lunesta did you take?
>Best bets for a stock bet (in my opinion) is the long acting Ambien.
I agree. It would be useful to have an Ambien CR tablet with an immediate release outer layer + a controlled release inner layer.
Kind regards
~Ed
Posted by jerrympls on July 27, 2005, at 16:56:10
In reply to Re: Where are all the INSOMNIA sufferers??? » Jakeman, posted by ed_uk on July 27, 2005, at 16:50:45
> Hi Jake,
>
> >I recently tried Restoril but switched back to Lunesta.
>
> What do you prefer about Lunesta? What doses of Restoril and Lunesta did you take?
>
> >Best bets for a stock bet (in my opinion) is the long acting Ambien.
>
> I agree. It would be useful to have an Ambien CR tablet with an immediate release outer layer + a controlled release inner layer.
>
> Kind regards
>
> ~Edis Ambien CR released yet???
Posted by ed_uk on July 27, 2005, at 17:58:45
In reply to Re: Where are all the INSOMNIA sufferers??? » ed_uk, posted by jerrympls on July 27, 2005, at 16:56:10
Hi J!
No :-(
~ed x
Posted by jakeman on July 28, 2005, at 17:03:48
In reply to Re: Where are all the INSOMNIA sufferers??? » Jakeman, posted by ed_uk on July 27, 2005, at 16:50:45
>
> What do you prefer about Lunesta? What doses of Restoril and Lunesta did you take?
>Hi Ed,
The first night I took 15 mg. of Restoril. Next night 30 mg. Is 30 considered a low dose? I'm taking 4.5 mg Lunesta.
I could not get into a deep sleep with Restoril,
and I seemed to wake up often during the night. I had about the same experience with Sonata. With the Lunesta I do tend to sleep deeper and longer, although it's no way close to perfect.Regarding Ramelteon...if melatonin is difficult obtain in the UK, then it would appear there's a market waiting for a prescription drug which mimics melatonin.
warm regards ~Jake
Posted by ed_uk on July 28, 2005, at 17:59:05
In reply to Re: Where are all the INSOMNIA sufferers??? » ed_uk, posted by jakeman on July 28, 2005, at 17:03:48
Hi Jake!
>Is 30 considered a low dose?
Not really. 10mg would be a low dose.
>Regarding Ramelteon...if melatonin is difficult obtain in the UK, then it would appear there's a market waiting for a prescription drug which mimics melatonin.
Absolutely, I agree. I wonder whether ramelteon will be approved here.
Kind regards
~Ed
Posted by ed_uk on August 6, 2005, at 13:44:10
In reply to Re: Where are all the INSOMNIA sufferers??? » jerrympls, posted by ed_uk on July 27, 2005, at 17:58:45
Hi!!!
I just got your babblemail - will reply tonight :-D
Are you interested in ramelteon? I wondered whether it might be useful in improving your sleep at night without causing a hangover. Perhaps this would reduce your daytime drowsiness...
Kind regards
~Ed
Posted by ed_uk on August 6, 2005, at 14:25:59
In reply to FDA okays sleep drug Rozerem(TM) (ramelteon), posted by jrbecker on July 23, 2005, at 13:24:47
The manufacturer said Rozerem will be available (in the US) in late August. Is this still true?
~Ed
Posted by zeugma on August 13, 2005, at 6:31:11
In reply to Ramelteon - to zeugma, posted by ed_uk on August 6, 2005, at 13:44:10
> Hi!!!
>
Hi Ed! Please accept this delayed response.
>
> Are you interested in ramelteon? I wondered whether it might be useful in improving your sleep at night without causing a hangover. Perhaps this would reduce your daytime drowsiness...
>
The sleep docs were willing to recommend Xyrem, which sounds like a stronger version of ramelteon. But not for insomnia. I did suffer from severe sleep-onset difficulties that are overcome with NRI's- probably desipramine would work as well as nortriptyline for helping me sleep.
The problem is with how restorative the sleep is. The problem is that I feel like I have a limited quota of energy to divide throughout the week, and if I exert myself on Monday, for example, I will become that much more drained by Wednesday, no matter how early I go to bed in the interim. I don't know if the problem is with sleep per se or if it is a more general problem with CNS activation. I suspect the latter, because prior to treatment with antidepressants, I would feel more activated at sleep onset than I did while fully awake- hence the severe sleep disruption.Stims work on the other side of the equation to AD's- they do activate me (somewhat) during waking, as opposed to simply deactivating me during sleep. Remember I also have ADHD as well as a sleep disorder, so I do have to work on the waking side of things- I sleep well at night, and one interesting thing about NRI's (Strattera as well as TCA) is that they give me the semblance of a circadian cycle, although they do not help me with many of the processes associated with waking, such as fully engaged perceptual systems (the world is like a blur) and executive function. (Oddly, my perception would intensify at sleep onset, causing the sudden jolting arousals.)
Got to run now, hence the fragmentary nature of this reply.
-z
> Kind regards
>
> ~Ed
Posted by ed_uk on August 13, 2005, at 7:58:57
In reply to Re: Ramelteon - to zeugma, posted by zeugma on August 13, 2005, at 6:31:11
Hi Z!
>Please accept this delayed response.
Of course :-)
>The sleep docs were willing to recommend Xyrem.......
Did they suggest that it would enhance the restorative nature of sleep?
~Ed
Posted by zeugma on August 13, 2005, at 13:57:23
In reply to Re: Ramelteon - to zeugma » zeugma, posted by ed_uk on August 13, 2005, at 7:58:57
> Hi Z!
>
> >Please accept this delayed response.
>
> Of course :-)
>
> >The sleep docs were willing to recommend Xyrem.......
>
> Did they suggest that it would enhance the restorative nature of sleep?
>
> ~EdYes, that was the rationale.
-z
Posted by ed_uk on September 10, 2005, at 15:38:39
In reply to Re: Ramelteon - to zeugma » ed_uk, posted by zeugma on August 13, 2005, at 13:57:23
Someone just posted to say that ramelteon tablets (Rozerem) are now available in pharmacies in the US.
~Ed
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