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Dr. Bob is Robert Hsiung, MD,
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Posted by Cybertao on July 14, 2002, at 22:39:46
In reply to I am new at this and Effexor XR, posted by valenphy on March 27, 2002, at 14:47:32
My doctor prescribed Effexor XR 150mg. The first day was like hell. I felt hot and cold sensations, a lot of sweating... Just like in a bad flu. I felt my wrists very painful. Also my jaw seemed to be stiff, and I would yawn involutarialy. I also felt dizzy. However, the most terrible side effect was urinary rentention.... No matter how hard I tried, I could barely leak just a few drops... I tried to drink a lot of water, but it also did not work well...
I never had so many side effects with a drug in its first day of use!! Has anyone ever gone through this? Should I continue taking it?!
Cybertao
Posted by sly on July 15, 2002, at 7:42:21
In reply to Re: Use food as comfort = weight gain on ADs? Sly » jannbeau, posted by Reneb on July 12, 2002, at 20:39:09
I do exercise, but it's not about that, at first it was about a fear of gaining weight, so many people reported problems with that I was terrified. Now it's about control, I'm a perfectionist, that's the root of my problems. With depression and anxiety I felt like my life was in chaos, controlling my food and weight became something I could excel at and master. I lost a lot of weight, 20 lbs, I'm 5ft 5in, 109 lbs. and people started bugging me about my size and watching me, so I had to eat "normally" which caused more fear and guilt. I started fasting and taking laxatives to keep the weight off - it's not easy to stop.
Posted by jannbeau on July 15, 2002, at 11:12:32
In reply to Effexor and Urinary Retention? , posted by Cybertao on July 14, 2002, at 22:39:46
>Hi, Most docs start people out on much lower doses of Effexor-XR. 37.5 mg/day for one week, then 75 mg/day for one week, then going up from there.
Urinary retention is a listed side effect of Effexor. Has it gone away? Urinary retention may be a medical emergency. You should immediately notify your physician of this effect.
Other things that you describe are also known side effects of this medication. These effects MAY disappear with time or with an adjustment of your dose. Yawning, dizziness, alternating chills and feeling of warmth, etc.
lso, Effexor should not be taken with some other medications because it can induce "serotonin syndrome". Your doctor should know all the medications that you are taking.
Cheers,
jannbeauIt seems possible that 150 mg/day to start may have been too much for you?
My doctor prescribed Effexor XR 150mg. The first day was like hell. I felt hot and cold sensations, a lot of sweating... Just like in a bad flu. I felt my wrists very painful. Also my jaw seemed to be stiff, and I would yawn involutarialy. I also felt dizzy. However, the most terrible side effect was urinary rentention.... No matter how hard I tried, I could barely leak just a few drops... I tried to drink a lot of water, but it also did not work well...
>
> I never had so many side effects with a drug in its first day of use!! Has anyone ever gone through this? Should I continue taking it?!
>
> Cybertao
Posted by Kat26 on July 15, 2002, at 16:18:04
In reply to Re: Use food as comfort = weight gain on ADs? Sly, posted by sly on July 15, 2002, at 7:42:21
Sly,
I am approximately the same size as you and people tell me I am too skinny so you know that says the same thing about you.Kat26
Posted by LynnPerley on July 15, 2002, at 21:18:50
In reply to Re: Use food as comfort = weight gain on ADs? Sly, posted by sly on July 15, 2002, at 7:42:21
Sly, have you talked to your doc or counselor about this? I don't want to belabor the point, but I'm 5'5" and at 114 pounds I looked like death warmed over. The low end of the healthy body weight range is in the low 120's. I'm glad you understand their is a problem, and I wish you the best of luck. I have not been frequenting this board for too long, but I've seen your good advice before and I hope you will not take this advice in a negative way.
Posted by Reneb on July 16, 2002, at 22:43:11
In reply to Re: Use food as comfort = weight gain on ADs? Sly » sly, posted by LynnPerley on July 15, 2002, at 21:18:50
> Sly, have you talked to your doc or counselor about this? I don't want to belabor the point, but I'm 5'5" and at 114 pounds I looked like death warmed over. The low end of the healthy body weight range is in the low 120's. I'm glad you understand their is a problem, and I wish you the best of luck. I have not been frequenting this board for too long, but I've seen your good advice before and I hope you will not take this advice in a negative way.
Sly, I agree. Obviously you know what you are doing is not healthy. If it's the meds that are making you feel this way maybe you should consider going on something else.
Posted by sly on July 17, 2002, at 8:43:57
In reply to Re: Use food as comfort = weight gain on ADs? Sly » LynnPerley, posted by Reneb on July 16, 2002, at 22:43:11
I don't know if the meds are causing this - I think they might be. Before the Effexor I was severely depressed, but eventually I thought I was starting to feel better, I was having "good days". But now I'm beginning to think the sense of calm I have is really anhedonia, a complete loss of pleasure. It's not that I don't feel depressed, I feel nothing. Yesterday I broke up with my boyfriend, we've been together for one year, I cried for about 10 mins., and then nothing, I felt empty. I couldn't eat, couldn't sleep, I put on a pair of shorts this morning, zipped them up, and they fell off, I've lost 2 more lbs. But who cares? I still feel nothing, like I'm more invisible than ever.
Posted by jannbeau on July 17, 2002, at 11:35:54
In reply to Re: weight loss anhedonia, posted by sly on July 17, 2002, at 8:43:57
> Sly, it is no longer an option! You MUST go to your doctor immediately about this problem!! For whatever reason, you are NOT getting better, whether it's meds or for other reasons. Please go! "Who Cares?" is not an appropriate response to the things that are happening to you!
jannbeau
I don't know if the meds are causing this - I think they might be. Before the Effexor I was severely depressed, but eventually I thought I was starting to feel better, I was having "good days". But now I'm beginning to think the sense of calm I have is really anhedonia, a complete loss of pleasure. It's not that I don't feel depressed, I feel nothing. Yesterday I broke up with my boyfriend, we've been together for one year, I cried for about 10 mins., and then nothing, I felt empty. I couldn't eat, couldn't sleep, I put on a pair of shorts this morning, zipped them up, and they fell off, I've lost 2 more lbs. But who cares? I still feel nothing, like I'm more invisible than ever.
Posted by abc123 on July 20, 2002, at 12:49:49
In reply to Re: Effexor and Urinary Retention? , posted by jannbeau on July 15, 2002, at 11:12:32
I have tried every anti-depressant on the market starting as far back as the early 80s. Recently, my shrink decided to switch me from Prozac (and Remeron) to Effexor. I have always had problems with exagerated side effects from anti-depressants and Effexor is no different. Although I am on a VERY low dose (12.5 mg per day) - that's 1/2 the lowest dose, I am experiencing nausa, disorientation and insomnia. I have been on effexor approx. 2 weeks. I feel like hell and am not sure where to turn. Prozac helps me for a while (at 10 mg. a day), but I always end up having to go off it because of hand tremors. Does anyone have any suggestions for an anti-depressant with minimal side-effects? Remeron helps, but I've gained 30 pounds.
Posted by fairnymph on July 20, 2002, at 14:57:02
In reply to new to Effexor, posted by abc123 on July 20, 2002, at 12:49:49
Have you considered these AD's: trazadone, wellbutrin, reboxetine, nefazadone?
Do you prefer a sedating or a stimulating AD?
Posted by hellokitty on July 20, 2002, at 15:40:27
In reply to Anyone had success on Effexor XR? , posted by jp on October 24, 1999, at 14:59:14
I have suffered from separation anxiety all of my life. I get nervous when away from home/family and usually experience panic attacks when traveling. Two months ago,I finally decided to seek help and my Doctor prescribed Effexor XR. I have been taking 75mg for 7 weeks now and I feel pretty good. Although the side effects were disturbing during the initial 3-4 weeks (sleeplessness, bruxism, tremors, loss of appetite), they have completely subsided. I truly feel that Effexor XR has helped decrease my anxiety, but I am worried about when to start weaning off. Has anyone taken this medication for anxiety (specifically separation anxiety) and had positive results? Also, has anyone stopped taking Effexor XR and their anxiety hasn't come back?
Posted by xena on July 21, 2002, at 10:27:16
In reply to Anyone had success on Effexor XR? , posted by jp on October 24, 1999, at 14:59:14
I am a 22 year old female, who has recently been given some effexor by my doctor. I have never tried any AD before, and quite nervous about starting. I understand the side effects, but I still can't comprehend the benefits. I can't believe a pill will be able to make me feel any better. Any feedback would be appreciated.
Posted by xena on July 22, 2002, at 12:16:21
In reply to Anyone had success on Effexor XR? , posted by jp on October 24, 1999, at 14:59:14
Well, despite my reservations, I took my first dose of Effexor 37.5mg I figure my doctor would not of given me the drug unless she thought I was in need of it, right? I still find it hard to believe that a small pill can make me feel any better about myself, or life in general, but at this point I am willing to try just about anything. How can this pill make me feel "normal", when I don't know what normal is anymore? Thinking back, I don't know when the last time was that I felt happy, or good about myself. Here's hoping for a miracle.
Posted by katekite on July 22, 2002, at 13:39:04
In reply to New to effexor, posted by xena on July 21, 2002, at 10:27:16
First of all, of course a pill can make you feel better. You've probably woken up in the past (just in normal life, not when depressed) and felt like a couch potato, and then you have some caffeine and presto, you are up and going. Caffeine is a drug and it could just as easily come in a pill. What you are looking for with Effexor is that one day in 2-6 weeks you will notice that everything is a little simpler, a little easier, that you aren't just going through the motions but actually enjoying things again. You'll notice, it's not something you could miss, because its a wonderful feeling to be ok again.
There are several things to keep in mind with effexor:
1. That the people on this website come here mostly because something isn't working, not because they are so happy they want to share. Which means if you read about people's experiences here it may scare you, but there are many many more people out there who had good experiences, no side effects, etc.
2. That when you do go off of it for whatever reason you need to taper slowly or you will have side effects. When you get ready to go off of it read up on how to taper at the right pace. This is more important for Effexor than for lots of other medications.
3. That if it doesn't work -- studies show people who weren't helped the first anti-depressant they tried or had bad side effects, were usually helped by the second one they tried. So if this one doesn't work it doesn't mean you should give up on pills altogether. Try to give it 6 weeks if you can, but if side effects like nausea etc are troubling you after the end of the first two weeks its probably time to try a different one.
Hope it works for you. Hang in there.
Kate
Posted by katekite on July 22, 2002, at 13:47:19
In reply to Anyone taken Effexor XR for Separation Anxiety?, posted by hellokitty on July 20, 2002, at 15:40:27
Doctors usually say to stay on an antidepressant or anti-anxiety med for at least 6 months.
I would let the drug do its thing by itself for maybe another month and just enjoy life. Then I would, with the aid of the drug, actively work on the fears with the aid of a therapist. Cognitive behavioral therapy is especially good for this, although therapy in general always helps some. If you can really change your thinking you will be in good shape to try going off of it.
The truth with these drugs is that if its a lifetime problem and nothing in our environment changes, then when we go off of them the anxieties would be expected to return. The times when short term (less than a year) medication works and then its never needed again are if the problem was initially set off by a life circumstance or if the person makes a lot of progress in therapy.
I'm glad it seems to be helping!
Kate
Posted by Gabbi on July 22, 2002, at 13:48:32
In reply to Re: New to effexor » xena, posted by katekite on July 22, 2002, at 13:39:04
You have a gift, concise, yet possibilities covered and obvious concern, its appreciated.
Posted by Gabbi on July 22, 2002, at 14:17:19
In reply to Re: New to effexor » xena, posted by katekite on July 22, 2002, at 13:39:04
Kates' point about people writing when things go wrong is really important I think.
When I first saw a Pdoc I was scared silly, having previously taken nothing more than cough syrup.The medication worked but as soon as I started feeling better I'd research the side-effects and stop taking it. For me it was a bad move, depression can reappear so slowly, that you don't see it as "depression" you see it as reality, and twice I've become suicidal because of that.
You probably know this, most people aren't fortunate enough to have their first medication work. And the struggle to keep trying new ones when you are depressed is overwhelming. As well as the fear of "what are these meds doing to me"
I suffered from excruciating anxiety, as well as depression, and several well meaning G.P's put me on ("calming" A.D's) which would make sense. But I only got worse. I was fortunate enough to find a psychiatrist who is an artist with medication, and he gave me dexedrine, which I thought would put me through the roof, it didn't. It augmented my medication enough so that the depression lifted, and when that was gone so was the anxiety.
However I didn't get to see him much (out of town)
and my Gp's were very anti-pill as was I, they would refuse to refill my prescription, or prescribe a benzo for my anxiety, and inevitably I became hopeless and mired in depression againI'm now resigned to my pill cocktail, because for me the side effect of not taking it S.I is worse than all the physical side effects I was warned of.
I'm not saying there aren't significant potential side-effects, but if you can't find a reason to live, you need help. and If you search the web hard enough you could find a site devoted to people who's lives were ruined by Asprin I'm sure. Or how about people who die from eating peanuts?
I personally think keeping it in perspective is crucial. I wish I could have.
Posted by xena on July 23, 2002, at 3:48:57
In reply to Anyone had success on Effexor XR? , posted by jp on October 24, 1999, at 14:59:14
Can anyone tell me the difference between the two drugs? Is one more potent than the other? The side effects seem to be the same. Any information would be much appreciated.
Many thanks.
Posted by sly on July 23, 2002, at 7:28:41
In reply to Apo-fluvoxamine vs. Effexor XR, posted by xena on July 23, 2002, at 3:48:57
Are you Canadian?
Effexor XR is the trade name. APO refers to the Canadian drug company "Apotex" which makes generic versions of the original. Drug companies like Wyeth-Ayerst which first invent a drug get to patent it for 7 years to recoup the R & D costs, after that, it's open to the market and everyone starts spinning out generic versions (much like you call all pain relievers "aspirin", but only Bayer makes Aspirin, all other generic versions are just acetaminophen). This is a good thing, it means the drug should become cheaper. The only difference is usually the fillers, sometimes these can cause slight variations in side effects, but overall should have the same effects as the original drug.
Posted by jannbeau on July 23, 2002, at 11:14:06
In reply to Re: Apo-fluvoxamine vs. Effexor XR, posted by sly on July 23, 2002, at 7:28:41
> Sorry, Guys, but there is a lot of incorrect information in the post below!
Fluvoxamine is the generic name for LUVOX, a selective serotonin reuptake inhibitor (SSRI). Although the manufacturer says fluvoxamine is "chemically unrelated" to other SSRI's, fluvoxamine apparently is thought to have effects similar to those of other SSRI's--Prozac, for instance. Effexor (trade name for venlafaxine, on the other hand, is not an SSRI, but also inhibits reuptake of norepinephrine. These may be technical differences, but, still, if one is going to proffer information, one may as well get it right.
Which leads to the second set of inaccurate information: "Aspirin" is not acetaminophen, but acetylsalicylic acid. Acetylsalicylic acid, or ASA, is the chemical name for aspirin, a generic name coined by Felix Hoffman in 1897. ASA is a derivative of salicin, a compound extracted from the bark of the willow tree as early as the 5th century BC. Although Bayer patented "aspirin" or ASA, that patent has long since expired. Generic aspirin has been available for many, many years. By the way, patents in the US usually run for seventeen years, but may be extended under certain circumstances.
Acetaminophen, on the other hand, is 4 -hydroxyacetanilide, is a nonopiate, non-salicylate
analgesic and antipyretic, the generic name for Tylenol. Acetaminophen is NOT the same drug as aspirin, having different properties, including a much reduced if not absent antiinflammatory effect. Many companies now market acetaminophen, too, just as they do aspirin.In the US, the generic drug act states that any drug marketed as a generic must have the same efficacy as those of the original patented drug. By the way, "fillers" are considered to be "inert" and to have no effects and, therefore, cannot have "side effects." The term "side effects" is generally used to refer to nontherapeutic effects of the active ingredient or ingredients in a formulation.
Cheers,
JannbeauAre you Canadian?
>
> Effexor XR is the trade name. APO refers to the Canadian drug company "Apotex" which makes generic versions of the original. Drug companies like Wyeth-Ayerst which first invent a drug get to patent it for 7 years to recoup the R & D costs, after that, it's open to the market and everyone starts spinning out generic versions (much like you call all pain relievers "aspirin", but only Bayer makes Aspirin, all other generic versions are just acetaminophen). This is a good thing, it means the drug should become cheaper. The only difference is usually the fillers, sometimes these can cause slight variations in side effects, but overall should have the same effects as the original drug.
Posted by xena on July 23, 2002, at 11:21:09
In reply to Re: Apo-fluvoxamine vs. Effexor XR, posted by jannbeau on July 23, 2002, at 11:14:06
Yes I am Canadian. And at the risk of sounding like a total moron, I am more confused than ever. Is one drug more potent than the other, if so, which one? Thanks for your patience.
Posted by jannbeau on July 23, 2002, at 13:01:39
In reply to Re: Apo-fluvoxamine vs. Effexor XR, posted by xena on July 23, 2002, at 11:21:09
> Hi, Zena--no question is moronic. Some are more complex than others, that's all!
Effexor and Luvox are not directly comparable with respect to "potency." Potency is a pharmacological term defined as the amount of any substance it takes to produce the same effect to the same degree. For instance, if it takes 10 milligrams of Paxil to increase the amount of time that one molecule of serotonin stays in the synaptic cleft by 1 second and it takes 100 mg of Prozac to do the same, then Paxil is 10 times as potent as Prozac. Effexor and Luvox are different drugs that may have different spectra of effects.
I suspect that the question you are trying to ask is "which of these drugs is more effecacious in treating depression/anxiety?" Efficacy is the ability of a drug to treat the problem for which it is prescribed. Efficacy is not synonymous with potency, and the answer to the question is probably more complex than the "potency" question and will depend, to some degree, upon your problem. Most of the time, with the CNS drugs, finding the right drug may be more trial and error than when prescribing an antibiotic, for instance. You may have to try more than one medication or a combination of meds to get the result you need.
Hope this info has helped.
jannbeau
Yes I am Canadian. And at the risk of sounding like a total moron, I am more confused than ever. Is one drug more potent than the other, if so, which one? Thanks for your patience.
Posted by sly on July 23, 2002, at 15:26:01
In reply to Re: Apo-fluvoxamine vs. Effexor XR, posted by jannbeau on July 23, 2002, at 11:14:06
calm down Jannbeau!
It's not like you invented the stuff.
And I think you're missing the point.
Apo refers to a Canadian drug company that produces generic versions of the original. Any medication in Canada that starts with apo- is generic, just take that off and you've got the chemical name. All she needs to do is look up Fluvoxamine.
The difference is SSRI vs. SNRI. Effexor also inhibits norepinephrine reuptake. It claims to be more efficacious, but we're all different. Since none of us are medical Doctor's none of us are in a position to offer recommendations on medication - and I hope Xena would consult her Dr. if she's concerned.
fyi - I also took chemistry, biochemistry, pharmacology, neurology, and psychopharmacology, but I guess I forgot to read up on them before responding to the email, I didn't realize I'd be tested on my answers. And quite frankly, I have better things to do. I was only trying to help.
ASA or acetaminophen, seven or seventeen years, whatever, how does that help Xena, you get the point don't you? If not, get a life.
When I was very depressed I used to waste hours at work researching and responding to every critical statement in an email defending my opinion and point of view, kind of like you here - again, you didn't invent the stuff - but proving someone wrong was a hollow victory, when I got better I finally realised, NOBODY CARES! only I did, and in the process I alienated my co-workers/friends.
Think about it. The tone of your email was highly defensive and took cheap shots at me. Why?
Posted by jannbeau on July 23, 2002, at 18:07:20
In reply to Re: Apo-fluvoxamine vs. Effexor XR, posted by sly on July 23, 2002, at 15:26:01
>Sorry, Sly. I didn't intend to offend you or anyone else. Why ARE you offended, anyway? I'm not offended by your response and I didn't take any more cheap shots at you than you fired off at me! "Me thinketh the fellow protesteth too much!"--
Cheers,
Jannbeaucalm down Jannbeau!
>
> It's not like you invented the stuff.
>
> And I think you're missing the point.
>
> Apo refers to a Canadian drug company that produces generic versions of the original. Any medication in Canada that starts with apo- is generic, just take that off and you've got the chemical name. All she needs to do is look up Fluvoxamine.
>
> The difference is SSRI vs. SNRI. Effexor also inhibits norepinephrine reuptake. It claims to be more efficacious, but we're all different. Since none of us are medical Doctor's none of us are in a position to offer recommendations on medication - and I hope Xena would consult her Dr. if she's concerned.
>
> fyi - I also took chemistry, biochemistry, pharmacology, neurology, and psychopharmacology, but I guess I forgot to read up on them before responding to the email, I didn't realize I'd be tested on my answers. And quite frankly, I have better things to do. I was only trying to help.
>
> ASA or acetaminophen, seven or seventeen years, whatever, how does that help Xena, you get the point don't you? If not, get a life.
>
> When I was very depressed I used to waste hours at work researching and responding to every critical statement in an email defending my opinion and point of view, kind of like you here - again, you didn't invent the stuff - but proving someone wrong was a hollow victory, when I got better I finally realised, NOBODY CARES! only I did, and in the process I alienated my co-workers/friends.
>
> Think about it. The tone of your email was highly defensive and took cheap shots at me. Why?
Posted by xena on July 23, 2002, at 23:01:43
In reply to Re: Apo-fluvoxamine vs. Effexor XR » xena, posted by jannbeau on July 23, 2002, at 13:01:39
Many thanks for all of the information. I think I understand more clearly the difference between the two drugs.
I did not mean to cause friction on this page! I hope all is well now.
X.
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