Psycho-Babble Medication Thread 1096797

Shown: posts 1 to 25 of 29. This is the beginning of the thread.

 

How far is Rapastinel from being approved?

Posted by Lamdage22 on February 1, 2018, at 7:39:19

Hey folks,

i am having bad times here. I think tomorrow i will take 75 mg of Trazodone again!

What about Rapastinel? I may end up trying.

 

Re: How far is Rapastinel from being approved?

Posted by SLS on February 1, 2018, at 8:30:22

In reply to How far is Rapastinel from being approved?, posted by Lamdage22 on February 1, 2018, at 7:39:19

> Hey folks,
>
> i am having bad times here. I think tomorrow i will take 75 mg of Trazodone again!
>
> What about Rapastinel? I may end up trying.

I'm sorry to hear that you are feeling so bad that you should feel it necessary to return to an antidepressant. I know how much you would like to discontinue all of the drugs that you currently take.

As you know, Rapastinel does many of the same things that ketamine does, but has a reduced liability for producing dissociation. That's really its only advantage. Unfortunately, both drugs must be delivered IV. I have some experience with ketamine delivered intranasally. It didn't help me, but it was totally clean. I experienced absolutely no side effects. A friend of mine who, after years and years of treatment resistance to antidepressants, was brought to remission by intranasal ketamine. She was able to discontinue all of the other drugs she was taken. She felt better after only 3 days. Generally speaking, you would know by one or two weeks if it were going to work. It is not worth taking it beyond two weeks. Intranasal ketamine is more widely accepted now.


- Scott

 

Re: How far is Rapastinel from being approved?

Posted by SLS on February 1, 2018, at 8:49:20

In reply to Re: How far is Rapastinel from being approved?, posted by SLS on February 1, 2018, at 8:30:22

> > Hey folks,
> >
> > i am having bad times here. I think tomorrow i will take 75 mg of Trazodone again!
> >
> > What about Rapastinel? I may end up trying.
>
> I'm sorry to hear that you are feeling so bad that you should feel it necessary to return to an antidepressant. I know how much you would like to discontinue all of the drugs that you currently take.
>
> As you know, Rapastinel does many of the same things that ketamine does, but has a reduced liability for producing dissociation. That's really its only advantage. Unfortunately, both drugs must be delivered IV. I have some experience with ketamine delivered intranasally. It didn't help me, but it was totally clean. I experienced absolutely no side effects. A friend of mine who, after years and years of treatment resistance to antidepressants, was brought to remission by intranasal ketamine. She was able to discontinue all of the other drugs she was taken. She felt better after only 3 days. Generally speaking, you would know by one or two weeks if it were going to work. It is not worth taking it beyond two weeks. Intranasal ketamine is more widely accepted now.

I just wanted to add that Allergan (formerly Naurex) had another ketamine-like drug in development that can be taken orally. I don't know what its status is. I will be curious to see if any drug companies decide to develop hydroxynorketamine (HNK). (It might not be patentable). It is an active metabolite of ketamine that can be taken orally and does not produce dissociation or psychosis. It promotes BDNF without blocking NMDA receptors. Several studies have demonstrated its efficacy in treating depression.

* BDNF = brain-derived neurotrophic factor. It is found naturally in the brain and maintains the health and growth of neurons.

* Response or non-response to ketamine seems to be associated with the version of BDNF that gene one has.


- Scott

 

Re: How far is Rapastinel from being approved?

Posted by Lamdage22 on February 1, 2018, at 8:51:44

In reply to How far is Rapastinel from being approved?, posted by Lamdage22 on February 1, 2018, at 7:39:19

Ketamine for a former sufferer of psychosis? That cant be good. I read that Rapastinel will be approved 2021

 

Re: How far is Rapastinel from being approved?

Posted by Lamdage22 on February 1, 2018, at 8:56:33

In reply to Re: How far is Rapastinel from being approved?, posted by SLS on February 1, 2018, at 8:49:20

And is it safe and feasible long term? Can i get it as a layman?

 

Re: How far is Rapastinel from being approved?

Posted by Lamdage22 on February 1, 2018, at 9:19:03

In reply to Re: How far is Rapastinel from being approved?, posted by SLS on February 1, 2018, at 8:49:20

, i wish i could just not wake up anymore

 

Help please

Posted by Lamdage22 on February 1, 2018, at 10:13:45

In reply to Re: How far is Rapastinel from being approved?, posted by Lamdage22 on February 1, 2018, at 9:19:03

What can i do? Low dose doxepin? Can i avoid the sexual side effects?

 

im doing a seroquel XR GENERIC experiment

Posted by Jeroen on February 1, 2018, at 12:40:11

In reply to Re: How far is Rapastinel from being approved?, posted by SLS on February 1, 2018, at 8:30:22

maybe it will kick in again because its generic?

i sure hope so im going trough a misery here
all i want is myself back from the depression :!

 

i hate sex side effects thats what psychosis is al

Posted by Jeroen on February 1, 2018, at 12:46:28

In reply to Help please, posted by Lamdage22 on February 1, 2018, at 10:13:45

i hate sex side effects thats what psychosis is all about and feeling great like listening to music, your daily job, psychiatry doesnt like normal sexual stamina in humans, because that sounds perverted?? im no pervert that is not my main goal, music is i do know some people who are oversexed... :O

they rather like the war in Syria where over 300,000 people have died already.

crazy delusional statement or not, thats what it is.

Bleauberry where are you?????? Please come back to the forum

 

Re: i hate sex side effects thats what psychosis is al

Posted by Lamdage22 on February 1, 2018, at 12:52:40

In reply to i hate sex side effects thats what psychosis is al, posted by Jeroen on February 1, 2018, at 12:46:28

thanks for hijacking my thread and thanks for the apology/explaination.

 

Re: Help please

Posted by Lamdage22 on February 1, 2018, at 13:23:51

In reply to Help please, posted by Lamdage22 on February 1, 2018, at 10:13:45

Imipramine produces sexual side effects in 10% of people?

 

im sorry didnt mean to hijack your post

Posted by Jeroen on February 1, 2018, at 13:44:46

In reply to Re: i hate sex side effects thats what psychosis is al, posted by Lamdage22 on February 1, 2018, at 12:52:40

sorry didnt mean it!

 

Re: im sorry didnt mean to hijack your post

Posted by Lamdage22 on February 1, 2018, at 13:49:44

In reply to im sorry didnt mean to hijack your post, posted by Jeroen on February 1, 2018, at 13:44:46

ok apology accepted. im just having a hard time and i need some help here.

 

Re: Help please Lamdage22

Posted by SLS on February 1, 2018, at 14:48:56

In reply to Re: Help please, posted by Lamdage22 on February 1, 2018, at 13:23:51

> Imipramine produces sexual side effects in 10% of people?

Imipramine had absolutely no sexual side effects for me. Clomipramine did, though.


- Scott

 

Re: Help please

Posted by Lamdage22 on February 2, 2018, at 1:22:29

In reply to Re: Help please Lamdage22, posted by SLS on February 1, 2018, at 14:48:56

Hi Scott,

would imipramine be safe with my other meds?

 

Re: Help please

Posted by Lamdage22 on February 2, 2018, at 10:27:13

In reply to Re: Help please, posted by Lamdage22 on February 2, 2018, at 1:22:29

googling psychemeds is the most frustrating activity out there. All you see is people suffering and the reviews done by people that get paid to write them. 2 in 3 drug reviews are from pharma reps. If not more.

 

Re: Help please Lamdage22

Posted by SLS on February 2, 2018, at 10:48:10

In reply to Re: Help please, posted by Lamdage22 on February 2, 2018, at 1:22:29

> Hi Scott,
>
> would imipramine be safe with my other meds?

I can't see any negative drug interactions. In the past, imipramine was the gold standard by which other drugs were compared. I would just mention that imipramine can produce significant anticholinergic side effects including dry mouth, blurred vision, and constipation. Have you tried any other tricyclics yet? Nortripyline produces milder side effects and works well with Effexor.

Have you ever been manic?


- Scott

 

Re: Help please

Posted by Lamdage22 on February 2, 2018, at 10:50:42

In reply to Re: Help please Lamdage22, posted by SLS on February 2, 2018, at 10:48:10

> > Hi Scott,
> >
> > would imipramine be safe with my other meds?
>
> I can't see any negative drug interactions. In the past, imipramine was the gold standard by which other drugs were compared. I would just mention that imipramine can produce significant anticholinergic side effects including dry mouth, blurred vision, and constipation. Have you tried any other tricyclics yet? Nortripyline produces milder side effects and works well with Effexor.
>
> Have you ever been manic?
>
>
> - Scott

Have i ever been manic is debatable. I was psychotic at times from MAOI. And imipramine only causes sexual side effects in 5-10% of people?

 

Re: Help please

Posted by Lamdage22 on February 2, 2018, at 10:56:28

In reply to Re: Help please, posted by Lamdage22 on February 2, 2018, at 10:50:42

Nortriptyline gave me a weak boner;)

 

SLS, can you describe your mania from anti depress

Posted by Jeroen on February 2, 2018, at 12:00:35

In reply to Re: Help please Lamdage22, posted by SLS on February 2, 2018, at 10:48:10

SLS, can you describe your mania from anti depressants? i have been trough this aswell for 5 years, i taught i never would get better then i stumbled upon schizophrenia.com and tried their Sarcosine from Brainvitaminz (im not working for them its just me Jeroen) after 2 months i had to quit it, it also is better then Sipralexa, strong anti depressant, and anti psychotic, i quit because i upped my dose and got vibrations in my penis every bloody 15 minutes, and it didnt go away after a few days

you do need to be very carefull when taking this with meds like seroquel for your heart, ilearned it the hard way it also doesnt work with Clozapine, they cancel each other out, sais enough.


It has saved me and ive been trough a one year relationship i was lucky to meet new girlfriend but we recently broke up, now shes in the hospital but shes better now too she didnt sleep for 12+ days straight!

 

Re: SLS, can you describe your mania from anti depress

Posted by Lamdage22 on February 2, 2018, at 13:41:01

In reply to SLS, can you describe your mania from anti depress, posted by Jeroen on February 2, 2018, at 12:00:35

Hey Jeroen,

as far as i know we are not talking about SLS but about me.

The manias included a lot of talking. But also crying. My mood was very unstable. They were all medication induced so...

I am thinking wellbutrin right now.

 

Re: SLS, can you describe your mania from anti depress

Posted by SLS on February 3, 2018, at 9:18:00

In reply to SLS, can you describe your mania from anti depress, posted by Jeroen on February 2, 2018, at 12:00:35

> SLS, can you describe your mania from anti depressants?

It was actually a severe, psychotic mania. The two main components were religiosiity and ideas of reference. I also had pressure of speech and spoke too loud. Racing thoughts. Delusions without hallucinations. It was intense.


- Scott

 

Re: SLS, can you describe your mania from anti depress

Posted by Lamdage22 on February 3, 2018, at 9:31:13

In reply to Re: SLS, can you describe your mania from anti depress, posted by SLS on February 3, 2018, at 9:18:00

That crushes you somehow. It feeks like i am not the same person anymore that i was before

> It was actually a severe, psychotic mania. The two main components were religiosiity and ideas of reference. I also had pressure of speech and spoke too loud. Racing thoughts. Delusions without hallucinations. It was intense.

 

Mine was with hallucinations they are gone

Posted by Jeroen on February 3, 2018, at 10:18:44

In reply to Re: SLS, can you describe your mania from anti depress, posted by SLS on February 3, 2018, at 9:18:00

they are gone this type of hallucination for 2 years nows, i tried Sarcosine for 2 months with miraculous results, its an amino acid with stronger anti depressant properties also anti psychotic, its affordable and it works on Glutamate, it has the potential to reverse brain damage psychotic medication induced traumas... it clearly did... i am living proof

 

Re: Mine was with hallucinations they are gone

Posted by Lamdage22 on February 4, 2018, at 4:54:30

In reply to Mine was with hallucinations they are gone, posted by Jeroen on February 3, 2018, at 10:18:44

Hi Jeroen,

i too tried sarcosine and it helped a bit but unfortunately it gave me akathisia. I am back on the meds bandwagon. I have upped the trazodone from 50mg to 100mg. I still want to get rid of alot of the tranquilizers.

I guess now i will really know if Trazodone gives me OCD.


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