Psycho-Babble Medication Thread 1094392

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what is trazodone doing to me receptors?

Posted by porkpiehat on August 10, 2017, at 12:06:36

The action at 5ht1 is confusing to me. the 5ht2 blockade is pretty obvious.

I am taking 50mgs to sleep with parnate. I'm apathetic in the morning and then horny and emotionally open for the first part of the day.

Then I'm grumpy and my social anxiety increases mid-day. Also I get immediately tired and weak after taking my parnate, whereas it used to fire me up for a few hours.

I'm running low on sleep options. Does Doxepin have benefits over trazodone?

 

Re: what is trazodone doing to me receptors?

Posted by linkadge on August 10, 2017, at 17:31:35

In reply to what is trazodone doing to me receptors?, posted by porkpiehat on August 10, 2017, at 12:06:36

Doxapin is very sedating (very strong antihistamine). It would probably have a more uniform action (trazodone, like you note, does have metabolites which have different activity than trazodone itself). Seroquel might be an option too. I took Seroquel when on parnate (my brief stint with parnate, which gave me insomnia). The two seemed to work well together.

Another option would be trimipramine. It is a TCA antidepressant, and more sedating than doxepin. The benefit is that it has no effect on serotonin or norepinephrine reuptake. This may be a "safer" option to take with an maoi.

Linkadge

 

Re: what is trazodone doing to me receptors?

Posted by rjlockhart37 on August 16, 2017, at 2:29:35

In reply to what is trazodone doing to me receptors?, posted by porkpiehat on August 10, 2017, at 12:06:36

all the doctors that i saw, they always choose trazadone for first choice sleep aid, at the psych, but sometimes its not pleasant, it blocks rep uptake or serotonin, but it also blocks their release on some receptors, doxepin is similar but its much stronger than trazadone, trazadone sometimes would make me glued to the bed in the morning, yukky sleep aid sometimes

there's something called Rozerem, its not particularly know to be a well-recieved sleeping aid but it effects the melatonin receptors, another newer sleep med is Belsomra, it's a seems to be a controlled substance yet it doenst have much of the reputation of like benzos abuse......

seems like these new sleep aids are just wishy washy with trying to find a better way than the old generation of barbiturates and benzodiazepines, they work very well for sleep, but it's all that tolerance and wanting the feeling of them after a while, i think that's why they've been checked out.....i think all the sleep aids can cause dependence, because you needs them to go sleep.....

seroquel which is big big sleeping aid for off label use ask about rozerm if available were you live

 

Re: what is trazodone doing to me receptors? rjlockhart37

Posted by porkpiehat on August 28, 2017, at 13:31:35

In reply to Re: what is trazodone doing to me receptors?, posted by rjlockhart37 on August 16, 2017, at 2:29:35

FWIW I switched from 50 trazodone to 5 mgs doxepin last night. Sedation lasted longer into the day but I didn't feel so "whatever, why bother getting up" feeling that I did on Trazodone.

Hoping there's not a trazodone withdrawal. At <10 mgs doxepin I don't think there's much going on aside from histaminergic activity. Based on some positive reactions from hydroxyzine and trazodone the 5ht2 activity may have been beneficial.

 

Re: what is trazodone doing to me receptors? porkpiehat

Posted by phidippus on November 25, 2017, at 11:48:49

In reply to what is trazodone doing to me receptors?, posted by porkpiehat on August 10, 2017, at 12:06:36

doxepin appears to inhibit the reuptake of serotonin and norepinephrine and to have antihistamine, adrenergic and serotonin receptor antagonistic, and anticholinergic activities; at low doses used to treat insomnia it appears to be selective for the histamine H1 receptor.

Its is broader acting than Trazodone.

Eric


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