Psycho-Babble Medication Thread 75408

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Re: Nardil and MAOI diet restrictions Chairman_MAO

Posted by Sad Panda on February 20, 2004, at 7:56:01

In reply to Re: Nardil and MAOI diet restrictions Sad Panda, posted by Chairman_MAO on February 19, 2004, at 7:37:05

> I would give up tyramine-rich foods like aged cheeses--which I love dearly--in a heartbeat if I got euthymia and energy in return! There's no contraindication for cannabis, anyway. :) Wellbutrin seems to be doing an OK job, but I am so agitated and paranoid at times that I want to bite down on a block of wood. I've tried Effexor, Celexa, Lexapro, Remeron, desipramine, trazodone, Wellbutrin for depression. When does this madness end?!? Perhaps someday I will get a sympathetic doctor that will trust me with my own freaking life enough to prescribe Parnate.
>

I haven't asked my doc about Parnate yet, I'm hoping a higher dose of Efexor is going to give me some motivation. If it doesn't work my only other activating med choices here are Reboxetine, Nortriptyline or Parnate.

Cheers,
Panda.


 

Re: Nardil and MAOI diet restrictions cornycon

Posted by Sad Panda on February 20, 2004, at 8:19:55

In reply to Re: Nardil and MAOI diet restrictions Chairman_MAO, posted by cornycon on February 20, 2004, at 5:50:04

> Nardil is a high level side effect generator. If you decide to commence a self tretment program then I would strongly advise you to also put in place some sort of monitoring program.
>
> With regards the warning on Tomatoes: This item is included on the list because there is a certain level generated via Alkaloid biosynthesis. This level is variable and is dependant on the growing environment, contact with insects (they stimmulate response mechanisims as well as depositing protiens onto and into the fruit), stage of development and control sprays used during the growth cycle.
>
> There are a lot of things that I havent tried, so I can't give an answer on your question regarding Provolone. However based on its characteristics I would say that it would have high levels of Tyramine.
>
> I have come across some research that may be of interest. The drug Selegiline ( Eldepryl. Deprenyl) is selective for MOA type B, which is the accepted triggering agent for the Tyramine reaction. It appears that with small doses of this drug the MOAB levels are inhibited to the extent that significant levels of Tyramine can be tolerated before there is any reaction.
>
> The down side to this is that if you take too much with your MAOI you could end up in BIG trouble. For more info consult the following site ( It may not appear like a relavent site but carefully read the info): http:www.parkinsons-information-exchange-network-online.com/drugdb/120.html
>
> RE: Parnate. Have you checked out what this supposed salvation drug can and will do to you???? For more info. check out the following site:
> http://www.psyweb.com/Drughtm/tranyl.html
> Rather you than me is all I can say.
>
> Regards and best of luck to all
>
> Cornycon
>

Thanks for the heads up Cornycon. :) I won't be self medicating as that costs too much money that I don't have ATM.

A snip from that page http://www.psyweb.com/Drughtm/tranyl.html

"Uses: Treatment of major depressive episode without melancholia. Not a first line of therapy; is used when clients have failed to respond to other drug therapy. Investigational: Alone or as an adjunct to treat bulimia, obsessive compulsive disorder, and manifestations of psychotic disorders. Also, treatment of social phobia, seasonal affective disorders, adjunct to treat multiple sclerosis, and to treat idiopathic orthostatic hypotension (e.g., Shy-Drager syndrome) refractory to conventional therapy."

This med looks nearly like it was made for me as I am having a "major depressive episode without melancholia"(Atypical) + some social phobia + some problems with obsession + nil drive or motivation. I guess if I end up on Parnate I will soon work out what I can & can't have to eat. :)

Cheers,
Panda.


 

Re: Nardil and MAOI diet restrictions gardenergirl

Posted by Sad Panda on February 20, 2004, at 8:33:34

In reply to Re: Nardil and MAOI diet restrictions cornycon, posted by gardenergirl on February 20, 2004, at 6:17:29

> Provolone, like mozzarella, is not an aged cheese. It is fresh, and thus, unless it is well past an expiration date, it usually contains low to insignificant levels of tyramine.
>
> I'm not sure what you were highlighting with the link. Perhaps the list of side effects? I have to admit, I've seen as long a list on many other drugs. Most of MAOI side effects are tolerable and/or go away in time. Like any drug, there are some SE's that are deal-breakers. This is an individual decision between a patient and doctor. And of course you know that everyone does not respond alike to meds.
>
> I respect your opinion based on your needs, but please do not disrespect the decisions made by others.
>
> gg
>
>

That web page would be just the drug monograph that typically comes with any drug. It list every possibly side effect for legal reasons I guess.

When my doc wanted to put me on Efexor, I was fearful of my BP going up since, every bit of data I have seen on the net seems to indicate Efexor's main side effect was to make BP rise. I already have high BP & am taking an ACE inhibitor for it & my doc assured me that if Efexor worked for me that it would lower my BP & so far this has been the case. So I guess when people say YMMV it really is true. :)

Cheers,
Panda.


 

Re: Nardil and MAOI diet restrictions cornycon

Posted by Sad Panda on February 20, 2004, at 9:26:09

In reply to Re: Nardil and MAOI diet restrictions Chairman_MAO, posted by cornycon on February 20, 2004, at 5:50:04

> I have come across some research that may be of interest. The drug Selegiline ( Eldepryl. Deprenyl) is selective for MOA type B, which is the accepted triggering agent for the Tyramine reaction. It appears that with small doses of this drug the MOAB levels are inhibited to the extent that significant levels of Tyramine can be tolerated before there is any reaction.
>

Below 20mg/day you don't need to be on the diet, but being an MAO-B inhibitor means that it doesn't increase the levels of Serotonin or Norepinephrine which makes it not an anti-depressant. Above 20mg/day makes it no longer selective & you have to be on the diet. It will be awhile before we get to see the patch.

"In controlled clinical trials, selegiline caused slight improvement in motor performance at the start of therapy and worsening at its discontinuance; it also delayed the development of disability that requires the addition of levodopa. Selegiline was approved by the FDA in June 1989."

In Australia you can't have Selegiline until AFTER you are on levodopa--decarboxylase inhibitor combinations. We are a backwards country.

Cheers,
Panda.

 

Re: Nardil and MAOI diet restrictions

Posted by cornycon on February 21, 2004, at 6:32:11

In reply to Re: Nardil and MAOI diet restrictions cornycon, posted by Sad Panda on February 20, 2004, at 9:26:09

> > I have come across some research that may be of interest. The drug Selegiline ( Eldepryl. Deprenyl) is selective for MOA type B, which is the accepted triggering agent for the Tyramine reaction. It appears that with small doses of this drug the MOAB levels are inhibited to the extent that significant levels of Tyramine can be tolerated before there is any reaction.
> >
>
> Below 20mg/day you don't need to be on the diet, but being an MAO-B inhibitor means that it doesn't increase the levels of Serotonin or Norepinephrine which makes it not an anti-depressant. Above 20mg/day makes it no longer selective & you have to be on the diet. It will be awhile before we get to see the patch.
>
> "In controlled clinical trials, selegiline caused slight improvement in motor performance at the start of therapy and worsening at its discontinuance; it also delayed the development of disability that requires the addition of levodopa. Selegiline was approved by the FDA in June 1989."
>
> In Australia you can't have Selegiline until AFTER you are on levodopa--decarboxylase inhibitor combinations. We are a backwards country.
>
> Cheers,
> Panda.
>
>

The suggestion of Selegiline was purly for its inhibitor effect and as adjunct to the other meds. With the med streams that are currently in place the manifest benifits that would ensue from investigation of the effect and what other meds could be used along with it seem to be a pipe dream of the desperate diet restricred nail biting people stuck with the narrow minds of the med profession that wants to avoid any possibility of legal repercussions.

Regards Cornycon

 

Re: Nardil and MAOI diet restrictions

Posted by cornycon on February 21, 2004, at 7:28:12

In reply to Re: Nardil and MAOI diet restrictions cornycon, posted by gardenergirl on February 20, 2004, at 6:17:29

> Provolone, like mozzarella, is not an aged cheese. It is fresh, and thus, unless it is well past an expiration date, it usually contains low to insignificant levels of tyramine.
>
> I'm not sure what you were highlighting with the link. Perhaps the list of side effects? I have to admit, I've seen as long a list on many other drugs. Most of MAOI side effects are tolerable and/or go away in time. Like any drug, there are some SE's that are deal-breakers. This is an individual decision between a patient and doctor. And of course you know that everyone does not respond alike to meds.
>
> I respect your opinion based on your needs, but please do not disrespect the decisions made by others.
>
> gg


It is not a decision between a patient and his doctor. Doctor refused to prescribe, and patient is acting on own decision.

I neither offered nor implied any disrespect to anybodys decision. It was a message of caution and a stated personal position.

With respect to the issue of side effects, tollerence levels et al. if you have followed the thread then you will find that my position has been that each individuals situation is unique, being tied to so many other factors, that an overall generalisation is not possible. However even given the previus statement the inherent risks of a drug that has so many side effects that are directly attributible to reactions with a large number of substances. Substances contained in (But not measured or controlled) in a wide variety of foods, drinks, medications and natural substances. has a greater risk factor than a drug that mearly has a large number of side effects as a direct result of the actions of that drug. In the latter case the severity can be moderated by changing the dosage to allow normalisation/adaption of the body's processes. However in the first situation the type, level of reaction is dependant on almost random, and hard to control external factors.

My stated position remains, he is welcome to his action but care and monitoring systems should be put into place prior to comencement, as he is not doing this with the doctor.

The direction to the relevant web site was to provide information in order to be able to make a more informed decision. That decision being based on the impact that use of it will have on personal lifestyle/conditions.

regards Cornycon

 

Re: Nardil and MAOI diet restrictions Sad Panda

Posted by cornycon on February 21, 2004, at 8:07:48

In reply to Re: Nardil and MAOI diet restrictions cornycon, posted by Sad Panda on February 20, 2004, at 8:19:55

> > Nardil is a high level side effect generator. If you decide to commence a self tretment program then I would strongly advise you to also put in place some sort of monitoring program.
> >
> > With regards the warning on Tomatoes: This item is included on the list because there is a certain level generated via Alkaloid biosynthesis. This level is variable and is dependant on the growing environment, contact with insects (they stimmulate response mechanisims as well as depositing protiens onto and into the fruit), stage of development and control sprays used during the growth cycle.
> >
> > There are a lot of things that I havent tried, so I can't give an answer on your question regarding Provolone. However based on its characteristics I would say that it would have high levels of Tyramine.
> >
> > I have come across some research that may be of interest. The drug Selegiline ( Eldepryl. Deprenyl) is selective for MOA type B, which is the accepted triggering agent for the Tyramine reaction. It appears that with small doses of this drug the MOAB levels are inhibited to the extent that significant levels of Tyramine can be tolerated before there is any reaction.
> >
> > The down side to this is that if you take too much with your MAOI you could end up in BIG trouble. For more info consult the following site ( It may not appear like a relavent site but carefully read the info): http:www.parkinsons-information-exchange-network-online.com/drugdb/120.html
> >
> > RE: Parnate. Have you checked out what this supposed salvation drug can and will do to you???? For more info. check out the following site:
> > http://www.psyweb.com/Drughtm/tranyl.html
> > Rather you than me is all I can say.
> >
> > Regards and best of luck to all
> >
> > Cornycon
> >
>
> Thanks for the heads up Cornycon. :) I won't be self medicating as that costs too much money that I don't have ATM.
>
> A snip from that page http://www.psyweb.com/Drughtm/tranyl.html
>
> "Uses: Treatment of major depressive episode without melancholia. Not a first line of therapy; is used when clients have failed to respond to other drug therapy. Investigational: Alone or as an adjunct to treat bulimia, obsessive compulsive disorder, and manifestations of psychotic disorders. Also, treatment of social phobia, seasonal affective disorders, adjunct to treat multiple sclerosis, and to treat idiopathic orthostatic hypotension (e.g., Shy-Drager syndrome) refractory to conventional therapy."
>
> This med looks nearly like it was made for me as I am having a "major depressive episode without melancholia"(Atypical) + some social phobia + some problems with obsession + nil drive or motivation. I guess if I end up on Parnate I will soon work out what I can & can't have to eat. :)
>
> Cheers,
> Panda.
>
>
>

Hey Panda

Do a lot of cross checking first, then if think it might be your "Holy Grail" then you use your charm an persuasive personality so that you can end up on it. And like I have said all along care, care and more care. Panda's are an endangered species and I hate the idea that a little bit of carelesness may cost us another one. So for the sake of us all, when trying any new things take the time to be shure about any adverse reactions that may be starting to manifest.

Keep a list of all of the things that could potentially cause a problem, and in a very conspiciuos place, for consultation purposes.

As a victim of a number of reactive effects there are times that it is not a hell of a lot of fun. Doudle vision, fuzzing, shaking, minor seizures, heart palpitations, loss of muscle control, etc. etc. and they are difficult to combat as the interactions are so numerous and the lists are getting very long.

Best to you

Cornycon

 

Re: Nardil and MAOI diet restrictions bobbiedobbs

Posted by cornycon on February 21, 2004, at 8:59:02

In reply to Re: MAOI diet restrictions, posted by bobbiedobbs on December 18, 2003, at 19:22:35

> You will spare yourself alot of unnecessary worry and deprivation if you consult some of the historical posts involving contemporary allowed MAOI diets. Sounds like you are working off of some archaic diet lists! If you do a search under Bobbiedobbs (me) you should find guidance re soy-based products and links to medical studies concerning tyramine and MAOIs.
> I used MAOs for over 20 years (up to 60 mg.) and only had reactions to anchovy paste and decongestants. I regularly consumed alcohol (all forms are OK except draft beer, microbrewed beer and non-alcoholic beer) and the soft cheese such as ricotta and mozarella. But please don't take my word for anything (as I'm sure you won't). Do yourself a favor and spend some time and consult some of the historical posts on this site. Best posters were jessica and elizabeth. You should find some links to these folks earlier in this string. Best of luck. Nardil is a great drug if you excercise proper care.
> p.s. You might also think about carrying one of of the generally recognized antidotes, such as procardia. Sorry can't give you more details but leaving for a week for vacation. good luck. --Phil


To all of those people out there who need information and come to this site, head me and beware.

From the point of view of some of the contributors, there is almost nothing that you can't have with regards food/drink. However annecdotal evidence of people posting to this site show that the sensitivities to foods/drinks is so varied that the broad statement of Phil above is a dangerous message to listen to.

Work it out for yourself, and use the longest list you can find to start with. Then with personal experience you can start to cross items off, post cautions on others and red flag those that are outright a definite no-no.

Too carefull is not good from the dietary aspect, but too free will kill you faster.

I've spent a lot of time with a lot of different problems, requiring their own sets of meds and dietary restrictions, to throw it to the wind by being irresponsable in this area. If you have done your homework with regards your own set of guidelines and follow them at all times (Just like your med routine) then why would you need to carry an antidote.

Continue to strive

Cornycon

 

Starting a new MAOI med for social phobia

Posted by Bigdave on March 17, 2004, at 6:13:36

In reply to MAOI diet restrictions, posted by Bigdave on December 17, 2003, at 20:23:14

Hi everyone,

This is sort of a follow-up post to <a href="http://www.dr-bob.org/babble/20031213/msgs/291105.html">my post</a> last year concerning MAOI meds for social phobia.

At the time, I was trying to by Nardil online from a UK company without prescription since my doctor wouldn't prescribe it. It proved unsuccessful in the end getting any Nardil, but now, 3 months later, I'm on Manerix under the guidance of a pdoc. Manerix is a newer reversible MAOI which is specifically for social phobia.

It's only my first day on the med today and I'm not feeling any side effects yet and I hope it will continue to be the case. I'm keeping a journal of my progress on this med for the benefit of other social phobia sufferers and to gage the effectiveness of Manerix for treating social phobia.

Will keep you updated

Bye for now

BigDave

 

Re: Starting a new MAOI med for social phobia

Posted by RobertPalsing on June 3, 2004, at 21:54:20

In reply to Starting a new MAOI med for social phobia, posted by Bigdave on March 17, 2004, at 6:13:36

Does anyone know if these foods are safe to consume if you haven't taken the medicine in 12/24/etc. hours? I just got a prescription for Nardil and am just wondering. I feel very buzzed like I'm kind of drunk and I'm having trouble finding words. I hope I don't stay mentally dulled because I'm definitely feeling pretty stumped right now. I don't really feel any anxiety though.. just out of it.

I assume Soy cheese is out too? I will venture to say before someone tells me that soy cheese is NOT ok to consume on MAOI.

Thanks.
"Bob"

 

Re: Starting a new MAOI med for social phobia RobertPalsing

Posted by Carlos C on June 5, 2004, at 2:43:32

In reply to Re: Starting a new MAOI med for social phobia, posted by RobertPalsing on June 3, 2004, at 21:54:20

If you experiment (slowly, at a level you and your doctor feel comfortable) you'll most likely find that the diet restrictions are over-hyped.

Personally I didn't have to modify my diet at all. I ate aged-cheeses, drank wine, and even took amphetamines while on 90mg of Nardal. None of which raised my blood pressure much. At least not to an alarming rate.

 

Re: Starting a new MAOI - how long to expect?

Posted by RobertPalsing on June 5, 2004, at 16:11:07

In reply to Re: Starting a new MAOI med for social phobia RobertPalsing, posted by Carlos C on June 5, 2004, at 2:43:32

Never taken an MAOI (the only category I haven't touched). With SSRIs I usually noticed a change(if it was going to happen)within 2 weeks, with APs about a week, with TCA around 1-2 weeks. I felt different the first Nardil I took but I still have anxiety. Is there anyone who had massive anxiety that was helped by Nardil that can tell me about their experience in the first few weeks? Just the basics would help. THanks much.

Take care,
"Bob"

 

Re: Nardil and MAOI diet restrictions

Posted by hungry for info on October 11, 2004, at 16:38:29

In reply to Re: Nardil and MAOI diet restrictions Chairman_MAO, posted by Sad Panda on February 20, 2004, at 7:56:01

I returned from a session with a Psycharist this am. I've been on tri-cyclics & SSRI's since 1980, with on and off relief. In addition to clinial depression, I have primary insomnia as confirmed by a sleep study. Like some of the other posts, I feel I've been popping pills with no real benefit. The Dr. I saw today suggested I consider MAOI's, and said they weren't the dangerous drugs they made out to be. This fellow is an Assoc.Prof. of Psychiatry at Vanderbilt and had good recommendations from his peers, so I tend to feel comfortable with what he says.

Since he suggested I "consider" them, I thought I'd better check them out, and landed here through Google. Boy, the posts don't sound encouraging! I can handle dietary restrictions, but am concerned about dizzyness, fainting, and the other side effects mentioned. How does one function driving, at work, etc. with those kind of side effects. I'm 62 and jobs are tough to come by at my age. I hate to think of jepordizing it by experiencing some of the side effects at work, or not being able to drive.

The SSRI's (& I think I've taken most of them)have made me a zombie also, but still haven't really taken care of the depression. I'm unproductive, getting very clumsy, have no libido (no wise cracks about the age, please!), force myself to do things on weekends; well, really, just not a lot of fun. Outside of the first prescription of tri-cyclics (which seemed to stop working after a year or so), I have had no relief. The insomnia is making everything else worse (or is everything else making the insomnia worse? Good zen question).

Anyway, I'm to the point of trying most anything. But it seems a lot of the side effects discussed are what I'm trying to get away from.
I don't see the Dr. until next month, so have time to ruminate on it. Any inputs would be appreciated.

Thanks.

 

Re: Nardil and MAOI diet restrictions

Posted by Tai Chi on October 11, 2004, at 21:26:54

In reply to Re: Nardil and MAOI diet restrictions, posted by hungry for info on October 11, 2004, at 16:38:29

I have struggled with depression for the past 35 years and finally went on Prozac in 1990. However, I soon developed treatment resistance, finding many drugs ( SSRIs, Effexor, Serzone, TCAs, Wellbutrin) either intolerable or ineffective. I did have a successful therapeutic run of four years with Remeron. After the Remeron gave out, I went through 8 months of hell trying different combinations of medications, as well as ECT. A little over a year ago, I started Nardil. Nardil has turned out to be a wonder drug for me, completely alleviating my anxiety and depression. Im currently taking 45 mg a day.

 

Re: Nardil and MAOI diet restrictions

Posted by bobbiedobbs on October 11, 2004, at 23:40:33

In reply to Re: Nardil and MAOI diet restrictions, posted by Tai Chi on October 11, 2004, at 21:26:54

I've taken several SSRIs besides all three MAOIs. My experience has been that the side effects from the MAOIs are no worse and in some cases more benign than with the SSRIs; generally less fatigue. Dizziness went away after a week or so. Sexual side effects have been dehabiliting on Nardil and Marplan but not on Parnate; however, there are a number of permissable remedies. Finally, many of the diet restrictions are quite (out)dated. You can safely drink all alcohol except draft/microbrew beer, and any of the soft or processed cheeses, including mozarella, processed American slices, ricotta. I would certainly encourage you to try an MAOI based on your experience. The MAOIs have helped me far more than any of the SSRIs.
Phil

 

Re: Nardil and MAOI diet restrictions bobbiedobbs

Posted by gardenergirl on October 12, 2004, at 20:54:40

In reply to Re: Nardil and MAOI diet restrictions, posted by bobbiedobbs on October 11, 2004, at 23:40:33

Phil,
Can you even drink aged Scotch or other aged liquors? I've really been missing margaritas.

gg

 

Re: Nardil and MAOI diet restrictions gardenergirl

Posted by bobbiedobbs on October 13, 2004, at 0:18:49

In reply to Re: Nardil and MAOI diet restrictions bobbiedobbs, posted by gardenergirl on October 12, 2004, at 20:54:40

Can you even drink aged Scotch or other aged liquors? I've really been missing margaritas.
>
>My immediate answer would be yes. The manufacturer does not include aged liquors (except Sherry and Chianti) in the list of foods to avoid. Nor do any of seven or so recent studies of MAOI diets published within the past several years, of which I have copies. (There's a lot of controvery, by the way, about whether Sherry and Chianti even need to be restricted.) The only type of alcohol that shows up on the "to be avoided" list in any of these studies are draft/tap beers, and other beer or wine above certain daily quantities (the conservative consensus is an allowance of no more than four ounces of wine per day (no restriction on red) and no more than 2 bottled or canned beers per day; however, these are way conservative in that the studies show you'd pass out before consuming a tyramine level significant enough to have any effect.
A couple of suggestions: post the question about aged liquors on the Yahoo group on MAOIs (Go to Yahoo groups, then search.) You might also wish to contact Kenneth Shulman at the Dept. of Psychiatry, Sunnybrook Health Science Center, 2075 Bayview Ave, Toronto Canada M4N 3M5.
He probably has studied this issue more than anyone and responds to written requests.
Skoal. Phil
>> gg

 

Re: Nardil and MAOI diet restrictions

Posted by Sad Panda on October 13, 2004, at 22:14:14

In reply to Re: Nardil and MAOI diet restrictions, posted by hungry for info on October 11, 2004, at 16:38:29

> I returned from a session with a Psycharist this am. I've been on tri-cyclics & SSRI's since 1980, with on and off relief. In addition to clinial depression, I have primary insomnia as confirmed by a sleep study. Like some of the other posts, I feel I've been popping pills with no real benefit. The Dr. I saw today suggested I consider MAOI's, and said they weren't the dangerous drugs they made out to be. This fellow is an Assoc.Prof. of Psychiatry at Vanderbilt and had good recommendations from his peers, so I tend to feel comfortable with what he says.
>
> Since he suggested I "consider" them, I thought I'd better check them out, and landed here through Google. Boy, the posts don't sound encouraging! I can handle dietary restrictions, but am concerned about dizzyness, fainting, and the other side effects mentioned. How does one function driving, at work, etc. with those kind of side effects. I'm 62 and jobs are tough to come by at my age. I hate to think of jepordizing it by experiencing some of the side effects at work, or not being able to drive.
>
> The SSRI's (& I think I've taken most of them)have made me a zombie also, but still haven't really taken care of the depression. I'm unproductive, getting very clumsy, have no libido (no wise cracks about the age, please!), force myself to do things on weekends; well, really, just not a lot of fun. Outside of the first prescription of tri-cyclics (which seemed to stop working after a year or so), I have had no relief. The insomnia is making everything else worse (or is everything else making the insomnia worse? Good zen question).
>
> Anyway, I'm to the point of trying most anything. But it seems a lot of the side effects discussed are what I'm trying to get away from.
> I don't see the Dr. until next month, so have time to ruminate on it. Any inputs would be appreciated.
>
> Thanks.
>
>

Which TCA's have you tried? Some of them are pretty good for insomnia. A frequent problem with MAOI's is insomnia.

Cheers,
Paul.


 

Re: Nardil and MAOI diet restrictions

Posted by gardenergirl on October 13, 2004, at 23:20:18

In reply to Re: Nardil and MAOI diet restrictions gardenergirl, posted by bobbiedobbs on October 13, 2004, at 0:18:49

Thanks!
gg

 

Cheddar Cheese?

Posted by jparsell82` on October 14, 2004, at 13:47:29

In reply to Re: Nardil and MAOI diet restrictions, posted by Sad Panda on October 13, 2004, at 22:14:14

I'm on day 8 of Nardil 45mg and I'm thinking of bumping it up to 60mg because I'm really not experience any side effects. I sleep a little longer and my appetite's a bit increased but nothing much. I also haven't had any problems with what I've consumed so far.... alcohol, parmesan, mozzarella cheese, etc. The one I really miss though is cheddar cheese. The other night we had tacos and I didn't know what I should do cheese-wise. I ended up just sprinkling a little bit of cheddar cheese and had no problem. Is there any kind of cheddar cheese that's safe? Oh, and is pepperoni ok? Because I've been eating it too without problems so far. Thanks,

Josh

 

Re: Cheddar Cheese? jparsell82`

Posted by King Vultan on October 14, 2004, at 14:49:57

In reply to Cheddar Cheese?, posted by jparsell82` on October 14, 2004, at 13:47:29

If you eat enough cheddar cheese, you will suffer a hypertensive crisis, but the amount required varies from person to person, and Nardil is not as bad as Parnate. Generally, the more aged the cheese, the worse it is, but even medium cheddar contains a substantial amount of tyramine. I believe your risk also goes up with increasing MAOI dosage, as you will have more MAO-A inhibition at the higher dosages. I do not have the exact figures in front of me, but even one slice of cheddar cheese can induce a BP change in someone on 20 mg Parnate. For someone on 60 mg Nardil, it takes about 4 times as much tyramine to raise a person's BP 30 mm HG as it does on 20 mg Parnate, based on a tyramine pressor study in "Clinical Advances in Monoamine Oxidase Inhibitor Therapies".

I am on 50 mg Parnate and was on a high dose of Nardil for some months before that and have so far avoided anything with any amount whatsoever of cheddar cheese in it. I may be overcautious, but cheese is by far the food most associated with inducing hypertensive crises in case reports. I suppose what I could do is pick a food that I have been avoiding that contains cheddar cheese, such as Cheetos, check my BP, eat a small number of them, and then monitor my BP afterwards to see if it goes up. If not, then the next day, I could try doubling the amount, and see if that makes a difference, and the next day, double it again. This may sound ridiculous, but this methodology is similar to what is actually used in tyramine pressor tests on volunteer patients, except that they would probably use tyramine capsules with a known amount of tyramine in them.

As for pepperoni, I do eat pepperoni on pizza, but only certain brands that I have a high confidence level in, and you need to make sure that the cheese used is mozzarella or another low tyramine variety. I have read two anecdotes from different people who suffered hypertensive crises while on Parnate from eating pepperoni pizza at small, local pizza shops, but I do not know if it was the pepperoni that got them, or if it was the cheese.

Todd

 

Re: Cheddar Cheese? King Vultan

Posted by bobbiedobbs on October 14, 2004, at 21:23:09

In reply to Re: Cheddar Cheese? jparsell82`, posted by King Vultan on October 14, 2004, at 14:49:57

Re Pepperoni - it is on all of the no-no lists. However, a 1999 study by the Dept. of Psychiatry at Sunnybrook Health Science Center in Toronto found no significant tyramine levels in double pepperoni/double cheese pizzas from large Pizza Hut, McDonalds, Pizza Pizza and Dominos. "Conclusion: pizzas from larger commercial outlets are safe for coneumption with MAOIs." FYI, I've eaten pepperoni in fairly large quantities for many years while taking MAOIs without adverse consequence. Cheddar cheese is a whole nother story. You might try Velveeta, Cheeze Whitz or Kraft Mac and Cheese, cheap but safe cheddar substitutes.

 

Re: Nardil and loss of appetite and diarrhea

Posted by mack2099 on April 13, 2005, at 8:48:38

In reply to Re: Nardil and loss of appetite and diarrhea, posted by cosis on April 20, 2003, at 1:06:52

I have been taking Nardil off and on (mostly on) for 18 years! I have been taking it regularly for the last 6 years. I have found on several occasions during the last 18 years that when I exercise regularly (at least 30 mins. daily of aerobic exercise) that my appetite is greatly supressed and losing weight is very easy. However, during the last 2 years I have gained @ 80 lbs. and have felt very tired--getting very little exercise as I just didn't feel up to it. We moved out of state and before I could get an appt. with a new dr. I saw that my current supply of Nardil would run out, so I began tapering off from 60 mg. daily down to 45, 30, 15 and completely off after tapering off for @ 4 wks. Several days after I was completely off my appetite changed suddenly from ravenous (expecially for sweets and alcoholic beverages--especially wine) to normal. I began to lose weight and actually feel better and not as tired. My whole attitude has improved tremendously. Has anyone else experienced symptoms similar to these??? I'm thinking now that I don't want to return to Nardil--especially not for a while.

> > Hello
> > I took Nardil for 4 weeks and suffered loss of appretite, diarhea and lost 10 lbs. I was stopped by the police for driving while impaired. Has anybody else had any similar experiences. My doctor has vaguely suggested a hypoglycemic attack. He says the usual side effect is constipation not diarrhea but the diarrhea stopped when I stopped the Nardil and I are ravenously for several days after, so there does seem to be a correlation. Any help would be appreciated.
> > Mairwen
>
> Most of the people have a weight gain instead of loss... My appetite definately changed more towards sweet tasting foods which is responsible for about 10 lbs of weight gained...
>
> I am not sure I understand your police issue.. You were impaired from Nardil? When I drive sometimes I almost fall asleep.. It is kind of dangerous so I usually get out and move around then I am usually fine.. Or smack myself in the face a few times :)
>
>

 

Re: Nardil and loss of appetite and diarrhea mack2099

Posted by ed_uk on April 13, 2005, at 9:45:11

In reply to Re: Nardil and loss of appetite and diarrhea, posted by mack2099 on April 13, 2005, at 8:48:38

Hi,

>I'm thinking now that I don't want to return to Nardil--especially not for a while.

Do you think you would try Parnate if you need an antidepressant in future? It's claimed to cause less weight gain than Nardil.

Regards,
Ed.

 

Re: Nardil and loss of appetite and diarrhea

Posted by bill.e on April 23, 2005, at 9:04:55

In reply to Re: Nardil and loss of appetite and diarrhea, posted by cosis on April 20, 2003, at 1:06:52

> > Hello
> > I took Nardil for 4 weeks and suffered loss of appretite, diarhea and lost 10 lbs. I was stopped by the police for driving while impaired. Has anybody else had any similar experiences. My doctor has vaguely suggested a hypoglycemic attack. He says the usual side effect is constipation not diarrhea but the diarrhea stopped when I stopped the Nardil and I are ravenously for several days after, so there does seem to be a correlation. Any help would be appreciated.
>

I've been taking nardil for 15 years so maybe I can help. I take the pills throughout the day, not more than one at a time. More than one 15mg pill at a time will give me some diarrhea the next day. Eating something around pill time can help alot. Increasing the dose gives me some diarrhea or constipation and some cycling between the two until I adjust to it.
When I first started nardil I lost 15 lbs but all these years later I've put it all back and then some... age catching up with me.
Too high a dose can bring symptoms of hypermania - could be the reason for your driving incident.


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