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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by bulldog2 on September 16, 2009, at 17:27:52
Saw this quote
"Antidepressants, tricyclic - Amphetamines may enhance the activity of tricyclic or sympathomimetic agents; d-amphetamine with desipramine or protriptyline and possibly other tricyclics cause striking and sustained increases in the concentration of d-amphetamine in the brain; cardiovascular effects can be potentiated"
Does anyone have any clue as to the process that causes the above to happen? Seems to be saying that amphetamine potentiates certain tricyclics and in return d-amphetamine levels are raised in the brain.
Any ideas? I know some think tcas my be nmda antagonists and that can prevent stimulant tolerance. Any connection?
Posted by desolationrower on September 16, 2009, at 17:49:43
In reply to How Does Amphetamine Potentiate Tricyclics?, posted by bulldog2 on September 16, 2009, at 17:27:52
probably jsut means additive effects of an NRI with stimulants which are also NRIs as well as DRIs and sometiems catecholamine releasers.
-d/r
Posted by rjlockhart04-08 on September 17, 2009, at 13:29:32
In reply to Re: How Does Amphetamine Potentiate Tricyclics?, posted by desolationrower on September 16, 2009, at 17:49:43
Prozac increases d-amphetamine's effect's, i do not know why. I would think Wellbutrin would be boosted. I took Wellbutrin while taking adderall xr, it was good it leveled the mood out a bit.
Posted by West on September 17, 2009, at 13:41:13
In reply to Re: How Does Amphetamine Potentiate Tricyclics?, posted by desolationrower on September 16, 2009, at 17:49:43
Check they don't compete for the same enzyme.
Posted by bulldog2 on September 17, 2009, at 17:09:27
In reply to Re: How Does Amphetamine Potentiate Tricyclics?, posted by West on September 17, 2009, at 13:41:13
> Check they don't compete for the same enzyme.
I called shire. The person I spoke to seemed to think they competed for the same enzyme.
This is the end of the thread.
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