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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 2 of 2. This is the beginning of the thread.
Posted by iforgotmypassword on February 19, 2007, at 10:31:42
can a drug increase prolactin by antagonizing dopamine AUTO-receptors alone?
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and how did it cause dystonia in another poster here at low dose?
could it be that low dose amisulpride has enough antagonism to saturate ventral tegmental area (VTA) post-synaptic dopamine receptors?
VTA problems seem linked to bruxism and akathisia, and crucial pleasure/reward motivational effects in the brain:
(SSRI bruxism & VTA) http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16802163&query_hl=1&itool=pubmed_docsum
(SSRI akathisia & VTA) http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=9744293&query_hl=5&itool=pubmed_docsum
the VTA seems mentioned in parkinson's a lot as opposed to TD, which may link this form of permanent effect to a different mechanism than TD, and explain the different effects than TD, and explain my complaints of apathy.
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http://en.wikipedia.org/wiki/Ventral_tegmental_area
so if my permanent bruxism and akathisia is tied to this area, i am basically screwed?
are my dopaminergic neurons there just dead and that's final? or are the neurons just "polarized" wrong or something?
i should add that doing ANYTHING in a day is like voodoo in my head and the amount of internal negotiation, coaxing and just plain chance that it takes to get things done is how i haven't worked for five years. seen many friends. finished high school (i am 22.)
i should also mention that apathy and honest non-automatic expression of emotions is a huge problem. i can laugh uncontrollably over something i don't think is funny, nervously talk your ear off even though i don't know if i like you (i am clingy by reflex,) but not be able to tell you my likes and dislikes, make any decision, or live at all, do anything i "like".
this is where i stand. ugh. do ANY doctors on the planet focus on this?! they are all shutting me out. i don't know what i am expected to do. just rot and die?
Posted by Chairman_MAO on February 21, 2007, at 13:00:28
In reply to why does low-dose amisulpride increase prolactin?, posted by iforgotmypassword on February 19, 2007, at 10:31:42
Do benzodiazepines help your issues?
This is the end of the thread.
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