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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 25 of 55. This is the beginning of the thread.
Posted by PeterMartin on March 3, 2020, at 13:15:00
I've been running queries on pubmed (https://www.ncbi.nlm.nih.gov/pubmed/) looking to see if meds/supplements I've taken may have antiviral properties. With the risk of coronavirus becoming a reality here are my 3 I have things taken based on my searches that could be helpful:
Lithium (has positive effects against herpes/hiv)
Stinging Nettle (Tested against other coronavirus w some positive effects)
DandelionAnyone else have any recollection of medicines or supplements they've taken that may have had antiviral or prolung properties?
I figure since our bodies can beat it any slight edge we can give the immune system could be significant.
Might be nice to go back on a low dose of Li in my case also (so long as it doesn't spike my bp like last time I took it w Marplan).
Hope everyone is doing well!
Posted by beckett2 on March 3, 2020, at 14:29:44
In reply to Medicines/Supplement that might help 4 coronavirus, posted by PeterMartin on March 3, 2020, at 13:15:00
I came across this. While influenzas are not corona viruses, this is interesting nonetheless.
Posted by PeterMartin on March 3, 2020, at 16:51:59
In reply to Re: Medicines/Supplement that might help 4 coronavirus, posted by beckett2 on March 3, 2020, at 14:29:44
> I came across this. While influenzas are not corona viruses, this is interesting nonetheless.
>
> https://www.ncbi.nlm.nih.gov/pubmed/31067470It is interesting....but that's just OTC Aleve?
Posted by sigismund on March 3, 2020, at 20:14:46
In reply to Re: Medicines/Supplement that might help 4 coronavirus, posted by PeterMartin on March 3, 2020, at 16:51:59
Pubmed seems to be down but there is this....
Palmitoylethanolamide (PEA) is a food component known for more than 50 years. ... Since 1970, the anti-inflammatory and other immune-modulating properties of PEA have been shown in a number of placebo-controlled double-blind clinical trials on influenza and common cold.
Posted by sigismund on March 3, 2020, at 20:21:11
In reply to Re: Medicines/Supplement that might help 4 coronavirus, posted by sigismund on March 3, 2020, at 20:14:46
Posted by beckett2 on March 3, 2020, at 20:27:26
In reply to Re: Medicines/Supplement that might help 4 coronavirus, posted by PeterMartin on March 3, 2020, at 16:51:59
> > I came across this. While influenzas are not corona viruses, this is interesting nonetheless.
> >
> > https://www.ncbi.nlm.nih.gov/pubmed/31067470
>
> It is interesting....but that's just OTC Aleve?
>
>
>Yes. Interesting. Somewhere I read about using the molecule as a scaffold for anti-viral treatment. Maybe this, but at this point forward above my pay grade.
https://pubs.acs.org/doi/full/10.1021/acs.jmedchem.8b00557
Posted by rjlockhart37 on March 3, 2020, at 23:51:36
In reply to Re: Medicines/Supplement that might help 4 coronavirus, posted by PeterMartin on March 3, 2020, at 16:51:59
they said they have, or on their way to having a vaccine, already in development right now, it hasn't spread near my area, its low in texas, but still its growing, i've never seen anything like this before, crazy
Posted by PeterMartin on March 4, 2020, at 1:12:35
In reply to Re: Medicines/Supplement that might help 4 coronavirus, posted by sigismund on March 3, 2020, at 20:14:46
> Pubmed seems to be down but there is this....
>
> Palmitoylethanolamide (PEA) is a food component known for more than 50 years. ... Since 1970, the anti-inflammatory and other immune-modulating properties of PEA have been shown in a number of placebo-controlled double-blind clinical trials on influenza and common cold.
I need to look into this one more. It's bizarre but I came across it a few weeks ago but I can't remember why. At first I thought it was the other PEA that you can't take w MAOis. Confusing they have the same abreviation.
Posted by beckett2 on March 4, 2020, at 1:50:42
In reply to Re: Medicines/Supplement that might help 4 coronavirus, posted by sigismund on March 3, 2020, at 20:21:11
> https://www.ncbi.nlm.nih.gov/pubmed/24066256
Have you taken this?
Posted by Lamdage22 on March 4, 2020, at 1:58:34
In reply to Re: Medicines/Supplement that might help 4 coronavirus » sigismund, posted by beckett2 on March 4, 2020, at 1:50:42
I am taking this and it may be the reason why I am still in the (home)gym. I'm a veteran of elbow tendonitis and this time, I was able to avert the full-blown elbow tendonitis and I am still working out.
Posted by undopaminergic on March 4, 2020, at 7:57:24
In reply to Re: Medicines/Supplement that might help 4 coronavirus, posted by PeterMartin on March 4, 2020, at 1:12:35
> > Palmitoylethanolamide (PEA) ...
>
> I need to look into this one more. It's bizarre but I came across it a few weeks ago but I can't remember why. At first I thought it was the other PEA that you can't take w MAOis. Confusing they have the same abreviation.
>Phenylethylamine, yes. You can take it with MAOIs with caution. Its mechanism of action is the same as for amphetamines.
-undopaminergic
Posted by Hugh on March 4, 2020, at 11:30:13
In reply to Medicines/Supplement that might help 4 coronavirus, posted by PeterMartin on March 3, 2020, at 13:15:00
Low-dose naltrexone (LDN) modulates the immune system. I've been taking it off and on for over ten years, and have noticed that I get fewer colds while I'm taking it. Other people who have taken LDN have said that it strengthens their immune system.
To find a doctor who will prescribe LDN:
Posted by sigismund on March 4, 2020, at 12:40:25
In reply to Re: Medicines/Supplement that might help 4 coronavirus » sigismund, posted by beckett2 on March 4, 2020, at 1:50:42
Yes, I am taking it now. For discomfort. I've no idea about CV.
Posted by PeterMartin on March 4, 2020, at 14:28:49
In reply to Re: Medicines/Supplement that might help 4 coronavirus, posted by undopaminergic on March 4, 2020, at 7:57:24
> > > Palmitoylethanolamide (PEA) ...
> >
> > I need to look into this one more. It's bizarre but I came across it a few weeks ago but I can't remember why. At first I thought it was the other PEA that you can't take w MAOis. Confusing they have the same abreviation.
> >
>
> Phenylethylamine, yes. You can take it with MAOIs with caution. Its mechanism of action is the same as for amphetamines.
>
> -undopaminergic
>
>Right but this is a -different- PEA. It's not phenylalanine it's Palmitoylethanolamide. Both are abbreviated PEA.
The one that could be helpful again viruses is Palmitoylethanolamide.
Posted by alexandra_k on March 4, 2020, at 18:33:50
In reply to Re: Medicines/Supplement that might help 4 coronavirus, posted by Lamdage22 on March 4, 2020, at 1:58:34
> I am taking this and it may be the reason why I am still in the (home)gym. I'm a veteran of elbow tendonitis and this time, I was able to avert the full-blown elbow tendonitis and I am still working out.
Have you tried foam rolling (firmly massaging) your triceps and also the muscles on the meaty part of your forearm?
I just say this because sometimes runners experience 'shin splits' or a sort of nagging irritation that can be relieved somewhat by foam rolling / massaging the front of their shin (tibialis anterior).
And sometimes nagging irritations around the elbow region can be linked (in part) to tight muscles in the triceps region, particularly.
I have personally found that when I have elbow irritation it is fixed up by foam rolling my triceps that tend to get a bit over-active from my overhead pressing.
just a thought.
Posted by beckett2 on March 4, 2020, at 21:31:37
In reply to Medicines/Supplement that might help 4 coronavirus, posted by PeterMartin on March 3, 2020, at 13:15:00
This channel I subscribe discusses a study on Vit D and viruses. Tne upshot is daily doses (not high)has a beneficial effect.
https://www.youtube.com/watch?v=gmqgGwT6bw0
Here is the study he discusses:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121423/pdf/ijms-19-02419.pdf
Posted by beckett2 on March 4, 2020, at 21:32:27
In reply to Re: Medicines/Supplement that might help 4 coronavirus » beckett2, posted by sigismund on March 4, 2020, at 12:40:25
> Yes, I am taking it now. For discomfort. I've no idea about CV.
Does it help?
Posted by sigismund on March 5, 2020, at 0:10:11
In reply to Re: Medicines/Supplement that might help 4 coronavirus, posted by beckett2 on March 4, 2020, at 21:32:27
>Does it help?
I have so many different types of discomfort I thought it should help one of them.
oooooohhhhhh, yes rather than no, I guess.
Posted by PeterMartin on March 5, 2020, at 1:14:28
In reply to Re: Medicines/Supplement that might help 4 coronavirus, posted by Lamdage22 on March 4, 2020, at 1:58:34
> I am taking this and it may be the reason why I am still in the (home)gym. I'm a veteran of elbow tendonitis and this time, I was able to avert the full-blown elbow tendonitis and I am still working out.
I searched this just now and found your earlier post about (palmitoylethanolamide) from last November.
Are you still losing weight w/ it?
Do you think it could be a risk for manic breaks? Or does it not really seem to affect your mood much?
I'm currently taking Marplan (MAOi) so I wouldn't want to take anything that could be extremely risky but the research makes it tempting at this moment.
Posted by PeterMartin on March 5, 2020, at 1:23:18
In reply to Re: Medicines/Supplement that might help 4 coronavirus, posted by PeterMartin on March 5, 2020, at 1:14:28
n/m this seems to suggest palmitoylethanolamide supplementation could pose some risk for bipolars of which I am one.
https://www.tandfonline.com/doi/abs/10.1080/15622975.2018.1449966
Don't need a manic episode right now so unless I"m reading that wrong this is one sup I'll skip. It's interesting that pot has almost always been in my system when I've gone manic (many times from '99 to '09). Ever since I stopped in 2009 I've only had had one break in 2015 when I had to discontinue Marplan and started Belviq (now off the market).
==
Familial abnormalities of endocannabinoid signaling in schizophrenia
=
Objectives: Epidemiological and experimental evidence suggests that the endocannabinoid system plays a pathophysiological role in schizophrenia. This is reflected by elevated cerebrospinal levels of the endocannabinoid anandamide in schizophrenia and its initial prodromal states.Methods: We analyzed plasma concentrations of anandamide, 2-arachidonoyl-sn-glycerol, palmitoylethanolamide and oleoylethanolamide from 25 twin pairs discordant for schizophrenia, six discordant for bipolar disorder and eight healthy twin pairs to determine hereditary traits.
Results: Twin pairs discordant for schizophrenia or bipolar disorder had significantly higher levels of anandamide and palmitoylethanolamide compared to healthy twins (both P < 0.002). Non-affected twins discordant for schizophrenia, who developed a psychotic disorder within 5 years follow-up showed lower anandamide (P = 0.042) and 2-arachidonoyl-sn-glycerol levels (P = 0.049) than twins who remained healthy.
Conclusions: We suggest that the protective upregulation of endocannabinoid signalling reflects either a hereditary trait or mirrors a modulating response to genetically influenced cerebral function involving, e.g., other neurotransmitters or energy metabolism.
Posted by undopaminergic on March 5, 2020, at 3:11:02
In reply to Re: Medicines/Supplement that might help 4 coronavirus, posted by PeterMartin on March 4, 2020, at 14:28:49
> > > > Palmitoylethanolamide (PEA) ...
> > >
> > > I need to look into this one more. It's bizarre but I came across it a few weeks ago but I can't remember why. At first I thought it was the other PEA that you can't take w MAOis. Confusing they have the same abreviation.
> > >
> >
> > Phenylethylamine, yes. You can take it with MAOIs with caution. Its mechanism of action is the same as for amphetamines.
> >
> > -undopaminergic
> >
> >
>
> Right but this is a -different- PEA. It's not phenylalanine it's Palmitoylethanolamide. Both are abbreviated PEA.
>I realised that much.
Phenylethylamine, not phenylalanine, the latter is the precursor.
-undopaminergic
Posted by Hugh on March 5, 2020, at 14:02:19
In reply to Medicines/Supplement that might help 4 coronavirus, posted by PeterMartin on March 3, 2020, at 13:15:00
> Anyone else have any recollection of medicines or supplements they've taken that may have had antiviral or prolung properties?
Specialized pro-resolving mediators (SPMs). This is a new supplement. I like it a lot. It's an anti-inflammatory that resolves inflammation rather than blocking it.
https://www.lifeextension.com/magazine/2019/ss/resolve-and-repair-inflammatory-damage
17-HDHA is one of the ingredients in the SPMs capsule I take. It enhances the immune response against the influenza virus.
https://www.ncbi.nlm.nih.gov/pubmed/25392529
SPMs are prolung. They're being investigated as a treatment for chronic inflammation and infection in cystic fibrosis.
https://www.frontiersin.org/articles/10.3389/fphar.2019.00252/full
The kind I take is "Pro-Resolving Mediators" from https://www.lifeextension.com
Here are some other brands:
https://thegreenpharmacy.com
As "SPM Complete"https://www.nhc.com
As "PRM Resolve"https://www.metagenics.com
As "SPM Active"
Posted by PeterMartin on March 5, 2020, at 18:14:14
In reply to Re: Medicines/Supplement that might help 4 coronavirus, posted by Hugh on March 5, 2020, at 14:02:19
Thanks Hugh for that suggestion. Looking into it.
Does it have any effect on mood? Do you think it would be contradicted w/ any common psych meds?
Looks to be related to EPA in fish oil is that right?
Posted by alexandra_k on March 5, 2020, at 21:51:34
In reply to Re: Medicines/Supplement that might help 4 coronavirus, posted by PeterMartin on March 5, 2020, at 18:14:14
Lots of suggestions, here.
The Journal Nature is making Coronavirus research freely available.
Posted by Hugh on March 6, 2020, at 13:08:24
In reply to Re: Medicines/Supplement that might help 4 coronavirus, posted by PeterMartin on March 5, 2020, at 18:14:14
You're welcome. I don't know of any contraindications with psyche meds, but specialized pro-resolving mediators haven't been available for very long. You might try taking it every other day or every third day in the beginning to see how it affects you. I can feel the effects of one capsule for over 48 hours.
You're right, it is derived from fish oil. But it's far more effective than any fish oil I've ever tried, and I've tried a lot. It does elevate my mood.
This is where I order it:
https://www.lifeextension.com/search#q=pro-resolving%20mediators&t=coveo4A2453FD
You should use one of these discount codes at checkout:
https://www.coupons.com/coupon-codes/life-extension/
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Dr. Bob is Robert Hsiung, MD,
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