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Re: self-destructive behaviours, please read! omega man

Posted by turalizz on June 17, 2002, at 5:50:08

In reply to Re: self-destructive behaviours, please read! turalizz, posted by omega man on June 16, 2002, at 19:45:24

> its the distraction..the rush of the headlong risk..which is something your body gets physically addicted to..whether jumping of cliff with a parachute or trying to push the brain to some out there intellectual nugget...
>
> From what I know the more you push your andrenalin system the bigger the risk you need the next time...also I read that the more time you spend stopping these behaviours the more toned down your glands get..so really this school of thought says the only answer is to fight these urges, using CBT type self assesment as you find the impulse hitting you..
>
> its my opinion you can try and get some fruitfull pursuit where you can run rampant on andrenaline all the time..I did hockey..which is great fun..eveything is on the edge all the time..thats why you can only shift for about a minute..one good game a week keeps you straight and keeps the craziness in that place..but I wrecked my body and i'm only 35...
>
> I'm not sure If I go for the relaxation program..its a real strain...but if you choose the crazy route just make sure its a sustainible one for your mind and body..

Thanks a lot. I found the article below, which I assume to be related to my situation:

Reward deficiency syndrome:
genetic aspects of behavioral disorders
by
Comings DE, Blum K
Department of Medical Genetics,
City of Hope Medical Center,
Duarte, CA 91010, USA.
dcomings@earthlink.net
Prog Brain Res 2000; 126:325-41

ABSTRACT
The dopaminergic and opioidergic reward pathways of the brain are critical for survival since they provide the pleasure drives for eating, love and reproduction; these are called 'natural rewards' and involve the release of dopamine in the nucleus accumbens and frontal lobes. However, the same release of dopamine and production of sensations of pleasure can be produced by 'unnatural rewards' such as alcohol, cocaine, methamphetamine, heroin, nicotine, marijuana, and other drugs, and by compulsive activities such as gambling, eating, and sex, and by risk taking behaviors. Since only a minority of individuals become addicted to these compounds or behaviors, it is reasonable to ask what factors distinguish those who do become addicted from those who do not. It has usually been assumed that these behaviors are entirely voluntary and that environmental factors play the major role; however, since all of these behaviors have a significant genetic component, the presence of one or more variant genes presumably act as risk factors for these behaviors. Since the primary neurotransmitter of the reward pathway is dopamine, genes for dopamine synthesis, degradation, receptors, and transporters are reasonable candidates. However, serotonin, norepinephrine, GABA, opioid, and cannabinoid neurons all modify dopamine metabolism and dopamine neurons. We have proposed that defects in various combinations of the genes for these neurotransmitters result in a Reward Deficiency Syndrome (RDS) and that such individuals are at risk for abuse of the unnatural rewards. Because of its importance, the gene for the [figure: see text] dopamine D2 receptor was a major candidate gene. Studies in the past decade have shown that in various subject groups the Taq I A1 allele of the DRD2 gene is associated with alcoholism, drug abuse, smoking, obesity, compulsive gambling, and several personality traits. A range of other dopamine, opioid, cannabinoid, norepinephrine, and related genes have since been added to the list. Like other behavioral disorders, these are polygenically inherited and each gene accounts for only a small per cent of the variance. Techniques such as the Multivariate Analysis of Associations, which simultaneously examine the contribution of multiple genes, hold promise for understanding the genetic make up of polygenic disorders.


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